- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01720615
Detection of Consciousness by EEG and Auditory Evoked Potentials
October 31, 2012 updated by: Gerhard Schneider, Technical University of Munich
The objective of the present investigation is to analyze EEG and auditory evoked potentials at the transition from consciousness to unconsciousness and vice versa.
A set of electroencephalographic and auditory evoked potential parameters should be identified that allows separation of consciousness from unconsciousness (reflected by responsiveness/unresponsiveness to command).
The study is based on data of 80 patients undergoing general anesthesia with remifentanil and either sevoflurane or propofol.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
During the past years, monitoring of anesthetic effects on the main target of anesthesia, the brain, has gained increasing attention.
Monitoring of the spontaneous electroencephalogram (EEG) and of auditory evoked potentials (AEP) has been suggested.
Even if EEG and AEP reflect effects of anesthetic drugs, a visual interpretation is not expedient.
As a consequence, several processing methods have been suggested that reduce the electroencephalogram to a numerical value.
In the current study, a set of EEG- and AEP parameters based on different analysis methods is tested with respect to the parameters ability in separating consciousness (reflected by responsiveness to command) from unconsciousness at the transition between these stages.
Therefore data of 80 unpremedicated patients undergoing general anesthesia with remifentanil and either sevoflurane or propofol is used.
The study period is from induction of anesthesia until patients follow command after surgery and includes a reduction of the hypnotic agent after tracheal intubation until patients follow command.
The isolated forearm technique is applied before muscle relaxants are given to maintain the ability to squeeze hand to command.
Study Type
Interventional
Enrollment (Actual)
80
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Bavaria
-
Munich, Bavaria, Germany
- Technische Universität München, Klinikum rechts der Isar, Department of Anesthesiology
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- American Society of Anesthesiologists (ASA) physical status 1-2
- Adult patients
Exclusion Criteria:
- Patients with contraindications to the study drugs
- psychiatric or neurologic disease
- drug abuse or medication known to affect the central nervous system
- pregnancy
- indication for rapid sequence induction
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: Propofol or Sevoflurane
General anesthesia
|
General anesthesia: Loss of consciousness and standard clinical practice
General anesthesia: Loss of consciousness and standard clinical practice
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes in EEG- and AEP-parameters during loss- and return of consciousness
Time Frame: 1 day
|
1 day
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Impact of muscle activity on EEG- and AEP-parameters
Time Frame: 1 day
|
1 day
|
Influence of anesthetics on EEG- and AEP-parameters
Time Frame: 1 day
|
1 day
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Chair: Eberhard F Kochs, MD, Klinikum rechts der Isar Technische Universität München
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2001
Primary Completion (Actual)
November 1, 2001
Study Completion (Actual)
April 1, 2003
Study Registration Dates
First Submitted
October 29, 2012
First Submitted That Met QC Criteria
October 31, 2012
First Posted (Estimate)
November 2, 2012
Study Record Updates
Last Update Posted (Estimate)
November 2, 2012
Last Update Submitted That Met QC Criteria
October 31, 2012
Last Verified
October 1, 2012
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Physiological Effects of Drugs
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Analgesics
- Sensory System Agents
- Anesthetics, Intravenous
- Anesthetics, General
- Anesthetics
- Platelet Aggregation Inhibitors
- Analgesics, Opioid
- Narcotics
- Hypnotics and Sedatives
- Anesthetics, Inhalation
- Remifentanil
- Propofol
- Sevoflurane
Other Study ID Numbers
- 2001
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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