Clinical Trials on Functional Insufficiency

Total 13720 results

Karolinska Institutet

Recruiting

Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia

Acute Kidney Injury | Pulmonary Hypertension | Congenital Diaphragmatic Hernia | Multiple Organ Failure | Hyperchloremia

Sweden
APR Applied Pharma Research s.a.
Lavin Consulting, LLC

Completed

Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure (COVID-AIV)

Acute Lung Injury | Corona Virus Infection | Acute Respiratory Distress Syndrome (ARDS) | Critical COVID-19 With Respiratory Failure

United States
Assistance Publique Hopitaux De Marseille

Completed

Acute Kidney Dysfunction in COVID-19 and Non-COVID-19 Related ARDS (URICOV)

COVID-19 Acute Respiratory Distress Syndrome | Acute Kidney Injury Due to COVID-19

France
Oslo University Hospital
The Research Council of Norway

Completed

Survival Rates and Longterm Outcomes After COVID-19

Covid19 | Acute Respiratory Distress Syndrome | Acute Respiratory Failure | Survivorship | Post Intensive Care Unit Syndrome

Norway
University of Calgary
Alberta Health services

Unknown

CORONA (COvid pRONe hypoxemiA): Prone Positioning for Hypoxemic COVID-19 Patients With Do-not-intubate Goals (CORONA)

COVID-19 | Acute Respiratory Distress Syndrome | ARDS | Severe Acute Respiratory Syndrome Coronavirus 2 | Hypoxemic Respiratory Failure

Canada
bluebird bio

Terminated

Observational Study to Evaluate Allogeneic HSCT Outcomes for Cerebral Adrenoleukodystrophy (CALD)

Cerebral Adrenoleukodystrophy (CALD) | Adrenoleukodystrophy (ALD) | X-Linked Adrenoleukodystrophy (X-ALD)

United States, United Kingdom, Argentina, Canada, Germany, Italy, Netherlands
Masonic Cancer Center, University of Minnesota
National Marrow Donor Program

Completed

Stem Cell Transplant for Hemoglobinopathy

Sickle Cell Disease | Thalassemia | Severe Congenital Neutropenia | Diamond-Blackfan Anemia | Shwachman-Diamond Syndrome

United States
University Hospital, Rouen

Unknown

Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation (VONIVOO)

Obesity | Acute Respiratory Failure | Hypercapnic Respiratory Failure | Apnea, Obstructive | Hypoventilation Syndrome | Respiratory Acidosis
Masonic Cancer Center, University of Minnesota

Completed

Stem Cell Transplant for Bone Marrow Failure Syndromes

Diamond-Blackfan Anemia | Shwachman-Diamond Syndrome | Kostmann's Neutropenia

United States
University Hospital, Angers
University of Angers, Angers

Unknown

Neuropsychological Assessment of Children and Adolescents With Turner Syndrome (ENEAST)

Isolated Growth Hormone Deficiency | Turner Syndrome | Pediatrics | Social Cognition | Cognitive Functions
D'Or Institute for Research and Education
Oswaldo Cruz Foundation; Rio de Janeiro State Research Supporting Foundation... and other collaborators

Not yet recruiting

Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure

Pneumonia | Acute Respiratory Distress Syndrome (ARDS) | Severe Acute Respiratory Syndrome (SARS)

Brazil
Northside Hospital, Inc.
Blood and Marrow Transplant Group of Georgia

Not yet recruiting

CAR T-cell Therapy in Patients With Renal Dysfunction

Multiple Myeloma | Acute Lymphoblastic Leukemia, Adult | Non-hodgkin Lymphoma,B Cell

United States
SwanBio Therapeutics, Inc.

Recruiting

A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN) (PROPEL)

AMN | AMN Gene Mutation | X-ALD

Netherlands, United States
Thomas Benfield

Recruiting

Changes in Weight, Body Composition and Metabolic Parameters After Discontinuing Dolutegravir or Tenofovir Disproxil (AVERTAS-2)

HIV Infections | Obesity | Renal Insufficiency | Osteoporosis | Hiv | Weight Gain | HIV Lipodystrophy

Denmark
Leipzig University Medical Center

Recruiting

Quality of Life in Women With X-linked Adrenoleukodystrophy (X-ALD_QoL)

X-linked Adrenoleukodystrophy

Germany
Association pour le Développement et l'Organisation...

Recruiting

Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases (DVD)

Neuromuscular Diseases | Interstitial Lung Disease | Acute Respiratory Failure | Obesity Hypoventilation Syndrome | Acute Exacerbation of COPD | Acute Exacerbation of Bronchiectasis | Acute Exacerbation of Asthma

France
Leipzig University Medical Center
European Leukodystrophy Association

Completed

SMART-ALD - A New Lifestyle Intervention to Improve Quality of Life in Women With X-linked Adrenoleukodystrophy (X-ALD)

X-linked Adrenoleukodystrophy

Germany
bluebird bio

Active, not recruiting

Long-term Follow-up of Participants With Cerebral Adrenoleukodystrophy Who Were Treated With Lenti-D Drug Product

Cerebral Adrenoleukodystrophy (CALD) | Adrenoleukodystrophy (ALD) | X-Linked Adrenoleukodystrophy (X-ALD)

United States, Argentina, Australia, Brazil, France, Germany, Netherlands, United Kingdom, Italy
Central Clinical Hospital of the Russian Academy...
Ural State Medical University; De Haar Research Task Force; De Haar Research... and other collaborators

Terminated

Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging (REALITY)

Coronary Artery Disease | Alzheimer Disease | Contrast-induced Nephropathy | Coronary Atherosclerosis | Cerebrovascular Disease | Stable Chronic Angina | Chronic Coronary Insufficiency

Netherlands, Russian Federation, Estonia
Novacescu Alexandru
University of Medicine and Pharmacy "Victor Babes" Timisoara

Completed

Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients

Acute Respiratory Distress Syndrome | COVID-19 Pneumonia | COVID-19 Respiratory Infection | Acute Respiratory Failure

Romania
University Hospital, Grenoble
French Society for Intensive Care; Act For Chronic Diseases

Unknown

Prone Position and Renal Resistive Index (PRO-KIDNEY)

Acute Kidney Injury | Acute Respiratory Distress Syndrome | Intra-Abdominal Hypertension | Prone Position
NeuroVia, Inc.

Unknown

A Study to Prospectively Assess Disease Progression in Male Children With X-ALD

X-Linked Adrenoleukodystrophy

United States
Seattle Children's Hospital
Actelion

Withdrawn

Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients

Pulmonary Hypertension | Acute Respiratory Distress Syndrome | Congenital Heart Defects | Neonatal Hypoxic Respiratory Failure | Persistent Pulmonary Hypertension of Newborn
Minoryx Therapeutics, S.L.

Recruiting

Disease Progression in Women With X-linked Adrenoleukodystrophy

X-linked Adrenoleukodystrophy

France
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Qilu Hospital of Shandong University; Yunnan Cancer Hospital

Not yet recruiting

Effect of Sodium Thiosulfate on Nephrotoxicity of Cisplatin Intraperitoneal Heat-perfusion Chemotherapy

Epithelial Ovarian Cancer | Acute Kidney Injury Due to Circulatory Failure
Evangelismos Hospital

Recruiting

Intermediate Normal Versus High Normal Oxygen Levels in the Emergency Department for Severe Traumatic Brain Injury (INACHOS)

Traumatic Brain Injury | Acute Respiratory Distress Syndrome | Acute Respiratory Failure | Acute Brain Injury

Greece
Massachusetts General Hospital
European Leukodystrophy Association

Recruiting

Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy

Restless Legs Syndrome | Adrenoleukodystrophy

United States, Netherlands
Viking Therapeutics, Inc.

Recruiting

A Study to Assess the Pharmacodynamics of VK0214 in Male Subjects With AMN

Adrenomyeloneuropathy Form (AMN) of X-linked Adrenoleukodystrophy (X-ALD)

United States, France, Germany, Italy, United Kingdom
R3 Stem Cell

Not yet recruiting

Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions

Stroke | Autoimmune Diseases | Kidney Diseases | Urologic Diseases | Renal Insufficiency | Arthritis | Renal Failure | Alzheimer Disease | Erectile Dysfunction | Cardiomyopathies | Pulmonary Disease | Neurologic Disorder | Orthopedic Disorder | COPD | Cardiac Event | CHF | Neuropathy;Peripheral
Ziqiang Li

Active, not recruiting

Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation

Complete and Accurate Statistical Data of 60 Patients | CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately | Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients | According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the... and other conditions

China
Ryazan State Medical University

Completed

Associations of Combinations of Single-nucleotide Polymorphisms in Women With Premature Ovarian Failure

Cardiovascular Diseases | Coronary Disease | Arrhythmias, Cardiac | Primary Ovarian Insufficiency | Menopause, Premature | Pulmonary Embolism | Polymorphism, Single Nucleotide

Russian Federation
Genetic Disease Investigators

Completed

Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life

Venous Insufficiency | Postural Orthostatic Tachycardia Syndrome | Dysautonomia | Ehlers Danlos Syndrome | External Hydrocephalus

United States
Minoryx Therapeutics, S.L.

Active, not recruiting

A Clinical Study in Male Pediatric Patients With Cerebral X-linked Adrenoleukodystrophy (Cald) to Assess the Effects of MIN-102 Treatment on Disease Progression Prior to Human Stem Cell Transplant (HSCT) (NEXUS)

Cerebral Adrenoleukodystrophy

Spain, Germany, France, Argentina
Oxford University Clinical Research Unit, Vietnam
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

Completed

Awake Prone Positioning in Moderate to Severe COVID-19

COVID-19 | SARS-CoV2 Infection | Respiratory Distress Syndrome, Adult | Acute Hypoxemic Respiratory Failure | COVID-19 Acute Respiratory Distress Syndrome

Vietnam
The University of Texas Health Science Center at...
The Claude D. Pepper Older Americans Independence Centers

Withdrawn

Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS (RAPA-CARDS)

Respiratory Failure | Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) | Sars-CoV2

United States
Ascendance Biomedical

Completed

Inovium Ovarian Rejuvenation Trials

Infertility | Menopause | Menopause, Premature | Infertility, Female | Premature Ovarian Failure | Menopause Related Conditions | Perimenopausal Disorder | Infertility Unexplained | Menopause Premature Symptomatic | Menopause Premature Asymptomatic | Premature Ovarian Failure, Familial | Premature Ovarian Failure... and other conditions

United States
Baylor Research Institute
Shire

Unknown

A One Visit Follow Up of Adults With Fabry Disease Who Started Long-term Enzyme Replacement Therapy As Children

Quality of Life | Renal Insufficiency | Cardiac Event

United States
Thomas S. Scanlan

Withdrawn

Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD)

Adrenomyeloneuropathy | X-Linked Adrenoleukodystrophy

United States
Bristol-Myers Squibb

Completed

Pharmacokinetic Study of BMS-914143 in Participants With Normal Renal Function and Mild, Moderate, Severe and End-stage Renal Dysfunction (PK)

Chronic Hepatitis C Virus Infection | Chronic Hepatitis B Virus Infection

United States
Australian and New Zealand Intensive Care Research...
The Alfred

Not yet recruiting

Trial of ECMO to De-Sedate, Extubate Early and Mobilise in Hypoxic Respiratory Failure (REDEEM)

Pneumonia | Extracorporeal Membrane Oxygenation | Mechanical Ventilation Complication | Hypoxemia | COVID-19 Respiratory Infection | Acute Respiratory Distress Syndrome Due to COVID-19

Australia, Germany
King's College Hospital NHS Trust
King's College London

Completed

SELF-BREATHE RCT for Chronic Breathlessness

Liver Failure | Cancer | Asthma | Renal Failure | Cystic Fibrosis | Chronic Heart Failure | Sickle Cell Disease | Interstitial Lung Disease | COPD | Dyspnea | Post COVID-19 | Bronchiectasis Adult

United Kingdom
Arch Biopartners Inc.

Completed

LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19)

Severe Acute Respiratory Syndrome | Acute Kidney Injury | COVID | Acute Respiratory Distress Syndrome | Sars-CoV2

United States, Turkey, Canada
Willows Health
Nottingham Trent University

Not yet recruiting

Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY) (BRANCH-P)

Depression | Heart Diseases | Cardiovascular Diseases | HIV Infections | Obesity | Diabetes | Cancer | Chronic Kidney Diseases | Arthritis | Bulimia | Alzheimer Disease | Cellulitis | Cirrhosis | Eczema | Osteoporosis | Appendicitis | Bronchitis | Bowel Disease | Gout | Alcoholic Liver Disease | Flu | High Cholesterol | Allergies | Indigestion | ... and other conditions

United Kingdom
University College, London
Ministry of Health and Child Welfare, Zimbabwe; Biomedical Research and Training... and other collaborators

Recruiting

Evaluating the NeoTree in Malawi and Zimbabwe

Neonatal Encephalopathy | Prematurity | Neonatal Seizure | Neonatal Jaundice | Neonatal Sepsis | Neonatal Death | Neonatal Respiratory Failure | Neonatal Hypoglycemia | Neonatal Disorder | Neonatal Hypothermia

Zimbabwe, Malawi
Allegheny Singer Research Institute (also known...
ElectroCore INC

Terminated

Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms (SAVIORII)

Respiratory Failure | COVID | Corona Virus Infection | Respiratory Distress Syndrome, Adult | SARS (Severe Acute Respiratory Syndrome) | ARDS, Human

United States
Hôpital Louis Mourier

Completed

Extended Prone Position Duration COVID-19-related ARDS: a Retrospective Study

Pressure Ulcer | Hypoxemic Respiratory Failure | COVID-19 Acute Respiratory Distress Syndrome | Respiratory Distress Syndrome, Acute

France
National Eye Institute (NEI)

Completed

Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

Menopause | Turner Syndrome | Ovarian Failure, Premature | Sex Chromosome Aberrations | Perimenopause

United States
Massachusetts General Hospital

Recruiting

Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders (BMT)

Autoimmune Diseases | Multiple Myeloma | Hodgkin Disease | AL Amyloidosis | Myelofibrosis | Chronic Kidney Disease | Sickle Cell Anemia | Thalassemia | Aplastic Anemia | Chronic Lymphocytic Leukemia (CLL) | Acute Myeloid Leukemia (AML) | Acute Lymphoblastic Leukemia (ALL) | Myelodysplastic Syndrome (MDS) | Non-Hodgkin... and other conditions

United States
University of Missouri-Columbia
National Library of Medicine (NLM)

Completed

Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow

Depression | HIV Infections | Hypertension | Obesity | Diabetes Mellitus | Back Pain | Urinary Incontinence | Irritable Bowel Syndrome | Insomnia | Asthma | Anxiety | Sinusitis | Shoulder Pain | Allergic Rhinitis | Urinary Tract Infection | Vaginitis | Bursitis | Hyperlipidemia | Esophageal Reflux | Benign Prostatic Hypertrophy | Osteoporosis... and other conditions

United States
University of Michigan
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

Obstructive Sleep Apnea | Down Syndrome | Tolerance | Trisomy 21 | Hypertonia, Muscle | Nasal Airway Obstruction

United States

Clinical Trials on Functional Insufficiency

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