Clinical Trials on Degenerative Diseases, Nervous System

Total 192111 results

Princess Anna Mazowiecka Hospital, Warsaw, Poland
Medical University of Warsaw; Institute of Mother and Child

Recruiting

Targeted vs Standard Fortification of Breast Milk

Weight Gain | BPD - Bronchopulmonary Dysplasia | NEC - Necrotizing Enterocolitis | VLBW - Very Low Birth Weight Infant | ROP - Retinopathy of Prematurity

Poland
Eunice Kennedy Shriver National Institute of Child...

Recruiting

Natural History Study of Patients With Excess Androgen

Congenital Adrenal Hyperplasia (CAH) | Familial Male-Limited Precocious Puberty (FMPP)

United States
UNC Lineberger Comprehensive Cancer Center
AstraZeneca; Celgene

Active, not recruiting

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

Carcinoma, Squamous Cell | Esophageal Cancer | Oral Cancer | Oropharynx Cancer | Larynx Cancer | Lip Cancer

United States
University of Michigan

Terminated

Ultraviolet (UVA and UVB) Light Therapy in the Treatment of Inflammatory Skin Conditions

Psoriasis | Mycosis Fungoides | Atopic Dermatitis | Alopecia | Urticaria | Stretch Marks | Dermatoses

United States
University Medical Centre Ljubljana

Unknown

Skeletal Muscle Oxygenation in Critically Ill

Heart Failure | Sepsis | Septic Shock | Cardiogenic Shock

Slovenia
Università Politecnica delle Marche

Not yet recruiting

Endobronchial Ultrasound Needle Aspiration With and Without Suction

Lymphoma | Lung Neoplasms | Tuberculosis | EGF-R Positive Non-Small Cell Lung Cancer | Sarcoidosis | Mediastinal Lymphadenopathy | Hilar Lymphadenopathy | ROS1 Gene Mutation | PDL1 Gene Mutation | ALK Translocation

Italy
Dana-Farber Cancer Institute
Genentech, Inc.

Terminated

A Study of Alectinib in RET-rearranged Non-small Cell Lung Cancer or RET-mutated Thyroid Cancer

ALK-positive Non-small Cell Lung Cancer (NSCLC) | RET-positive Non-small Cell Lung Cancer (NSCLC) | RET-positive Thyroid Cancer

United States
University Hospital, Geneva

Terminated

Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery

Surgery | Severe Sepsis | Emergency

Switzerland
Amsterdam UMC, location VUmc

Completed

Experimental Determination of Atot en Ka in the Critically Ill

Sepsis | CABG

Netherlands
Virginia Commonwealth University

Completed

Ascorbic Acid (Vitamin C) Infusion in Human Sepsis

Sepsis | Septic Shock | Hypotension | Acute Lung Injury

United States
Shanghai Jiao Tong University School of Medicine

Recruiting

Treatment of Advanced Endocrine Tumor With Iindividualized mRNA Neoantigen Vaccine (mRNA-0523-L001)

Medullary Thyroid Cancer | Pancreatic Neuroendocrine Tumor | Adrenal Cortical Carcinoma | Thymic Neuroendocrine Carcinoma

China
Sun Yat-sen University
Hutchmed

Recruiting

Pamiparib Plus Surufatinib in Patients With Platinum-resistant Ovarian Cancer

Ovarian Cancer | Platinum-resistant Ovarian Cancer | Primary Peritoneal Cancer | Ovarian Carcinoma | Fallopian Tube Carcinosarcoma

China
Indiana University
University of California, San Francisco; Indiana Clinical and Translational... and other collaborators

Completed

Compression Therapy for Leg Ulcers and Kaposi Sarcoma in Western Kenya

Kaposi Sarcoma | HIV/AIDS and Infections | Chronic Leg Ulcer

Kenya
Ariad Pharmaceuticals

Completed

A Study of Ponatinib in Japanese Participants With Chronic Myeloid Leukemia (CML) and Ph+ Acute Lymphoblastic Leukemia (ALL)

Chronic Myeloid Leukemia (CML) | Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

Japan
Ariad Pharmaceuticals

Approved for marketing

Expanded Access Program of Ponatinib

Chronic Myeloid Leukemia (CML) | Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

United States
St. Jude Children's Research Hospital
Genzyme, a Sanofi Company

Completed

A Pediatric Study of a Plerixafor Containing Regimen In Second Allogeneic Stem Cell Transplantation

Acute Myeloid Leukemia | Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia | Myelodysplastic Syndrome

United States
Shen Lei

Not yet recruiting

Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI

Sepsis

China
Cantonal Hospital Zenica

Completed

Euthyroid Sick Syndrome in Septic Shock

Septic Shock

Bosnia and Herzegovina
HaEmek Medical Center, Israel

Completed

The Correlation Between The New Sepsis Scores - SOFA, Quick SOFA and Calibrated Automated Thrombogram Values

Sepsis | Coagulopathy

Israel
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Unknown

Gut Microbiome Dysbiosis in Sepsis-induced Coagulopathy

Sepsis

China
University Hospital, Motol
Charles University, Czech Republic

Completed

Thromboelastometry in Assessment of Sepsis Coagulopathy

Sepsis | Thrombelastography
George A. Kaysen, M.D.
Beth Israel Medical Center

Terminated

The Effect of Thalidomide in Suppression of the Systemic Inflammatory Response Syndrome in Hemodialysis Patients (ICM)

Hypoalbuminemia

United States
University of British Columbia

Completed

Predicting Complications in Women With Toxaemia

Toxemia

United Kingdom, Canada, New Zealand
University of Versailles
Assistance Publique - Hôpitaux de Paris

Completed

Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock (COIITSS)

Septic Shock

France
University of California, San Francisco
National Institute of Dental and Craniofacial Research (NIDCR)

Not yet recruiting

People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity

HIV Infections | Oropharyngeal Squamous Cell Carcinoma | Oral Squamous Cell Carcinoma

United States
MuReva Phototherapy Inc.

Active, not recruiting

Photobiomodulation to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Head & Neck Cancer Patients

Head and Neck Cancer | Oral Mucositis (Ulcerative) | Oral Mucositis (Ulcerative) Due to Radiation | Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy

United States
Dana-Farber Cancer Institute
Eli Lilly and Company

Withdrawn

ERK 1/2 Signaling in Ibrutinib Resistant B-cell Malignancies

Waldenstrom Macroglobulinemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia
Masonic Cancer Center, University of Minnesota

Terminated

Reduced Intensity Conditioning and Haploidentical Related Bone Marrow for Patients With Hematologic Diseases

Chronic Myelogenous Leukemia | Acute Leukemias | Burkitt's Lymphoma

United States
Timmune Biotech Inc.
Hunan Provincial People's Hospital

Unknown

Treatment of Hematological Malignancy With Novel CAR-T Cells.

Multiple Myeloma | B-cell Acute Lymphoblastic Leukemia | B-cell Non Hodgkin Lymphoma

China
King Abdullah International Medical Research Center

Completed

Effect of Tahneek on Hypoglycemia in Newborn Infants (THIN)

Intrauterine Growth Restriction | Premature Infant | Infant, Small for Gestational Age | Neonatal Hypoglycemia | Macrosomia, Fetal | Neonatal; Hypoglycemia, Diabetes, Maternal

Saudi Arabia
University of Michigan Rogel Cancer Center
National Institutes of Health (NIH); National Center for Advancing Translational...

Recruiting

Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

Follicular Lymphoma | Myelodysplastic Syndromes | Hematologic Diseases | Mantle Cell Lymphoma | Non Hodgkin Lymphoma | Diffuse Large B Cell Lymphoma | Graft Vs Host Disease | Acute Leukemia in Remission | Graft-versus-host-disease | Chronic Myelogenous Leukemia - Chronic Phase | Chronic Myelogenous Leukemia... and other conditions

United States
Wellmarker Bio
Merck Sharp & Dohme LLC

Recruiting

Study of WM-A1-3389 in Participants With Advanced or Metastatic Solid Tumors and Non-Small Cell Lung Cancer (MK-3475-E90/KEYNOTE-E90)

Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Lung Cancer | Non Small Cell Lung Cancer | Cholangiocarcinoma | Advanced Solid Tumor | Metastatic Solid Tumor

Korea, Republic of
Center for International Blood and Marrow Transplant...
National Marrow Donor Program; Pediatric Blood and Marrow Transplant Consortium

Active, not recruiting

Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies

Juvenile Myelomonocytic Leukemia | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Myelodysplasia | Acute Lymphoblastic Leukemia/Lymphoma

United States
Walter K. Kraft
Merck Sharp & Dohme LLC

Completed

Doravirine, Rifapentine and Isoniazid Interaction (DORIIS)

Latent Tuberculosis | Human Immunodeficiency Virus | Drug Interaction Potentiation | Rifamycins Causing Adverse Effects in Therapeutic Use

United States
St. Jude Children's Research Hospital
Assisi Foundation

Completed

Pilot Study of Haploidentical Natural Killer Cell Infusions for Poor Prognosis Non-AML Hematologic Malignancies

Non-Hodgkin's Lymphoma | Juvenile Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome | Chronic Myelogenous Leukemia

United States
Shanghai Changzheng Hospital

Not yet recruiting

Treating Donors With Intravenous Immunoglobulin to Reduce Donor-Derived Infections

Bacteremia | Viremia | Acute Rejection of Renal Transplant
AIMST University Malaysia
Putra Medical Centre, Malaysia; Twin Catalyst Sdn Bhd, Malaysia

Completed

Umbilical Cord Care in Term Neonates: The Role of Wondaleaf Adhesive Pouch (WLAP)

Neonatal Sepsis | Umbilical Cord Infection | Umbilical Sepsis

Malaysia
Policlinico Hospital
Eli Lilly and Company

Completed

Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock

Septic Shock | Severe Sepsis

Italy
University of Athens

Unknown

Reactivation of CMV Infection in Immunocompetent Patients Under Severe Stress (RECYSTRESS)

Stress, Physiological | Cytomegalovirus Viraemia | Receptor, Hormonal; Disorder | Other Deficiency of Cell-mediated Immunity

Greece
Fraser Health
SterileCare Inc.; Center for Health Evaluation & Outcome Services

Recruiting

CLiCK in the Critical Care Unit (CLiCK)

Central Venous Catheter Thrombosis | Catheter Infection | Catheter Complications | Catheter | Catheter Blockage | Catheter Dysfunction | Central Line-associated Bloodstream Infection (CLABSI) | Central Venous Catheter Related Bloodstream Infection

Canada
Xinhua Hospital, Shanghai Jiao Tong University...

Recruiting

Oral Administration or Nasal Feeding of Huzhangxiefei Decoction for Treatment in Sepsis Induced Acute Lung Injury

Sepsis | Acute Lung Injury

China
Nanfang Hospital of Southern Medical University
Peking University People's Hospital; Sun Yat-sen University; Guangzhou First... and other collaborators

Unknown

MSCs With or Without Peripheral Blood Stem Cell for Treatment of Poor Graft Function and Delayed Platelet Engraftment

Hematological Diseases | Stem Cell Transplantation, Hematopoietic | Delayed Platelet Engraftment | Poor Graft Function

China
M.D. Anderson Cancer Center
AstraZeneca; Aravive Biologics Inc

Active, not recruiting

AVB-S6-500 and Durvalumab in Treating Patients With Platinum-Resistant or Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Platinum-Resistant Fallopian Tube Carcinoma | Platinum-Resistant Primary Peritoneal Carcinoma | Platinum-Resistant Ovarian Carcinoma | Refractory Ovarian Carcinoma | Refractory Fallopian Tube... and other conditions

United States
Mater Dei Hospital, Malta
European Society of Intensive Care Medicine; University of Malta

Recruiting

Molecular Endotype-Specific Dynamics of Lung Endothelial Barrier Integrity in Sepsis (MENDSEP)

Pneumonia | Sepsis | Septic Shock

Malta
Southeast University, China

Completed

Effect of Different Strategies for Titrating a High MAP on Microcirculation

Hypertension | Septic Shock

China
Fifth Affiliated Hospital, Sun Yat-Sen University

Recruiting

Thiotepa, Cyclophosphamide, Clarithromycin and Cytarabine (TCCA)

Burkitt Lymphoma | Acute Lymphoblastic Leukemia, Adult | Lymphoblastic Lymphoma, Adult

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI); ADC Therapeutics S.A.

Recruiting

ADCT-602 in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia

Recurrent B Acute Lymphoblastic Leukemia | Refractory B Acute Lymphoblastic Leukemia | Philadelphia Chromosome Positive | Blasts 5 Percent or More of Bone Marrow Nucleated Cells | CD22 Positive

United States
Daiichi Sankyo

Active, not recruiting

Valemetostat Tosylate (DS-3201b), an Enhancer of Zeste Homolog (EZH) 1/2 Dual Inhibitor, for Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01)

Relapsed/Refractory Peripheral T-Cell Lymphoma | Adult T Cell Leukemia/Lymphoma

United States, Spain, Japan, United Kingdom, Korea, Republic of, France, Italy, Australia, Canada, Germany, Netherlands, Taiwan
RedHill Biopharma Limited
Louisiana State University Health Sciences Center in New Orleans; Apogee Biotechnology...

Withdrawn

Early Phase Evaluation of ABC294640 in Patients With Refractory/Relapsed Diffuse Large B-cell Lymphoma or Kaposi Sarcoma (ABC-102)

Diffuse Large B Cell Lymphoma | Kaposi Sarcoma

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors

Ovarian Cancer | Leydig Cell Tumor | Childhood Germ Cell Tumor

Clinical Trials on Degenerative Diseases, Nervous System

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