Clinical Trials on Feasibility and Acceptability of the TOPS Program in South Africa

Total 388 results

Eastern Virginia Medical School
Gilead Sciences; United States Agency for International Development (USAID); FHI... and other collaborators

Active, not recruiting

Project Engage: Oral PrEP Acceptability

Adherence, Medication | Acceptability of Health Care

South Africa, Zimbabwe
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride

Acute Intermittent Porphyria | Anti-Psychotic | Management of Manifestations of Psychotic Disorders | Treatment of Schizophrenia | Control Nausea and Vomiting | Relief of Restlessness and Apprehension Before Surgery | Adjunct in the Treatment of Tetanus | Control Manifestations of the Manic Type... and other conditions

South Africa
Arthrex, Inc.

Recruiting

Evaluate the Continued Safety and Performance of the Foot and Ankle Products

Hyperpronated Foot | Reconstruction Surgeries of the Foot | Fixation of Fractures and Fusion (Bunionectomy Osteotomies) of the Foot/Ankle | Fixation of Small Bone Fragments of the Foot/Ankle | Lisfranc Arthrodesis | Mono or Bi-cortical Osteotomies in the Forefoot | First Metatarsophalangeal Arthrodesis and other conditions

Germany, United States, South Africa
University of Cape Town

Unknown

Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction

Biliary Stricture | Cancer of the Pancreas | Bile Duct Obstruction, Extrahepatic | Cancer of the Bile Duct

South Africa
DePuy International

Terminated

A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Post-traumatic Arthritis | Congenital Hip Dysplasia | Slipped Capital Femoral Epiphysis | Collagen Disorders | Nonunion of Femoral Fractures

South Africa
Harriet Shezi Children's Clinic

Unknown

Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra (RBT)

Children With Confirmed HIV Infection | Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose | Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment

South Africa
International Atomic Energy Agency

Unknown

Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients

Cancer of the Cervix

India, South Africa, Tanzania, Uganda, Zimbabwe
Antiva Biosciences

Completed

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection.

Cervical Cancer | Human Papilloma Virus | HSIL, High Grade Squamous Intraepithelial Lesions | Cervical Dysplasia | HSIL of Cervix | High-Grade Cervical Intraepithelial Neoplasia | HIV Negative | CIN - Cervical Intraepithelial Neoplasia | Cervical Neoplasm

South Africa
University of Washington
National Cancer Institute (NCI)

Completed

Cisplatin and Radiation Therapy With or Without Erlotinib Hydrochloride in Treating Patients With Stage III or Stage IV Head and Neck Cancer

Stage III Squamous Cell Carcinoma of the Hypopharynx | Stage III Squamous Cell Carcinoma of the Larynx | Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity | Stage III Squamous Cell Carcinoma of the Nasopharynx | Stage III Squamous Cell Carcinoma of the Oropharynx | Stage IV Squamous... and other conditions

United States
Arthrex, Inc.

Recruiting

Web Based Orthopaedic Sports Medicine Registry

Degenerative and Traumatic Pathology of the Knee | Degenerative and Traumatic Pathology of the Shoulder and Elbow | Degenerative and Traumatic Pathology of the Foot and Ankle | Degenerative and Traumatic Pathology of the Hand and Wrist | Degenerative and Traumatic Pathology of the Hip

United States, United Kingdom, Canada, Puerto Rico, South Africa
University of the West of Scotland
Swansea University

Completed

The Influence of a High Intensity Physical Activity Intervention on a Selection of Health Related Outcomes: An Ecological Approach

To Assess the Impact of the HIT Intervention on Physiological Responses | To Assess the Role of a Secondary High School as a Setting for Promoting Healthy Eating and PA Behaviours | To Determine the Associations Between CVD Risk Factors at Baseline in 15 - 18 Year Old Youth

United Kingdom
International Atomic Energy Agency
Tata Memorial Centre; University of Maryland, College Park; Centro de Lucha contra... and other collaborators

Unknown

Resource Sparing Curative Radiotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck: The HYPNO Trial (HYPNO)

Squamous Cell Carcinoma of the Head and Neck

India, Argentina, Cuba, Indonesia, Pakistan, Philippines, South Africa, Thailand, Uruguay
AO Clinical Investigation and Publishing Documentation
AOCMF

Completed

Bilateral Condylar Fractures Registry (BCFx)

Bilateral Condylar Fracture of the Mandible

United States, Taiwan, Switzerland, South Africa, Finland, Slovenia, Pakistan, Spain, Germany, Malaysia, Mexico, Netherlands, Ukraine, Uruguay
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal Cancer

Adenocarcinoma of the Gastroesophageal Junction | Stage IV Gastric Cancer | Recurrent Gastric Cancer | Adenocarcinoma of the Esophagus | Recurrent Esophageal Cancer | Stage IV Esophageal Cancer | Diffuse Adenocarcinoma of the Stomach | Intestinal Adenocarcinoma of the Stomach | Mixed Adenocarcinoma...

United States
AO Clinical Investigation and Publishing Documentation
DePuy Synthes

Active, not recruiting

Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures (FROST)

Tibial Fracture | Fracture of the Tibia Type AO/OTA 42

United States, Hong Kong, Korea, Republic of, Switzerland, Singapore, Germany, South Africa, United Kingdom, Belgium
Washington University School of Medicine
Celgene Corporation

Active, not recruiting

Nab-Paclitaxel and Cisplatin or Nab-paclitaxel as Induction Therapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (HNSCC) (APA)

Head and Neck Cancer | Squamous Cell Carcinoma of the Head and Neck | Cancer of Head and Neck | Neoplasms, Head and Neck | Cancer of the Head and Neck | Carcinoma, Squamous Cell of the Head and Neck

United States
Medical University of South Carolina
Johns Hopkins University; University of North Carolina; Cook Endoscopy; Thoraxklinik-Heidelberg...

Completed

22-gauge ProCore Needle v. Standard 22-gauge (P00030500)

Quantity of Tissue Obtained | Quality of Tissue Obtained | Ease of Use of 22-gauge ProCore EBUS Needles and the Standard 22-gauge Needles

United States
Taiwan Liposome Company

Completed

A Phase 2, Open Label, PK Study of TLC599 in Subject With Osteoarthritis of the Knee

OSTEOARTHRITIS OF THE KNEE

Taiwan, United States
Sheffield Hallam University

Unknown

Mod of Cognitive Flexibility by tDCS, Tyrosine Polymorphisms in the COMT Gene

Modulation of Cognitive Flexibility by Transcranial Direct Current Stimulation, Tyrosine Administration and Polymorphisms in the COMT Gene

United Kingdom
AstraZeneca

Completed

A Study of the Efficacy and Safety of MEDI7352 in Subjects With Painful Osteoarthritis of the Knee (BESPOKE)

Painful Osteoarthritis of the Knee

Spain, United Kingdom, South Africa, Poland, Estonia, Denmark, Germany
Queensland Health
Merck Sharp & Dohme LLC

Recruiting

Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell Carcinoma (DESQUAMATE)

Head and Neck Cancer | Cutaneous Squamous Cell Carcinoma of the Head and Neck

Australia
Keythera Pharmaceuticals (Australia) Pty Ltd

Recruiting

A Study of KF-0210 in Advanced Solid Tumors Patients

Gastric Cancer | Colorectal Cancer | Lung Cancer | Bladder Cancer | Advanced Solid Tumor | Squamous Cell Carcinoma of the Esophagus

Australia
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of California, Los Angeles; Merck... and other collaborators

Active, not recruiting

HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV (COVENANT)

HIV Infection | AIDS-Related Human Papillomavirus Infection | High Grade Cervical Squamous Intraepithelial Neoplasia

Uganda, Kenya, Zimbabwe, South Africa, Malawi
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Patient Specific Instrumentation in TKR

Osteoarthritis of the Knee

United Kingdom
Ampio Pharmaceuticals. Inc.

Terminated

Open Label Extension to Assess the Safety of Long-Term Treatment With Ampion for Severe Osteoarthritis (OA) of the Knee

Severe Osteoarthritis of the Knee

United States
InGeneron, Inc.
Sanford Health

Recruiting

Healing Osteoarthritic Joints in the Wrist With Adult ADRCs

Osteoarthritis of the Wrist

United States
GlaxoSmithKline

Completed

GSK2018682 FTIH in Healthy Volunteers (P1A114070)

Multiple Sclerosis

Australia
Paragon 28

Recruiting

Patient Specific Talus Spacer Post Approval Study

Avascular Necrosis of the Talus

United States
Pacira Pharmaceuticals, Inc

Completed

Pharmacokinetic and Pharmacodynamic Study of FX006 in Patients With Osteoarthritis of the Knee

Osteoarthritis of the Knee

Australia
Xgene Pharmaceutical Group
Novotech (Australia) Pty Limited

Completed

A Study of Topical XG004 in Participants With Osteoarthritis of the Knee

Pain

Australia
GlaxoSmithKline

Completed

Effectiveness Of Single Doses Of Ibuprofen In Patients With Osteoarthritis Of The Knee

Osteoarthritis

Australia
Royal North Shore Hospital

Completed

Prostate-Rectal Separation With PEG Hydrogel and Its Effect on Decreasing Rectal Dose

Cancer of the Prostate

Australia
Tarveda Therapeutics

Recruiting

PEN-866 in Patients With Advanced Solid Malignancies

Neoplasms | Carcinoma | Small Cell Lung Carcinoma | Gastric Cancer | Pancreatic Adenocarcinoma | Solid Tumor | Gastric Adenocarcinoma | Small-cell Lung Cancer | Advanced Cancer | Pancreatic Ductal Adenocarcinoma | Adenocarcinoma of the Pancreas | Endometrial Adenocarcinoma | Squamous Cell Carcinoma of the Penis | Gastroesophageal... and other conditions

United States
GeNeuro Australia PTY Ltd

Completed

Single Ascending Doses Study With GNbAC1 in Healthy Male Volunteers

Multiple Sclerosis

Australia
Medical University of South Carolina
National Cancer Institute (NCI)

Completed

Docetaxel and Lycopene in Metastatic Prostate Cancer

Adenocarcinoma of the Prostate

United States
GlaxoSmithKline

Completed

GSK239512 DDI Study

Multiple Sclerosis

Australia
Pfenex, Inc

Completed

Comparison Study of PF530 and Betaferon in Healthy Subjects

Multiple Sclerosis

Australia
Regeneron Pharmaceuticals
Teva Pharmaceutical Industries, Ltd.

Completed

Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip (FACT LTS & OA)

Osteoarthritis of the Knee or Hip

United States, Bulgaria, Chile, Colombia, Denmark, Estonia, Germany, Hong Kong, Hungary, Italy, Lithuania, Mexico, Peru, Poland, Romania, Russian Federation, South Africa, Spain, Sweden, Ukraine, United Kingdom
GlaxoSmithKline

Completed

Assessment of Repeat Ascending Doses of GSK2018682 in Healthy Volunteers (P1A114347)

Multiple Sclerosis, Relapsing-Remitting

Australia
University of Michigan
Medical University of South Carolina; Emory University; Medical College of Wisconsin and other collaborators

Completed

Genetic Determinants of Congenital Heart Disease Outcomes (GECHO)

Congenital Heart Disease | Hypoplastic Left Heart Syndrome | Hypoplastic Right Heart Syndrome | d-Transposition of the Great Arteries

United States, Australia
Noah Hahn, M.D.
Pfizer; Hoosier Cancer Research Network

Terminated

Neoadjuvant Cisplatin, Gemcitabine, Sunitinib Malate + Radical Cystectomy for TCC

Transitional Cell Carcinoma of the Bladder

United States, United Kingdom
Olatec Therapeutics LLC

Completed

Phase 2 Efficacy Trial of OLT1177 Gel in Subjects With Moderate to Severe Pain Associated With OA of the Knee

Osteoarthritis of the Knee

United States
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Recruiting

Phenotype, Genotype and Biomarkers 2 (PGB2)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Progressive Muscular Atrophy | Hereditary Spastic Paraplegia

United States, South Africa
Biotronik, Inc.

Terminated

Safety and Performance Study of the Siello S Pacing Lead (SIELLO)

Safety and Effectiveness of the Siello S Lead

United States
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Ischemic Preconditioning, Exercise Tolerance and Multiple Sclerosis

Multiple Sclerosis

United Kingdom
Janssen Research & Development, LLC

Recruiting

A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN) (AZALEA)

Hemolytic Disease of the Fetus and Newborn

Israel, Brazil, Australia, United States, United Kingdom
Sheffield Hallam University
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Feasibility and Acceptability of Orthotic Shorts for People With Multiple Sclerosis

Multiple Sclerosis

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield Hallam University

Completed

High Intensity Interval Training for People With Mild Multiple Sclerosis: A Feasibility Study (HIIT-MS)

Multiple Sclerosis

United Kingdom
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps (FORTE)

Adenocarcinoma of the Rectum | Adenocarcinoma of the Colon

United States
GlaxoSmithKline

Completed

Healthy Volunteer Study Using 3 Different Formulations of Firategrast

Multiple Sclerosis, Relapsing-Remitting

Australia

Clinical Trials on Feasibility and Acceptability of the TOPS Program in South Africa

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