Clinical Trials on Genetic Mutation in France

Total 2443 results

Institut National de la Santé Et de la Recherche...

Recruiting

Molecular Diagnosis of Systemic Autoinflammatory Diseases (SAIDiag)

Genetic Disease | Inflammatory Disease | Somatic Mutation | Molecular Sequence Variation | Molecular Pathway Deregulation

France
Centre Hospitalier Universitaire de Besancon

Completed

IMpact of Breast cAncer Gene Status on Survival in Adjuvant Breast Cancer (IMBASSA) (IMBASSA)

Breast Cancer | BRCA1 Mutation | BRCA2 Mutation

France
Federation Francophone de Cancerologie Digestive

Recruiting

Cohort of Tumors With POLE/D1 Mutation

Tumors | POLD1 Gene Mutation | POLE Exonuclease Domain Mutation

France
Assistance Publique - Hôpitaux de Paris

Unknown

Screening of Pulmonary Veino Occlusive Disease in Heterozygous EIF2AK4 Mutation Carriers (DELPHI-4)

Genetic Syndrome | Mutation

France
Assistance Publique - Hôpitaux de Paris

Recruiting

Macrophages, GM-CSF and MARS Proteinosis (MacroMARS)

Genetic Mutation | Pulmonary Alveolar Proteinosis (PAP) | MARS

France
Institut Curie

Recruiting

COsegregation of VARiants in Panel of Genes (COVAR)

Genetic Predisposition | Gene Mutation-Related Cancer

France, Guadeloupe, Martinique, Réunion
University Hospital, Montpellier

Completed

Management of Women With BRCA1/2 Mutation

BRCA1 Mutation | BRCA2 Mutation

France
Centre Hospitalier Universitaire de Nīmes

Completed

The Injury and Its Consequences in the Sports Lower Limb Amputee (PREV'AMP SPORT)

Traumatic Amputation | Leg Lower Amputation

France
Assistance Publique - Hôpitaux de Paris

Completed

Validation of Respiratory Epithelial Functional Assessment to Predict Clinical Efficacy of Orkambi®. (PREDICT-CF)

Cystic Fibrosis | Homozygous F508del Mutation

France
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer

BRCA1 Gene Mutation | BRCA2 Gene Mutation | Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7 | BRIP1 Gene Mutation | PALB2 Gene Mutation | ATM Gene Mutation | ATR Gene Mutation | CHEK2 Gene Mutation | NBN Gene Mutation | RAD51 Gene Mutation | CHEK1 Gene Mutation | FANCA Gene... and other conditions

United States, Canada
Centre Jean Perrin
International Cancer Research Group; Institut Max Planck d'optique quantique

Active, not recruiting

Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening (ICRG0101)

BRCA1 Mutation | BRCA2 Mutation | Breast Cancer Female

France
University Hospital, Montpellier
Hôpital Cochin; Hôpital Necker-Enfants Malades; Foch Hospital, Suresnes, FRANCE

Recruiting

Validation of Therapeutic Efficacy Targeting the Splicing Variants in Cystic Fibrosis and CFTR Pathologies (ONB-CFTR)

Cystic Fibrosis | CFTR Gene Mutation

France
Hospices Civils de Lyon

Completed

Clinical Evaluation of Bilateral Hand Allograft: Pilot Study of 7 Cases

Amputation

France
Hospices Civils de Lyon

Unknown

Bilateral Upper Limb Amputation Observatory (ARMOBS)

Bilateral Upper Limb Amputation | Transverse Short Amputation of the Hand | Arm Amputation

France
FondationbHopale

Recruiting

Psychometric Qualities IPAQ-SF (QUAPSY)

Amputation | Lower Extremity Amputation | Gait Analysis | Questionnaires

France
Institut Curie

Completed

Circulating Tumor DNA and Follow-up of BRCA1 Mutation Carriers (CirCa 01)

Women With BRCA1 Germline Deleterious Mutation

France
Institut Bergonié

Recruiting

Cancer Risk Assessment in Patients With a Constitutional Alteration of the PTEN Gene (COCO)

PTEN Gene Mutation

France
Centre Hospitalier Universitaire Dijon

Completed

Validation of the SIGAM/VF Mobility Grade (SIGAM)

Amputation

France
University Hospital, Strasbourg, France

Terminated

The Occlusive Dressing

Fingertips Traumatic Amputations

France
Centre Hospitalier Universitaire Dijon

Recruiting

Study of Locomotor Expectations for Ascending/Descending Slope and Stairs in Patients With Limb Amputations (JCE)

Lower Limb Amputation

France
FondationbHopale
Lille Catholic University

Recruiting

Walking Strategies in Usual Locomotion of Lower Limb Amputees (STRAAL)

Lower Limb Amputation

France
Assistance Publique - Hôpitaux de Paris
France Parkinson Association

Unknown

Measure of Microglial Activation in the Brain of Parkinson Disease Patients With PET (INFLAPARK)

Healthy Controls | Parkinson's Disease With LRRK2 Mutation | Parkinson's Disease Without LRRK2 Mutation

France
Centre Hospitalier Universitaire Dijon

Completed

Overall Functional Evaluation After Amputation of the Lower Limb; Locomotion, Energy Efficiency and Strategies to Adapt to the Prosthesis (PROTEOR)

Lower Limb Amputation

France
Otto Bock France SNC
Euraxi Pharma

Completed

Compensatory Movements With Axon-Hook and Greifer in Transradial Amputees

Transradial Amputation

France
Groupe Francophone des Myelodysplasies
Aprea Therapeutics

Unknown

Study of the Safety and Efficacy of APR-246 in Combination With Azacitidine

Chronic Myelomonocytic Leukemia | Myeloproliferative Neoplasm | Acute Myeloid Leukemia With Gene Mutations | Myelodysplastic Syndrome With Gene Mutation

France
Assistance Publique - Hôpitaux de Paris

Completed

Osteoporosis in RETT Syndrome (OSRETT)

RETT Syndrome With Proven MECP2 Mutation

France
Centre Hospitalier Departemental Vendee

Recruiting

Early Evaluation of the Introduction of Pre- and Post-operative Psychological and Physiotherapeutic Follow-up in Vascular Surgery in Amputee Patients (EPKIVA)

Amputation

France
Nantes University Hospital

Terminated

Analysis of Oculo-motor Deficiencies Associated With FMR1 Gene Expression (Genetic Abnormality Predisposing to a Neurodegenerative Disease)

Pre-mutation on FMR1 Gene

France
Sensorion

Recruiting

Natural History in Children up to 10 Years With Moderate to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes (Otoconex)

Sensorineural Hearing Loss, Bilateral | Congenital Deafness | AUNB1 | DFNB1A | DFNB9 | OTOF Gene Mutation | GJB2 Gene Mutation

France
Centre Hospitalier Universitaire de Nīmes

Completed

Asymmetry of the Center of Pressure During Gait After Amputation of Lower Limbs (ASCOPALL)

Lower Limb Amputation Below Knee (Injury) | Lower Limb Amputation Above Knee (Injury)

France
Hospices Civils de Lyon

Recruiting

Characterization of a Functional Test for Mediterranean Family Fever Screening - 2 (DEPIST-FMF 2)

Familial Mediterranean Fever | MEFV Gene Mutation

France
Össur Ehf
Clin-Experts

Unknown

Daily Socket Comfort in Transtibial Amputee With an Active Vacuum Suspension System

Amputation

France
University Hospital, Grenoble
TIMC-IMAG

Completed

Analyzing Stump-socket Interface Pressure to Improve Gait in Above-knee Amputee

Lower Limb Amputation Above Knee (Injury)

France
xCures
Cancer Commons

Available

Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies

Melanoma | Head and Neck Cancer | Glioblastoma | Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Small Bowel Cancer | Ovarian Cancer | Non Small Cell Lung Cancer | Cholangiocarcinoma | Bladder Cancer | Thyroid Cancer | ERK Mutation | MAPK Gene Mutation | KRAS Activating... and other conditions

United States
Novartis Pharmaceuticals

Completed

Safety, Efficacy, Pharmacokinetics, Pharmacodynamics of ACZ885 in Patients With NALP3 Mutations and Clinical Symptoms

NALP3 Mutation

United Kingdom, France, Germany, India, Spain
University Hospital, Angers

Completed

Comparing New Prothesis PROPRIO-FOOT® Versus Usual Prothesis Tasks Tibial Amputees (PROPRIO-FOOT)

Lower Limb Amputation at Ankle (Injury)

France
CHU de Reims

Recruiting

Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time (PARALSTER)

Duration of Hospitalization in Intensive Care Unit

France
Hospices Civils de Lyon

Recruiting

Double Upper Limb Allograft: Intervention and Clinical Evaluation. A Pilot Study of 5 Cases (DAMIE)

Bilateral Amputation of Upper Limb

France
Assistance Publique - Hôpitaux de Paris

Recruiting

Hematological Anomalies in Children With Rasopathy (RAS-HEMATO)

RAS Mutation

France
Centre Hospitalier Universitaire Dijon

Recruiting

Study of the Value of hPG80 (Circulating Progastrin) for the Diagnosis of Neuroendocrine Tumours in Patients With an MEN1 Mutation (PRO-NEM1)

Neuroendocrine Tumors | MEN1 Mutation

France
Hospices Civils de Lyon

Recruiting

Medical Economic Evaluation of Bilateral Allograft of Hands and Forearms (ARMEDIC)

Bilateral Traumatic Amputation of Upper Limbs

France
Centre Hospitalier Universitaire Dijon

Recruiting

Virtual Reality Applied to the Evaluation and Rehabilitation of Locomotion - Study of Tolerance in the Lower Limb Amputee (REVA)

Unilateral Amputation of the Lower Limb

France
University Hospital, Brest

Recruiting

Lipofilling Versus Conservative Treatment in Fingertips Injuries Sequelae (LIPOFILLING)

Distal Amputation of the Fingers

France
Centre Hospitalier Universitaire de Saint Etienne

Completed

Hyperekplexia in Patients With CTNNB1 Mutation (CTNNB1)

CTNNB1 Gene Mutation | Hyperekplexia

France
Centre Hospitalier Universitaire de Nice

Unknown

Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.

Mitochondrial Diseases | Diagnosis | DNA Mutations

France
Assistance Publique - Hôpitaux de Paris

Completed

Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene. (MetPAP)

Pulmonary Alveolar Proteinosis | Mutation Ala393Thr of the MARS Gene | mutationSer567Leu of the MARS Gene

France
University Hospital, Angers

Terminated

Revofit™ System Evaluation on Residual Limb Pain in Amputee Patients

Amputation | Adult Disease

France
Hospices Civils de Lyon

Completed

ASYMMETRIC LACK OF KNEE FLEXION AS A SYMPTOM OF DLM IN CHILDREN

Highlights a New Clinical Sign Which Point Out a Meniscus Posterior Luxation Because of a MCA-type DLM

France
Columbia University
Ludwig-Maximilians - University of Munich; Moorfields Eye Hospital NHS Foundation... and other collaborators

Recruiting

CNGB1 and Allied Disorders

Retinitis Pigmentosa Associated With CNGB1 Mutations

United States, France, Germany, United Kingdom
Blueprint Medicines Corporation

Completed

(PROSPECTOR) Screening Study Evaluating the Prevalence of the KIT D816V Mutation in Patients With Systemic Mast Cell Activation

Systemic Mast Cell Activation | KIT D816V Mutation

United States, France, United Kingdom, Italy, Germany, Belgium, Spain, Switzerland

Clinical Trials on Genetic Mutation in France

Sponsors and Collaborators

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Drug Interventions

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CROs in Kyrgyzstan

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