Clinical Trials on HER2-expression in Portugal

Total 45 results

Amunix, a Sanofi Company
Merck Sharp & Dohme LLC

Recruiting

To Access the Safety and Effects of Intravenous Administration of AMX-818 Alone and in Combination With Pembrolizumab in Adult Participants With Locally Advanced or Metastatic HER2-Expressing Cancers

Locally Advanced or Metastatic HER2-Expressing Cancers

Australia, Spain, France, Portugal
Puma Biotechnology, Inc.

Completed

A Study to Characterize Colon Pathology in Patients With HER2 Amplified Breast Cancer Treated With Neratinib

HER2 Amplified Breast Cancer

Portugal
University of Coimbra

Enrolling by invitation

Be a Mom: Effectiveness of a Web-based Preventive Intervention for Postpartum Depression (BeAMom)

PostPartum Depression

Portugal
University of Coimbra
Fundação para a Ciência e a Tecnologia

Recruiting

bBeAMom: Effectiveness of a Cognitive-Behavioral Blended Intervention for Postpartum Depression (bBeAMom)

Postpartum Depression

Portugal
University Institute of Maia
University of Limerick; VU University of Amsterdam; INESC TEC; Center of Psychology... and other collaborators

Unknown

iCare4Depression: Effectiveness of a Blended Cognitive-Behavioral Therapy in Routine Practice (iCare4Dep)

Major Depression

Portugal
University of Évora
Universitätsklinikum Hamburg-Eppendorf

Recruiting

Metacognitive Training in the Older Adults With Depressive Symptoms (MCT-Silver)

Depressive Symptoms

Portugal
University of Minho

Recruiting

Interventions in Adults With Depressive and Anxious Symptoms

Depression | Anxiety

Portugal
University of Minho
Fundação para a Ciência e a Tecnologia; Centro de Investigação em Estudos da... and other collaborators

Unknown

Healthy Bellies - Intervention Program During Pregnancy on Women and Newborn

Physical Activity | Depressive Symptoms | Dietary Habits | Lifestyle

Portugal
University of Lisbon
University of Coimbra; Fundação para a Ciência e a Tecnologia

Recruiting

Efficacy Study of a Child-centered Version of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Children (UP-C/C)

Emotional Disorders | Childhood Anxiety | Childhood Depression

Portugal
Fundacao Champalimaud

Recruiting

In Vivo Cortical Excitability Modulation in Major Depressive Disorder (PDM-TMS)

Major Depressive Disorder

Portugal
University of Coimbra
Foundation for Science and Technology (FCT)

Completed

HEPPI: Efficacy of a Cognitive-Emotional Intervention for Homebound Older Adults (HEPPI)

Depressive Symptoms | Mild Cognitive Impairment | Anxiety State

Portugal
University of Coimbra
Foundation for Science and Technology (FCT)

Completed

Homebound Elderly People Psychotherapeutic Intervention (HEPPI)

Depressive Symptoms | Mild Cognitive Impairment | Anxiety State

Portugal
Universidade do Porto

Suspended

Effectiveness of an Online Training and Support Program (iSupport) for Informal Dementia Caregivers (iSupportPT)

Depressive Symptoms | Anxiety Symptoms | Caregiver Subjective Burden

Portugal
Associacao para Investigacao e Desenvolvimento...
University of Lisbon; Fundação para a Ciência e a Tecnologia; Instituto Politécnico...

Recruiting

Influence of Nutrition in Depression Treatment (INDEPT) (INDEPT)

Major Depressive Disorder - MDD

Portugal
Centro Hospitalar Lisboa Norte

Unknown

Psychobiological Characterization of Depression in Hepatitis C

Depression | Hepatitis c

Portugal
Iolanda Costa Galinha
DGArtes - Direção Geral das Artes; CIS-Iscte - Centro de Investigação e Intervenção...

Completed

Singing Groups for Seniors: Well-Being, Cognitive Function and Health (Sing4Health)

Depression | Quality of Life | Body Weight | Stress | Sleep | Anxiety | Blood Pressure | Cognitive Function | Blood Glucose | Loneliness | Physical Function | Medication Compliance | Balance | Memory | Biomarker | Well-Being | Respiratory Function | Social Identification | Cholesterol | C-reactive Protein | Erythrocyte Sedimentation Rate and other conditions

Portugal
MedSIR
Daiichi Sankyo, Inc.

Completed

DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease (DEBBRAH)

Advanced Breast Cancer | HER2-positive Breast Cancer | Brain Metastases | Leptomeningeal Metastasis

Spain, Portugal
Sanofi

Completed

An Eight-week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression

Depressive Disorder

Canada, Germany, Portugal, Estonia, Mexico, Croatia, Chile, Czechia
Sanofi

Completed

An Eight-Week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression

Depressive Disorder

France, Canada, Germany, Portugal, Czech Republic, Mexico, Croatia, Chile
Hoffmann-La Roche

Completed

A Study to Evaluate Patient Preference and Satisfaction of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Participants With HER2-Positive Early Breast Cancer (PHranceSCa)

HER2-Positive Early Breast Cancer

United States, Finland, Hong Kong, Panama, Portugal, Spain, Mexico, Sweden, Brazil, Serbia, Argentina, Lebanon, Cuba, Qatar, Saudi Arabia, Chile, Jordan
Celltrion
Nippon Kayaku Co., Ltd.

Completed

Efficacy and Safety Evaluating Study of CT-P6 in Her2 Positive Early Breast Cancer

HER2-positive Carcinoma of Breast

Italy, South Africa, Mexico, Japan, Taiwan, Russian Federation, Philippines, Hungary, Romania, Spain, Bosnia and Herzegovina, India, Peru, Ukraine, Latvia, Argentina, Georgia, Belarus, Chile, France, Poland, Portugal
AstraZeneca

Recruiting

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6) (SERENA-6)

ER-Positive HER2-Negative Breast Cancer

United States, Israel, Spain, Korea, Republic of, Italy, Poland, Belgium, Norway, Bulgaria, France, Germany, United Kingdom, Japan, Taiwan, Canada, Hungary, Australia, Austria, Portugal, Turkey, Russian Federation, Slovakia, Switzer...
AstraZeneca

Active, not recruiting

A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer (SERENA-2)

Advanced ER-Positive HER2-Negative Breast Cancer

United States, Italy, Spain, Belgium, Poland, Canada, Germany, Korea, Republic of, Russian Federation, France, Israel, Hungary, Portugal, United Kingdom, Georgia, Ukraine
COMPASS Pathways

Completed

The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression (P-TRD)

Treatment Resistant Depression

United States, Netherlands, Ireland, Germany, United Kingdom, Canada, Czechia, Denmark, Portugal, Spain
Puma Biotechnology, Inc.

Completed

A Study of Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Breast Cancer Who Have Received Two or More Prior HER2 Directed Regimens in the Metastatic Setting (NALA)

HER2+ Metastatic Breast Cancer (MBC)

United States, Canada, Spain, Singapore, Korea, Republic of, Taiwan, United Kingdom, Israel, Australia, Japan, Hong Kong, Finland, Ireland, Italy, France, Portugal, Germany, Sweden, Belgium, Brazil, Czechia, Switzerland, Argentina, Au... and more
Seagen Inc.
Merck Sharp & Dohme LLC

Recruiting

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer (HER2CLIMB-05)

HER2 Positive Breast Cancer

United States, Taiwan, Canada, Korea, Republic of, Austria, China, Spain, Japan, France, Italy, Switzerland, Australia, Belgium, Brazil, Germany, Portugal, United Kingdom, Netherlands, Czechia, Greece, Chile, Finland, Poland
AstraZeneca

Active, not recruiting

A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease (SERENA-4)

ER-Positive HER2-Negative Breast Cancer

Austria, Belgium, France, Germany, Italy, United Kingdom, United States, Canada, India, Taiwan, Russian Federation, Korea, Republic of, Hungary, Japan, Mexico, Turkey, China, Malaysia, Spain, Czechia, Portugal, Poland, Norway, Bulgaria, Slovaki... and more
Seagen Inc.

Completed

A Study of Tucatinib vs. Placebo in Combination With Capecitabine & Trastuzumab in Patients With Advanced HER2+ Breast Cancer (HER2CLIMB)

HER2 Positive Breast Cancer

United States, Spain, Belgium, Germany, Israel, France, United Kingdom, Austria, Denmark, Italy, Australia, Canada, Czechia, Portugal, Switzerland
Olema Pharmaceuticals, Inc.

Recruiting

OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer (OPERA-01)

Breast Cancer | Advanced Breast Cancer | Metastatic Breast Cancer | HER2 Negative Breast Carcinoma | ER Positive Breast Cancer

United States, Korea, Republic of, Australia, Taiwan, Hong Kong, Malaysia, Thailand, Argentina, Belgium, Portugal, Italy, Czechia, Mexico, Poland
Hoffmann-La Roche

Recruiting

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer

Belgium, Korea, Republic of, United States, Canada, China, Italy, France, Brazil, Australia, Argentina, Hong Kong, Portugal, Spain, Taiwan, India, Costa Rica, Israel, Thailand, Germany, New Zealand, Poland, Chile, Colombia, Guatemala, H...
Centro Hospitalar Universitario do Algarve
Universidade do Porto; Universidade do Algarve

Recruiting

Neuropsychological Sequelae and Long COVID-19 Fatigue (PostCoV2Psy)

COVID-19 | Mental Fatigue | Post Traumatic Stress Disorder | Anxiety Depression | Fatigue Syndrome, Chronic

Portugal
Hoffmann-La Roche

Active, not recruiting

A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)

Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer

United States, Italy, Korea, Republic of, Canada, Germany, United Kingdom, Australia, Belgium, Brazil, China, Denmark, France, Hong Kong, Portugal, Spain, Taiwan, Turkey, Japan, Argentina, Mexico, Israel, Poland, Russian Federation, A... and more
Daiichi Sankyo, Inc.
AstraZeneca; NSABP Foundation Inc; German Breast Group; Spanish Breast Cancer Research...

Active, not recruiting

A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

HER2-Positive Primary Breast Cancer | Residual Invasive Breast Cancer

United States, Spain, France, Germany, Korea, Republic of, United Kingdom, Denmark, Israel, Belgium, Taiwan, Chile, Italy, Japan, Peru, Portugal, China, Turkey, Canada, Ireland, Australia, Greece, Czechia, Singapore, Poland, Romania, Arge... and more
Novartis Pharmaceuticals

Active, not recruiting

Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.

Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation

Spain, Italy, Austria, Netherlands, United Kingdom, Germany, Thailand, France, Belgium, China, Argentina, Greece, Turkey, Malaysia, Portugal, Hungary, Brazil, United States, India
Bayer

Recruiting

First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

Hong Kong, United States, Taiwan, Spain, Belgium, China, Japan, France, Korea, Republic of, Singapore, Poland, Israel, Italy, Netherlands, Portugal, Brazil
AstraZeneca

Completed

Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients (RUBY)

Major Depressive Disorder | Treatment Resistant Depression

Bulgaria, Italy, United Kingdom, Germany, Hungary, Romania, Austria, Belgium, Denmark, Portugal, Slovakia, Australia, Spain
Rsocialform - Geriatria, Lda

Completed

Comparison Study of the Different Abbreviated Versions of the Geriatric Depression Scale

Depressive Disorder | Depression | Neurocognitive Disorders | Dementia

Portugal
University of Minho
King's College London; University of Coimbra; University of Athens; Universidad... and other collaborators

Completed

Impact of COVID-19 Pandemic in Perinatal Mental Health (RISEUP-PPD-COVID-19)

Depression | Anxiety | Post Traumatic Stress Disorder | Psychological Distress

United Kingdom, Chile, Greece, Israel, Albania, Brazil, Bulgaria, Cyprus, France, Malta, Portugal, Spain, Turkey
Rsocialform - Geriatria, Lda

Completed

Older Adults' Perceptions of the Impact COVID-19 Pandemic

Quality of Life | Cognitive Impairment | Loneliness | Depression, Anxiety | COVID-19 Pandemic

Portugal
Alliance Foundation Trials, LLC.
Pfizer; Syneos Health; UNICANCER; German Breast Group; SOLTI Breast Cancer Research... and other collaborators

Active, not recruiting

Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer (PATINA)

HER-2 Positive Breast Cancer | Estrogen Receptor Positive Breast Cancer

United States, Spain, France, Italy, Germany, Australia, Portugal, New Zealand
Janssen-Cilag International NV

Completed

A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder (ESCAPE-TRD)

Depressive Disorder, Major

Israel, Hungary, Korea, Republic of, Taiwan, Portugal, Turkey, Germany, Malaysia, Denmark, Bulgaria, Czechia, Belgium, Poland, Brazil, Netherlands, Argentina, Finland, Greece, South Africa, Austria, Kazakhstan, Norway, Sweden, United...
Celgene

Completed

Evaluate Risk/Benefit of Nab Paclitaxel in Combination With Gemcitabine and Carboplatin Compared to Gemcitabine and Carboplatin in Triple Negative Metastatic Breast Cancer (or Metastatic Triple Negative Breast Cancer) (tnAcity)

Breast Cancer | Metastatic Breast Cancer | Stage IV Breast Cancer | Triple-negative Breast Cancer | Recurrent Breast Cancer | Breast Tumor | Cancer of the Breast | Triple-negative Metastatic Breast Cancer | Estrogen Receptor- Negative Breast Cancer | HER2- Negative Breast Cancer | Progesterone Receptor- Negative...

United States, United Kingdom, Italy, Germany, Spain, Canada, Portugal, Australia, Austria, Greece, Brazil, France
Janssen Research & Development, LLC

Recruiting

A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD) (VENTURA-LT)

Depressive Disorder, Major

United States, Korea, Republic of, Taiwan, Slovakia, Spain, Bulgaria, Poland, Belgium, Argentina, Czechia, Hungary, South Africa, Sweden, Italy, France, Australia, China, Brazil, Portugal
MacroGenics

Completed

Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer (SOPHIA)

HER-2 Positive Breast Cancer | Metastatic Neoplasm

United States, Spain, Italy, Canada, Israel, Belgium, Germany, Czechia, Austria, Korea, Republic of, Denmark, United Kingdom, Portugal, France, Poland, Netherlands, Finland, Puerto Rico
Janssen Research & Development, LLC

Recruiting

A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy (VENTURA-1)

Anhedonia | Depressive Disorder, Major

United States, Spain, Bulgaria, Italy, Poland, Belgium, Argentina, Czechia, Hungary, Sweden, Brazil, Australia, Portugal

Clinical Trials on HER2-expression in Portugal

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