Clinical Trials on Corneal Toxicity

Total 2564 results

Laboratoires Thea
Samil Pharmaceutical Co., Ltd.

Completed

Evaluation of the Effect and Tolerance of Preservative Free NAAGA on the Inflammatory Component and Symptoms of Dry Eye Syndrome in Allergic Conjunctivitis Patients

Allergic Conjunctivitis

Korea, Republic of
Santen SAS

Completed

Double-Masked Trial of NOVA22007 (Ciclosporin 0.1%) Versus Vehicle in Patients With Moderate to Severe Dry Eye Syndrome

Moderate to Severe Dry Eye Syndrome

France
Rigshospitalet, Denmark

Completed

Treatment With Allogeneic Adipose-derived Mesenchymal Stem Cells in Patients With Aqueous Deficient Dry Eye Disease (MESADDE)

Dry Eye | Kerato Conjunctivitis Sicca | Aqueous Tear Deficiency

Denmark
InMode MD Ltd.

Completed

Clinical Evaluation of Safety and Efficacy of Radio Frequency (Forma Eye) Treatment for Dry Eye Disease Due to Meibomian Gland Dysfunction

Improvement of Dry Eye Disease

United States
Massachusetts Eye and Ear Infirmary

Terminated

The Prophylactic Use of Topical Cyclosporine A 0.05% to Prevent Graft Versus Host Disease Related Dry Eye

Dry Eye

United States
Sylentis, S.A.

Completed

Pilot Study to Evaluate SYL1001 Safety and Effect in Patients With Ocular Pain

Ocular Pain | Dry Eye Syndrome

Spain
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Liposomal Doxorubicin for Cancer

Breast Cancer | Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cavity Cancer | Endometrial Cancer | Drug/Agent Toxicity by Tissue/Organ

United States
Bausch & Lomb Incorporated

Completed

Perfluorohexylcotane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction (Gobi Study)

Dry Eye Disease (DED)

United States
Alcon Research

Completed

Comparison Between iLux and LipiFlow in the Treatment of Meibomian Gland Dysfunction (MGD): A 12-month, Multicenter Study

Meibomian Gland Dysfunction | Evaporative Dry Eye Disease

United States
The Cleveland Clinic

Unknown

Combination Chemotherapy Plus Amifostine in Treating Patients With Advanced Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Unspecified Adult Solid Tumor, Protocol Specific | Multiple Myeloma and Plasma Cell Neoplasm | Precancerous Condition | Drug/Agent Toxicity by Tissue/Organ

United States
Eyedetec Medical, Inc.

Completed

Clinical Study Using Eye Lipid Mobilizer (ELM) With Heat and Vibration To Treat Evaporative Dry Eye Disease (ELM)

Meibomian Gland Dysfunction | Evaporative Dry Eye Disease

United States
Instituto Universitario de Oftalmobiología Aplicada...

Completed

Effect of Thermal Pulsation System (Lipiflow) Treatment for Ocular Surface Disease Due to Meibomian Gland Dysfunction

Evaporative Dry Eye Disease

Spain
University of Waterloo
Allergan

Completed

Pilot Study on the Use of Artificial Tears to Treat Dry Eye in Glaucoma Patients (IVES)

Glaucoma | Dry Eyes

Canada
Guizhi Du

Recruiting

The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved

Colorectal Cancer Metastatic | Survival Rate | General Anesthetics Toxicity | Lymphocyte Destruction | Molecular Mechanism of Pharmacological Action

China
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Rituximab, Bendamustine Hydrochloride, and Bortezomib Followed by Rituximab and Lenalidomide in Treating Older Patients With Previously Untreated Mantle Cell Lymphoma

Lymphoma | Neurotoxicity | Therapy-related Toxicity

United States, Canada
Michael Bau Mortensen

Completed

Treatment of Peritoneal Carcinomatosis With Pressurized IntraPeritoneal Aerosol Chemotherapy - (PIPAC-OPC2)

Quality of Life | Peritoneal Neoplasms | Chemotherapy Effect | Chemotherapeutic Toxicity | Peritoneal Metastases | Peritoneum; Carcinomatosis | Histologic Progression

Denmark
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, II, or IIIA Breast Cancer Undergoing Chemo

Breast Cancer | Fatigue | Neurotoxicity | Neuropathy | Chemotherapeutic Agent Toxicity

United States
Daiichi Sankyo, Inc.

Completed

Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer

Head and Neck Cancer | Radiation Toxicity | Oral Complications

United States
University of California, San Francisco
Hoffmann-La Roche

Terminated

Nicotine Patches in Reducing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine For Metastatic Breast Cancer

Breast Cancer | Palmar-plantar Erythrodysesthesia | Chemotherapeutic Agent Toxicity

United States
Ophthalmic Consultants of Long Island
Allergan

Completed

Diurnal Variation in Tear Osmolarity

Dry Eye Disease

United States
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical...

Recruiting

Diadenosine Polyphosphates and Mucin Associated With Ocular Surface Disorders

Dry Eye Syndromes | Graft Vs Host Disease | Superior Limbic Keratoconjunctivitis

Taiwan
University of Alabama at Birmingham
Shire

Withdrawn

Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease

Ocular Inflammation | Dry Eye | Keratoconjunctivitis Sicca | Contact Lens Complication | Ocular Discomfort
Peking Union Medical College

Unknown

Observation on the Herpes Simplex Keratitis (OHSV)

Keratitis, Herpetic

China
University Hospital, Clermont-Ferrand

Completed

Dry Eye Syndrome Description During Cataract Surgery, With Multimodal Analysis of the Ocular Surface (C-SS0)

Dry Eye Syndrome | Ocular Surface Disease

France
Protherics Medicines Development Limited
Resonance Health

Recruiting

Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate

Acute Kidney Injury | Drug Toxicity

Spain, France, Italy
Nova Scotia Health Authority
Canadian Institutes of Health Research (CIHR); Canadian Cancer Society (CCS)

Recruiting

Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2) (EXACT 2)

Cardiovascular Diseases | Cardiotoxicity | Cancer, Breast

Canada
The People's Hospital of Leshan
Jiangsu HengRui Medicine Co., Ltd.

Unknown

A Study of Apatinib Treatment in for Advanced Ovarian Cancer

Ovarian Cancer | Chemotherapeutic Toxicity

China
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

SWOG-9342 Chemotherapy in Treating Women Enrolled in the SWOG-8897 Clinical Trial

Breast Cancer | Cardiac Toxicity

United States
Cancer Trials Ireland

Completed

CADY Study ICORG 08-01

Breast Cancer | Cardiac Toxicity

Ireland
Texas Tech University
National Cancer Institute (NCI); American Cancer Society, Inc.

Completed

Selenium in the Treatment of Arsenic Toxicity and Cancers (SETAC)

Arsenical Melanosis | Arsenical Keratosis | Arsenical Cancers | Arsenicosis | Arsenic Exposure | Arsenic Toxicity | Arsenic Poisoning

Bangladesh
Direction Centrale du Service de Santé des Armées

Recruiting

Preventive TREatment of Dry Eye in Patients Receiving Repeated Intravitreal Injections for Age-related Macular Degeneration (TREDIA)

Age-Related Macular Degeneration | Dry Eye Syndromes

France
National Taiwan University Hospital

Completed

Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries

Diabetic Retinopathy | Corneal Epithelial Defect | Penetrating Keratoplasty

Taiwan
Sun Yat-sen University

Recruiting

Induction Immuno-chemotherapy and Concurrent Chemoradiotherapy With or Without Apatinib in Unresectable, Locally Advanced Esophageal Squamous Cell Carcinoma

Efficacy | Toxicity | Esophageal Squamous Cell Carcinoma

China
Center for Vascular Pathology, Moscow

Enrolling by invitation

The Efficacy and Safety of Beta-blockers Drugs in Adults With Spinal Hemangioma

Spinal Tumor | Spinal Hemangioma | Beta Blocker Toxicity

Russian Federation
Zhejiang Cancer Hospital

Unknown

Rituximab Combined With Chidamide and Lenalidomide for r/r AITL (AITL)

Angioimmunoblastic T-cell Lymphoma | Chemotherapy Effect | Chemotherapeutic Toxicity

China
First Affiliated Hospital of Kunming Medical University

Recruiting

Clincal Study of Reduced Target Radiotherapy in Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma | Toxicity Due to Radiotherapy

China
Ulla Schierup Nielsen
Central Denmark Region; Mental Health Services in the Capital Region, Denmark; North Denmark Region

Recruiting

PROSA: Prolactin, Sex Hormones, Growth and Metabolic Biomarkers in Children and Adolescents on Antipsychotics (PROSA)

Metabolic Syndrome | Growth Disorders | Hyperprolactinemia | Puberty Disorders | Antipsychotics and Neuroleptics Toxicity

Denmark
Massachusetts General Hospital
University of Colorado, Denver; Mayo Clinic; National Heart, Lung, and Blood... and other collaborators

Recruiting

Genetics of QT Prolongation With Antiarrhythmics (DOFEGEN)

Long QT Syndrome | Drug Toxicity

United States
Air Force Military Medical University, China

Completed

GP VS TP in the Treatment of Advanced Nasopharyngeal Carcinoma in Northwest China

Toxicity Due to Radiotherapy | Nasopharyngeal Squamous Cell Carcinoma

China
Novartis Pharmaceuticals

Completed

A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease

Dry Eye

United States
Shenzhen Hospital of Southern Medical University

Unknown

Study on Prevention and Treatment of Dry Eye in Patients Using Glaucoma Drops

Dry Eye | MGD-Meibomian Gland Dysfunction

China
Meir Medical Center

Unknown

Three Dimension Tomography of Eye Structures by White Light Imaging Device (3D-WLT)

Healthy Subjects | Moderate to Severe Keratoconjunctivitis Sicca (KCS) | Dry Eye Syndrome (DES)
University of Minnesota

Recruiting

Treatment of LSCD With DM

Limbal Stem-cell Deficiency | Congenital Aniridia

United States
C.O.C. Farmaceutici S.r.l.

Completed

PMCF Study to Evaluate Performance and Safety of "Optrex Double Action Soothing and Lubricating Drops"

Dry Eye | Allergic Conjunctivitis | Dry Eye Disease

Italy
C.O.C. Farmaceutici S.r.l.

Completed

PMCF Study to Evaluate Performance and Safety of "Xanoftal Next"

Dry Eye | Allergic Conjunctivitis | Dry Eye Disease

Italy
Sloan W. Rush, MD

Completed

Corneal Epithelial Stem Cells and Dry Eye Disease

Ocular Inflammation | Dry Eye | Dry Eye Syndromes | Ocular Surface Disease | Blepharitis | Ocular Discomfort

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S1013: Validation of Cancer Questionnaire for Skin Toxicities in Patients With Colorectal Cancer or Lung Cancer Receiving Cetuximab, Panitumumab, or Erlotinib Hydrochloride

Colorectal Cancer | Lung Cancer | Dermatologic Complications | Therapy-related Toxicity

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery

Breast Cancer | Cardiac Toxicity

United States
University of South Florida
National Cancer Institute (NCI)

Completed

Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab

Breast Cancer | Cardiac Toxicity

United States
Menoufia University

Enrolling by invitation

Adverse Effects of Ivermectin Used in Egypt During COVID-19

Covid19 | Drug Toxicity | Drug Side Effect | Ivermectin Poisoning

Egypt

Clinical Trials on Corneal Toxicity

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Drug Interventions

CROs by country

CROs in Uganda

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Drug Interventions

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