Clinical Trials on Familial Hypercholesterolemia - Heterozygous

Total 2125 results

Novartis Pharmaceuticals

Active, not recruiting

Efficacy and Safety of Inclisiran as Monotherapy in Patients With Primary Hypercholesterolemia Not Receiving Lipid-lowering Therapy. (V-Mono)

Hypercholesterolemia

United States, Germany, Hungary, Colombia, Mexico
S.LAB (SOLOWAYS)
Center of New Medical Technologies

Completed

Evaluating the Efficacy of AI-Guided (GenAIS TM) vs. Standard Physician-Guided Dietary Supplement Prescriptions for Lowering LDL Cholesterol in Hypercholesterolemic Patients

Hypercholesterolemia

Russian Federation
Organon and Co

Completed

Ezetimibe Plus (+) Simvastatin Versus Atorvastatin Comparative Study (0653A-092)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

To Evaluate Ezetimibe Plus Atorvastatin Versus Atorvastatin in Patients With High Cholesterol Not Controlled on Atorvastatin 20 mg (0653-079)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

MK0653A (Ezetimibe (+) Simvastatin) Compared to an Approved Drug (Atorvastatin) for the Treatment of High Cholesterol (0653A-051)(COMPLETED)

Hypercholesterolemia
University of Bologna
SCHARPER Spa

Completed

Food Supplementation With Eufortyn Colesterolo Plus for LDL Modulation in Subjects With Polygenic Hypercholesterolemia (ANEMONE)

Hypercholesterolemia

Italy
University of Bologna

Completed

Lipid-lowering Effect of Phytosterols, Red Yeast Rice and Their Combination

Hypercholesterolemia

Italy
University of Bologna

Completed

Diet and Plant Sterols in the Control of Cholesterolemia (DESCO) (DESCO)

Hypercholesterolemia

Italy
Kowa Company, Ltd.

Completed

K-924 Phase III Confirmatory Study

Hypercholesterolemia

Japan
Mylan Inc.
Mylan Österreich GmbH; Mylan Germany GmbH; Mylan Healthcare Sp. z o.o.

Completed

Observation of the Effects of Guideline-driven Lifestyle Interventions, Including Use of a Red-yeast Based Nutraceutical

Hypercholesterolemia

Germany, Austria
University of Erlangen-Nürnberg Medical School
Bristol-Myers Squibb

Completed

Effect of Irbesartan on Endothelial Function of the Retinal Vasculature in Patients With Hypercholesterolemia

Hypercholesterolemia

Germany
University of Georgia
National Cottonseed Products Association; Cotton Incorporated; University of...

Completed

Oil Consumption and Cholesterol

Hypercholesterolemia

United States
Akeso
AD Pharma (Guangdong)

Completed

A Long-term Study of AK102 in Patients With Hypercholesterolemia

Hypercholesterolemia

China
Regeneron Pharmaceuticals

Completed

Study of Evinacumab (REGN1500) in Participants With Persistent Hypercholesterolemia

Hypercholesterolemia

United States, Spain, Australia, Netherlands, Japan, Jordan, Denmark, Israel, Sweden, South Africa, Canada, Austria, Czechia, France, Italy, New Zealand, Norway, Poland, Russian Federation, United Kingdom
Institut Pasteur de Lille

Completed

Effect of Oleactiv® on LDL Oxidability (e-POL)

Hypercholesterolemia

France
Universidad de Granada
Maimónides Biomedical Research Institute of Córdoba; Hospital Universitario...

Completed

Hypocholesterolemic Effect of a Phytosterol-enriched Spreadable Cream Prepared With Virgin Olive Oil

Hypercholesterolemia

Spain
Sanofi

Completed

A Study to Evaluate the Efficacy and the Safety of Single Pill Combination (SPC) Ezetimibe/Rosuvastatin in Chinese Adult Patients With Primary Hypercholesterolemia Not Adequately Controlled on Statin Therapy (ROZEL)

Hypercholesterolemia

China
Esperion Therapeutics, Inc.

Completed

A Study of the Efficacy and Safety of ETC-1002 in Participants With Statin Intolerance

Hypercholesterolemia

United States
LIB Therapeutics LLC

Completed

Open-Label Extension to Evaluate the Longer Term Efficacy and Safety of LIB003

Hypercholesterolemia

United States
Organon and Co

Completed

Observational Study to Evaluate LDL-C Lowering Effect of Ezetimibe (0653-070)

Hypercholesterolemia
Organon and Co

Completed

Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224)

Hypercholesterolemia
Organon and Co

Completed

Study to Evaluate the Cholesterol Lowering Effects of Two Marketed Drugs in Patients With Elevated Cholesterol Levels (0653A-058)

Hypercholesterolemia
Organon and Co

Completed

A Study of MK0653A (Ezetimibe (+) Simvastatin) in Patients With Hypercholesterolemia (0653A-038)

Hypercholesterolemia
Organon and Co

Completed

MK0653C in High Cardiovascular Risk Patients With High Cholesterol (Switch Study)(MK-0653C-162)

Hypercholesterolemia
Organon and Co

Completed

A Study to Evaluate the Effectiveness of Ezetimibe/Atorvastatin 10 mg/40 mg Combination Tablet Compared to Marketed Ezetimibe 10 mg and Atorvastatin 40 mg Tablets in Participants With High Cholesterol (MK-0653C-190 AM1)

Hypercholesterolemia
Raisio Group

Completed

Lipid Lowering Effect of Plant Stanol Ester in a Spoonable Non-dairy Product

Hypercholesterolemia

Finland
Chinese University of Hong Kong

Completed

Genome-wide Analysis of Lipid-lowering Efficacy and Drug Level of Simvastatin and Rosuvastatin

Hypercholesterolemia

Hong Kong
Regeneron Pharmaceuticals
Sanofi

Completed

Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo

Hypercholesterolemia

United States, Bulgaria, Chile, Estonia, Japan, Mexico, Russian Federation, South Africa, Ukraine
JW Pharmaceutical

Completed

Efficacy and Safety of Pitavastatin in a Real-world Setting (PROOF)

Hypercholesterolemia
UCSF Benioff Children's Hospital Oakland
Merck Schering-Plough

Completed

Effects of Ezetimibe on the Absorption of Oxidized Cholesterol

Hypercholesterolemia

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Actual Use Trial of Atorvastatin Calcium 10 mg

Hypercholesterolemia

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Bioequivalence Study Comparing A New 80 Mg Atorvastatin Tablet To A 80 Mg Atorvastatin Commercial Tablet

Hypercholesterolemia

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Canadians Achieve Cholesterol Targets Fast With Atorvastatin Stratified Titration (CANACTFAST)

Hypercholesterolemia

Canada
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Bioequivalence Study Of Pediatric Appropriate Formulation

Hypercholesterolemia

United States
Catabasis Pharmaceuticals

Completed

A 2-Part, Phase 1, Single and Multiple Ascending Dose Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of CAT-2054 in Healthy Subjects

Hypercholesterolemia

United States
AstraZeneca
Parexel

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8233 in Healthy Male Subjects With Increased Elevated LDL-C Levels.

Hypercholesterolemia

United States
AB Biotics, SA
University of Extremadura

Completed

Combination of AB-LIFE Probiotic Plus Monacolin K to Reduce Blood Cholesterol

Hypercholesterolemia
Azienda di Servizi alla Persona di Pavia

Completed

Artichoke and Bergamot Phytosome

Hypercholesterolemia

Italy
Regeneron Pharmaceuticals
Sanofi

Terminated

Praluent® (Alirocumab) Pregnancy Exposure Registry: An OTIS Pregnancy Surveillance Study

Hypercholesterolemia

United States
Chong Kun Dang Pharmaceutical

Completed

Clinical Trial to to Compare of the Efficacy and Safety of Lipilou® 20 mg and Lipilou® 10 mg

Hypercholesterolemia

Korea, Republic of
Regeneron Pharmaceuticals
Sanofi

Completed

Study of Alirocumab (REGN727/SAR236553) in Patients With Primary Hypercholesterolemia and Moderate, High, or Very High Cardiovascular (CV) Risk, Who Are Intolerant to Statins (ODYSSEY ALTERNATIVE)

Hypercholesterolemia

United States, France, Italy, Israel, United Kingdom, Austria, Canada, Norway
Merck Sharp & Dohme LLC

Completed

A Study of the Safety and Efficacy of Anacetrapib (MK-0859) Among Participants With Hypercholesterolemia When Added to Ongoing Statin Therapy (MK-0859-022)

Hypercholesterolemia
NeuroBo Pharmaceuticals Inc.

Completed

Efficacy and Safety of Gemcabene in Hypercholesterolemic Patients as Monotherapy or in Combination With Atorvastatin

Hypercholesterolemia
NeuroBo Pharmaceuticals Inc.

Completed

Pharmacokinetics and Pharmacodynamics Study of Gemcabene in Healthy Volunteers

Hypercholesterolemia
NeuroBo Pharmaceuticals Inc.

Completed

Efficacy and Safety of Gemcabene in Hypercholesterolemic Patients on Stable Statin Therapy

Hypercholesterolemia
Esperion Therapeutics, Inc.

Completed

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg When Added to PCSK9 Inhibitor Therapy

Hypercholesterolemia

United States
Pfizer

Completed

Pharmacokinetics And Relative Bioavailability Of Bococizumab (PF-04950615; RN316) When Administered To The Abdomen, Thigh Or Upper Arm

Hypercholesterolemia

United States
Amgen

Completed

Open-label Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Hypercholesterolemia

Canada, Netherlands, Spain, Belgium, United States, Russian Federation, Czechia, Mexico, Korea, Republic of, Australia, United Kingdom, Argentina, Israel, France, Hungary, Germany, Greece, Poland, Switzerland, Italy, Brazil, Sweden, Norwa... and more
University of California, Los Angeles

Terminated

Effects of a Supplement Derived From Palm Oil on Cholesterol Levels in the Blood (TRF)

Hypercholesterolemia

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety of Alirocumab in Patients With Hypercholesterolemia Not Adequately Controlled With Non-statin Lipid Modifying Therapy or the Lowest Strength of Statin (ODYSSEY-NIPPON)

Hypercholesterolemia

Japan

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