Clinical Trials on Drug Toxicity

Total 3612 results

University of British Columbia
Eli Lilly and Company; Merck Sharp & Dohme LLC; Pfizer; Canadian Institutes of... and other collaborators

Recruiting

National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children

Adverse Drug Reaction (ADR)

Canada
Population Council

Completed

An Open-label Study to Evaluate the Effects of Concurrent Administration of Vaginal Antimycotic Medication Miconazole Nitrate on the Pharmacokinetics of Nestorone and Ethinyl Estradiol Delivered by a Contraceptive Vaginal Ring in Normal Ovulating Women

Antifungal Drug Adverse Reaction

United States
Sophie JACOB
Institut National de la Santé Et de la Recherche Médicale, France; Clinique... and other collaborators

Completed

BreAst Cancer and Cardiotoxicity Induced by RAdioTherapy: the BACCARAT Study (BACCARAT)

Breast Cancer | Cardiac Toxicity

France
National Guard Health Affairs

Suspended

Early Predictor of Herceptin Cardio Toxicity in Breast Cancer Patients

Breast Cancer

Saudi Arabia
M.D. Anderson Cancer Center
Massachusetts General Hospital

Completed

Early Detection and Prediction of Chemotherapy Induced Cardiac Toxicity in Breast Cancer Patients

Breast Cancer

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery

Breast Cancer | Cardiac Toxicity

United States
University of South Florida
National Cancer Institute (NCI)

Completed

Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab

Breast Cancer | Cardiac Toxicity

United States
Avera McKennan Hospital & University Health Center

Terminated

Use of Metformin to Reduce Cardiac Toxicity in Breast Cancer

Breast Cancer | Breast Tumors

United States
Henry Ford Health System
Helen L. Kay Charitable Trust

Completed

Prevention Using Exercise Rehabilitation to Offset Cardiac Toxicities Induced Via Chemotherapy (HF-PROACTIVE)

Leukemia | Breast Cancer | Gastric Cancer | Doxorubicin Induced Cardiomyopathy

United States
Heba Allah Ali Abd El-Halim Mabrouk
Tanta University

Unknown

Alpha Lipoic Acid as an Adjuvant Treatment in Acute Phosphide Poisoning (ALA)

Toxicity
NaviFUS Corporation
Taipei Veterans General Hospital, Taiwan

Completed

Safety of Using NaviFUS System in Patients With Drug Resistant Epilepsy

Drug Resistant Epilepsy | Epilepsy, Drug Resistant | Intractable Epilepsy | Refractory Epilepsy | Drug Refractory Epilepsy | Epilepsy, Drug Refractory | Epilepsy, Intractable | Medication Resistant Epilepsy

Taiwan
University Hospital, Basel, Switzerland
Toppharm Apotheke Hersberger, Spalenberg 41, CH-4051 Basel

Recruiting

Pharmacogenetic Testing of Patients With Unwanted Adverse Drug Reactions or Therapy Failure

Adverse Drug Reaction | Therapy Failure

Switzerland
University of Tennessee

Enrolling by invitation

Inpatient Penicillin Delabeling for Low-Risk Patients

Drug Allergy | Penicillin

United States
Istanbul University - Cerrahpasa (IUC)

Completed

Perioperative Hypersensitivity in Children

Drug Allergy

Turkey
University Hospital, Gentofte, Copenhagen
Research Unit Of General Practice, Copenhagen

Completed

Drug Allergy Labels After Drug Allergy Investigation

Drug Hypersensitivity

Denmark
McGill University
Canadian Institutes of Health Research (CIHR)

Completed

Using Novel Canadian Resources to Improve Medication Reconciliation at Discharge

Adverse Drug Events | Medication Reconciliation

Canada
University Hospital, Grenoble

Unknown

Divided Drug Delivery (DEFIMED-1)

Hospitalized for Voluntary Drug Intoxication

France
Companion Dx Reference Lab, LLC

Unknown

Utility of PharmacoGenomics for Reducing Adverse Drug Effects (UPGRADE)

Genetics of Drug Metabolism

United States
Kadmon Corporation, LLC
Quotient Sciences

Completed

Drug-drug Interaction Between Belumosudil, Itraconazole, Rifampicin, Rabeprazole, and Omeprazole in Healthy Volunteers

Autoimmune Diseases | Drug-drug Interaction | Fibrotic Disease

United Kingdom
National Cheng-Kung University Hospital

Recruiting

Strategy Therapy on Cancer Therapy-Related Cardiac Dysfunction

Heart Failure | Lymphoma | Breast Cancer | Cardiotoxicity | Chemotherapeutic Toxicity

Taiwan
University Hospital, Strasbourg, France

Recruiting

GERAP's Epidemiological Survey on Perioperative Hypersensitivity Reactions (SERAP)

Hypersensitivity, Drug

France
Romanian Society of Anesthesia and Intensive Care

Unknown

Romanian Entropy Clinical Study Network (ROEntropy)

General Anesthetic Drug Adverse Reaction

Romania
Dana-Farber Cancer Institute
Novartis Pharmaceuticals

Completed

Study of Omalizumab as Adjuvant Therapy in Chemotherapy Desensitization

Drug Allergy

United States
University Hospital Hradec Kralove

Completed

Factors Affecting the Effective End-tidal Concentration of Desflurane Anaesthesia

General Anesthetic Drug Adverse Reaction

Czech Republic
University Hospital, Grenoble

Terminated

Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo) (BdDAllergo)

Allergic Hypersensitivity Drug Reaction Versus Non-allergic Hypersensitivity Drug Reaction Cross Reaction

France
The University of Hong Kong

Not yet recruiting

A Training Program of Drug Allergy for Healthcare Professionals

Drug Allergy

Hong Kong
Peking Union Medical College Hospital

Unknown

Prediction of Rituximab Hypersensitivity and Desensitization Treatment

Drug Hypersensitivity Reaction

China
Damanhour Teaching Hospital

Recruiting

Postoperative Effects of Propofol Versus Sevoflurane Anesthesia

General Anesthetic Drug Adverse Reaction

Egypt
The University of Texas Health Science Center,...
Blue Cross Blue Shield

Completed

Reducing Costs by Deprescribing Medications

Deprescribing | Polypharmacy | Adverse Drug Reaction

United States
Poznan University of Medical Sciences

Completed

PKPD of Rocuronium and Sugammadex Profile in Pediatric Patients

General Anesthetic Drug Adverse Reaction

Poland
CHU de Reims

Completed

Adverse Drug Reactions in Pediatrics: Experience of a Regional Pharmacovigilance Center (Pediatry ADR)

Child With Adverse Drug Reactions
Boston Medical Center
Boston University; National Institute on Drug Abuse (NIDA); RTI International

Completed

Assessing Screening Plus Brief Intervention's Resulting Efficacy (ASPIRE) to Stop Drug Use (ASPIRE)

Drug Abuse | Drug Usage | Drug Dependence

United States
Fundació Institut de Recerca de l'Hospital de la...

Recruiting

Influence of Timing PTCy in AlloSCT

Cyclophosphamide Toxicity | Allogenic Haematopoetic Transplantation

Spain
Kennon Heard
McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Completed

Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days (Non-Drinker)

Drug Induced Liver Injury

United States
Human Biome Institute S.A.

Recruiting

Fecal Microbiota Transplantation (FMT) to Decolonize Antibiotic - Resistant Bacteria (ARB) - New Protocol (STOP-ARB2)

Antimicrobial Drug Resistance | Drug Resistance, Bacterial

Poland
Universitair Ziekenhuis Brussel
University Ghent; Vrije Universiteit Brussel

Not yet recruiting

Investigating Paclitaxel Toxicity in Breast Cancer: The Roles of Physical Activity and Body Composition. (PABTOX)

Breast Cancer | Body Weight | Chemotherapeutic Toxicity | Physical Inactivity | Chemotherapeutic Agent Toxicity | Paclitaxel Adverse Reaction

Belgium
Peking Union Medical College Hospital

Recruiting

Anesthesia Neurodevelopmental Impact in Congenital Scoliosis Children

General Anesthetics Toxicity

China
University Medical Center Goettingen

Recruiting

Efficacy of Structured SOcial COnsultation and Support in Reducing the FINancial Burden of Radiotherapy (SOCOFIN-1)

Financial Toxicity

Germany
Sohag University

Not yet recruiting

Evaluation of the Role of Poisoning Severity Score, Serum Procalcitonin and C-reactive Protein in Acute Hydrocarbon Intoxicated Cases Admitted to the Poison Control Center Ain Shams University Hospitals

Acute Hydrocarbon Toxicity

Egypt
Thomas Jefferson University

Active, not recruiting

Ropivacaine Pharmacokinetics in ESP Blocks

Pain | Quality of Recovery | Local Anesthetic Systemic Toxicity

United States
Montefiore Medical Center

Terminated

Mechanisms and Treatment of Chronic Allograft Injury (CAI) Due to Calcineurin Inhibitor (CNI) Toxicity

Chronic Allograft Injury | Calcineurin Inhibitor Toxicity

United States
National Institutes of Health Clinical Center (CC)

Completed

Probiotic Ingestion and Isoagglutinin Titers

Isoagglutinin-Mediated Hemolysis | Probiotic Toxicity

United States
Radboud University Medical Center
Astellas Pharma Inc

Recruiting

Determining the Clinical Relevance of the Interaction Between Enzalutamide and the Opioid Morphine and the DOAC Edoxaban (MIND THE GAP)

Drug-drug Interaction

Netherlands
Korea Institute of Oriental Medicine
DongGuk University; Korean Medicine Hospital of Pusan National University; Semyung... and other collaborators

Active, not recruiting

A Multicenter Observational Study on Safety of the Herbal Medicines at Inpatient Setting

Drug Induced Liver Injury | Drug-Induced Kidney Injury | Herbal Medicine Adverse Reaction

Korea, Republic of
Zhong Wang

Suspended

Post-marketing Safety Surveillance of Breviscapine Powder-Injection : a Registry Study

Adverse Drug Event | Adverse Drug Reaction | Chinese Medicine | Anaphylactic Reaction

China
Sohag University

Not yet recruiting

Evaluation of High Dose Methotrexate Toxicity

Methotrexate Toxicity
Duke University
United States Navy

Enrolling by invitation

Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 2)

Oxygen Toxicity

United States
Duke University
United States Navy

Enrolling by invitation

Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 1)

Oxygen Toxicity

United States
Hopital Louis Pradel

Unknown

Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.

Fluid Overload | Hypovolemia | Diuretic Toxicity

France
Assaf-Harofeh Medical Center

Completed

Hyperbaric Oxygen Therapy Effects on Pulmonary Functions (PulmHBOT)

Hyperoxia | Oxygen Toxicity

Israel

Clinical Trials on Drug Toxicity

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Medical Conditions

Drug Interventions

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CROs in Kazakhstan

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Rare Diseases

Drug Interventions

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