Clinical Trials on Familial Hypercholesterolemias

Total 2108 results

Organon and Co
Merck Sharp & Dohme LLC

Completed

Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

An Extension Study of An Investigational Drug in Patients With Hypercholesterolemia (0653A-038)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Post-marketing Surveillance of the Safety, Tolerability and Efficacy of Vytorin (Ezetimibe + Simvastatin) Tablet Among Filipino Patients (Study P05647)

Hypercholesterolemia
Organon and Co

Completed

A Study to Evaluate the Effectiveness of Ezetimibe/Atorvastatin 10 mg/20 mg Combination Tablet Compared to Marketed Ezetimibe 10 mg and Atorvastatin 20 mg Tablets in Participants With High Cholesterol (MK-0653C-185 AM1)

Hypercholesterolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Comparison of Ezetimibe Added to Ongoing Statin Therapy Versus Doubling the Dose of Statin in the Treatment of Hypercholesterolemia (P04355)

Hypercholesterolemia
Organon and Co

Completed

EZETROL® Re-examination Study (MK0653-175)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Evaluation of the LDL-C Lowering Effects of Ezetimibe Achieved in Co-administration Therapy With Statins in an Indonesian Population (Study P04276)(COMPLETED)

Hypercholesterolemia
Raisio Group

Active, not recruiting

Lipid Lowering Effect of Plant Stanol Ester in a Drinkable Non-dairy Product

Hypercholesterolemia

Finland
University of Roehampton

Completed

The Efficacy of Cholesterol-lowering Probiotic Lactobacillus Plantarum LPLDL® in Hypercholesterolemic Adults. (ProLoChol)

Hypercholesterolemia

United Kingdom
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Bioavailability Study for New Atorvastatin Formulation

Hypercholesterolemia

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Efficacy And Safety Study Of Atorvastatin Versus Simvastatin In Type 2 Diabetic Subjects With Hypercholesterolemia

Hypercholesterolemia

Italy
Amgen

Completed

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-4 (GAUSS-4)

Hypercholesterolemia

Japan
Manchester University NHS Foundation Trust

Completed

Effect of Tredaptive on Serum Lipoproteins and Inflammatory Markers

Hypercholesterolemia

United Kingdom
Raisio Group

Completed

Lipid-lowering Effect of Plant Stanol Drink

Hypercholesterolemia

Sweden
Civi Biopharma, Inc.

Completed

A First In Human Study to Assess CiVi007 in Subjects With an Elevated LDL-Cholesterol Level

Hypercholesterolemia

United Kingdom
Universitat de Lleida

Completed

Hypocholesterolemic Effect of Fibracep (FIBRACEP)

Hypercholesterolemia

Spain
Esperion Therapeutics, Inc.

Completed

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg, Ezetimibe 10mg, and Atorvastatin 20 mg Triplet Therapy in Patients With Elevated LDL-C

Hypercholesterolemia

United States
Shanghai Junshi Bioscience Co., Ltd.

Completed

A Single Dose Escalation Study of PCSK9 Inhibitor (JS002) in Health Subjects

Hypercholesterolemia

China
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate the Effects of Extended Release (ER) Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites in Subjects With High Cholesterol (0524A-075)(COMPLETED)

Hypercholesterolemia
A. Menarini Industrie Farmaceutiche Riunite S.r.l.

Completed

Effect of a Treatment With a Nutraceutical Combination on Sub-optimal LDL Cholesterol Levels (NATCOL)

Hypercholesterolemia

Italy
Sanofi
Regeneron Pharmaceuticals

Completed

Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY EAST)

Hypercholesterolemia

China, India, Thailand
Eli Lilly and Company

Completed

A Study of LY3015014 in Participants With High Cholesterol

Hypercholesterolemia

Poland, Netherlands, United States, Denmark, Canada, Japan, Czechia, Puerto Rico
Esperion Therapeutics, Inc.
Medpace, Inc.

Completed

Evaluation of ETC-1002 vs Placebo in Patients Receiving Ongoing Statin Therapy

Hypercholesterolemia

United States
Montefarmaco OTC SpA

Completed

Efficacy of a Red Yeast Rice Based Nutraceutical Plus Probiotic in Patients With Moderate Hypercholesterolemia

Hypercholesterolemia

Italy
Arjuna Natural Limited

Unknown

Effect of Indian Gooseberry Extract (AMX160) in Hypercholesterolemia

Hypercholesterolemia

Armenia
Sanofi
Regeneron Pharmaceuticals

Completed

Open Label Study of Long Term Safety Evaluation of Alirocumab (ODYSSEY OLE)

Hypercholesterolemia

United States, Argentina, Austria, Belgium, Bulgaria, Canada, Czechia, Denmark, Finland, France, Germany, Hungary, Israel, Italy, Mexico, Netherlands, Norway, Portugal, Romania, Russian Federation, South Africa, Spain, Sweden, United...
Aegerion Pharmaceuticals, Inc.

Completed

Evaluate Safety and Efficacy of AEGR-733 and Atorvastatin vs Atorvastatin Monotherapy in Hypercholesterolemia

Hypercholesterolemia

United States
University Hospital of Ferrara

Completed

Nutraceutical in Cardiovascular Primary Prevention (NIRVANA)

Hypercholesterolemia

Italy
Foundation for Atlanta Veterans Education and Research...
AstraZeneca

Completed

Effect of Crestor on Lipoprotein Metabolism in Humans

Hypercholesterolemia

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Effect of Alirocumab on Lipid Metabolism in Adults With Elevated LDL-Cholesterol

Hypercholesterolemia

United States
Merck Sharp & Dohme LLC

Completed

A Study of the Safety and Efficacy of Anacetrapib (MK-0859) When Added to Ongoing Statin Therapy (MK-0859-021)

Hypercholesterolemia
University of Bologna

Completed

Effect of Red Yeast Rice, Phytosterols and L-tyrosol on Lipid Profile and Endothelial Function

Hypercholesterolemia

Italy
Danone Spain

Completed

Effect of the Consumption of a Fermented Milk Enriched With Plant Sterols (Spain)

Hypercholesterolemia

Spain
Danone Research

Completed

Effects of Lactobacillus Delbruckii Lactis DN111244 Fermented Milk Consumption on Plasma Lipids Levels in Hypercholesterolaemic Adults

Hypercholesterolemia

Czech Republic
Daewon Pharmaceutical Co., Ltd.

Completed

Phase 3 Study to Evaluate the Efficacy and Safety of the DW0929 in Patients With Primary Hypercholesterolemia

Hypercholesterolemia

Korea, Republic of
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) in Patients With Primary Hypercholesterolemia on Stable Atorvastatin Therapy in Japan

Hypercholesterolemia

Japan
Sanofi
Regeneron Pharmaceuticals

Completed

Effect of Alirocumab (SAR236553/REGN727) Administered on Top of Ezetimibe or Fenofibrate on Lipid Profiles in Healthy Subjects

Hypercholesterolemia

France
Yonsei University

Completed

Nattokinase Supplementation and Hemostatic Factors

Hypercholesterolemia

Korea, Republic of
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Safety and Tolerability of Varying Load and Dose of ISIS 301012 in People With Elevated LDL-cholesterol Levels

Hypercholesterolemia

Germany
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Dose-escalating Safety Study in Subjects on Stable Statin Therapy

Hypercholesterolemia

Netherlands, United States
Sanofi

Terminated

Evaluation of Efficacy and Safety of AVE5530 Co-administered With Atorvastatin in Primary Hypercholesterolemia

Hypercholesterolemia

United States, Puerto Rico
Sanofi

Terminated

Evaluation of Safety and Efficacy of AVE5530 as add-on to Ongoing Statins in Patients With Primary Hypercholesterolemia

Hypercholesterolemia

United States, France, Canada, Poland, Russian Federation, Germany, Netherlands, Spain, Sweden, Belgium, Czech Republic, Denmark, Hungary, Israel, Norway, Australia
Cardinal Tien Hospital

Completed

Evaluation of the Effects of Simvastatin 40mg

Hypercholesterolemia
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) When Co-administered With High Dose of Atorvastatin in Patients With Primary Hypercholesterolemia

Hypercholesterolemia

United States
NYU Langone Health

Completed

Using Nudges to Implement Comparative Effectiveness

Hypercholesterolemia

United States
Sun Yat-sen University

Completed

Retinoic Acid Supplementation and Subjects With Hypercholesterolemia

Hypercholesterolemia

China
US Department of Veterans Affairs
University of Pittsburgh

Completed

Systematic Management of High Cholesterol Utilizing Computer Monitoring

Hypercholesterolemia

United States
Daiichi Sankyo, Inc.

Completed

A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Pravastatin for at Least 4 Weeks.

Hypercholesterolemia

United States
Daiichi Sankyo, Inc.

Completed

A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Simvastatin for at Least 4 Weeks.

Hypercholesterolemia

United States
Regeneron Pharmaceuticals
Sanofi

Completed

Ascending Multi-dose Study of REGN727(SAR236553) With and Without Concomitant Atorvastatin

Hypercholesterolemia

United States

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