Clinical Trials on Focal Brain Injury in United States

Total 15676 results

Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures

Epilepsy, Partial Seizures | Epilepsy, Primary Generalized Tonic-Clonic Seizures

United States, Korea, Republic of, Taiwan, Lebanon, Singapore, Malaysia, China, Spain, Bulgaria, Czechia, United Kingdom, Israel, Russian Federation, France, Belarus, Belgium, Bosnia and Herzegovina, Germany, Greece, Hungary, India and more
University of Calgary

Active, not recruiting

A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion (TEMPO-2)

Stroke, Acute

United Kingdom, Australia, Canada, Singapore, New Zealand, Brazil, Ireland, Spain, Austria, Finland
Biogen

Active, not recruiting

A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205

Alzheimer's Disease

Korea, Republic of, United States, Spain, Belgium, Italy, Australia, Canada, Switzerland, Portugal, Taiwan, France, Poland, Germany, Netherlands, Sweden, Austria, Denmark, Japan, United Kingdom, Finland
Axsome Therapeutics, Inc.

Enrolling by invitation

A Study to Assess the Long-term Safety and Efficacy of AXS-05 in Subjects With Alzheimer's Disease Agitation

Alzheimer Disease | Agitation in Patients With Dementia of the Alzheimer's Type | Agitation, Psychomotor

United States, Canada
University of Nottingham
Nottingham University Hospitals NHS Trust; Action for A-T

Completed

Whole Body MRI for Cancer Surveillance in A-T

Ataxia Telangiectasia

United Kingdom
Takeda
Zinfandel Pharmaceuticals Inc.

Terminated

Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset (TOMMORROW)

Mild Cognitive Impairment Due to Alzheimer's Disease

United States, Germany, Switzerland, United Kingdom, Australia
Population Health Research Institute

Recruiting

EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF) (ENRICH-AF)

Atrial Fibrillation | Intracranial Hemorrhages

Spain, Germany, United States, Belgium, United Kingdom, Switzerland, Egypt, Canada, Austria, China, Czechia, India, Nepal, Portugal, Argentina
AbbVie

Completed

A Study to Evaluate the Safety and Tolerability of ABBV-951 in Subjects With Parkinson's Disease (PD)

Parkinson's Disease (PD)

United States, Australia, Belgium, Canada, Denmark, Germany, Italy, Japan, Netherlands, Russian Federation, Spain, Sweden, United Kingdom
Friedreich's Ataxia Research Alliance

Recruiting

Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study (UNIFAI)

Friedreich Ataxia

United States, Canada, New Zealand, Australia, France, Austria, Belgium, Brazil, Czechia, Germany, Greece, Ireland, Italy, Spain, United Kingdom, India, Netherlands
Natalie Garratt

Completed

The Kidney and The Brain Study - Assessment of Cognitive Impairment in Advanced CKD

Chronic Kidney Diseases | Cognitive Impairment | Dementia | End Stage Renal Disease | Hemodialysis Complication | Renal Transplant | Peritoneal Dialysis Complication

United Kingdom
European Huntington's Disease Network

Completed

REGISTRY-JHD - an Observational Study of the European Huntington's Disease Network (EHDN) (JHD)

Huntington Disease, Juvenile

Germany, United Kingdom
University Hospital Birmingham NHS Foundation Trust

Completed

Anti-Cytokine Therapy for Vasculitis (ACTIVE)

Wegener's Granulomatosis | Microscopic Polyangiitis | Renal Limited Vasculitis

United Kingdom
UCB Pharma

Completed

Trial to Assess Parkinson's Disease (PD) Symptom Control to Four Doses of Rotigotine in a Transdermal Patch

Parkinson's Disease

United States, Chile, Mexico, India, Peru
Otsuka Pharmaceutical Development & Commercialization...
Otsuka Pharmaceutical Co., Ltd.

Completed

"SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia

Inappropriate ADH Syndrome | Water Intoxication | Hyponatremias | Water-Electrolyte Imbalances

United States
Otsuka Pharmaceutical Development & Commercialization...

Terminated

Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia (SALACIA)

Hyponatremia | Inappropriate ADH Syndrome | Dilutional Hyponatremia

United States
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Terminated

Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy

Lung Cancer | Pulmonary Complications | Radiation Fibrosis

United States
Adamas Pharmaceuticals, Inc.

Completed

Extended Release Amantadine Safety and Efficacy Study in Levodopa-Induced Dyskinesia (EASED Study) (EASED)

Parkinson's Disease | Dyskinesia | Levodopa Induced Dyskinesia

United States
Newron Pharmaceuticals SPA

Completed

Safinamide in Idiopathic Parkinson's Disease (IPD) With Motor Fluctuations, as add-on to Levodopa (SETTLE)

Idiopathic Parkinson's Disease

Korea, Republic of, Israel, Thailand, New Zealand, Spain, Canada, United States, Switzerland, Netherlands, Taiwan, United Kingdom, Belgium, Estonia, Germany, Hungary, India, Australia, Austria, France, Malaysia, Slovakia
Cancer Research UK

Completed

Olaparib and Temozolomide in Treating Patients With Relapsed Glioblastoma

Brain and Central Nervous System Tumors

United Kingdom
Genentech, Inc.

Completed

A Post-Marketing Study of the Immunogenicity of Somatropin (Ribosomal Deoxyribo Nucleic Acid [rDNA] Origin) Injection (Nutropin AQ®) in Children With Growth Hormone Deficiency

Growth Hormone Deficiency

United States
Massachusetts General Hospital

Active, not recruiting

Light Therapy for PD - Dose Selection

Fatigue | Parkinson Disease | Sleep Disorder

United States
Jazz Pharmaceuticals

Recruiting

A Study of Suvecaltamide in Adults With Moderate to Severe Residual Tremor in Parkinson's Disease

Parkinson Disease | Tremor

United States, Spain, Germany, Poland
UCB Biopharma SRL

Active, not recruiting

A Study to Test the Safety and Tolerability of Long-term UCB0107 Administration in Study Participants With Progressive Supranuclear Palsy

Progressive Supranuclear Palsy

Belgium, Germany, Spain, United Kingdom
Cancer Research UK
Immatics Biotechnologies GmbH

Completed

Vaccine Therapy, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Brain and Central Nervous System Tumors

United Kingdom
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Metastatic Renal Cell Carcinoma | Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Melanoma | Stage IV Lung Cancer AJCC v8 | Stage IV Renal Cell... and other conditions

United States
Novo Nordisk A/S

Active, not recruiting

A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)

Early Alzheimer's Disease

Canada, United States, Spain, Netherlands, United Kingdom, Korea, Republic of, Portugal, Italy, Australia, Argentina, Hungary, Germany, Brazil, Poland, Denmark, Czechia, Ireland, Norway, Japan, Romania, South Africa, Sweden, Mexico, F... and more
Eli Lilly and Company

Terminated

A Study of LY3202626 on Disease Progression in Participants With Mild Alzheimer's Disease Dementia (NAVIGATE-AD)

Alzheimer's Disease

United States, Australia, Canada, Japan
Travere Therapeutics, Inc.

Terminated

Efficacy and Safety Study of Fosmetpantotenate (RE-024) in PKAN Participants (PKAN)

Pantothenate Kinase-Associated Neurodegeneration

United States, Canada, Czechia, France, Germany, Italy, Norway, Poland, Spain
Penumbra Inc.

Completed

Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil (SMART)

Intracranial Aneurysm

United States, Canada
Santhera Pharmaceuticals

Completed

Patient Reported Outcomes in Friedreich's Ataxia Patients After Withdrawal From Treatment With Idebenone (PROTI) (PROTI)

Friedreich's Ataxia

Netherlands, Austria, Germany, United Kingdom
Boehringer Ingelheim

Completed

Rt-PA in the Treatment of Acute Ischemic Stroke

Cerebrovascular Accident

Austria, Belgium, Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Italy, Netherlands, Norway, Poland, Portugal, Slovakia, Spain, Sweden, Switzerland, United Kingdom
UK Kidney Association

Recruiting

National Registry of Rare Kidney Diseases (RaDaR)

Vasculitis | AL Amyloidosis | Tuberous Sclerosis | Fabry Disease | Cystinuria | Focal Segmental Glomerulosclerosis | IgA Nephropathy | Bartter Syndrome | Pure Red Cell Aplasia | Membranous Nephropathy | Atypical Hemolytic Uremic Syndrome | Autosomal Dominant Polycystic Kidney Disease | Cystinosis | Nephronophthisis | BK Nephropathy and other conditions

United Kingdom
Novo Nordisk A/S

Active, not recruiting

A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)

Early Alzheimer´s Disease

Canada, United States, Taiwan, Netherlands, United Kingdom, Spain, Austria, Korea, Republic of, Portugal, Italy, Australia, Argentina, Hungary, Germany, Brazil, China, Poland, Denmark, Czechia, Ireland, Japan, South Africa, Romania, S... and more
Cerevel Therapeutics, LLC

Enrolling by invitation

Open-label Trial in Parkinson's Disease (PD) (TEMPO-4)

Parkinson Disease

Poland, United States, Spain, Australia, Bulgaria, Canada, Czechia, France, Germany, Hungary, Israel, Italy, Serbia, Ukraine
Eisai Inc.

Completed

Efficacy, Safety, and Tolerability of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations

Parkinson's Disease

United States, Canada
Allon Therapeutics

Completed

Study to Evaluate the Safety and Efficacy of Davunetide for the Treatment of Progressive Supranuclear Palsy

Progressive Supranuclear Palsy

United States, Australia, France, Canada, Germany, United Kingdom
Jazz Pharmaceuticals

Recruiting

Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures

Seizure in Participants With Tuberous Sclerosis Complex | Seizure in Participants With Dravet Syndrome | Seizure in Participants With Lennox-Gastaut Syndrome

United States
Tonix Pharmaceuticals, Inc.
Premier

Completed

A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine (PREVENTION)

Chronic Migraine | Chronic Migraine, Headache | Chronic Migraine Without Aura | Aura Migraine

United States
UCB Biopharma SRL

Active, not recruiting

A 18-month Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Oral UCB0599 in Study Participants With Early-stage Parkinson's Disease (ORCHESTRA)

Early-stage Parkinson's Disease

United States, Canada, France, Germany, Italy, Netherlands, Poland, Spain, United Kingdom
University Hospital Inselspital, Berne
Medtronic

Completed

Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke (SWIFT DIRECT)

Ischemic Stroke

Spain, France, Germany, Canada, United Kingdom, Austria, Finland, Switzerland
Boehringer Ingelheim

Completed

A Randomized, Double-blind, Placebo-controlled, Five Parallel Groups Efficacy and Safety Study of NS 2330 (Tesofensine) (0.125 mg, 0.25 mg, 0.5 mg and 1.0 mg) Administered Orally Once Daily Over 14 Weeks in Levodopa Treated Parkinson Patients With Motor Fluctuations

Parkinson Disease

Spain, Germany, France, Austria, United Kingdom, Netherlands
Alzheimer's Disease Cooperative Study (ADCS)
National Institute on Aging (NIA); Northern California Institute of Research...

Completed

Alzheimer's Disease Neuroimaging Initiative Grand Opportunity (ADNI-GO)

Mild Cognitive Impairment | Alzheimer's Disease

United States, Canada
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor

Brain Tumor | Central Nervous System Tumor

United States, Canada, Australia, Puerto Rico
University of Edinburgh
Weston Brain Institute

Withdrawn

Establishing Alpha-synuclein RT-QuIC Assay as a Diagnostic Technique in REM Sleep Behaviour Disorder

Sleep Disorder Rem Sleep Behavior | Parkinson's Disease, Lewy Body

United Kingdom
Helse Stavanger HF
King's College London; Lund University

Completed

Efficacy and Safety of Memantine for Parkinson's Disease Dementia (PDD) and Dementia With Lewy Bodies (DLB) (MEMPDD)

Dementia With Lewy Bodies | Dementia Associated With Parkinson's Disease

United Kingdom, Norway, Sweden
Versartis Inc.

Completed

Versartis Trial in Children to Assess Long-Acting Growth Hormone (VERTICAL)

Pediatric Growth Hormone Deficiency

United States
Solvay Pharmaceuticals

Completed

SLV308 for Treatment of Patients With Parkinson's Disease Experiencing Motor Fluctuations

Advanced Stage Parkinson's Disease

Argentina, United States, Brazil, Bulgaria, Canada, Chile, Colombia, Latvia, Lithuania, Peru, Russian Federation, Ukraine
Solvay Pharmaceuticals

Completed

An Open Label SLV308 Safety Extension to Study S308.3.003 in Early PD Patients

Early Stage Parkinson's Disease

United States, Australia, Czech Republic, Estonia, Germany, India, Italy, Lithuania, Malaysia, Netherlands, Poland, Portugal, South Africa, Taiwan, Thailand
Hennepin Healthcare Research Institute
National Health and Medical Research Council, Australia; National Cancer Institute... and other collaborators

Active, not recruiting

Aspirin in Reducing Events in the Elderly (ASPREE)

Depression | Stroke | Cancer | Bleeding | Dementia | Heart Disease | Functional Disability

United States, Australia
Idorsia Pharmaceuticals Ltd.

Completed

Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping (CONSCIOUS-2)

Aneurysmal Subarachnoid Hemorrhage

United States, Spain, Denmark, Hong Kong, India, Norway, Canada, Switzerland, China, France, Australia, Serbia, Latvia, Sweden, Austria, Germany, Slovenia, Belgium, Croatia, Czechia, Finland, Italy, Korea, Republic of, New Zealand, Poland, Russian Federation and more

Clinical Trials on Focal Brain Injury in United States

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