Clinical Trials on Familial Frontotemporal Dementia in Germany

Total 434 results

University Hospital, Bonn

Completed

Auditory Beat Stimulation and Behavioural Variant of Frontotemporal Dementia

Anxiety | bvFTD

Germany
University of Rostock
German Center for Neurodegenerative Diseases (DZNE); Fraunhofer Institute

Completed

SAMi Intervention Study to Evaluate Smartwatch Interventions in Persons With MCI and Dementia (SAIN_UMR)

Dementia | Alzheimer Disease | Mild Cognitive Impairment | Dementia, Vascular | Dementia, Mixed | Dementia With Lewy Bodies | Dementia Frontotemporal

Germany
Technical University of Munich
University of Melbourne

Completed

RHAPSODY-plus: Online Counseling for Family Caregivers of Patients With Young Onset Dementia (RHAPSODY-plus)

Frontotemporal Dementia | Early Onset Alzheimer Disease

Germany
Axon Neuroscience SE

Unknown

A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia (AIDA)

Primary Progressive Nonfluent Aphasia

Germany
TauRx Therapeutics Ltd

Completed

Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD)

Behavioral Variant Frontotemporal Dementia (bvFTD)

United States, Australia, Canada, Croatia, Poland, Netherlands, United Kingdom, Spain, Germany, Italy, Romania, Singapore
Alector Inc.

Active, not recruiting

A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2)

Frontotemporal Dementia

Canada, United States, Germany, United Kingdom, Italy, Netherlands
Ludwig-Maximilians - University of Munich

Recruiting

Clearance Mechanisms in Atypical Neurodegenerative Diseases (PeptiClear)

Neurodegenerative Diseases | Frontotemporal Degeneration

Germany
TauRx Therapeutics Ltd

Terminated

Open-Label Study of Leuco-methylthioninium Bis(Hydromethanesulfonate) (LMTM) in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD)

Alzheimer's Disease | Behavioral Variant Frontotemporal Dementia

Korea, Republic of, United States, Spain, Taiwan, Canada, Belgium, Malaysia, United Kingdom, Australia, Singapore, Croatia, Finland, France, Germany, Netherlands, Romania, Russian Federation
CENTOGENE GmbH Rostock

Active, not recruiting

Epidemiological Study in FRONtoTemporal Dementia (EFRONT)

Frontotemporal Dementia

Italy, Spain, Belgium, Turkey, Portugal, Germany, Greece
Alector Inc.

Active, not recruiting

A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3)

Frontotemporal Dementia

Spain, United States, Portugal, United Kingdom, France, Germany, Netherlands, Belgium, Australia, Italy, Turkey, Switzerland, Argentina, Canada, Greece, Sweden
Transposon Therapeutics, Inc.

Active, not recruiting

A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD

Amyotrophic Lateral Sclerosis | Frontotemporal Dementia

Spain, United States, Belgium, France, Germany
CENTOGENE GmbH Rostock

Withdrawn

Biomarker for Transthyretin-Related Familial Amyloidotic Polyneuropathy (BioTRAP) (BioTRAP)

Transthyretin Amyloidosis | Transthyretin Amyloid Cardiopathy | Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy

India, Germany
Alnylam Pharmaceuticals

Completed

The Study of an Investigational Drug, Revusiran (ALN-TTRSC), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Whose Disease Has Continued to Worsen Following Liver Transplant

ATTR Amyloidosis | Transthyretin (TTR)-Mediated Amyloidosis | Familial Amyloidotic Polyneuropathy (FAP) | Familial Amyloid Neuropathies

France, Germany, Portugal, United Kingdom, Sweden, Spain
CENTOGENE GmbH Rostock

Withdrawn

Biomarker for Niemann Pick Type C Disease (BioNPC) (BioNPC)

Niemann-Pick Disease, Type C | Niemann-Pick Disease

Germany, India, Sri Lanka
University Hospital, Bonn
Charite University, Berlin, Germany; University of Erlangen-Nürnberg; University... and other collaborators

Completed

Bupropion for the Treatment of Apathy in Alzheimer's Dementia (APA-AD)

Apathy in Dementia

Germany
Prof. Dr. Dieter Willbold
Medical University of Vienna; Alzheimer's Association; Helmholtz-Gemeinschaft... and other collaborators

Completed

MAD Phase I Study to Investigate Contraloid Acetate

Alzheimer Disease | Alzheimer Dementia

Germany
UniQure Biopharma B.V.

Completed

Glybera Registry, Lipoprotein Lipase Deficient (LPLD) Patients (GENIALL)

Lipoprotein Lipase Deficiency | Familial Hyperlipoproteinemia Type 1 | Familial Hyperchylomicronemia

Germany
Prof. Dr. Dieter Willbold
Medical University of Vienna; Helmholtz-Gemeinschaft Deutscher Forschungszentren... and other collaborators

Completed

SAD Phase I Study (First-in-human) to Investigate Contraloid Acetate

Alzheimer Disease | Alzheimer Dementia

Germany
Charite University, Berlin, Germany

Withdrawn

Influence of tDCS on Cortical Plasticity in Patients With Dementia of the Alzheimer Type

Dementia of Type Alzheimer

Germany
University Medicine Greifswald

Terminated

Immunoadsorption for Treatment of Alzheimer's Disease (IMAD)

Alzheimer Dementia

Germany
IntraBio Inc

Completed

N-Acetyl-L-Leucine for Niemann-Pick Disease, Type C (NPC)

Niemann-Pick Disease, Type C

United States, United Kingdom, Germany, Slovakia, Spain
GE Healthcare

Completed

Dopamine Transporter Scintigraphy Imaging (DAT-Imaging) in Patients With Lewy Body Dementia

Vascular Dementia | Lewy Body Dementia | Alzheimer's | Non-DLB Dementia

Germany
Ludwig-Maximilians - University of Munich
Hoffmann-La Roche; University of Southern California; Eisai Limited; ki:elements; Johanniter-Unfall-Hilfe e.V...

Recruiting

Davos Alzheimer's Collaborative Healthcare System Preparedness to Increase Cognitive Assessment Rates for Older Adults

Alzheimer Dementia | Subjective Cognitive Decline

Germany
University of Leipzig
German Center for Neurodegenerative Diseases (DZNE)

Completed

Talking Time: Telephone Support Groups for Informal Caregivers of People With Dementia

Caregivers of People With Dementia

Germany
MindAhead UG
University Medical Center Göttingen

Recruiting

Efficacy of MindAhead's Digital Behavioral Activation Therapy in Adults With MCI or Mild Dementia

Mild Cognitive Impairment | Mild Dementia

Germany
Technical University of Munich
Bavarian State Ministry of Health and Care; German Alzheimer Society

Completed

Advanced Dementia and End-of-life

Advanced Dementia

Germany
Washington University School of Medicine
Eli Lilly and Company; Hoffmann-La Roche; Avid Radiopharmaceuticals; National Institute... and other collaborators

Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001 (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, Argentina, Australia, Colombia, France, Ireland, Mexico, Netherlands, Puerto Rico, Spain, United Kingdom, Brazil, Japan, Germany
KemPharm Denmark A/S

Completed

A Prospective Non-therapeutic Study in Patients Diagnosed With Niemann-Pick Disease Type C

Niemann-Pick Disease, Type C

Spain, France, United Kingdom, Switzerland, Denmark, Poland, Italy, Germany
Washington University School of Medicine
National Institute on Aging (NIA); Alzheimer's Association; Eisai Inc.; Accelerating...

Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, Argentina, Australia, Colombia, Netherlands, Puerto Rico, Spain, United Kingdom, France, Ireland, Mexico, Brazil, Japan, Germany
University of Rostock
DZNE, German Center for Neurodegenerative Disorders, Germany

Unknown

Effect of Cognitive Intervention in Alzheimer's Disease (AD) on Functional Cortical Networks in fMRI (ECIF)

Dementia of the Alzheimer Type

Germany
Technical University of Munich
German Federal Ministry of Education and Research; Centre Hospitalier Universitaire... and other collaborators

Completed

IssuEs in Palliative Care for People in Advanced and Terminal Stages of Young-onset and Late-Onset Dementia in GErmany (EPYLOGE)

Palliative Care | Advanced Dementia Stages

Germany
Technische Universität Dresden
RECK-Technik GmbH & Co. KG

Completed

Physical Activity Training Program for Patients With Alzheimer's Dementia (MOTODEM)

Dementia

Germany
IntraBio Inc

Active, not recruiting

A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type C

Niemann-Pick Disease, Type C

United States, Australia, United Kingdom, Germany, Slovakia, Netherlands, Czechia, Switzerland
Mandos LLC

Completed

VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease

Niemann-Pick Disease, Type C

United States, Australia, United Kingdom, Germany, France, New Zealand, Singapore, Spain, Turkey
H. Lundbeck A/S

Completed

Memantine Versus Placebo in Parkinson's Disease Dementia or Dementia With Lewy Bodies

Dementia With Lewy Bodies | Parkinson's Disease Dementia

Germany
ZevraDenmark

Active, not recruiting

Arimoclomol Prospective Study in Participants Diagnosed With Niemann-Pick Disease Type C

Niemann-Pick Disease, Type C

United States, Spain, United Kingdom, Denmark, France, Germany, Italy, Poland, Switzerland
University of Rostock
German Center for Neurodegenerative Diseases (DZNE)

Completed

Short-term Caregiver Psychotherapy

Caregiver Burden of People With Dementia

Germany
Mandos LLC

Terminated

Adrabetadex to Treat Niemann-Pick Type C1 (NPC1) Disease

Niemann-Pick Disease, Type C

United States, Australia, United Kingdom, Turkey, Switzerland, Germany, New Zealand, Singapore, France
Washington University School of Medicine
Hoffmann-La Roche; Genentech, Inc.; National Institute on Aging (NIA); Alzheimer...

Suspended

A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, France, Spain, Ireland, Argentina, Australia, Colombia, Germany, Mexico, Netherlands, Puerto Rico, United Kingdom
Pfizer

Completed

An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid Polyneuropathy

Familial Amyloid Polyneuropathy | ATTR-PN

Sweden, Brazil, Germany, Argentina, France, Portugal
Heidelberg University
Hannover Medical School; University of Leipzig; University Hospital Heidelberg; University of Giessen and other collaborators

Completed

BMPR2 Mutations and Iron Metabolism in Pulmonary Arterial Hypertension (AMIA)

Pulmonary Arterial Hypertension

Germany
Wuerzburg University Hospital
Kyowa Kirin, Inc.

Completed

Anti-FGF23 (Burosumab) in Adult Patients With XLH (BurGER)

X-linked Hypophosphatemia

Germany
Universitätsklinikum Hamburg-Eppendorf
Pfizer; Actelion

Completed

Endothelial Function in Patients With Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension | Hypertension, Pulmonary | Genetics | Pathophysiology

Germany
Novartis Pharmaceuticals

Terminated

Extension to a Randomized, Double-blind, Placebo Controlled Study of LCQ908 in Subjects With Familial Chylomicronemia Syndrome.

Familial Chylomicronemia Syndrome (FCS) (HLP Type I)

South Africa, Germany, United Kingdom, France, United States, Canada, Netherlands
Heidelberg University

Completed

Effect of Pharmacologic Interaction Between ERAs and PDE-5 Inhibitors on Medication Serum Levels and Clinical Disease Status in Patients With PAH (EPIC)

Pulmonary Arterial Hypertension

Germany
Cyclo Therapeutics, Inc.

Recruiting

Phase 3 Study to Evaluate Intravenous Trappsol(R) Cyclo(TM) in Pediatric and Adult Patients With Niemann-Pick Disease Type C1 (TransportNPC)

Niemann-Pick Disease, Type C1

United States, Spain, Israel, Taiwan, Brazil, Germany, Australia, Poland, Turkey, Italy, United Kingdom
CENTOGENE GmbH Rostock
Alnylam Pharmaceuticals

Recruiting

TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive Subjects (TRAMmoniTTR)

Cardiomyopathies | Polyneuropathies | Transthyretin Amyloidosis | Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy | Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy

Germany, Austria, Switzerland
Novartis Pharmaceuticals

Completed

A Randomized, Double-blind, Placebo Controlled Study to Assess Efficacy, Safety and Tolerability of LCQ908 in Subjects With Familial Chylomicronemia Syndrome

Familial Chylomicronemia Syndrome (FCS)

South Africa, Spain, France, Germany, United Kingdom, United States, Canada, Netherlands
Hannover Medical School

Terminated

Combination Therapy of Bosentan and Aerosolized Iloprost in Idiopathic Pulmonary Arterial Hypertension (IPAH)

Hypertension

Germany
Anglia Ruskin University
University of Melbourne; Alzheimer's Society; Norwegian Academy of Music; Cambridgeshire... and other collaborators

Completed

Home-based Family Caregiver-delivered Music and Reading Interventions for People With Dementia (HOMESIDE)

Depression | Quality of Life | Dementia | Dementia, Vascular | Dementia, Mixed | Dementia With Lewy Bodies | Dementia Alzheimers | Behavioural and Psychiatric Symptoms of Dementia

United Kingdom, Australia, Germany, Norway, Poland

Clinical Trials on Familial Frontotemporal Dementia in Germany

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mozambique

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations