Clinical Trials on Glaucoma, Primary Open Angle in United States

Total 353 results

Alcon Research
University of California, San Diego

Completed

Study of the Intraocular Pressure (IOP)-Lowering Efficacy of Azopt 1.0% Compared to Timolol 0.5% in Patients With Glaucoma or Ocular Hypertension

Primary Open Angle Glaucoma | Ocular Hypertension

United States
InnFocus Inc.

Completed

InnFocus MicroShunt Versus Trabeculectomy Study (IMS)

Primary Open Angle Glaucoma

Spain, United States, United Kingdom, France, Netherlands, Italy
Ocular Therapeutix, Inc.

Completed

A Study to Evaluate the Long Term Safety of OTX-TP (Sustained Release Travoprost) Intracanalicular Insert

Open Angle Glaucoma and Ocular Hypertension

United States
Nova Eye, Inc.
Nova Eye Medical GmbH

Recruiting

Multicenter Glaucoma Study Investigating Standalone Canaloplasty (MAGIC)

Primary Open Angle Glaucoma

United Kingdom, Germany, Spain
Bp Consulting, Inc

Completed

Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG)

Ocular Hypertension | Open-Angle Glaucoma

United States
Guy's and St Thomas' NHS Foundation Trust

Unknown

Surgical Approaches in Treating Uncontrolled Glaucoma in Black African and African-Caribbeans (PEACE)

Primary Open Angle Glaucoma

United Kingdom
Moorfields Eye Hospital NHS Foundation Trust

Completed

Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension (LIGHT)

Primary Open Angle Glaucoma | Ocular Hypertension

United Kingdom
Alcon Research

Recruiting

Hydrus® Microstent New Enrollment Post-Approval Study (CONFIRM)

Primary Open Angle Glaucoma

United States
Sight Sciences, Inc.

Terminated

Randomized Study of the Safety and Effectiveness of the Sight Sciences VISCO™360 Viscosurgical System Versus SLT in Primary Open Angle Glaucoma (VISCO360 Study)

Open-Angle Glaucoma

United States
Betaliq, Inc.
Trial Runners, LLC; Summit Analytical, LLC

Completed

Nebivolol 0.5, 1.0, or Timolol 0.5 Suspension Compared to Timolol 0.5 Solution to Treat Glaucoma/Ocular Hypertension

Ocular Hypertension | Open-Angle Glaucoma

United States
Aerie Pharmaceuticals

Completed

Double-masked Study of PG324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-angle Glaucoma

United States
Aerie Pharmaceuticals

Completed

Double-masked Study of PG324 Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-angle Glaucoma

United States
Aerie Pharmaceuticals

Completed

Double-masked Study of AR-13324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension (Rocket-1)

Ocular Hypertension | Open-angle Glaucoma

United States
Aerie Pharmaceuticals

Completed

Evaluation of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma and Ocular Hypertension

Ocular Hypertension | Open-angle Glaucoma

United States
Vistakon Pharmaceuticals

Completed

A Comfort Survey of Open-angle Glaucoma or Ocular Hypertension Patients Treated With 2 Drugs

Ocular Hypertension | Open-angle Glaucoma

United States
Mati Therapeutics Inc.
QLT Inc.

Completed

A Phase 2 Study of Punctal Placement of the Latanoprost Punctal Plug Delivery System (L-PPDS)

Ocular Hypertension | Open-Angle Glaucoma

United States
Alcon Research

Completed

Adjunctive Study of AL-37807 Ophthalmic Suspension

Ocular Hypertension | Open-Angle Glaucoma

United States
Alcon Research

Completed

A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-angle Glaucoma

United States
Ivantis, Inc.

Completed

Hydrus Microstent for Refractory Open-Angle Glaucoma (SUMMIT)

Open-angle Glaucoma

Spain, United States, United Kingdom, Philippines, Colombia
AqueSys, Inc.

Completed

Evaluation of the XEN Implant in Moderate Primary Open Angle Glaucoma (POAG) Participants

Primary Open Angle Glaucoma

Spain, Austria, Belgium, Italy, Germany, Poland, Switzerland, United Kingdom, Venezuela
Alcon Research

Completed

Phase 3 Study to Evaluate IOP Lowering Therapy in Open Angle Glaucoma and Ocular Hypertension C-01-69

Ocular Hypertension | Open-Angle Glaucoma

United States
Alcon Research

Completed

Phase 3 Study Comparing IOP Lowering in OAG or OH in Japanese Subjects C-01-98

Ocular Hypertension | Open-Angle Glaucoma

United States
Wills Eye
IOP Ophthalmics

Terminated

Patch Graft Material Safety and Effectiveness in Covering Glaucoma Drainage Device Tube

Primary Open Angle Glaucoma | Neovascular Glaucoma | Uveitic Glaucoma | Pseudoexfoliation Glaucoma | Primary Angle Closure Glaucoma | Pigmentary Glaucoma | Traumatic Glaucoma

United States
59th Medical Wing
Nanodropper, Inc.

Recruiting

Nanodropper Use in Primary Open-Angle Glaucoma Patients: A Non-Inferiority Trial

Primary Open Angle Glaucoma | Ocular Hypertension

United States
Aerie Pharmaceuticals

Completed

Study of Netarsudil Ophthalmic Solution in Japanese/Japanese-American Subjects With Open-angle Glaucoma or Ocular Hypertension

Primary Open Angle Glaucoma or Ocular Hypertension

United States
Altheos, Inc.

Completed

ATS907 Ph2a Open-Label Dose-ranging Safety and Tolerability in Primary Open Angle Glaucoma (POAG) and Ocular Hypertension (OHT) Subjects

Primary Open Angle Glaucoma | Ocular Hypertension

United States
Alcon Research

Completed

IOP Lowering Efficacy of Travoprost/Brinzolamide Fixed Combination Ophthalmic Suspension in Patients With Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-angle Glaucoma

United States
Alcon Research

Completed

Dose Response Study of AL-37807 Ophthalmic Solution in Patients With Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-Angle Glaucoma

United States
University of California, Los Angeles
National Eye Institute (NEI)

Active, not recruiting

Advanced Glaucoma Progression Study (AGPS)

Primary Open Angle Glaucoma | Chronic Angle Closure Glaucoma | Pseudoexfoliative Glaucoma

United States
Inotek Pharmaceuticals Corporation

Completed

A Dose-Escalation Study Designed to Evaluate the Tolerability, Safety, Pharmacokinetics (PK), and Efficacy of Chronic Topical Ocular Application of INO-8875 in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma

Ocular Hypertension | Glaucoma

United States
MediPrint Ophthalmics, Inc.

Completed

Study of LL-BMT1 in Patients With Elevated Intraocular Pressure

Primary Open Angle Glaucoma | Ocular Hypertension

United States
Allergan

Recruiting

18 Month Prospective Efficacy and Safety Study of Bimatoprost Intracameral Implant (DURYSTA) (ARGOS)

Ocular Hypertension | Open-angle Glaucoma

United States
Alcon Research

Completed

A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-angle Glaucoma

United States
Alcon Research

Terminated

A Dose-Volume Study of a Treatment for Elevated IOP Due to Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-Angle Glaucoma

United States
Alcon Research

Completed

A Phase II Study of AL-37807 to Treat Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-Angle Glaucoma

United States
Alcon Research

Completed

Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension

Open-angle Glaucoma | Oular Hypertension

United States
AbbVie

Recruiting

Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma

Open-Angle Glaucoma

United States, Australia
Santen Inc.

Completed

Safety and Efficacy Trial to Treat Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-angle Glaucoma

United States
Alcon Research

Completed

Phase II Safety and Efficacy Study to Evaluate a Glaucoma Therapy in Open-Angle Glaucoma or Ocular Hypertension Patients

Ocular Hypertension | Open-Angle Glaucoma

United States
Uzoma Chinyei Joan

Recruiting

Comparison of Preserved and Preservative-free Latanoprost 0.005% in Primary Open Angle Glaucoma and Ocular Hypertensive Patients, at Guinness Eye Centre, Lagos.

Effect of Drug

Nigeria
Nicox Ophthalmics, Inc.

Recruiting

Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution (Whistler)

Open Angle Glaucoma

United States
iSTAR Medical

Recruiting

Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma. (STAR-V)

Glaucoma

United States
University of Nebraska

Completed

Effects of Selective Laser Trabeculoplasty on Aqueous Humor Dynamics

Open Angle Glaucoma

United States
University of Alabama at Birmingham
Alcon Research

Completed

Determinants of Compliance With Glaucoma Therapy

Open Angle Glaucoma

United States
Qlaris Bio, Inc.

Recruiting

Qlaris Study of QLS-111 in Combination With a PGA for OAG and/or OHT Patients

Glaucoma | Open-angle Glaucoma (OAG) | Ocular Hypertension (OHT)

United States
[Redacted]

Withheld

[Trial of device that is not approved or cleared by the U.S. FDA] (FRONTIER)

Primary Open Angle Glaucoma | Open Angle Glaucoma | Pseudoexfoliation Glaucoma | Pigmentary Glaucoma

United States, Germany, Italy, Philippines, Spain, United Kingdom
AbbVie

Completed

A Phase 3b Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-Angle Glaucoma

United States
Glaukos Corporation

Active, not recruiting

Multicenter Post-Approval Study Of The Glaukos® iStent® Trabecular Micro-Bypass Stent System In Conjunction With Cataract Surgery

Primary Open Angle Glaucoma

United States
Novartis

Completed

Tolerability, Safety and Efficacy of RKI983 Eye Drops in Subjects With Primary Open Angle Glaucoma and Ocular Hypertension

Ocular Hypertension | Glaucoma

United States
University of California, San Francisco
Icare Finland Oy; Nanodropper, Inc.

Recruiting

Efficacy of the Nanodropper Device on Intraocular Pressure in Patients With Glaucoma

Ocular Hypertension | Glaucoma | Open Angle Glaucoma

United States

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