Clinical Trials on Encephalopathy, Hepatic

Total 3517 results

Neurocrine Biosciences

Enrolling by invitation

Extension Study to Evaluate How Safe and Tolerable NBI-921352 is as an Adjunctive Therapy for Participants With SCN8A-DEE

SCN8A Developmental and Epileptic Encephalopathy Syndrome

United States
Rigshospitalet, Denmark

Completed

Cerebral Microdialysis in Patients With Fulminant Hepatic Failure

Fulminant Hepatic Failure

Denmark
University Medical Center Groningen

Completed

Non-invasive Measurement of Hemoglobin Concentration With Pulse Co-oximetry

Elective Hepatic Resection

Netherlands
Sanofi

Completed

A Pharmacokinetic and Tolerability Study of Fexinidazole in a Single Oral Dose in Adult Participants With Mild and Moderate Hepatic Impairment

Hepatic Function Abnormal

Bulgaria, France
Sanofi

Completed

Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Mild Hepatic Impairment Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Belgium
Sanofi

Terminated

Pharmacokinetics of Amcenestrant in Female Hepatic Impaired Participants as Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

Korea, Republic of, Germany
Case Comprehensive Cancer Center

Completed

Comparison of Yttrium-90 Absorbed Doses Using PET/CT Versus PET/MR Imaging for Hepatic Malignancies

Hepatic Malignancies

United States
NGM Biopharmaceuticals, Inc

Completed

Study of Aldafermin (NGM282) in Participants With Impaired Hepatic Function

Impaired Hepatic Function

United States
Tetraphase Pharmaceuticals, Inc.

Completed

A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects

Impaired Hepatic Function

United States
University of Dublin, Trinity College
Health Research Board, Ireland

Enrolling by invitation

Follow-up of Inflammatory Responses and Multiorgan Outcomes FoLlowing Neonatal Brain injurY (FIREFLY)

Neonatal Encephalopathy

Ireland
University of Rochester
Olympic Medical

Completed

CoolCap Followup Study-Coordination of Participating Centers

Neonatal Encephalopathy

United States
Genfit

Completed

Nitazoxanide Pharmacokinetic Parameters in Hepatic Impaired Patients

Liver Diseases | Moderate Hepatic Impairment | Severe Hepatic Impairment

United States
Acerta Pharma BV
AstraZeneca

Completed

Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolite

Hepatic Insufficiency | Healthy Subjects | Hepatic Impairment

United States
Fuzhou General Hospital

Unknown

The Plasma Diafiltration Therapy of Hepatic Failure

Hepatic Failure | Plasma Exchange

China
Boston University
Mayo Clinic; National Institute of Neurological Disorders and Stroke (NINDS); NYU Langone Health and other collaborators

Completed

The DIAGNOSE-CTE Research Project (DIAGNOSE-CTE)

Chronic Traumatic Encephalopathy

United States
The University of Texas Medical Branch, Galveston

Terminated

Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure

Acute and Chronic Hepatic Failure With Developing Coma

United States
Taisho Pharmaceutical Co., Ltd.

Completed

A Pharmacokinetic Study of TS-142 in Patients With Hepatic Impairment

Patients With Mild or Moderate Hepatic Impairment

Japan
Hamilton Health Sciences Corporation
McMaster University

Not yet recruiting

Functional Imaging of Baby Brains (FIBB)

Hypoxia-Ischemia, Brain | Hypoxic-Ischemic Encephalopathy | Hypoxia Ischemia, Cerebral | Hypoxia Neonatal

Canada
Karolinska Institutet

Completed

Intra-operative Feed Back on Traction Force During Vacuum Extraction: Safe Vacuum Extraction Alliance (SVEA)

Hypoxic Ischemic Encephalopathy | Neonatal Convulsions | Subgaleal Hematoma

Sweden
Mansoura University Children Hospital

Completed

Reno-protective Effect of Brain Cooling in Newborn With Hypoxia

Hypoxic Ischemic Encephalopathy

Egypt
Assiut University

Not yet recruiting

Radiological Evaluation of Hypoxic Ischemic Encephalopathy

Hypoxic Ischemic Encephalopathy
University Hospital, Tours

Recruiting

Copeptin Kinetics in Critically Ill Patients With Posterior Reversible Encephalopathy Syndrome (XPRESSE)

Posterior Reversible Encephalopathy Syndrome

France
Brighton and Sussex University Hospitals NHS Trust
European Union

Completed

NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy

Circulatory Failure

United Kingdom
Xiao Chen

Recruiting

Role of FAPI PET/MR Combined With Gadoxetate Disodium in Assessing Hepatic Malignancies

Hepatic Malignancies

China
M.D. Anderson Cancer Center

Recruiting

Stereotactic Liver Ablation Assisted With Intra-Arterial CT Hepatic Arteriography and Ablation Confirmation Software Assessment (STEREOLAB)

Liver Ablation | Hepatic

United States
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study of Effects of Selpercatinib in Hepatically Impaired Participants and Healthy Participants

Healthy | Hepatic Impairment

United States
The University of Texas Health Science Center at...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Active, not recruiting

Empagliflozin and Hepatic Glucose Metabolism

Hepatic Glucose Metabolism

United States
Institute for Clinical and Experimental Medicine

Completed

Monitoring of Hepatic Fat Metabolism Using Magnetic Resonance Methods

Hepatic Fat Content

Czechia
Centre Hospitalier Universitaire, Amiens

Completed

Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects. (PORTEAU)

Hepatic Flow Changes

France
Huazhong University of Science and Technology

Completed

MASIMO Radical 7 and Laboratory Measurement

Major Hepatic Surgery

China
Brigham and Women's Hospital
Medtronic

Recruiting

Transcutaneous Carbon Dioxide Monitoring in Neonates Receiving Therapeutic Hypothermia for Neonatal Encephalopathy

Neonatal Encephalopathy

United States
Polyganics BV
Genae

Completed

Safety and Performance of a Synthetic Tissue Sealant in Reducing Fluid Leakage in Hepatobiliary and Pancreatic Surgery (SHIELDS)

Pancreatectomy | Hepatic Resection

Germany
AstraZeneca

Completed

Open-label Study to Assess the Pharmacokinetics of NKTR-118 in Patients With Impaired Hepatic Function

Hepatic; Functional Disturbance

United States
Taiho Oncology, Inc.

Completed

Evaluating Patients With Impaired Hepatic Function

Impaired Hepatic Function

United States
Children's Hospital Los Angeles

Recruiting

Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1) (ICHOR 1)

TBI (Traumatic Brain Injury) | Hypoxic-Ischemic Encephalopathy | Hemodynamic Instability | TBI | HIE

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...
Koninklijke Nederlandse VoetbalBond (KNVB)

Not yet recruiting

Heading in Football: Impact on Neural Blood Biomarkers (HEADLINE)

Concussion, Mild | Neurodegeneration | Head Injury, Minor | CTE - Chronic Traumatic Encephalopathy
Semmelweis University

Recruiting

Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates (UniCort)

Hypotension | Asphyxia | Hypoxic-Ischemic Encephalopathy | Circulatory Failure Neonatal

Hungary
Nemours Children's Clinic
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries (CORDMILK)

Hypoxic-Ischemic Encephalopathy | Birth Asphyxia

India
Boston Children's Hospital

Recruiting

Genetics of Epilepsy and Related Disorders

Epilepsy | Dravet Syndrome | Infantile Spasms | Epileptic Encephalopathy | Ohtahara Syndrome | Early Myoclonic Epileptic Encephalopathy | PCDH19-related Epilepsy and Related Conditions | KCNQ2-Related Epileptic Encephalopathy | Epilepsy of Infancy With Migrating Focal Seizures (Disorder)

United States
Astellas Pharma Europe B.V.

Completed

A Study to Investigate the Effect of Mirabegron (YM178) on Subjects With Mild or Moderate Hepatic Impairment Compared to Healthy Subjects

Healthy Subjects | Pharmacokinetics | Mild and Moderate Hepatic Impairment

Slovakia
Assistance Publique - Hôpitaux de Paris

Completed

The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure

Hepatitis

France
Kristin R Hoffman

Terminated

Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy

Hypoxic Ischemic Encephalopathy

United States
Neurocrine Biosciences

Completed

Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-827104 in Pediatric Subjects With Epileptic Encephalopathy With Continuous Spike-and-Wave During Sleep

Epileptic Encephalopathy | Continuous Spike and Wave During Sleep

United States, Denmark, Spain, Switzerland, United Kingdom, Canada
University Health Network, Toronto
The Weston A. Price Foundation

Recruiting

Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study

Chronic Traumatic Encephalopathy

Canada
Hospices Civils de Lyon

Completed

Becoming Children With Perinatal Anoxo-Ischemic Encephalopathy Without Indication of Therapeutic Hypothermia (SARNATUN)

Anoxic-Ischemic Encephalopathy

France
Thomas Jefferson University
Lata Mangeshkar Hospital, NKP Salve Institute of Medical Sciences, Nagpur...

Completed

Umbilical Cord Milking for Neonates With Hypoxic Ischemic Encephalopathy

Hypoxic Ischemic Encephalopathy | Umbilical Cord Milking

India
National University Hospital, Singapore
National Medical Research Council (NMRC), Singapore

Completed

Autologous Cord Blood Cells for Brain Injury in Term Newborns

Hypoxic Ischemic Encephalopathy

Singapore
Atea Pharmaceuticals, Inc.

Recruiting

Study of Bemnifosbuvir in Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment | Healthy Volunteer

United States
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

An Investigational Study of SHR3680 in Participants With Mild to Moderate Liver Impairment and Healthy Participants

Hepatic Impairment | Healthy Participants

China

Clinical Trials on Encephalopathy, Hepatic

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