Clinical Trials on Drug Mechanism

Total 3195 results

Desitin Arzneimittel GmbH
BioPharma Services, Inc

Completed

Bioavailability and Food Effect of Sodium Valproate Minitablets in Healthy Subjects.

Food-drug Interaction

Canada
Sichuan Provincial People's Hospital

Completed

Effective Dose of Remimazolam Combined With Propofol in Painless Gastroscopy

Effect of Drug

China
Il-Yang Pharm. Co., Ltd.

Completed

Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Naproxen, Aceclofenac, Celecoxib and Ilaprazole

Drug Interaction Potentiation

Korea, Republic of
University of Illinois at Chicago
Oregon State University

Completed

Licorice Botanical Dietary Supplements - Metabolism and Safety in Women

Food-drug Interaction

United States
Taipei Veterans General Hospital, Taiwan

Completed

Modeling and Application of Triple Drug Response Surface Models

Pharmacodynamics | Drug Interactions

Taiwan
Tetraphase Pharmaceuticals, Inc.
Department of Health and Human Services

Completed

Safety and Pharmacokinetic (PK) Study to Assess Bronchopulmonary Disposition of IV Eravacycline (TP-434) in Healthy Men and Women (BAL)

Normal Drug Tolerance

United States
University of Illinois at Chicago

Completed

Red Clover Botanical Dietary Supplements - Metabolism and Safety in Women

Food-drug Interaction

United States
Dow University of Health Sciences

Completed

Efficacy of Lidocaine and Xylometazoline Intranasal Spray in Anesthetizing Maxillary Teeth

Effect of Drug

Pakistan
University Hospital Inselspital, Berne
Bayer

Completed

Rivaroxaban Hypericum Trial

Drug Interaction Study

Switzerland
F-star Therapeutics, Inc.
PRA Health Sciences

Completed

A Fixed-Sequence, Drug-Drug Interaction Study Between Multiple Oral Doses of Inarigivir Soproxil and a Single Oral Dose of Midazolam in Healthy Subjects

Drug Interaction Potentiation

Netherlands
Brandeis University
Medical University of South Carolina; University of South Carolina; William Jennings... and other collaborators

Completed

SCOSI-M: Preventing Prescription Drug Problems

Prescription Drug Problems

United States
University of Washington
Fred Hutchinson Cancer Center; National Institute of General Medical Sciences...

Completed

Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions

Adverse Drug Interactions

United States
Akebia Therapeutics

Completed

Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin

Drug Interaction Potentiation

Canada
Lawson Health Research Institute

Completed

Coffee Interaction With the Antihypertensive Drug Felodipine

Food-Drug Interactions

Canada
LEO Pharma

Completed

Open-label, Single Center, Non-randomized, Fixed Sequence Phase 1 Drug-drug Interaction Study With LEO 32731 and Midazolam

Drug Interaction Potentiation

Germany
Il-Yang Pharm. Co., Ltd.
Severance Hospital

Completed

Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Clarithromycin, Amoxicillin and Ilaprazole (DDI)

Drug Interaction Potentiation

Korea, Republic of
University of Utah
Cubist Pharmaceuticals LLC

Completed

Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin

Pharmacokinetics | Drug Interactions

United States
Nivalis Therapeutics, Inc.
Davita Clinical Research

Completed

A Drug-Drug Interaction Study of N91115 +/- Rifampin in Healthy Adult Subjects

Drug Interaction Potentiation

United States
SK Chemicals Co., Ltd.

Completed

Pharmacokinetic Interaction Study of Dapoxetine 30mg and Mirodenafil 100mg

Drug Interaction Potentiation
Rockefeller University

Completed

Correlates and Consequences of Increased Immune Activation in Injection Drug Users

Intravenous Drug Usage

United States
Medstar Health Research Institute

Unknown

Prevalence and Level of Thienopyridine Resistance Seen in a Contemporary Percutaneous Coronary Intervention or Coronary Artery Bypass Graft Population (VASP)

Increased Drug Resistance

United States
Technical University of Munich

Completed

Neural Mechanisms of Sevoflurane Induced Anesthesia: an EEG fMRI Study in Healthy Volunteers

Anesthesia | Drug Effects

Germany
Vifor Pharma

Completed

A Drug-Drug Interaction Study of Losartan and PA21

Drug Interaction Potentiation

United States
Vifor Pharma

Completed

A Drug-Drug Interaction Study of Warfarin and PA21

Drug Interaction Potentiation

United States
Vifor Pharma

Completed

A Drug-Drug Interaction Study of Digoxin and PA21

Drug Interaction Potentiation

United States
Centre hospitalier de l'Université de Montréal...
Centre de Recherche du Centre Hospitalier de l'Université de Montréal

Completed

Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin

Drug Interaction Potentiation

Canada
Pfizer

Completed

Single Dose Study Of The Effect Of Cyclosporine On The Pharmacokinetics Of PF-04991532 In Health Volunteers

Healthy | Drug Interaction

Belgium
Massachusetts General Hospital
National Institute of Allergy and Infectious Diseases (NIAID)

Not yet recruiting

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing (DACAT)

Drug Hypersensitivity | Drug-Induced Anaphylaxis | Antibiotic Allergy | Drug Allergy | Beta Lactam Adverse Reaction | Cephalosporin Allergy | Cephalosporin Reaction

United States
POLYSAN Scientific & Technological Pharmaceutical...

Recruiting

Remaxol® in Patients With Drug-induced Liver Injuries During Cancer Chemotherapy

Cancer | Drug Induced Liver Injury

Russian Federation
Centers for Disease Control and Prevention
Boston University; Pfizer; Columbia University; University of Texas; University of... and other collaborators

Completed

Linezolid Pharmacokinetics (PK) in Multi-Drug Resistant (MDR)/Extensively-Drug Resistant (XDR) Tuberculosis (TB) (S30PK)

Multi-Drug Resistant Tuberculosis | Extensively Drug Resistant Tuberculosis

South Africa
Tongji Hospital
Xinxiang Central Hospital

Not yet recruiting

Effect of Equivalent Dose Sufentanil and Afentanil in Bronchoscopic Treatment (EOEDSAAIBT)

Effect of Drug

China
Cairo University

Not yet recruiting

Effect of Dexmedetomidine on Oxygenation and Lung Mechanics

Dexmedetomidine | Drug Use

Egypt
Tongji Hospital

Recruiting

ED90 of Remimazolam Anesthesia Induction in Drug-induced Sleep Endoscopy in Adults

Effect of Drug

China
Orinove, Inc.
Fosun Pharma

Active, not recruiting

Treatment of Patients With Advanced Solid Tumors With Oral Agent ORIN1001 and in Combination With Standard of Care.

Effect of Drug

China
University Hospital, Akershus
Oslo University Hospital; Helse Stavanger HF; Sorlandet Hospital HF; Sykehuset... and other collaborators

Terminated

Fecal ESBL Resurgence During Antibiotic Treatment

Antibiotic Drug Resistance
Washington State University
National Center for Complementary and Integrative Health (NCCIH); Office of...

Active, not recruiting

Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon

Interaction Drug Food

United States
Washington State University
National Center for Complementary and Integrative Health (NCCIH)

Completed

Assessing Goldenseal-drug Interactions Using a Probe Drug Cocktail Approach

Interaction Drug Food

United States
Ensysce Biosciences
Dr. Vince Clinical Research

Completed

A Study to Evaluate the Oral Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users

Recreational Drug Use

United States
Ensysce Biosciences

Completed

A Study to Evaluate the Intranasal Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users

Recreational Drug Use

United States
SignalChem Lifesciences Corporation
Syneos Health

Completed

Crossover Study to Evaluate the Effect of Food on the Pharmacokinetics of SLC-391 in Healthy Adult Subjects

Food-drug Interaction

Canada
Xspray Pharma AB
Axis Clinicals Limited

Completed

Evaluating the Effects of Omeprazole on the Pharmacokinetics of XS004 (Dasatinib) Tablets in Healthy Adult Subjects Under Fasting Conditions

Pharmacokinetics | Drug Interactions

United States
Tianjin Hemay Oncology Pharmaceutical Co., Ltd

Unknown

A Food-Effect Study of Hemay022 in Healthy Participants

Food-drug Interaction

China
South Valley University
Tanta University

Completed

Median Effective Dose of Dexmedetomidine in Elective Upper Limb Lidocaine Intravenous Regional Anesthesia (dexdix)

Intravenous Drug Usage

Egypt
CTI BioPharma
Covance

Completed

To Evaluate the Effect of Clarithromycin on the Systemic Exposure of Pacritinib in Healthy Subjects

Drug Interaction Study

United States
Akebia Therapeutics

Completed

Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide

Drug Interaction Potentiation

Canada
Centre Hospitalier Universitaire de Besancon

Completed

Prevalence of ESBL-producing Enterobacteriaceae as Carbapenem-resistant Enterobacteriaceae in Nursing Homes. (R'EHPAD)

Drug Resistance, Bacterial

France
Assiut University

Unknown

The Prevalence of Sub Optimal Anti Coagulation

Poor Drug Response
Medical University of South Carolina
National Center for Complementary and Integrative Health (NCCIH); Office of...

Completed

Drug Interactions and Bioavailability of Cranberry

Healthy | Drug Interactions

United States
Max Zeller Soehne AG

Unknown

Drug Cocktail Interaction Study of St. John's Wort Dry Extract Ze 117

Drug Interaction Study

Germany
Children's Mercy Hospital Kansas City
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Biomarkers of CYP2D6 and CYP3A4 Variability in Pediatrics

Drug Metabolism Phenotype

United States

Clinical Trials on Drug Mechanism

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in India

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations