Clinical Trials on Drug Interactions in Germany

Total 102 results

Gerd Mikus

Completed

Influence of CYP3A4-induction by St. John's Wort on the Steady State Pharmacokinetics of Bosentan

Drug Interactions

Germany
Gerd Mikus

Completed

Influence of Cytochrome CYP3A4-induction by St. John's Wort on the Steady State Pharmacokinetics of Ambrisentan

Drug Interactions

Germany
Bayer

Completed

Study to Learn More About the Effect of Itraconazole (ITZ) Given Repeatedly by Mouth on the Way How the Study Drug BAY1902607 Given One Time by Mouth Acts in the Human Body of Healthy Male Participants

Drug Interactions

Germany
Gerd Mikus

Completed

Influence of OATP1B1 and CYP2C9 Genotypes on the Pharmacokinetics of Bosentan Before and During Clarithromycin

Drug Interactions

Germany
Swedish Orphan Biovitrum
Parexel

Completed

A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers

Drug Drug Interaction

Germany
Bayer

Completed

Microgynon Riociguat Drug Interaction Study in Healthy Postmenopausal Women

Drug Interactions

Germany
Astellas Pharma Europe B.V.

Completed

Study to Evaluate the Effect of Solifenacin and Mirabegron on the Digoxin Concentrations in Blood in Healthy Subjects

Healthy Subjects | Pharmacokinetics | Drug-Drug Interaction (DDI)

Germany
Astellas Pharma Europe B.V.

Completed

Study to Evaluate the Effect of Solifenacin and Mirabegron on the Tamsulosin Hydrochloride (HCl) Concentrations in Blood in Healthy Male Subjects

Healthy Subjects | Pharmacokinetics | Drug-Drug Interaction (DDI)

Germany
LEO Pharma

Completed

Open-label, Single Center, Non-randomized, Fixed Sequence Phase 1 Drug-drug Interaction Study With LEO 32731 and Midazolam

Drug Interaction Potentiation

Germany
Max Zeller Soehne AG

Unknown

Drug Cocktail Interaction Study of St. John's Wort Dry Extract Ze 117

Drug Interaction Study

Germany
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Evaluate How a Drug That Alters Liver Enzymes (Rifampin) Affects the Metabolism of Enzalutamide in Men

Healthy Subjects | Drug-Drug Interaction (DDI) | Pharmacokinetics of Enzalutamide

Germany
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Interaction Between ASP1707 and Itraconazole in Healthy Female Subjects

Healthy Subjects | Pharmacokinetics | DDI (Drug-Drug Interaction)

Germany
Bayer

Completed

Sorafenib Drug Drug Interaction Study in Healthy Male Subjects

Drug Interactions

Germany
Klemens Budde
Novartis Pharmaceuticals

Completed

Influence of Pantoprazole on the Bioavailability of MMF and EC-MPS

Immunosuppression | Transplantation | Drug Interaction

Germany
University Medicine Greifswald

Completed

Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2

Pharmacokinetics | Pharmacodynamics | Drug Interactions | Intestinal Transporter Expression

Germany
Maastricht University
European Commission

Completed

Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers (REPO-STROKE1)

Safety Issues | Drug Drug Interaction

Germany
Astellas Pharma Europe B.V.
Cubist Pharmaceuticals LLC

Completed

A Study to Assess the Effects of Multiple Doses of Fidaxomicin on a Single Dose of Rosuvastatin in Healthy Male Subjects

Healthy Subjects | Drug-Drug Interaction (DDI) | Intestinal Absorption | Pharmacokinetics of Rosuvastatin | Pharmacokinetics of Fidaxomicin

Germany
Bayer

Completed

Drug-drug Interaction Study Using Rosuvastatin as a Breast Cancer Resistant Protein (Efflux Transporter), Organic Anion-transporting Polypeptide (OATP)1B1, and OATP1B3 (Uptake Transporters) Probe Substrate

Healthy Volunteers | Pharmacokinetics | Drug Interaction

Germany
University Medicine Greifswald

Completed

Pharmacokinetic Drug Interaction Between Ezetimibe and Sirolimus After Single Dose Administration in Healthy Subjects

Hypercholesterolemia | Pharmacokinetics | Immunosuppression | Drug Interactions

Germany
University Medicine Greifswald

Completed

Pharmacokinetic Drug Interaction Between Ezetimibe and Tacrolimus After Single Dose Administration in Healthy Subjects

Hypercholesterolemia | Pharmacokinetics | Immunosuppression | Drug Interactions

Germany
University of Cologne

Completed

Analysis of Mother-child Interaction and Regulation of Candidate Genes of Stress Signaling Pathways in Mature Infants

Mother-Child Interaction

Germany
Swiss Tropical & Public Health Institute
University of Basel

Completed

Influence of Dogs on Learning in Children

Learning | Human-animal Interaction

Germany
Charite University, Berlin, Germany

Completed

Questionnaire of the Section Perioperative Intensive Care of the European Society of Intensive Care Medicine (ESICM) on Standardized Drug Labelling

Drug Labelling

Germany
University Medical Center Goettingen

Completed

Open Label Pharmacokinetic-Pharmacogenetic Study on Polymorphisms in the Organic Cation Transporter OCT1 (PG-OCT)

Drug Metabolism | Membrane Transport

Germany
Technical University of Munich

Completed

Neural Mechanisms of Sevoflurane Induced Anesthesia: an EEG fMRI Study in Healthy Volunteers

Anesthesia | Drug Effects

Germany
Institut fuer anwendungsorientierte Forschung und...

Completed

Repeated Dose Study for the Investigation of Heritability of and Genetic Influences on Drug Pharmacokinetics

Membrane Transport | Drug Biotransformation

Germany
RWTH Aachen University
Ärztliche Zentrum für Qualität in der Medizin; Universitätsklinikum Bonn -...

Completed

Medication Reconciliation in Comparison to an Extensive Medication Safety Check

Elderly | Adverse Drug Event

Germany
Matthias Schwab

Completed

Open Label Study for the Functional Characterization of Drug Metabolism and Transport (IKP243)

Genotype-related Drug Metabolism

Germany
Technical University of Munich

Completed

Detection of Consciousness by EEG and Auditory Evoked Potentials

Anesthesia | Electroencephalography/ Drug Effect

Germany
Dr. Frank Behrens
Bionorica SE

Active, not recruiting

Impact of Silymarin Dosages to Decrease Drug-induced Elevated Liver Enzymes Compared to Placebo (SILVER)

Drug-induced Liver Injury

Germany
Bayer

Completed

Pharmacy Based Pharmacoepidemiological Observational Study With Aspirin Protect 100 mg

Aspirin | Drug Safety | Effects, Longterm

Germany
Heinrich-Heine University, Duesseldorf

Terminated

The Effect of Topical Brimonidine Tartrate on Hand-foot Syndrome (HFS) in Cancer Patients (BRIMOCAN)

Hand-foot Syndrome

Germany
Ferring Pharmaceuticals

Recruiting

NOCDURNA PASS Study Using Registries in Denmark, Germany and Sweden

Adverse Drug Event

Germany
Paracelsus Harz Clinic Bad Suderode.
KKS Netzwerk

Completed

Adherence to Drug Therapy in Patients With HFrEF During Inpatient Rehabilitation and After at 3 and 6-months.

Adherence to Drug Therapy in Patients With HFrEF

Germany
University Hospital Tuebingen
Robert Bosch Gesellschaft für Medizinische Forschung mbH

Completed

Ice Plant Intensive Cream for the Prevention of Hand-Foot Syndrome in Breast Cancer: Pilot Randomized Controlled Trial (WIn-HFS)

Breast Cancer | Hand-Foot Syndrome

Germany
InflaRx GmbH

Completed

Clinical Assessment of Safety and Tolerability of the New Monoclonal Humanized Antibody CaCP29

Drug Safety

Germany
LTS Lohmann Therapie-Systeme AG

Completed

Magnetic Marker Monitoring of Furosemide-containing Gastroretentive Formulation in Healthy Male Subjects (Fasting and Fed Conditions)

Gastroretentive Drug Formulation of Furosemide | Oedema

Germany
University of Cologne

Completed

Delivery Room Skin-to-skin Study (deisy)

Preterm Infant | Mother Child Interaction | Very Low Birthweight Infants

Germany
Universitätsklinikum Hamburg-Eppendorf

Completed

Pharmacokinetic of Posaconazole in Critically Ill Patients

Critical Illness | Therapeutic Drug Monitoring

Germany
Andreas Benesic, MD
MetaHeps GmbH

Unknown

Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity

Adverse Reaction to Drug | Drug-induced Disorder of Liver

Hong Kong, Australia, Germany, Japan, Korea, Republic of
University Medicine Greifswald

Completed

Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist®

MRI | Pharmacokinetics | Liver | Drug Transporter | Gd-EOB-DTPA

Germany
Pierre Fabre Medicament

Completed

Exploratory Study in the Relief of Drug-induced Xerostomia Associated With Hyposialia

Drug-induced Xerostomia

Germany
Universitätsklinikum Hamburg-Eppendorf

Completed

Adequacy of Perioperative Cefuroxime Dosage According to the BMI

Obesity; Drug

Germany
AIO-Studien-gGmbH

No longer available

A Randomized, Open-label Phase III Trial of Mapisal® Versus an Urea Hand-foot Cream as Prophylaxis for Capecitabine-induced Hand-foot Syndrome in Patients With Gastrointestinal Tumors or Breast Cancer (PROCAPP)

the Treatment Hand-foot Syndrome Patients With Gastrointestinal Tumors or Breast Cancer, Who Are Treated With Capecitabine

Germany
University of Cologne

Recruiting

Continuous Delivery Room Skin-to-skin-study for Moderate and Late Preterm Infants (COSY)

Preterm Birth | Infant Development | Mother-Infant Interaction

Germany
K. Lieb

Completed

Cognitive Hyper-performance - Effects of Stimulating Substances in Chess-players (CHESS)

Cognitively Healthy Subjects Influenced by Psychoactive Drugs

Germany
University Hospital Marburg

Recruiting

IF-MCT 16:8: Investigating the Influence of Intermittent Fasting With and Without MCTs in Patients With Drug-resistant Epilepsy (IF-MCT16:8)

Epilepsy | Intermittent Fasting

Germany
Foundation for Innovative New Diagnostics, Switzerland

Completed

Evaluation of Centralised TB Assay Solutions

Tuberculosis | Drug-resistant Tuberculosis

Georgia, Germany, India, Moldova, Republic of, South Africa
Air Liquide Santé International
Orion Corporation, Orion Pharma

Completed

Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery

Coronary Artery Disease | Coronary Artery Bypass Graft Surgery | General Anesthetic Drug Allergy

France, Italy, Germany, Netherlands
University of Cologne

Completed

Effects of Contact Restrictions During the COVID-19 Pandemic on Newborns and Their Parents

Mother-Child Interaction

Germany

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