Clinical Trials on Extrahepatic Cholestasis

Total 686 results

Jeffrey Rudolph
University of Pittsburgh

Approved for marketing

Compassionate Use of Omegaven® in the Treatment of Parenteral Nutrition Associated Hepatic Injury

Total Parenteral Nutrition-induced Cholestasis

United States
Pediatrix

Completed

Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants

Total Parenteral Nutrition-induced Cholestasis

United States
Rush University Medical Center

Approved for marketing

Intravenous Fish Oils in the Treatment of Parenteral Nutrition Liver Injury

Cholestasis | Total Parenteral Nutrition-induced Cholestasis

United States
Zekai Tahir Burak Women's Health Research and Education...

Unknown

Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.

Pregnancy

Turkey
Duke University

Terminated

BRIDGE Device for Post-operative Pain Control (BRIDGE)

Liver Diseases | Liver Failure | Pain, Postoperative | Liver Diseases, Alcoholic | Liver Cirrhosis, Biliary | Transplant; Failure, Liver

United States
Zhujiang Hospital

Completed

High Quality Fluorescent Cholangiography (HQFC)

Extrahepatic Biliary Tree Injury

China
Johane Allard
University of Alberta; Hamilton Health Sciences Corporation; St. Paul's Hospital... and other collaborators

Terminated

Fish Oil for Patients With Liver Disease Due to Parenteral Nutrition

Total Parenteral Nutrition-induced Cholestasis

Canada
Innovative Digestive Health Education and Research...
NinePoint Medical

Unknown

Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management Study (VLE-IOV)

Cholangiocarcinoma | Bile Duct Cancer | Primary Sclerosing Cholangitis | Bile Duct Diseases | Pancreatic Ductal Adenocarcinoma | Pancreas Cancer | Bile Duct Neoplasms | Biliary Stricture | Bile Duct Obstruction | Bile Duct Obstruction, Extrahepatic | Pancreatic Duct Stricture | Bile Duct Lesions | Bile Duct Neoplasms... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Gemcitabine Hydrochloride, Cisplatin, and Nab-Paclitaxel in Treating Patients With Advanced or Metastatic Biliary Cancers

Unresectable Extrahepatic Bile Duct Carcinoma | Unresectable Gallbladder Carcinoma | Stage IIIA Gallbladder Cancer AJCC v7 | Stage IIIB Gallbladder Cancer AJCC v7 | Stage IVA Gallbladder Cancer AJCC v7 | Stage IVB Gallbladder Cancer AJCC v7 | Stage III Intrahepatic Cholangiocarcinoma AJCC v7 | Stage... and other conditions

United States
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer

Intrahepatic Cholangiocarcinoma | Gallbladder Carcinoma | Advanced Biliary Tract Cancer | Extrahepatic Cholangiocarcinoma

China
Mirum Pharmaceuticals, Inc.

Completed

Safety and Efficacy Study of LUM001 (Maralixibat) With a Drug Withdrawal Period in Participants With Alagille Syndrome (ALGS) (ICONIC)

Alagille Syndrome

France, Belgium, Poland, Australia, Spain, United Kingdom
Wei Liu

Recruiting

Ursodeoxycholic Acid Prevents Total Parenteral Nutrition Cholestasis (UDACPPNAC)

Cholestasis of Parenteral Nutrition

China
Albireo

Completed

A4250, an IBAT Inhibitor in Pediatric Cholestasis

Pediatric Cholestasis

United Kingdom, Denmark, France, Germany, Sweden
Wake Forest University Health Sciences

Completed

Omegaven® in the Treatment of Parenteral Nutrition (PN) Induced Liver Injury

Total Parenteral Nutrition-induced Cholestasis

United States
307 Hospital of PLA
Changhai Hospital; The Affiliated Nanjing Drum Tower Hospital of Nanjing University...

Unknown

Radioactive Stents for Treatment of Unresectable Biliary Tract Cancer

Intrahepatic Cholangiocarcinoma | Biliary Obstruction | Cholangiocarcinoma of the Extrahepatic Bile Duct | Ampullary Carcinoma

China
Hospital Pediátrico de Sinaloa

Recruiting

Parenteral Nutrition Cycling for Prevention of Cholestatic Syndrome in Newborn

Cholestasis in Newborn

Mexico
M.D. Anderson Cancer Center

Active, not recruiting

Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Metastatic Intrahepatic Cholangiocarcinoma | Locally Advanced Intrahepatic Cholangiocarcinoma

United States
Mayo Clinic
National Cancer Institute (NCI)

Not yet recruiting

Radioembolization With Tremelimumab and Durvalumab for Locally Advanced Unresectable or Oligo-Metastatic Intrahepatic Cholangiocarcinoma

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Unresectable Intrahepatic Cholangiocarcinoma | Locally Advanced Intrahepatic Cholangiocarcinoma | Oligometastatic Intrahepatic Cholangiocarcinoma

United States
University Health Network, Toronto

Unknown

Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis

Hepatitis B | Hepatitis C | Autoimmune Hepatitis | Cholangitis, Sclerosing | Liver Cirrhosis, Biliary

Canada
University of Nebraska
Children's Hospital and Medical Center, Omaha, Nebraska

Approved for marketing

Compassionate Use of Omegaven® for the Treatment of Intestinal Failure Associated Liver Disease in Children

Total Parenteral Nutrition-Induced Cholestasis

United States
Emory University
National Cancer Institute (NCI)

Withdrawn

Preoperative Nab-paclitaxel, Cisplatin, and Gemcitabine Chemotherapy With or Without Infigratinib Targeted Therapy for the Treatment of Resectable Intrahepatic Cholangiocarcinoma, The OPTIC Trial

Stage II Intrahepatic Cholangiocarcinoma AJCC v8 | Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Resectable Intrahepatic Cholangiocarcinoma | Stage 0 Intrahepatic Cholangiocarcinoma AJCC v8 | Stage I Intrahepatic Cholangiocarcinoma AJCC v8

United States
Fudan University

Unknown

Clinical Trial of Adjuvant Chemotherapy Followed by Concurrent Chemoradiotherapy Compared With Adjuvant Chemotherapy Alone in Patients With Gallbladder Carcinoma and Extrahepatic Cholangiocarcinoma

Malignant Neoplasm Other Gallbladder/Extrahepatic Bile Duct

China
University of Rochester

Completed

Prospective Randomized Clinical Trial of Intravenous Lipids and Cholestasis

Parenteral Nutrition Associated Cholestasis

United States
OHSU Knight Cancer Institute
Oregon Health and Science University

Active, not recruiting

mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8 | Liver and Intrahepatic Bile Duct Carcinoma | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Unresectable Intrahepatic Cholangiocarcinoma

United States
Genzyme, a Sanofi Company

Completed

Vandetanib Gemcitabine Or Placebo Plus Gemcitabine Or Vandetanib Monotherapy In Advanced Biliary Tract Cancer (VANGOGH)

Biliary Tract Cancer | Gallbladder Cancer | Ampullary Carcinoma | Cancer Of The Extrahepatic Bile Duct

Italy
Emory University
National Cancer Institute (NCI); National Institutes of Health (NIH); Celgene

Active, not recruiting

Gemcitabine, Cisplatin, and Nab-Paclitaxel Before Surgery in Patients With High-Risk Liver Bile Duct Cancer

Resectable Cholangiocarcinoma | Stage IB Intrahepatic Cholangiocarcinoma AJCC v8 | Stage II Intrahepatic Cholangiocarcinoma AJCC v8 | Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8

United States
Arbor Research Collaborative for Health
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

A Prospective Database of Infants With Cholestasis (PROBE)

Biliary Atresia | Neonatal Cholestasis

United States, Canada
Massachusetts General Hospital
Exelixis

Completed

Cabozantinib (XL-184) Monotherapy for Advanced Cholangiocarcinoma

Bile Duct Cancer | Intrahepatic Cholangiocarcinoma | Cholangiocarcinoma of the Extrahepatic Bile Duct

United States
Massachusetts General Hospital

Terminated

A Pilot Study of Neoadjuvant Therapy With Gemcitabine and Cisplatin in Patients With Resectable or Unresectable Intrahepatic Cholangiocarcinoma

Resectable Intrahepatic Cholangiocarcinoma | Unresectable Intrahepatic Cholangiocarcinoma

United States
University of Michigan
University of Colorado, Denver; University of Florida; Seattle Children's Hospital and other collaborators

Completed

Standard Lipid Therapy vs IVFE Minimization for Prevention of PNALD

Cholestasis

United States
GlaxoSmithKline

Completed

Pharmacokinetics (PKs) and Metabolism of Radiolabelled Linerixibat

Cholestasis

United Kingdom
Children's Hospital Medical Center, Cincinnati

Completed

Compassionate Use of Omegaven to Reverse Parenteral Nutrition Induced Cholestasis

Cholestasis

United States
University of California, Los Angeles

Terminated

A Safety and Efficacy Study to Determine if Giving Intravenous Fish Oil Helps Children With Liver Disease (FO)

Cholestasis

United States
University of North Carolina, Chapel Hill
National Institutes of Health (NIH); Olympic Medical

Completed

A Randomized Controlled Trial (RCT) of Carbon Dioxide Versus Air Insufflation During Endoscopic Retrograde Cholangiopancreatography (ERCP)

Cholestasis

United States
SWOG Cancer Research Network
National Cancer Institute (NCI)

Active, not recruiting

Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8 | Stage III Gallbladder Cancer AJCC v8 | Stage IIIA Gallbladder Cancer AJCC v8 | Stage IIIB Gallbladder Cancer AJCC v8 | Unresectable Extrahepatic... and other conditions

United States
Geisinger Clinic

Approved for marketing

Compassionate Use of Omegaven

Cholestasis
GlaxoSmithKline

Completed

Dose-escalation Study of GSK2330672 in Japanese Healthy Male Volunteers

Cholestasis

Japan
University Hospital, Toulouse

Terminated

Inter-regional Cohort of Neonatal and Infant Cholestasis in the Greater Southwest Region (CHOLESTASE)

Cholestasis

France
Arbor Research Collaborative for Health
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Active, not recruiting

FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE) (FORCE)

Portal Hypertension | Cholestasis | Liver Fibrosis | Biliary Atresia | Alagille Syndrome | Alpha1 Anti-Trypsin Deficiency

United States, Canada
Carle Foundation Hospital

Unknown

Omegaven® as Parenteral Nutrition

Cholestasis

United States
NRG Oncology
National Cancer Institute (NCI)

Terminated

Radiation Therapy vs. Observation Following Gemcitabine and Cisplatin for Inoperable Localized Liver Cancer

Stage III Intrahepatic Cholangiocarcinoma | Stage IVA Intrahepatic Cholangiocarcinoma

United States, Canada
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

Capecitabine and Y-90 Radioembolization in Treating Patients With Advanced Bile Duct Cancer in the Liver That Cannot Be Removed by Surgery

Bile Duct Adenocarcinoma | Stage III Intrahepatic Cholangiocarcinoma | Stage IVA Intrahepatic Cholangiocarcinoma | Stage IVB Intrahepatic Cholangiocarcinoma

United States
National Taiwan University Hospital

Unknown

Retrospective Review of CT and MR in Pediatric Patients With Cholestasis

Children | Cholestasis

Taiwan
GlaxoSmithKline

Completed

Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Subjects

Cholestasis

United Kingdom
London North West Healthcare NHS Trust
Fresenius AG

Unknown

A Trial of Taurine Supplementation in Parenteral Nutrition 1

Cholestasis

United Kingdom
Georgetown University

Approved for marketing

Safer Parenteral Nutrition in Pediatric Short Bowel Syndrome to Decrease Liver Damage

Cholestasis of Parenteral Nutrition

United States
National Taiwan University Hospital

Enrolling by invitation

Dry Blood Spot Screening Test for Neonatal Cholestasis Patients (DBS-SCReNC)

Biliary Atresia | Cholestasis in Newborn Infant

Taiwan
Istituto Clinico Humanitas

Recruiting

A Study Comparing Sems Placement With and and Without Biliary Sphincterectomy in Patients With Malignant Biliary Obstruction

Bile Duct Obstruction

Italy
Xinhua Hospital, Shanghai Jiao Tong University...

Unknown

Dry Blood Spot Screening Test for Biliary Atresia（DBS-SCReBA）

Biliary Atresia | Hepatobiliary Disease | Neonatal Cholestasis

China
Asan Medical Center

Completed

Paclitaxel Eluting Covered Metallic Stent for Unresectable Malignant Bile Duct Obstruction

Bile Duct Obstruction

Korea, Republic of

Clinical Trials on Extrahepatic Cholestasis

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Greece

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations