Clinical Trials on Gastrointestinal Dysfunction in United Kingdom

Total 10394 results

National Institute of Arthritis and Musculoskeletal...

Unknown

Genetics of Fibromyalgia

Depression | Irritable Bowel Syndrome | Fibromyalgia | Chronic Fatigue Syndrome

United States
Phathom Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo for Relief of Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease (NERD)

Heartburn | Non-Erosive Gastro-Esophageal Reflux Disease

United States
Guardant Health, Inc.

Recruiting

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation (ORACLE)

Renal Cell Carcinoma | Pancreatic Adenocarcinoma | Gastric Adenocarcinoma | Squamous Cell Carcinoma of the Head and Neck | Non-small Cell Lung Cancer | Fallopian Tube Carcinoma | Endometrial Carcinoma | Bladder Carcinoma | Esophageal Carcinoma | Invasive Breast Carcinoma | Cutaneous Melanoma | Epithelial Ovarian... and other conditions

United States
Rutgers, The State University of New Jersey
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Extended Cancer Education for Longer-Term Survivors in Primary Care for Patients With Stage I-II Breast or Prostate Cancer or Stage I-III Colorectal Cancer

Stage I Breast Cancer | Stage II Breast Cancer | Stage I Prostate Cancer | Stage II Prostate Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIA Breast Cancer | Stage IIB Breast Cancer | Stage III Colorectal Cancer AJCC v7 | Stage IIIA Colorectal Cancer AJCC v7 | Stage IIIB Colorectal Cancer... and other conditions

United States
Acrotech Biopharma Inc.
Axis Clinicals Limited

Completed

Phase II Study of Folotyn With Leucovorin to Prevent/Reduce Mucositis in Patients With Hematological Malignancies

Refractory Peripheral T-Cell Lymphoma | Relapsed Peripheral T-Cell Lymphoma

United States
Bausch Health Americas, Inc.

Completed

Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis

Proctitis | Proctosigmoiditis

United States
Shire

Completed

A Study in Adolescents and Adults With Eosinophilic Esophagitis (EoE) Measuring Histologic Response and Determine if Reduction in Dysphagia is Achieved

Eosinophilic Esophagitis (EoE)

United States
Debiovision

Completed

Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding

Portal Hypertension | Esophageal Varices | Gastric Varices | Esophageal Bleeding

United States
Roswell Park Cancer Institute
National Comprehensive Cancer Network

Active, not recruiting

Use of Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy for the Treatment of Resectable Esophageal or Gastroesophageal Junction (GEJ) Adenocarcinoma

Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8 | Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8 | Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8 | Pathologic Stage III Esophageal Adenocarcinoma AJCC v8 and other conditions

United States
Braintree Laboratories

Completed

Safety and Efficacy Study of Axid Use in Infants Suffering From Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease | GERD | Heartburn

United States
University of Michigan
Genentech, Inc.

Completed

Inhaled Tissue Plasminogen Activator for Acute Plastic Bronchitis (PLATyPuS)

Healthy | Protein-Losing Enteropathies | Plastic Bronchitis

United States
National Cancer Institute (NCI)

Recruiting

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

HIV Infection | Anal Squamous Cell Carcinoma | Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage II Rectal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | AIDS-Related Anal Carcinoma | Rectal Squamous Cell Carcinoma | Stage I Anal Cancer AJCC... and other conditions

United States
Merck Sharp & Dohme LLC

Recruiting

Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)

Carcinoma, Hepatocellular | Colorectal Neoplasms | Esophageal Neoplasms | Endometrial Neoplasms | Pancreatic Ductal Adenocarcinoma | Biliary Tract Neoplasms

Israel, United States, Australia, Belgium, Chile, France, Korea, Republic of, Netherlands, Spain, New Zealand
Bausch Health Americas, Inc.

Completed

The Plecanatide Irritable Bowel Syndrome With Constipation Study (IBS-C) (IBS-C)

Irritable Bowel Syndrome Characterized by Constipation

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines

Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastric Cancer AJCC v8 | Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 | Metastatic Gastroesophageal Junction Adenocarcinoma | Metastatic... and other conditions

United States
Kyowa Kirin, Inc.

Completed

Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis

Digestive System Diseases | Gastrointestinal Diseases | Colonic Diseases | Intestinal Diseases | Abdominal Pain | Inflammatory Bowel Diseases | Ulcerative Colitis | Colitis | Colitis, Ulcerative | Autoimmune Disease

Hungary, Russian Federation, Serbia, United States, Poland, Czechia, Romania
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

Metastatic Colon Adenocarcinoma | Metastatic Rectal Adenocarcinoma | Stage III Colon Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage IV Colon Cancer AJCC v8 | Stage IV Rectal Cancer AJCC v8 | Unresectable Colon Adenocarcinoma | Unresectable Rectal Adenocarcinoma

United States, Puerto Rico
XenoPort, Inc.

Completed

A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease

United States, Canada
University of Cincinnati
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea

Obstructive Sleep Apnea | Acid Reflux Disease

United States
National Institute of Diabetes and Digestive and...
University of North Carolina, Chapel Hill

Completed

Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) (RIVUR)

Urinary Tract Infections | Vesicoureteral Reflux

United States
Dartmouth-Hitchcock Medical Center
National Cancer Institute (NCI)

Completed

Combination Chemotherapy Plus Filgrastim in Treating Patients With Advanced Solid Tumors

Sarcoma | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer | Bladder Cancer | Melanoma (Skin) | Carcinoma of Unknown Primary

United States
Loxo Oncology, Inc.
Eli Lilly and Company

Recruiting

A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001) (LIBRETTO-001)

Non-Small Cell Lung Cancer | Colon Cancer | Medullary Thyroid Cancer | Any Solid Tumor

United States, Japan, Taiwan, Australia, Korea, Republic of, Israel, Spain, Switzerland, Singapore, France, Canada, Italy, Germany, United Kingdom, Hong Kong, Denmark
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Anal Canal Squamous Cell Carcinoma | Anal Margin Squamous Cell Carcinoma | Stage I Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Infliximab or Vedolizumab in Treating Immune Checkpoint Inhibitor-Related Colitis in Patients With Genitourinary Cancer or Melanoma

Malignant Solid Neoplasm | Melanoma | Colitis | Lung Non-Small Cell Carcinoma | Malignant Genitourinary System Neoplasm

United States
University Health Network, Toronto
University of Florida; National Institute on Deafness and Other Communication...

Completed

Physiological Flow of Liquids Used in Dysphagia Management (Neuro)

Parkinson Disease | Amyotrophic Lateral Sclerosis | Dysphagia

United States
Bausch Health Americas, Inc.

Completed

Second Plecanatide Study In Irritable Bowel Syndrome With Constipation (IBS-C) (IBS-C)

Irritable Bowel Syndrome Characterized by Constipation

United States
Takeda

Completed

Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules in Treating Symptomatic Non-Erosive Gastroesophageal Reflux Disease in Adolescents

Gastroesophageal Reflux Disease

United States, Poland, Belgium, Portugal, Italy, Hungary, Mexico, Brazil
A2 Biotherapeutics Inc.
Tempus AI

Recruiting

A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Subjects With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression (EVEREST-1)

Cancer | Colorectal Neoplasms | Colorectal Cancer | Pancreatic Neoplasms | Pancreatic Cancer | NSCLC | Solid Tumor | Non Small Cell Lung Cancer | Colorectal Cancer Metastatic | Pancreas Cancer | Colorectal Adenocarcinoma | Solid Tumor, Adult | CRC | NSCLC, Recurrent | Non Small Cell Lung Cancer Recurrent | Non-Small Cell...

United States
Phoenix Children's Hospital

Recruiting

Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair (TEF)

Esophageal Atresia | Tracheoesophageal Fistula

United States
Molecular Templates, Inc.

Recruiting

Study of MT-8421 as Monotherapy and in Combination With Nivolumab in Patients With Selected Advanced Solid Cancer Types

Melanoma | Renal Cell Carcinoma | Cervical Cancer | Hepatocellular Carcinoma | Non Small Cell Lung Cancer | Mesothelioma | Squamous Cell Carcinoma of Head and Neck | Esophageal Squamous Cell Carcinoma | Urothelial Carcinoma | Microsatellite Instability High | Mismatch Repair Deficiency

United States
Bausch Health Americas, Inc.

Completed

Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis

Proctitis | Proctosigmoiditis

United States
Fate Therapeutics

Completed

FATE-NK100 as Monotherapy and in Combination With Monoclonal Antibody in Subjects With Advanced Solid Tumors

Melanoma | Renal Cell Carcinoma | Hepatocellular Carcinoma | Colorectal Cancer | Pancreatic Cancer | Non Small Cell Lung Cancer | Advanced Solid Tumors | HER2-positive Breast Cancer | Head and Neck Squamous Cell Carcinoma | HER2 Positive Gastric Cancer | EGFR Positive Solid Tumor

United States
Alzheimer's Light LLC

Recruiting

Longitudinal Cognitive Assessment by BoCA (BoCA)

Multiple Sclerosis | Parkinson Disease | Alzheimer Disease | Mild Cognitive Impairment | Frontotemporal Dementia | Vascular Dementia | TBI

United States
University of Oklahoma
OU Medical Center

Completed

Compassionate Use of Omegaven in Children

Infant, Premature, Diseases | Cholestasis | Gastroschisis | Intestinal Atresia | Short Bowel Syndrome | Cholestasis of Parenteral Nutrition | Total Parenteral Nutrition-induced Cholestasis

United States
University of California, Los Angeles

Unknown

Cysteine Supplementation in Critically Ill Neonates

Sepsis | Systemic Inflammatory Response Syndrome | Necrotizing Enterocolitis | Retinopathy of Prematurity | Bronchopulmonary Dysplasia

United States
EndoGastric Solutions

Completed

Transoral Incisionless Fundoplication (TIF) Registry Study for Treatment of Gastroesophageal Reflux Disease (GERD)

Hiatal Hernia | Gastroesophageal Reflux Disease

United States
Regeneron Pharmaceuticals
Sanofi

Active, not recruiting

Study Assessing Long-teRm Outcomes of dupiluMAb (DUPIXENT®) Treatment in Adult Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP) (AROMA)

Chronic Rhinosinusitis With Nasal Polyposis

United States, Italy, Canada, Japan, Germany, Netherlands
Seagen Inc.

Terminated

A Safety Study of SGN-CD47M in Patients With Solid Tumors

Melanoma | Soft Tissue Sarcoma | Colorectal Cancer | Non-small Cell Lung Carcinoma | Breast Carcinoma | Head and Neck Squamous Cell Carcinoma | Gastric Carcinoma | Ovarian Carcinoma | Exocrine Pancreatic Carcinoma

United States
Eisai Inc.

Completed

Rabeprazole Extended-Release, 50 mg, Versus Esomeprazole, 40 mg, for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease (GERD)

Chile, Canada, United States, Estonia, India, Hungary, Bulgaria, Croatia, Australia, Lithuania, Latvia, Argentina, France, Germany
Protagonist Therapeutics, Inc.

Completed

PN-943 in Adults With Moderate to Severe Active Ulcerative Colitis (UC)

Ulcerative Colitis Chronic Moderate | Ulcerative Colitis Chronic Severe

United States, Austria, Bulgaria, Canada, Georgia, Germany, Hungary, Italy, Korea, Republic of, Poland, Russian Federation, Serbia, Ukraine
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study

Low Anterior Resection Syndrome | Malignant Uterine Neoplasm | Rectal Carcinoma | Malignant Ovarian Neoplasm | Malignant Pelvic Neoplasm | Malignant Anal Neoplasm | Malignant Bladder Neoplasm | Malignant Cervical Neoplasm | Malignant Prostate Neoplasm | Malignant Vaginal Neoplasm | Malignant Vulvar Neoplasm

United States
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation

Irritable Bowel Syndrome With Constipation | Chronic Constipation

United States, Canada
Massachusetts General Hospital
Dana-Farber Cancer Institute

Recruiting

Infliximab for Treatment of Immune Checkpoint Inhibitor Colitis

Melanoma Stage IV | Melanoma Stage III | Drug Toxicity | Immune-related Adverse Event | Skin Cancer Stage III | Skin Cancer Stage IV | Drug-Induced Colitis

United States
TMRW Life Sciences
Dudley Associates Healthcare Marketing & Communications

Completed

The U.K. Embryologist Fatigue Study (FUSE-UK)

Gastrointestinal Diseases | Cardiovascular Diseases | Fatigue | Back Pain | Musculoskeletal Pain | Stress | Burnout, Professional | Chest Pain | Neck Pain | Sleep Disturbance | Syncope | Dizziness | Headache | Shortness of Breath

United States
TMRW Life Sciences
Dudley Associates Healthcare Marketing & Communications

Completed

The U.S. Embryologist Fatigue Study (FUSE)

Gastrointestinal Diseases | Cardiovascular Diseases | Fatigue | Back Pain | Musculoskeletal Pain | Stress | Burnout, Professional | Chest Pain | Neck Pain | Sleep Disturbance | Syncope | Dizziness | Headache | Shortness of Breath

United States
Beth Israel Medical Center

Terminated

The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study

Pneumonia | Cystitis | Bacteremia | Surgical Wound Infection | Enterocolitis, Pseudomembranous

United States
Ironwood Pharmaceuticals, Inc.

Completed

A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease

United States
Jerome Canady, M.D.

Active, not recruiting

Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor Sites

Stage IV Lung Cancer | Stage IV Bladder Cancer | Stage IV Pancreatic Cancer | Recurrent Malignant Solid Neoplasm | Stage IV Breast Cancer | Stage IV Renal Cell Cancer | Stage IV Prostate Cancer | Stage IV Colon Cancer | Stage IV Rectal Cancer | Stage IV Gastric Cancer | Stage IV Non-small Cell Lung Cancer | Stage... and other conditions

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Terminated

S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat

Pain | Head and Neck Cancer | Cancer-related Problem/Condition

Canada, United States
AstraZeneca

Completed

NEXIUM® in the Treatment of Moderate and Severe Erosive Esophagitis

Gastroesophageal Reflux Disease | Erosive Esophagitis | Reflux Esophagitis

United States

Clinical Trials on Gastrointestinal Dysfunction in United Kingdom

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