Clinical Trials on HER2 Mutation-Related Tumors in Canada
Total 202 results
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Puma Biotechnology, Inc.TerminatedSolid Tumors Harboring Somatic HER2 or EGFR Exon 18 MutationsFrance, United States, Spain, Belgium, United Kingdom, Serbia, Australia, Israel, Canada, Denmark, Ireland, Italy, Korea, Republic of
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Bristol-Myers SquibbCompletedSolid Tumors That Overexpress HER2 (HER2 Positive)United States, Canada
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AstraZenecaDaiichi Sankyo Co., Ltd.Active, not recruitingAdvanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,BreastItaly, Spain, United States, France, Korea, Republic of, Japan, Canada, Denmark, Belgium
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PfizerCompletedSolid Tumors Harboring a BRAF V600 MutationUnited States, France, Italy, Singapore, Australia, Spain, Switzerland, Canada, Belgium
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University Health Network, TorontoBayer; AstraZeneca; Amgen; AnHeart Therapeutics Inc.; Applied Health Research Centre and other collaboratorsRecruitingCancer | Malignancies Multiple | Malignant Solid Tumor | Cancer, Therapy-Related | Molecular Sequence Variation | Genetic Alteration | Gene Fusion | Receptor Tyrosine Kinase Gene Mutation | RTK Family Gene Mutation | Ras (Kras or Nras) Gene MutationCanada
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University Health Network, TorontoRecruitingGlioma | Solid Tumor | Cholangiocarcinoma | IDH MutationCanada
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Eli Lilly and CompanyActive, not recruitingPancreatic Cancer | Solid Tumor | Cutaneous Melanoma | Microsatellite Instability-High (MSI-H) Solid Tumors | Breast Cancer (HR+HER2-)Belgium, Spain, Korea, Republic of, United States, Taiwan, France, Canada
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AstraZenecaCompletedHER2-ve Metastatic Breast Cancer | Germline BRCA1/2 Mutations | Somatic BRCA1/2 MutationsItaly, Spain, Poland, Taiwan, Canada, France, Germany, Korea, Republic of, Hungary, Japan, Russian Federation, Turkey, United Kingdom, United States, Bulgaria
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British Columbia Cancer AgencyWithdrawnNeuroendocrine Tumors | Carcinoid Tumor | Gastrinoma | Insulinoma | Vipoma | Gastroenteropancreatic Neuroendocrine Tumor | Pulmonary Carcinoid TumorCanada
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National Cancer Institute (NCI)CompletedMetastatic Gastrointestinal Carcinoid Tumor | Recurrent Gastrointestinal Carcinoid Tumor | Recurrent Islet Cell Carcinoma | Pulmonary Carcinoid TumorCanada
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Vancouver Coastal HealthUnknownNeuroblastoma | Pheochromocytoma | Paraganglioma | Medullary Thyroid Carcinoma | Carcinoid TumorsCanada
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University Health Network, TorontoCompleted
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Rain Oncology IncTerminatedNSCLC Stage IIIB | NSCLC, Recurrent | NRG1 Fusion | EGFR Exon 20 Insertion Mutation | NSCLC, Stage IIIC | NSCLC, Stage IV | HER2-activating Mutation | ERBB FusionUnited States, Canada, Hong Kong
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Women's College HospitalCanadian Institutes of Health Research (CIHR); London Health Sciences Centre; H. Lee Moffitt Cancer Center and Research Institute and other collaboratorsUnknownBreast Cancer | Ovarian Cancer | BRCA1 Gene Mutation | BRCA2 Gene MutationCanada
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University Health Network, TorontoAbbVie; CelgeneTerminatedAcute Myeloid Leukemia | Relapsed Cancer | Refractory Cancer | IDH2 Gene MutationCanada
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The Hospital for Sick ChildrenCompletedBrain Tumor Treated With Cranial or Cranial-Spinal RadiationCanada
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British Columbia Cancer AgencyNo longer availableThyroid Cancer, Medullary | Neuroblastoma | Pheochromocytoma | Carcinoid Tumor | Paraganglioma | InsulinomaCanada
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University Health Network, TorontoWithdrawnFallopian Tube Cancer | Primary Peritoneal Cancer | Ovarian Endometrioid Tumor | TP53 MutationCanada
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National Cancer Institute (NCI)RecruitingMetastatic Pancreatic Neuroendocrine Tumor | Pancreatic Neoplasm | Stage III Pancreatic Neuroendocrine Tumor AJCC v8 | Stage IV Pancreatic Neuroendocrine Tumor AJCC v8 | Unresectable Pancreatic Neuroendocrine TumorUnited States, Canada
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Epizyme, Inc.CompletedSynovial Sarcoma | Epithelioid Sarcoma | Renal Medullary Carcinoma | Malignant Rhabdoid Tumors (MRT) | Rhabdoid Tumors of the Kidney (RTK) | Atypical Teratoid Rhabdoid Tumors (ATRT) | Selected Tumors With Rhabdoid Features | INI1-negative Tumors | Malignant Rhabdoid Tumor of Ovary | Poorly Differentiated... and other conditionsFrance, United States, Australia, Taiwan, Belgium, United Kingdom, Canada, Germany, Italy
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Jewish General HospitalCompleted
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AstraZenecaDaiichi Sankyo Co., Ltd.RecruitingPart 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer | Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal CancerCanada, Korea, Republic of, Taiwan, United States, Italy, United Kingdom, Thailand, Russian Federation, India, Belgium, Australia, Poland, Spain, Japan, Brazil, Czechia, Netherlands
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ArriVent BioPharma, Inc.RecruitingAdvanced Non-Small Cell Lung Cancer | Metastatic Non-Small Cell Lung Cancer | Non-Small Cell Lung Cancer (NSCLC) | HER2 Exon 20 Mutations | EGFR Exon 20 Mutations | EGFR Uncommon Mutations, Including G719X and S768IUnited States, Australia, Spain, United Kingdom, France, Italy, China, Korea, Republic of, Canada, Japan, Netherlands
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AmgenRecruitingAdvanced Solid Tumors | Kirsten Rat Sarcoma (KRAS) pG12C MutationUnited States, Italy, Taiwan, Spain, United Kingdom, Australia, Austria, Germany, Belgium, Japan, Netherlands, Korea, Republic of, Canada
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Day One Biopharmaceuticals, Inc.RecruitingMelanoma | Colorectal Cancer | Solid Tumor | Non Small Cell Lung Cancer | Bladder Cancer | Thyroid Cancer, Papillary | Pilocytic Astrocytoma | Bladder Urothelial Carcinoma | Non-Small Cell Adenocarcinoma | MEK Mutation | RAS Mutation | Pancreatic Acinar Carcinoma | RAF Mutation | CRAF Gene Amplification | RAF1 Gene Amplification and other conditionsUnited States, Canada, Korea, Republic of, Spain, Australia, Belgium, France
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Eli Lilly and CompanyActive, not recruitingRelapsed Solid Tumor | Refractory Solid TumorUnited States, Canada, France, Australia, Belgium, Germany, Spain, Italy
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Crinetics Pharmaceuticals Inc.Active, not recruitingCarcinoid Tumor | Carcinoid Syndrome | Carcinoid | Carcinoid Tumor of Ileum | Carcinoid Tumor of Cecum | Carcinoid Syndrome Diarrhea | Carcinoid Intestine Tumor | Carcinoid Tumor of Liver | Carcinoid Tumor of PancreasUnited States, Brazil, Argentina, Canada, Mexico, Peru, Poland
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Stanford UniversityAmgen; Pediatric Oncology Experimental Therapeutics Investigators' ConsortiumCompletedRefractory Leukemia | Refractory Solid Tumors | Relapsed Solid Tumors | Relapsed LeukemiaUnited States, Canada
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University Health Network, TorontoMerck Sharp & Dohme LLCCompletedAdvanced Ovarian Cancer | Malignant MelanomaCanada
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IpsenTerminatedPancreatic Neuroendocrine TumorSpain, Portugal
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Children's Oncology GroupNational Cancer Institute (NCI)CompletedSarcoma | Ovarian Cancer | Brain Tumor | Ototoxicity | Neuroblastoma | Liver Cancer | Central Nervous System Tumor | Extragonadal Germ Cell Tumor | Childhood Germ Cell TumorCanada, United States, Australia
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Children's Oncology GroupNational Cancer Institute (NCI)CompletedSarcoma | Lymphoma | Unspecified Childhood Solid Tumor, Protocol Specific | Leukemia | Ovarian Cancer | Brain and Central Nervous System Tumors | Neuroblastoma | Liver Cancer | Psychosocial Effects of Cancer and Its Treatment | Extragonadal Germ Cell Tumor | Childhood Germ Cell TumorUnited States, Puerto Rico, Canada, Switzerland
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Canadian Network for Observational Drug Effect...Canadian Institutes of Health Research (CIHR); Drug Safety and Effectiveness...CompletedDiabetes Mellitus, Type 2 | Diabetic Ketoacidosis | Lower Extremity Amputation | UrosepsisCanada
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David ClarkeRecruitingCystic Tumors of the Sellar/Parasellar RegionCanada
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C17 CouncilCompletedRelapsed Malignant Solid TumorCanada
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Children's Oncology GroupNational Cancer Institute (NCI)CompletedRecurrent Ewing Sarcoma | Recurrent Childhood Rhabdomyosarcoma | Previously Treated Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Peripheral Primitive Neuroectodermal TumorUnited States, Canada
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RayzeBio, Inc.Active, not recruitingNeuroendocrine Tumors | Carcinoid Tumor | Gastroenteropancreatic Neuroendocrine Tumor | Carcinoid | GEP-NET | Gastroenteropancreatic Neuroendocrine Tumor Disease | Pancreatic NETCanada, Spain, United States, Netherlands, Belgium, France, Brazil
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University of AlbertaCompletedLymphoma | Pancreas Adenocarcinoma | Pancreas Neoplasms | Gastrointestinal Stromal TumorCanada
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National Cancer Institute (NCI)Active, not recruitingMetastatic Digestive System Neuroendocrine Tumor G1 | Recurrent Digestive System Neuroendocrine Tumor G1 | Regional Digestive System Neuroendocrine Tumor G1 | Metastatic Neuroendocrine Tumor | Midgut Neuroendocrine Tumor G1 | Foregut Neuroendocrine Tumor | Hindgut Neuroendocrine Tumor | Neuroendocrine...Canada, United States
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Lexicon PharmaceuticalsCompletedCarcinoid SyndromeUnited States, Australia, Belgium, Canada, France, Germany, Israel, Italy, Netherlands, Spain, Sweden, United Kingdom
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Novartis PharmaceuticalsCompletedCarcinoid Tumor | Malignant Carcinoid SyndromeFrance, Spain, Netherlands, United States, Canada, Sweden, Italy, Australia, Germany, Greece, Belgium, Czech Republic, Slovakia, Finland, United Kingdom
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University Health Network, TorontoRecruitingMelanoma | Lymphoma | Kidney Cancer | Leukemia | Cancer | Breast Cancer | Head and Neck Cancer | Ovarian Cancer | Lynch Syndrome | Lung Cancer | Colon Cancer | Meningioma | BRCA1 Mutation | BRCA2 Mutation | Myeloma | Mutation | Uterine Cancer | Cowden SyndromeCanada
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Lexicon PharmaceuticalsCompletedCarcinoid SyndromeUnited States, Australia, Belgium, Canada, France, Germany, Israel, Spain, Sweden, United Kingdom, Netherlands
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Zymeworks Inc.Active, not recruitingHER2-expressing CancersUnited States, Canada, Korea, Republic of, Australia
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Novartis PharmaceuticalsTerminatedIslet Cell TumorFrance, Spain, United Kingdom, Belgium, Hungary, Turkey, Canada, Argentina, Sweden, Italy, Thailand, Germany, Netherlands, Brazil, Australia, Japan, United States, Denmark, New Zealand
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National Cancer Institute (NCI)CompletedLocally Advanced Pancreatic Neuroendocrine Tumor | Pancreatic Neuroendocrine Tumor G1 | Pancreatic Neuroendocrine Tumor G2 | Pancreatic Vipoma | Pancreatic Gastrinoma | Advanced Pancreatic Neuroendocrine TumorUnited States, Canada
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Jazz PharmaceuticalsActive, not recruitingHER2-expressing CancersUnited States, Canada, Korea, Republic of
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Novartis PharmaceuticalsCompletedAcromegaly | Carcinoid TumorGermany, Belgium, Canada, Netherlands, United States, Norway
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Lexicon PharmaceuticalsCompletedCarcinoid SyndromeUnited States, Australia, Belgium, France, Germany, Italy, Netherlands, Spain, Sweden, United Kingdom, Canada, Israel
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Ottawa Regional Cancer CentreCompletedSarcoma | Head and Neck Cancer | Brain and Central Nervous System Tumors | Malignant Mesothelioma | Liver Cancer | Pheochromocytoma | Adrenocortical CarcinomaCanada