Clinical Trials on Deficiency of N-glycanase 1

Total 1021 results

Medical University of South Carolina
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis

Chronic Pancreatitis

United States
Bristol-Myers Squibb

Completed

Bioequivalence Study of Individual Atazanavir and Cobicistat Compared With Atazanavir in Fixed-dose Combination With Cobicistat (Atazanavir)

Human Immunodeficiency Virus Type 1 (HIV-1)

United States
Bristol-Myers Squibb

Completed

Drug Interactions Between Voriconazole and Atazanavir Coadministered as Atazanavir/Ritonavir in Healthy Participants

HIV Infections | Human Immunodeficiency Virus Type 1 (HIV-1)

United States, Netherlands
Kasr El Aini Hospital

Completed

Efficacy of Ultrasound Guided Superficial Cervical Plexus Block for Tracheal Reconstruction Surgery:

Efficiency of Using Ultrasound-guided SCB for Providing Intra and Postoperative Analgesiatracheal Reconstruction Surgery

Egypt
Stockton University
Nova Southeastern University

Completed

The Impact of Exercise on Stress, Fatigue, and Quality of Life in Individuals With Primary Immunodeficiency Disease

Common Variable Immunodeficiency | Hypergammaglobulinemia | Primary Immune Deficiency Disorder | Specific Antibody Deficiency

United States
ANRS, Emerging Infectious Diseases
MSD France

Not yet recruiting

DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infection (ELDORADO)

HIV-1-infection

Brazil, Cambodia, Cameroon, Côte D'Ivoire, France, Mozambique
ST Pharm Co., Ltd.

Recruiting

A Clinical Trial of STP0404 in Treatment-Naïve Adults With HIV-1 Infection

HIV-1-infection

United States
Merck Sharp & Dohme LLC

Completed

Bioavailability of Doravirine (MK-1439) Experimental Nano Formulations in Healthy Adults (MK-1439-046)

Human Immunodeficiency Virus-1 (HIV-1)
King's College London
Guy's and St Thomas' NHS Foundation Trust; Action Medical Research

Recruiting

Developing Advanced Neuroimaging for Clinical Evaluation of Autoimmune Encephalitis (DANCE-AE)

Autoimmune Encephalitis | Anti-N-Methyl-D-Aspartate Receptor Encephalitis

United Kingdom
PepsiCo Global R&D

Unknown

Plant Based Extracts and Cognition (CEOPTB)

Change in Cognitive Function and Fatigue During Extended Performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 Hours Post Consumption | Change in Long Term Declarative Memory at 1, 3 and 6 Hours Post-intervention.

United Kingdom
Aeglea Biotherapeutics

Terminated

A Study of Safety of Weekly Subcutaneous Pegzilarginase in Subjects With Arginase 1 Deficiency

Arginase I Deficiency | Hyperargininemia

Canada
Aeglea Biotherapeutics

Completed

Efficacy and Safety of Pegzilarginase in Patients With Arginase 1 Deficiency

Arginase I Deficiency | Hyperargininemia

United States, Italy, Canada, France, United Kingdom, Austria, Germany
University Hospital, Basel, Switzerland
University Hospital, Zürich; University Hospital Freiburg; Krebsforschung Schweiz... and other collaborators

Recruiting

177Lu-PP-F11N for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer. (Lumed)

Thyroid Cancer, Medullary | Neuroendocrine Tumor of the Lung Grade 1 and 2 | Neuroendocrine Tumor of the Thymus Grade 1 and 2 | Neuroendocrine Tumor GEP Grade 1-3

Switzerland
Great Ormond Street Hospital for Children NHS Foundation...

Recruiting

Lentiviral Gene Therapy for p47 AR-CGD

P47-Phox, Deficiency of

United Kingdom
University of Calgary
Workers' Compensation Board, Alberta

Active, not recruiting

Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction

Anterior Cruciate Ligament Rupture | Anterior Cruciate Ligament Injury | Chronic Instability of Knee | Deficiency of Anterior Cruciate Ligament

Canada
ONY

Suspended

Administration of Surfactant Through an Instillation Device Infasurf® (Calfactant) in Neonates- A Pilot Study

Chronic Lung Disease | RDS of Prematurity | Surfactant Protein B Deficiency

United States
Pharvaris Netherlands B.V.

Completed

Dose-ranging Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema (RAPIDe-1)

Hereditary Angioedema | Hereditary Angioedema Type I | Hereditary Angioedema Type II | Hereditary Angioedema Types I and II | Hereditary Angioedema Attack | Hereditary Angioedema With C1 Esterase Inhibitor Deficiency | Hereditary Angioedema - Type 1 | Hereditary Angioedema - Type 2 | C1 Esterase Inhibitor... and other conditions

Bulgaria, United States, Spain, Israel, Germany, Canada, Czechia, France, Hungary, Italy, Netherlands, Poland, United Kingdom
Children's Hospital of Fudan University

Recruiting

Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM

Immunologic Deficiency Syndromes | Diabetes Mellitus, Type 1

China
Pharvaris Netherlands B.V.

Active, not recruiting

Dose-ranging Study of Oral PHA-022121 for Prophylaxis Against Angioedema Attacks in Patients With Hereditary Angioedema Type I or Type II (HAE CHAPTER-1)

Hereditary Angioedema | Hereditary Angioedema Type I | Hereditary Angioedema Type II | Hereditary Angioedema Types I and II | Hereditary Angioedema Attack | Hereditary Angioedema With C1 Esterase Inhibitor Deficiency | Hereditary Angioedema - Type 1 | Hereditary Angioedema - Type 2 | C1 Esterase Inhibitor... and other conditions

United States, Poland, Germany, Austria, Bulgaria, Canada, Ireland, Italy, United Kingdom
CSL Behring

Completed

Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency

Emphysema | Alpha1-proteinase Inhibitor Deficiency

Australia, Russian Federation, United States, Denmark, Estonia, Finland, Germany, Ireland, Poland, Romania, Sweden, Canada, Czech Republic
Grifols Therapeutics LLC

Terminated

Study of Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects With New-Onset Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

United States
IVI Madrid

Withdrawn

Differences in Ovarian Reserve Markers and Vitamin D Between Infertile Indian, Arabian and Caucasian Population

Vitamin D Deficiency | Hormone Deficiency | Female Infertility Due to Diminished Ovarian Reserve | Follicular Cyst of Ovary

Spain
University of Ulm

Completed

Early Versus Late Enteral Iron in Infants Less Than 1301 Grams

Iron Deficiency | Anemia of Prematurity

Germany
Gilead Sciences

Completed

Effectiveness, Safety, Adherence, and Health-related Quality of Life in HIV-1 Infected Adults Receiving Bictegravir/ Emtricitabine/Tenofovir Alafenamide (BIC-STaR)

HIV-1-infection

Canada
Kirby Institute
Gilead Sciences; Melanoma Institute Australia; St Vincent's Hospital, Sydney; Royal... and other collaborators

Active, not recruiting

Coronavirus (COVID-19) Outcomes Registries in Immunocompromised Individuals Australia (CORIA) (CORIA)

COVID-19 | Cancer | Primary Immune Deficiency Disorder | HIV-1-infection | Immunosuppression Disorders

Australia
Occyo GmbH
University Clinic for Ophthalmology and Optometry- Salzburg

Completed

CDL Validation Study

Limbal Stem-cell Deficiency | Cornea Disease | Eyes Dry Chronic | Chronic Conjunctivitis of Both Eyes | Eye Lesion | Eye Disease; Cataract | Eyes Dry Feeling of | Cornea Inflamed | Cornea; Injury, Abrasion | Cornea Infection

Austria
McGill University
Global Affairs Canada; World Vision Canada

Not yet recruiting

Evaluation of REACTS-IN, an Intervention to Improve Nutrition, Hygiene, and Sexual and Reproductive Health Services (REACTS-IN)

Stunting | Diet; Deficiency | Empowerment | Acceptability of Health Care | Gender Equality

Bangladesh, Kenya, Tanzania
Klinikum Lüdenscheid

Completed

Quality of Life After Interventional Thyroid Treatment (DSR)

Quality of Life | Thyroid; Deficiency

Germany
National Institute of Allergy and Infectious Diseases...

Recruiting

A Trial of Anti-CD4 Antibody UB-421 in Combination With Optimized Background Antiretroviral Therapy in Patients With Multi-Drug Resistant HIV-1 Infection

Multi-Drug Resistant Hiv-1 Infection | HIV-1 Infection

United States
University of Ulm

Completed

Neurodevelopment After Early Iron Supplementation

Iron Deficiency | Neurodevelopmental Delay | Anemia of Prematurity

Germany
Johann Wolfgang Goethe University Hospital

Withdrawn

Functional Improvement of Progenitor Cells and Endothelial Function by Vildagliptin in Diabetes Mellitus (FINNjA-DM). (FINNjA-DM)

SDF-1 is an Important Cytokine for Neovascularization. Cleavage of SDF-1 is Reduced by DPPIV Inhibitors

Germany
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); American Lebanese Syrian Associated Charities...

Recruiting

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Low Grade Glioma (LGG) of Brain With BRAF Aberration | High Grade Glioma (HGG) of the Brain With BRAF Aberration | Low Grade Glioma of Brain With Neurofibromatosis Type 1

United States
Assiut University

Not yet recruiting

Phenotyping of the Out-of-proportion Pulmonary Hypertension

1- Haemodynamic Phenotyping of the Out - of - Proportion PH to Guide Different Therapeutic Lines

Egypt
John Levine
National Cancer Institute (NCI)

Completed

A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD

GVHD | Graft-versus-host-disease

United States
Hospices Civils de Lyon

Recruiting

Psycho-social Impact of Anti-NMDAR Encephalitis (SAPIENCE)

NMDAR Antibody-associated Auto-immune Encephalitis

France
Tel-Aviv Sourasky Medical Center

Unknown

Pregabalin for Post-craniotomy Pain Control

To Assess the Beneficial Preemptive and Preventive Effects of PGL on the Immediate and Late (1- and 3 Months) Postoperative Analgesia Requirements
West China Hospital
First Affiliated Hospital of Chongqing Medical University; Sichuan Cancer Hospital... and other collaborators

Recruiting

Sintilimab Plus Hypofractionated Radiotherapy for MSI-H/dMMR Rectal Cancer

Rectal Cancer | Radiotherapy | Anti-PD-1 Antibody | MSI-H | Mmr Deficiency

China
National Human Genome Research Institute (NHGRI)

Recruiting

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Metabolic Disease | Purine-Pyrimidine Metabolism | AICDA, OMIM *605257, Immunodeficiency With Hyper-IgM, Type 2; HIGM2 | UNG, OMIM *191525, Hyper-IgM Syndrome 5 | NT5C3A<TAB>, OMIM *606224, Anemia, Hemolytic, Due to UMPH1 Deficiency | UMPS, OMIM *613891, Orotic Aciduria | DHODH, OMIM *126064,... and other conditions

United States
University Hospital, Strasbourg, France

Unknown

Diagnostic and Prognostic Value of p16INK4a Expression in Low Grade Squamous Intraepithelial Lesions of the Cervix.

Cervical Intraepithelial Neoplasia Grade 1 (CIN 1)

France
Eva Morava-Kozicz
Children's Hospital of Philadelphia; Seattle Children's Hospital

Not yet recruiting

A Study of GlcNAc on Tear Production in NGLY1-CDDG

NGLY1 Deficiency

United States
Eva Morava-Kozicz

Not yet recruiting

Evaluate Optimal Dosing and Long-term Safety of D-galactose in PGM1-CDG (AVTX-801)

PGM1-CDG - Phosphoglucomutase 1-Related Congenital Disorder of Glycosylation

United States
Hoffmann-La Roche

Completed

An Observational Study to Evaluate Physical Activity, Bleeding Incidence and Health Related Quality of Life, in Participants With Haemophilia A Without Inhibitors Receiving Standard of Care Treatment (POWER)

Haemophilia A | Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor | Severe Hereditary Factor VIII Deficiency Disease Without Inhibitor

Italy
University Health Network, Toronto
Novartis

Completed

Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant

Emphysema | COPD | Alpha-1 Antitrypsan Deficiency

Canada
Myogem Health Company, S.L.

Completed

Effect of MYODM on Quality of Life, Fatigue and Hypersomnia in Patients With Myotonic Dystrophy Type 1

Myotonic Dystrophy 1

Spain
Johns Hopkins Bloomberg School of Public Health
Johns Hopkins University; United States Agency for International Development... and other collaborators

Completed

Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh

Vitamin A Deficiency | Mortality Through Six Months of Age

Bangladesh
Iuliu Hatieganu University of Medicine and Pharmacy

Unknown

Anemia of Inflammation and Deficiency Anemia (AIDA)

Anemia, Iron Deficiency | Anemia of Chronic Disease

Romania
China Medical University Hospital

Unknown

The Related Factors With Resilience in Caregivers Whose Child With Leukemia

Condition 1. Children With ALL Are Still Alive and the Age of 18 Years of Age. | Condition 2. Has Been Completed to Guide the Treatment Regimen Were in Remission. | Condition 3. Caregiver Can or Taiwanese Language Communicator.

Taiwan
Universiti Putra Malaysia
Ministry of Higher Education Malaysia

Recruiting

Vitamin D Deficiency With Selected Vitamin D Receptor Gene Polymorphism in Gestational Hypertension

Vitamin D Deficiency | Hypertensive Disorder of Pregnancy

Malaysia
Ultragenyx Pharmaceutical Inc

Terminated

Study to Assess the Long Term Safety and Efficacy of UX007 in Participants With Glucose Type 1 Deficiency Syndrome (Glut1 DS)

Glucose Transporter Type 1 Deficiency Syndrome

United States, Spain, Denmark, United Kingdom, Australia
Universität des Saarlandes

Completed

Alpha-1-Antitrypsin-Deficiency in COVID-19 (CORSAAR-AAT)

Covid19

Germany

Clinical Trials on Deficiency of N-glycanase 1

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Congo, DR of

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

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