Clinical Trials on Genetic Mutations
Total 15404 results
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National Cancer Institute (NCI)CompletedAdult Solid Neoplasm | BRCA1 Mutation Carrier | BRCA2 Mutation CarrierUnited States
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Qian QinJanssen, LP; UT Southwestern Comprehensive Cancer CenterNot yet recruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | BRIP1 Gene Mutation | PALB2 Gene Mutation | CHEK2 Gene Mutation | FANCA Gene Mutation | RAD51B Gene Mutation | RAD54L Gene Mutation | Metastatic Hormone-sensitive Prostate Cancer (mHSPC) | Deleterious HRR Gene Mutation
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Al Baraka Fertility HospitalIbn Sina Hospital; Sadat City UniversityCompletedGenetic Diseases, Inborn | Mutation | Chromosome Abnormalities
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingAdvanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | KRAS Gene Mutation | Metastatic Malignant Solid Neoplasm | EGFR Gene Mutation | ERBB2 Gene Amplification | ERBB2 Gene Mutation | EGFR Gene Amplification | ERBB3 Gene Mutation | ERBB4 Gene MutationUnited States
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Massachusetts General HospitalRecruitingLynch Syndrome | Genetic Predisposition to Disease | Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation | Prostatic Neoplasm | ATM Gene Mutation | MMR MutationUnited States
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Istituto Scientifico Romagnolo per lo Studio e...UnknownAML | FLT3-ITD Mutation | FLT3-TKD MutationItaly
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Pasithea Therapeutics Corp.RecruitingAdvanced Solid Tumors | RAS Mutation | NF1 Mutation | RAF MutationUnited States
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Abramson Cancer Center at Penn MedicineRecruiting
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Shanghai Changzheng HospitalUnknownRefractory Cancer | Arsenic Trioxide | p53 Mutations | Intractable CancerChina
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Hillel Yaffe Medical CenterUnknown
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San Raffaele UniversityUnita' di Gastroenterologia - Policlinico Universitario di Bari; Unita' di... and other collaboratorsRecruitingLynch Syndrome | MLH1 Gene Mutation | MSH2 Gene Mutation | MSH6 Gene Mutation | PMS2 Gene Mutation | Lynch Syndrome II | Small Bowel Adenocarcinoma | Lynch Syndrome IItaly
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Changhai HospitalActive, not recruitingPregnancy Related | Chronic Pancreatitis | Genetic MutationChina
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Nested Therapeutics, IncRecruitingGlioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene MutationAustralia
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Aga Khan University Hospital, PakistanCompletedBreast Cancer | Genetic Predisposition | BRCA Mutation | Occult CancerPakistan
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AZ-VUBAstraZeneca; Kom Op Tegen KankerRecruitingAdvanced Cancers Harbouring Mutations in HRGBelgium
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Columbia UniversityRecruitingCancer | Insulin Resistance | MTOR Gene Mutation | PI3K Gene Mutation | AKT Gene MutationUnited States
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University Hospital, MontpellierCompleted
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Arog Pharmaceuticals, Inc.AvailableFLT3-ITD Mutation | FLT3/TKD Mutation | PDGFR-Alpha D842V | PDGFRA Gene AmplificationItaly
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University Hospital, GhentFox Chase Cancer Center; Ziekenhuis Oost-LimburgCompletedBRCA1 Mutation | BRCA2 Mutation | hCGBelgium
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D3 Bio (Wuxi) Co., LtdRecruitingAdvanced Solid Tumors With MAPK Pathway MutationsAustralia, China, United States
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Anita TurkEli Lilly and CompanyTerminatedCancer | Cancer Metastatic | BRAF V600E | MEK1 Gene Mutation | MEK2 Gene Mutation | ERK Mutation | RAF1 Gene MutationUnited States
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Fujian Cancer HospitalUnknown
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Case Comprehensive Cancer CenterNational Institutes of Health (NIH); National Institute of Environmental Health...Not yet recruiting
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Pathway GenomicsCompletedNeoplasms | MutationUnited States
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Deciphera Pharmaceuticals LLCNot yet recruitingMelanoma | Non-Small Cell Lung Cancer | Advanced Solid Tumor | Pancreatic Ductal Adenocarcinoma | BRAF Gene Mutation | RAS Mutation | NF1 Mutation | RAF Mutation | CRAF Gene MutationUnited States
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Dr Cipto Mangunkusumo General HospitalCompletedColorectal Cancer | APC Gene Mutation | TP53 Gene Mutation | PIK3CA Gene Mutation | KRAS Mutation-Related Tumors | MLH1 Gene MutationIndonesia
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Incyte CorporationTerminatedAdvanced or Metastatic Solid Tumors | FGFR Mutations | FGFR TranslocationsUnited States
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Boehringer IngelheimCompletedSolid Tumors, KRAS MutationJapan
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European Institute of OncologyIstituto Oncologico Veneto IRCCS; Ente Ospedaliero Ospedali Galliera; Istituto...Not yet recruitingDuctal Carcinoma in Situ | RAD51C Gene Mutation | RAD51D Gene Mutation | PALB2 Gene Mutation | Lobular Carcinoma in Situ | ATM Gene Mutation | CDH1 Gene Mutation | CHEK2 Gene Mutation | BRCA MutationItaly
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Astellas Pharma Global Development, Inc.WithdrawnSolid Tumors | Epidermal Growth Factor Receptor (EGFR) Mutations
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Thai Red Cross AIDS Research CentreChulalongkorn University; Queen Savang Vadhana Memorial Hospital, ThailandCompletedNVP Plasma Level | NVP Related Mutation | 3TC Related MutationThailand
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Johns Hopkins UniversityMuscular Dystrophy Association; Actio Biosciences, IncRecruiting
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IRCCS Azienda Ospedaliero-Universitaria di BolognaRecruitingCancer Gene MutationItaly
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Fujian Cancer HospitalUnknown
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Rabin Medical CenterCompletedBRCA1 Gene Mutation | BRCA2 Gene MutationIsrael
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Yang LiRuijin HospitalRecruitingPediatric Cancer | Li-Fraumeni Syndrome | p53 MutationsChina
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University of PennsylvaniaInovio PharmaceuticalsRecruiting
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University of California, San FranciscoThe Bluefield Project to Cure Frontotemporal DementiaCompletedProgranulin Mutation CarriersUnited States
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Columbia UniversityLudwig-Maximilians - University of Munich; Moorfields Eye Hospital NHS Foundation... and other collaboratorsRecruitingRetinitis Pigmentosa Associated With CNGB1 MutationsUnited States, France, Germany, United Kingdom
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NYU Langone HealthRecruitingMLH1 Gene Mutation | RAD51C Gene Mutation | BRIP1 Gene Mutation | MSH6 Gene Mutation | PMS2 Gene Mutation | BRCA-Mutated Ovarian Carcinoma | MSH2 A636P | EPCAMUnited States
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Weill Medical College of Cornell UniversityCompletedBreast Cancer | Gynecologic Cancer | BRCA1 Mutation | BRCA2 MutationUnited States
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Fondazione IRCCS Istituto Nazionale dei Tumori,...Istituto Oncologico di BariCompletedBreast Cancer | BRCA1 Mutation | BRCA2 Mutation | Dietary ModificationItaly
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Alliance for Clinical Trials in OncologyNational Cancer Institute (NCI); Eli Lilly and Company; Genentech, Inc.; Kazia... and other collaboratorsRecruitingMetastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain | NTRK Family Gene Mutation | CDK Gene Mutation | PI3K Gene Mutation | ROS1 Gene Mutation | KRAS G12C MutationUnited States
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Novartis PharmaceuticalsRecruitingNLRC4-GOF, AIFEC (Autoinflammation With Infantile Enterocolitis), XIAP Deficiency, CDC42 MutationsSpain, France, United States, Canada, Japan, United Kingdom, Turkey, Czechia, Italy
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Cancer Institute and Hospital, Chinese Academy...Not yet recruitingRefractory Lymphoma | DLBCL | MYD88 Gene Mutation | Relapse | CD79A Gene Mutation | CD79B Gene Mutation
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Changhai HospitalActive, not recruitingChronic Pancreatitis | Smoking, Tobacco | Drinking, Alcohol | Genetic Mutation
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Universitaire Ziekenhuizen KU LeuvenCompletedFamily Study HbA2 Leuven Mutation.Belgium
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University of California, Los AngelesBoston Children's Hospital; Duke University; Children's Hospital Medical Center...RecruitingBohring-Opitz Syndrome | ASXL1 Gene Mutation | Shashi-Pena Syndrome | ASXL2 Gene Mutation | Bainbridge-Ropers Syndrome | ASXL3 Gene MutationUnited States
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Sidney Kimmel Comprehensive Cancer Center at Johns...Merck Sharp & Dohme LLCActive, not recruitingHigh Tumor Mutation Burden | High TMB (Tumor Mutation Burden) | MSS (Microsatellite Stable)United States
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Boehringer IngelheimActive, not recruitingSolid Tumors, KRAS MutationSpain, United Kingdom, United States, Belgium