Clinical Trials on Deterioration, Clinical in South Africa

Total 73 results

University of KwaZulu
The ELMA Foundation; KwaZulu Natal Department of Health

Completed

An Evaluation of the Effectiveness of e-IMCI Implementation in Primary Health Care Clinics in South Africa.

Primary Health Care | Child Health | Clinical Practice Guidelines

South Africa
Chris Hani Baragwanath Academic Hospital
Masimo Corporation

Completed

Usefulness of Non-invasive Pulse Co-oximetry Haemaglobin Measurements in Critically Ill Black Patients

Critically Ill Black Patients

South Africa
University of Stellenbosch
Fresenius Kabi

Recruiting

Effect of Combined IV Bolus Amino Acid Supplementation and Mobilisation on Muscle Mass in Patients Over the First Week of ICU Care: RCT

Critical Illness

South Africa
University of Cape Town
National Institute of Mental Health (NIMH)

Completed

Task Sharing Counseling Intervention by Community Health Workers for Prenatal Depression in South Africa (AFFIRM-SA)

Postpartum Depression | Clinical Depression | Moderate Depression

South Africa
Advanced Imaging Projects, LLC
All India Institute of Medical Sciences, New Delhi; US Department of Veterans... and other collaborators

Not yet recruiting

Safety and Efficacy of Ga68 Αvβ3 IAC PET/CT for Diagnosis and Clinical Management in Angiogenic Breast Cancer Patients (Shiva)

Diagnosis and Clinical Management of Angiogenic Breast Cancer

South Africa, India
Erasmus Medical Center
Dutch Heart Foundation

Completed

CholGate - The Effect of Alerting Versus on Demand Computer Based Decision Support on Treatment of Dyslipidaemia by General Practitioners

Decision Support Systems, Clinical

Netherlands
The George Institute for Global Health, Australia

Completed

The Fluid Translation of Research Into Practice Study (Fluid-TRIPS)

Critical Care, Fluid Resuscitation

Australia
R3 Vascular Inc.

Recruiting

Evaluation of the MAGNITUDE® Bioresorbable Drug-Eluting Scaffold in the Treatment of Patients With Below the Knee Disease in Australia (MAGNITUDE-BTK)

Critical Limb Ischemia | Critical Lower Limb Ischemia | Critical Limb-Threatening Ischemia

Australia
Australian and New Zealand Intensive Care Research...
Baxter Healthcare Corporation

Active, not recruiting

Intensive Nutrition in Critically Ill Adults (INTENT)

Critical Illness | Critically Ill

Australia, New Zealand
South West Sydney Local Health District

Completed

Fluid Responsiveness After CArdiac Surgery Study (FRACAS)

Critically Ill | Hypovolemia

Australia
Takeda
Theravance Biopharma

Completed

A Randomized, Double-Blind Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of a Single Dose of Intravenous TD-8954 Compared With Metoclopramide in Critically Ill Patients With Enteral Feeding Intolerance

Enteral Feeding Intolerance

Australia
Applied Physiology Pty Ltd
Trident Clinical Research Pty Ltd

Completed

Registration Enabling Study of the Safety and Efficacy of the Use of the Navigator Circulatory Management System (NAV-1)

Critical Illness | Intensive Care

Australia
National Cancer Institute (NCI)

Suspended

Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery

Esophageal Adenocarcinoma | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Gastroesophageal Junction Adenocarcinoma | Clinical Stage II Esophageal Adenocarcinoma AJCC v8 | Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IVA Esophageal Adenocarcinoma... and other conditions

United States
Amgen

Completed

Registry Study for Talimogene Laherparepvec

Any Tumor Type Eligible for Treatment With Talimogene Laherparepvec in Amgen or BioVEX-sponsored Clinical Trial

Canada, Spain, United States, Germany, Austria, France, Greece, Hungary, Italy, Korea, Republic of, Poland, Russian Federation, South Africa, Switzerland, United Kingdom
Hasanuddin University

Completed

High Protein Formula on Enteral Feeding in Clinical Improvement and Malnutrition at Intensive Care Unit Patients

Critically Ill | Intensive Care Unit

Indonesia
The George Institute
National Health and Medical Research Council, Australia; University of British... and other collaborators

Completed

Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE - SUGAR STUDY)

Hyperglycemia | Critical Illness

Australia
Erasmus Medical Center

Completed

Music for Anxiety in Critically Ill Patients (RELACS)

Anxiety

Netherlands
Australian and New Zealand Intensive Care Research...

Active, not recruiting

INTENT-Muscle (A Sub-study of INTENT)

Critically Ill

Australia, New Zealand
GlaxoSmithKline

Completed

Evaluation of Single Doses of GSK962040 in Critically Ill Patients With Enteral Feed Intolerance

Gastroparesis

Australia
The George Institute

Completed

Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS (FluDReSS)

Septic Shock | Critically Ill

Australia
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastric Cancer AJCC v8 | Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 | Metastatic Gastric Adenocarcinoma | Metastatic Gastroesophageal Junction... and other conditions

United States, Puerto Rico
Australian and New Zealand Intensive Care Research...

Completed

The Augmented Versus Routine Approach to Giving Energy Trial (TARGET)

Critical Illness

Australia, New Zealand
Australian and New Zealand Intensive Care Research...

Recruiting

Indirect Calorimetry Guided Energy Provision in Critically Ill Patients With Obesity (DIRECT)

Obesity | Critical Illness

Australia
Daren K. Heyland
Ministry of Research, Innovation and Science, Ontario; Canadian Foundation...

Completed

PERFormance Enhancement of the Canadian Nutrition Guidelines by a Tailored Implementation Strategy: The PERFECTIS Study (PERFECTIS)

Critically Ill | Intensive Care Unit

Canada, United States
Abbott Medical Devices

Active, not recruiting

LIFE-BTK PK Sub-study

Critical Limb Ischemia (CLI)

Taiwan, United States, Australia
Brigham and Women's Hospital
National Institute of Mental Health (NIMH); Yale University; Orygen

Recruiting

AMP SCZ® Observational Study: PREDICT-DPACC (AMP SCZ)

Psychosis | Remission | Conversion | Clinical High Risk

United States, United Kingdom, Canada, Italy, Australia, Chile, China, Denmark, Germany, Hong Kong, Korea, Republic of, Singapore, Spain, Switzerland
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body

Clinical Stage IV Gastric Cancer AJCC v8 | Metastatic Gastric Adenocarcinoma | Clinical Stage IV Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IVA Gastric Cancer AJCC v8 | Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8 | Clinical... and other conditions

United States
Australian and New Zealand Intensive Care Research...

Recruiting

Bone Loss Prevention With Zoledronic Acid or Denosumab in Critically Ill Adults (BoneZone)

Critical Illness | Osteoporosis

Australia, New Zealand
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery

Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Unresectable Gastroesophageal Junction Adenocarcinoma | Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma... and other conditions

United States
Chantal Kats

Recruiting

External Validation of the Beta-lactam Target Non-attainment (BATMAN) Risk Score in Adult ICU Patients: a Diagnostic Multivariate Predictive Risk Model (BATMAN)

Infection, Bacterial | Beta-lactam Antibiotics | Critical Care | Risk Model | Therapeutic Drug Monitoring

Netherlands
Australian and New Zealand Intensive Care Research...
Monash University; The Alfred; St Vincent's Hospital, Sydney; Royal Prince Alfred... and other collaborators

Completed

Extracorporeal Membrane Oxygenation Physical Training (ECMO-PT)

Extracorporeal Membrane Oxygenation Complication | Critically Ill, Mechanically Ventilated

Canada, Australia
Australian and New Zealand Intensive Care Research...
National Health and Medical Research Council, Australia

Completed

Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients (SPICE III RCT)

Critical Illness and Mechanical Ventilation

Australia, United Kingdom, Italy, New Zealand, Malaysia, Ireland, Switzerland, Saudi Arabia
Millennium Pharmaceuticals, Inc.

Terminated

TAK-954 in Critically Ill Participants With Enteral Feeding Intolerance (EFI)

Critical Illness | Enteral Nutrition | Enteral Feeding Intolerance

United States, Canada, Australia, United Kingdom
Australian and New Zealand Intensive Care Research...
National Health and Medical Research Council, Australia; Intensive Care National... and other collaborators

Completed

Treatment of Invasively Ventilated Adults With Early Activity and Mobilisation (TEAM(III))

Critically Ill, Mechanically Ventilated

Australia, New Zealand, United Kingdom, Ireland, Germany
Abbott Medical Devices

Active, not recruiting

LIFE-BTK Randomized Controlled Trial (LIFE-BTK)

Critical Limb Ischemia (CLI)

United States, Hong Kong, Australia, New Zealand, Singapore, Taiwan
LimFlow, Inc.

Completed

PROMISE I Early Feasibility Trial of the LimFlow Stent Graft System

Critical Limb Ischemia

United States
AnGes USA, Inc.

Terminated

Efficacy and Safety of AMG0001 in Subjects With Critical Limb Ischemia (AGILITY)

Critical Limb Ischemia

United States, France, Belgium, Canada, Poland, Finland, Denmark, Netherlands, Hungary, Italy, Sweden
GlaxoSmithKline

Terminated

Nutritional Adequacy Therapeutic Enhancement in the Critically Ill. The NUTRIATE Study

Gastroparesis

Canada, Australia, United States
Australian and New Zealand Intensive Care Research...
National Health and Medical Research Council, Australia; Medical Research Institute... and other collaborators

Enrolling by invitation

The TEAM Long-Term Cohort Study (A Sub-study of TEAM(III))

Critically Ill | Mechanical Ventilation | Long Term Outcome

Australia
McMaster University
National Health and Medical Research Council, Australia; Canadian Institutes... and other collaborators

Completed

Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial (REVISE)

Gastrointestinal Hemorrhage (Clinically Important, Upper)

Canada, Australia, United States, Brazil, Kuwait, Pakistan, Saudi Arabia, United Kingdom
The George Institute
Sunnybrook Health Sciences Centre; Imperial College London

Completed

Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU)

Sepsis | Critical Illness | Septic Shock | Ventilator Associated Pneumonia

Australia, Canada, United Kingdom
National Cancer Institute (NCI)

Active, not recruiting

Testing Treatment With Ipilimumab and Nivolumab Compared to Treatment With Ipilimumab Alone in Advanced Melanoma

Unresectable Cutaneous Melanoma | Unresectable Melanoma | Clinical Stage III Cutaneous Melanoma AJCC v8 | Melanoma of Unknown Primary | Mucosal Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8

United States
National Cancer Institute (NCI)

Active, not recruiting

A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma

Clinical Stage III Cutaneous Melanoma AJCC v8 | Mucosal Melanoma | Acral Lentiginous Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8

United States
Duke University
Johns Hopkins University; National Institutes of Health (NIH); Vanderbilt University... and other collaborators

Terminated

DOSE Trial of Opioid Sparing Effect (DOSE)

Critically Ill | Dexmedetomidine | Mechanical Ventilation Complication

United States
C. R. Bard
Bard Ltd

Completed

Lutonix DCB Versus Standard Balloon Angioplasty for Treatment of Below-The-Knee (BTK) Arteries

Critical Limb Ischemia

United States, Japan, Austria, Canada, Switzerland, Italy, Belgium, Germany
APR Applied Pharma Research s.a.
Cavendish Impact Foundation; Clinigen, Inc.; Nephron Pharmaceuticals, Inc.

No longer available

ZYESAMI (Aviptadil) Intermediate Population Expanded Access Protocol (SAMICARE) (SAMICARE)

Critical COVID-19 With Respiratory Failure

United States
Australian and New Zealand Intensive Care Research...
National Health and Medical Research Council, Australia; The Alfred; National... and other collaborators

Recruiting

The EXCEL Registry of Patients Requiring ECMO

Cardiac Arrest | Critically Ill | Acute Respiratory Failure | Acute Heart Failure

Australia, New Zealand
Australian and New Zealand Intensive Care Research...
The Alfred

Completed

Recovery of Patients From COVID-19 After Critical Illness

COVID-19 | Critical Illness

Australia
National Cancer Institute (NCI)

Active, not recruiting

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

Metastatic Melanoma | Recurrent Melanoma | Unresectable Melanoma | Clinical Stage III Cutaneous Melanoma AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC v8

United States
LimFlow, Inc.

Active, not recruiting

PROMISE II: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia (PROMISE)

Vascular Diseases | Arterial Occlusive Diseases | Peripheral Arterial Disease | Peripheral Vascular Disease | Peripheral Artery Disease | Critical Limb Ischemia | Arterial Disease | Arterial Occlusion | Critical Lower Limb Ischemia | Chronic Limb-Threatening Ischemia | Peripheral Artery Occlusion | Peripheral...

United States, Puerto Rico

Clinical Trials on Deterioration, Clinical in South Africa

Sponsors and Collaborators

Medical Conditions

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CROs in Jordan

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