Clinical Trials on Disease of Lower Digestive Tract in South Africa

Total 8483 results

Bayer

Completed

FREEDOM - First Real-Life Evaluation of Enablex Done in ZA Overactive Bladder Patients During a 3 Months Period (FREEDOM)

Overactive Bladder

South Africa
University of Limpopo

Unknown

Effect of Vitamin D Supplementation in Young South African Children Hospitalized With Acute Lower Respiratory Infection

Pneumonia | Bronchiolitis | Acute Lower Respiratory Tract Infection

South Africa
University of Cape Town

Unknown

Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction

Biliary Stricture | Cancer of the Pancreas | Bile Duct Obstruction, Extrahepatic | Cancer of the Bile Duct

South Africa
Brown University

Completed

Schools Championing Safe South Africa

Prevention or Reduction of HIV Risk Behavior | Prevention or Reduction of Intimate Partner Violence

South Africa
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride

Acute Intermittent Porphyria | Anti-Psychotic | Management of Manifestations of Psychotic Disorders | Treatment of Schizophrenia | Control Nausea and Vomiting | Relief of Restlessness and Apprehension Before Surgery | Adjunct in the Treatment of Tetanus | Control Manifestations of the Manic Type... and other conditions

South Africa
University of Stellenbosch

Recruiting

Host Blood RNA Signatures for Diagnosis of TB (RADIANT)

Tuberculosis | Lower Respiratory Infection

South Africa
Pelvic Floor Research Foundation of South Africa
University of Cape Town

Unknown

To Evaluate the Use of Bioresorbable Tephaflex™ Sling for Stress Urinary Incontinence (Tephaflex)

Stress Urinary Incontinence

South Africa
FHI 360
United States Agency for International Development (USAID); University of Witwatersrand...

Completed

Assessing Preference for 3 Female Condoms: A Comparative Evaluation of the PATH Woman's Condom, FC2 and the Reddy 6

Contraception

South Africa
Centre Hospitalier Universitaire Vaudois
University of Witwatersrand, South Africa; Ecole Polytechnique Fédérale de... and other collaborators

Recruiting

Triage UltraSound in Tb Endemic Regions (TrUST)

Pneumonia | Tuberculosis | Lower Resp Tract Infection

Benin, Mali, South Africa
Icahn School of Medicine at Mount Sinai
Medical University of South Carolina; M.D. Anderson Cancer Center

Recruiting

Screening Women With Prior HPV for Anal Neoplasia (SWAN)

HPV-related Lower Genital Tract Neoplasias | HPV-related Anal Neoplasias | Early Stage Lower Genital Tract Cancers

United States
Nestlé

Terminated

Necrotizing Enterocolitis (Nec) and B. Lactis in Premature Babies

Necrotizing Enterocolitis

South Africa
University of KwaZulu

Completed

Isolated Vascularized Gastric Tube Biliary Enteric Drainage: A Paediatric Case Series Experience.

Biliary Obstruction | Choledochal Cyst

South Africa
AstraZeneca

Completed

Centralized Pan-South African Survey on the Undertreatment of Hypercholesterolaemia (CEPHEUS)

Undertreatment of Hypercholesterolaemia

South Africa
Eastern Virginia Medical School
Gilead Sciences; United States Agency for International Development (USAID); FHI... and other collaborators

Active, not recruiting

Project Engage: Oral PrEP Acceptability

Adherence, Medication | Acceptability of Health Care

South Africa, Zimbabwe
H. Lee Moffitt Cancer Center and Research Institute
Merck Sharp & Dohme LLC

Completed

Preparedness Study - HPV Vaccine

Sexual Transmission of Infection

United States, South Africa
University of Pretoria

Completed

A Randomized Trial Comparing Oxytocin and Oxytocin + Ergometrine for Prevention of Postpartum Haemorrhage at Caesarean Section

Prevention of Post Partum Haemorrhage

South Africa
University of KwaZulu
University of California, San Francisco; Centers for Disease Control and Prevention and other collaborators

Completed

Effectiveness of an HIV-adapted IMCI Training and Supervision Programme for Community Health Workers

Infant Feeding Practices | Prevention of Mother-to-child Transmission of HIV | Antenatal Health Care Utilization | Postnatal Health Care Utilization

South Africa
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

Drug-drug Interaction Study With MDV3100 and a Cocktail of Substrates

Castration Resistant Prostate Cancer (CRPC) | Pharmacokinetics of MDV3100

South Africa
University of Pretoria

Not yet recruiting

Kefazolin Versus Kefazolin Plus Metronidazole to Reduce Postpartum Infection

Prevention of Postpartum Sepsis

South Africa
GRI Bio, Inc.

Terminated

Trial to Examine the Effect of Two Doses of GRI-0621 in Patients With Chronic Liver Disease (GRI-201)

Chronic Liver Disease

South Africa
Council for Scientific and Industrial Research,...
Royal College of Surgeons, Ireland; European Union

Completed

Solar Disinfection of Drinking Water (SODISWATER)

Diarrhea | Dysentery (Bloody Diarrhea)

South Africa
Helen Joseph Hospital
University of Johannesburg; Abbott Point of Care; Lodox Systems (Ltd)

Completed

Early Point-Of-Care Blood Tests, ECG & X-rays in the Emergency Department (EPOC-BEX-ED)

Emergency Medicine | Point-of-Care Testing

South Africa
University of Johannesburg

Completed

The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency

Venous Insufficiency

South Africa
Sanofi Pasteur, a Sanofi Company

Completed

DTaP-IPV-HB-PRP-T Combined Vaccine as a Primary Series and a Second Year of Life Booster in HIV-Exposed Infected and Uninfected Infants

Hepatitis B | Pertussis | Tetanus | Diphtheria | Polio | Human Immunodeficiency Virus Infection

South Africa
University of Pretoria

Completed

Efficacy of Using a Closing Pack to Reduce Postpartum Sepsis

Prevention of Postpartum Sepsis

South Africa
University of Cape Town
King's College London; University of KwaZulu

Completed

Collaborative Care for the Detection and Management of Depression Among Adults Receiving Antiretroviral Therapy in South Africa (COBALT)

Depression | HIV/AIDS | Chronic Diseases of Lifestyle

South Africa
Duke University
The Emmes Company, LLC

Recruiting

Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana (BMS02)

HIV Infections | Lactating Women on Select DOI | Breastmilk Fed Infants of Mothers on Select DOI

South Africa
MedImmune LLC
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Trial To Assess Safety And Efficacy Of Influenza Virus Vaccine, Trivalent, Types A & B, Live Cold-Adapted (CAIV-T) In Adults Aged 60 Years And Older

Influenza

South Africa
University of Cape Town
Karolinska Institutet

Completed

Use of Low Sensitivity Pregnancy Test for Self-assessment of Medical Abortion (m-Assist+)

Completion of Medical Abortion

South Africa
Sanofi

Completed

Efficacy and Safety Study of New Ambroxol Hardboiled Lozenges in Acute Pharyngitis (DELICIOUS)

Pharyngitis

South Africa
DePuy International

Terminated

A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Post-traumatic Arthritis | Congenital Hip Dysplasia | Slipped Capital Femoral Epiphysis | Collagen Disorders | Nonunion of Femoral Fractures

South Africa
Sanofi

Completed

Antibody Persistence in Healthy Children After Primary and Booster DTaP-IPV-Hep B-PRP-T Vaccine or Control Vaccine

Hepatitis B | Whooping Cough | Tetanus | Diphtheria | Poliomyelitis

South Africa
Shin Poong Pharmaceutical Co. Ltd.
Medicines for Malaria Venture

Completed

COVID-19 Treatment in South Africa

COVID-19

South Africa
ImmunityBio, Inc.

Active, not recruiting

COVID-19 Vaccination Using a 2nd Generation (E1/E2B/E3-Deleted) Adenoviral Platform in Healthy South African Adults

Covid19

South Africa
University of the Western Cape

Completed

Interventions for Patients With a Shortened Dental Arch (SDA-RCT)

Anomaly of Dental Arch

South Africa
ImmunityBio, Inc.

Terminated

THEMBA II T-Cell Vaccine: Vaccination With saRNA COVID-19 Vaccines

COVID-19

South Africa
Johns Hopkins University

Completed

Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB

Tuberculosis, Pulmonary

South Africa
Sanofi Pasteur, a Sanofi Company

Completed

Comparison of DTaP-IPV-Hep B-PRP~T Combined Vaccine to CombAct-HIB® Concomitantly Given With Engerix B® Paediatric and OPV

Hepatitis B | Pertussis | Diphtheria | Polio | Haemophilus Influenzae Type b

South Africa
University of Virginia
University of Venda

Active, not recruiting

Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa

Environmental Exposure | Diarrhoea;Infectious;Presumed | Diarrhea, Infantile | Diarrhea Tropical | Enteropathy | Malnutrition, Child

South Africa
The Aurum Institute NPC
Johns Hopkins University; University of California

Completed

Safety Tolerability DDI Short Course Treatment of LTBI Infection With High-dose Rifapentine and Isoniazid or Standard Isoniazid Preventive Therapy in HIV+ Patients (DOLPHIN & DOLPHIN TOO) (IMPAACT4TB)

HIV Infections | Respiratory Tract Infections

South Africa
Harriet Shezi Children's Clinic

Unknown

Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra (RBT)

Children With Confirmed HIV Infection | Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose | Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment

South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); Medical Research Council, South Africa

Active, not recruiting

Siyakhana Peer: Evaluating a Peer Recovery Coach Model to Reduce Substance Use Stigma in South African HIV Care

Substance-Related Disorders | HIV | Substance Use | Substance Use Disorders | Treatment Adherence | Treatment Adherence and Compliance | Stigmatization | Delivery of Health Care | Stigma, Social | Attitude of Health Personnel | Community Health Workers | Health Personnel | Health Personnel Attitude | Health Care Seeking... and other conditions

South Africa
bioLytical Laboratories

Recruiting

Trial of Hepatitis C Self-Testing in the Hands of Untrained Lay Users

Hepatitis C

South Africa
Reig Jofre Group

Completed

Bioequivalence Study of Two Inhalation Formulations Containing Budesonide 200 µg

Allergy

South Africa
GlaxoSmithKline

Completed

Study to Asses DTPw-HBV/Hib at 15-18 Months (m) and Mencevax™ ACW at 24 to 30 m in Primed Subjects

Infections, Meningococcal

South Africa
Chris Hani Baragwanath Academic Hospital

Terminated

High Flow Oxygen Therapy vs Standard Care in Infants With Viral Bronchiolitis

Bronchiolitis, Viral

South Africa
University of KwaZulu
AstraZeneca; Medical Research Council, South Africa

Unknown

Paediatric and Adult African Spirometry II (PAASII)

Lung Diseases

South Africa
Novartis

Completed

A Quality of Life and Safety Study With Pimecrolimus Cream, 1% in Children (Age 2-12 Years) With Atopic Dermatitis

Atopic Eczema

South Africa
University of Witwatersrand, South Africa
University of Colorado, Denver; Emory University; Bill and Melinda Gates Foundation

Completed

Influenza Vaccine Trial in HIV Uninfected Pregnant Women (MatfluHIVneg)

Influenza

South Africa
Bial - Portela C S.A.

Completed

An Open-label, Single-dose, Single-centre Study, Investigating the Pharmacokinetics of BIA 2-093

Epilepsy

South Africa

Clinical Trials on Disease of Lower Digestive Tract in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Gambia

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Rare Diseases

Drug Interventions

Dietary Supplements

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