Clinical Trials on Drug Mechanism

Total 3240 results

Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Drug Interaction Study of Folic Acid and Oral Contraceptive Tablets Containing Norgestimate (NGM)/Ethinyl Estradiol (EE) in Healthy Women.

Contraception | Pharmacokinetics | Drug Interactions
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Drug Interaction Study of JNJ-31001074 and Ketoconazole in Healthy Volunteers

Healthy | Pharmacokinetics | Drug Interactions
Chulalongkorn University

Completed

Vitamin D Levels in Non-immediate Drug Hypersensitivity Case-control Study

Vitamin D Deficiency | Stevens-Johnson Syndrome | Maculopapular Exanthem | Drug Reaction With Eosinophilia and Systemic Symptom | Drug-Induced Rash

Thailand
Lobe Sciences Ltd.
Pharmaceutical Research Unit, Jordan

Completed

Evaluation of Safety, Rate and Extent of Absorption of Psilocin Mucate (Psilocin-1)

Side Effect of Drug

Jordan
Centre Hospitalier St Anne
Fondation de l'Avenir; Fondation pour les Sciences du Cerveau; Association NEUROREFS

Terminated

High Resolution Imaging of Cerebral Vasculature by Functional Micro-Doppler Sonography During Brain Surgery (ULYS)

Partial Drug-resistant Epilepsy

France
Beijing Center for Disease Control and Prevention

Unknown

Explore Active Surveillance Mode of the Community's Adverse Event Following Immunization(AEFI) (AEFI)

Adverse Reaction to Drug
Assiut University

Completed

Efficacy of Repetitive Trans-spinal Magnetic Stimulation on Axial Motor Symptoms in PD (rTSMS)

Adverse Effect of Drug Therapy Levodopa

Egypt
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Unknown

Paclitaxel, Folic Acid, and Lometrexol in Treating Patients With Locally Advanced or Metastatic Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific | Drug/Agent Toxicity by Tissue/Organ

United States
Centers for Disease Control and Prevention
Yale University; Columbia University; University of KwaZulu

Completed

TBTC Study 30: Safety and Tolerability of Low Dose Linezolid in MDR TB (LiMiT)

Multi-drug Resistant Tuberculosis | Extensively Drug Resistant Tuberculosis

South Africa
University of Bern

Recruiting

Efficacy of a Transdiagnostic Online Prevention Approach in Adolescents (EMPATIA) (EMPATIA)

Prevention | Mental Health Issue | Psychological Intervention | Online Intervention | Transdiagnostic Mechanisms | Adolescent Psychology | Mental Disorder in Adolescence, Subclinical

Switzerland
Qianfoshan Hospital

Recruiting

Intensive Monitoring Scheme of Lidocaine Cataplasms

Adverse Reaction to Drug

China
Jørgen Bjerggaard Jensen
Odense University Hospital; Karolinska University Hospital; Zealand University... and other collaborators

Active, not recruiting

NORTH-REG Dwell-Time Study

Side Effect of Drug

Sweden, Denmark, Iceland
Qure Healthcare, LLC

Completed

Clinical Utility of CDMT Among VillageMD Providers

Chronic Disease | Medication Adherence | Drug Drug Interaction

United States
Tabula Rasa HealthCare

Withdrawn

Assessment of Mortality Rates in COVID-19 Infected Populations Treated With Repurposed Medications

COVID | Drug Effect | Risk Reduction | Drug Interaction

United States
Swansea University
Abertawe Bro Morgannwg University Health Board; Hywel Dda Health Board

Completed

Medication Monitoring for Older Adults in Primary Care

Polypharmacy

United Kingdom
Swansea University
Cardiff University; Aneurin Bevan University Health Board

Completed

The Adverse Drug Reaction (ADRe) Profile for Polypharmacy (ADRe-p)

Polypharmacy

United Kingdom
Techpool Bio-Pharma Co., Ltd.
Center for ADR Monitoring of Guangdong

Unknown

Post-market Safety Reassessment of Ulinastatin for Injection

Adverse Reaction to Drug

China
University Hospital, Toulouse
Dixi Medical; Centre de recherche Cerveau et Cognition (CERCO)

Recruiting

Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy (NENUFAR)

Epilepsy

France
Beijing Pins Medical Co., Ltd
Peking University First Hospital; Beijing Tiantan Hospital

Recruiting

Rechargeable Implantable Vagus Nerve Stimulation System for Drug-Refractory Epilepsy

Drug-Refractory Epilepsy

China
Icahn School of Medicine at Mount Sinai
National Institute of Mental Health (NIMH)

Recruiting

Electrophysiological Read-Out of Interoceptive Processing

Drug-resistant Epilepsy

United States
St. Justine's Hospital
CIUSSS du Nord-de-l'Île-de-Montréal

Recruiting

Monitoring of Metabolic Adverse Events of Second Generation Antipsychotics in a Naive Pediatric Population (MEMAS)

Adverse Drug Event

Canada
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Medication Reconciliation Using Electronic Pharmaceutical Record: A Multicenter Study in the Hospitalized Elderly (CONCIPAGE)

Adverse Drug Event

France
Instituto Mexicano del Seguro Social

Completed

Efficacy, Tolerability and Adherence of the Modified Atkins Diet on Drug-resistant Epilepsy

Epilepsy, Drug Resistant

Mexico
University College Cork

Completed

Adverse Drug Event Prevention Using Structured Pharmacist Review

Adverse Drug Reactions

Ireland
University Hospital, Antwerp

Recruiting

Standardised Drug Provocation Testing in Perioperative Hypersensitivity

Hypersensitivity | Anaphylaxis | Allergic Reaction | Perioperative Complication | Immediate Hypersensitivity | Hypersensitivity, Drug | Anaphylactic Reaction

Belgium
Johns Hopkins University
DEKA S.r.l.

Not yet recruiting

Blood Naloxone Levels Following Intradermal Injection in Humans

Opioid Overdose
Brown University
National Institute on Drug Abuse (NIDA); New York University

Active, not recruiting

Preventing Overdose Using Information and Data From the Environment (PROVIDENT)

Drug Overdose | Opioid Overdose

United States
Seoul National University Hospital

Completed

A Clinical Study to Explore Biomarkers for Drug-induced Liver Injury (DILI)

Healthy

Korea, Republic of
Lykos Therapeutics

Completed

Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-1)

Psychological Effects of Study Drug

United States
Phoenix Children's Hospital

Completed

Evaluation of Implementation of the Phoenix PrEP (Pre-Exposure Prophylaxis) Access Project for Youth Aged 13-24

IV Drug Usage | Unsafe Sex

United States
Jupiter Orphan Therapeutics Inc.
National Institute on Aging (NIA)

Completed

JOTROL PK, Safety, and Food Effect Assessment

Pharmacokinetics | Food-drug Interaction | Safety

United States
King Faisal Specialist Hospital & Research Center

Completed

Interaction Between Drug and Placebo Effect:Randomized Placebo Controlled Trials May Not be Accurate in Determining Drug Effect Size

Placebo Effect | Placebo Drug Interaction

Saudi Arabia
Guangzhou Women and Children's Medical Center

Completed

The Effect of Age on the Median Effective Dose (ED50) of Intranasal Dexmedetomidine for Rescue Sedation Following Failed Sedation With Oral Chloral Hydrate During Magnetic Resonance Imaging

Aged | Drug | Dose-Response Relationship

China
US Department of Veterans Affairs

Completed

Randomized Controlled Trial of Enhanced Pharmacy Care in Older Veteran Outpatients

Geriatrics | Drug Therapy | Poly Pharmacy

United States
Cardiavent Inc.

Completed

Safety and Pharmacokinetics Study of CARD-024 in Healthy Subjects (CARD-024)

Drug Safety | Heart; Disease, Activity

United States
Basilea Pharmaceutica

Completed

Effect of Ceftobiprole on Human Intestinal Microflora

Drug Resistance | Antimicrobial Agent | Cephalosporins
Ajou University School of Medicine

Completed

Intubating Conditions During Propofol-remifentanil Anesthesia With Topical Lidocaine

Drug Usage

Korea, Republic of
University of Missouri-Columbia

Recruiting

Opioid Rapid Response System: Naloxone Training in Communities

Opioid Overdose

United States
Drug Induced Liver Disease Study Group
Beijing Union Pharmaceutical Factory

Recruiting

The Multi-Center, Randomized, Double-blind, Positive Controlled Clinical Trial of Bicyclol in the Treatment of Acute DILI

Drug-Induced Acute Liver Injury

China
Brown University
National Institute on Drug Abuse (NIDA)

Completed

The Rhode Island Prescription and Illicit Drug Study (RAPIDS)

Drug Overdose | Opioid Overdose

United States
Drug Induced Liver Disease Study Group
Beijing Union Pharmaceutical Factory

Completed

The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI

Drug-Induced Acute Liver Injury

China
Emory University
Centers for Disease Control and Prevention

Not yet recruiting

Response to Emerging Antimicrobial Resistance With Containment Microbiota Therapy (REACT)

Multi-Drug Resistant Organism Colonization

United States
Fundación Pública Andaluza para la Investigación...

Not yet recruiting

Proof-of-concept to Evaluate the Efficacy and Safety of Prednisone in Idiosyncratic Hepatotoxicity (DILICORT)

Prednisone | Hepatotoxicity | Idiosyncratic Drug Effect
Lykos Therapeutics

Not yet recruiting

Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-2)

Psychological Effects of Study Drug
University Hospital, Basel, Switzerland

Completed

DetectAB - Detecting Antibiotics (DetectAB)

Antibiotic Drug Concentration in Sweat

Switzerland
University of Milan
Federico II University; University of Milano Bicocca

Unknown

Educational and Informative Interventions to Tackle Inappropriate Use of Drugs in Italy (EDUREDRUG)

Inappropriate Drug Prescription and Use

Italy
Daiichi Sankyo, Inc.

Completed

Effect of Repeated Doses of DS-8500a on Pharmacokinetics of Rosuvastatin in Healthy Volunteers

Drug Pharmacokinetics in Healthy Volunteers

United States
Christoph Hatz
University of Zurich

Completed

The Effect of Hand Hygiene on Colonization Rates With Multidrug Resistant Enteric Pathogens in Travellers

Drug Resistance, Multiple | Travel Medicine

Switzerland
University Hospital, Caen

Active, not recruiting

Radiopharmaceuticals Analysis for Detailed Insights And INternational Tracking of Safety (RADIANTS)

Cancer | Side Effect of Drug

France
Centre for Innovation and Research in Aging, Canada
McGill University Health Centre/Research Institute of the McGill University... and other collaborators

Unknown

Spread and Scale of a Polypharmacy App

Deprescribing | Polypharmacy | Adverse Drug Event

Canada

Clinical Trials on Drug Mechanism

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Hong Kong

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations