Clinical Trials on Haemorrhagic Shock in South Africa

Total 486 results

Australian and New Zealand Intensive Care Research...
Australian and New Zealand Intensive Care Society Clinical Trials Group; Australasian... and other collaborators

Recruiting

Fibrinogen Early In Severe Trauma StudY II (FEISTY II)

Trauma | Coagulopathy | Haemorrhagic Shock

Australia
Sangart

Completed

Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients

Shock, Hemorrhagic | Acidosis, Lactic | Shock, Traumatic

France, United Kingdom, South Africa, Germany
Sangart

Withdrawn

Phase 2c Dose Comparison Study of MP4OX in Trauma

Trauma | Hemorrhagic Shock | Lactic Acidosis

New Zealand, United Kingdom, Israel, France, Switzerland, Australia, Belgium, Brazil, Germany, Norway, South Africa
Sangart

Completed

Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients

Shock, Hemorrhagic | Acidosis, Lactic | Shock, Traumatic

Norway, Singapore, Israel, France, United Kingdom, Germany, Switzerland, Australia, Brazil, South Africa, New Zealand, Colombia, Austria, Spain
Catalyst Biosciences

Completed

Study of Next-Generation Recombinant Factor IX Variant in Adult Subjects With Hemophilia B

Hemophilia B

South Africa
University of Athens

Recruiting

Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock (CORVICTES-ΥΜ)

Septic Shock

Greece
University of Pretoria

Completed

A Randomized Trial Comparing Oxytocin and Oxytocin + Ergometrine for Prevention of Postpartum Haemorrhage at Caesarean Section

Prevention of Post Partum Haemorrhage

South Africa
Wentworth Area Health Services
Abbott

Unknown

Levosimendan Versus Dobutamine in Shock Patients

Septic Shock | Cardiogenic Shock

Australia
University of Athens
Naval Hospital, Athens; General Hospital of Nikaia "Saint Panteleimon"

Recruiting

Vitamin C, Hydrocortisone and Thiamine for Septic Shock (CORVICTES)

Shock, Septic

Greece
The George Institute

Completed

Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS (FluDReSS)

Septic Shock | Critically Ill

Australia
Horizon Health Network
University of Manitoba; University of British Columbia; University of Michigan; Dalhousie University and other collaborators

Completed

Sonography in Hypotension and Cardiac Arrest in the Emergency Department. (SHoC-ED)

Shock | Hypotension | Point of Care Ultrasound

Canada, South Africa
St Vincent's Hospital, Sydney

Completed

Blood Management During ECMO for Cardiac Support (OBLEX)

Hemorrhage | Embolism | Venous Thrombosis | Arrhythmias, Cardiac | Shock, Cardiogenic | Blood Transfusion | Death, Sudden, Cardiac | Disseminated Intravascular Coagulation | HEART ARREST

Australia
South West Sydney Local Health District

Completed

Renin as a Biomarker of Haemodynamic Normalisation

Shock

Australia
Erasmus Medical Center

Completed

PULsecath mechanicaL Support Evaluation (PULSE)

Coronary Artery Disease | Heart Failure | Cardiogenic Shock

France, Netherlands, United Kingdom
The George Institute
National Health and Medical Research Council, Australia; Australian and New...

Completed

ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (ADRENAL)

Septic Shock

Australia, Denmark, Saudi Arabia, New Zealand, United Kingdom
Bayer

Completed

Study of FVIIa Variant BAY86-6150 (B0189) in Subjects With Moderate or Severe Hemophilia Types A or B With or Without Inhibitors (MATCHBOX)

Hemophilia A | Hemophilia B

South Africa, Poland, United Kingdom
Baxalta now part of Shire

Terminated

Study of Modified Recombinant Factor VIII (OBI-1) in Subjects With Congenital Hemophilia A

Hemophilia A

United States, South Africa, United Kingdom
TherOx

Withdrawn

Incorporating Supersaturated Oxygen in Shock (ISO-SHOCK)

Cardiogenic Shock | STEMI

United States
Novo Nordisk A/S

Completed

Epidemiological Study on Haemophilia Care and Orthopaedic Status in Developing Countries (HAEMOcare)

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors | Haemophilia A | Haemophilia B

India, Morocco, South Africa, Oman
Australian and New Zealand Intensive Care Research...

Recruiting

Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis (ARISE FLUIDS)

Shock, Septic

Australia
Sheffield Hallam University
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

The Effects of Posture on Cerebral Blood Flow Velocity During the Acute Phase of Stroke

Ischemic Stroke | Cerebrovascular Accident | Acute Stroke | Haemorrhagic Stroke

United Kingdom
University of Birmingham
King's College London; University College, London; University of Nairobi; World... and other collaborators

Completed

A Clinical Trial to Study the Effectiveness of a Care Bundle to Prevent Bleeding After a Woman Has Given Birth (E-MOTIVE)

Post-Partum Haemorrhage

South Africa, Kenya, Tanzania, Nigeria
South Valley University

Recruiting

Monitoring Effect Of Shock Wave On Microcirculation Changes In Type2 Diabetes Mellitus

Shock Wave and Nitric Oxide

Egypt
AstraZeneca

Completed

A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock

Septic Shock | Severe Sepsis

Czech Republic, France, Spain, Finland, Canada, Australia, Belgium
Spectral Diagnostics (US) Inc.

Recruiting

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study (TIGRIS)

Septic Shock | Endotoxemia

United States
The George Institute for Global Health, Australia

Completed

Days Alive and Out of Hospital for Patients With Sepsis

Sepsis | Septic Shock

Australia
Vega Therapeutics, Inc

Recruiting

Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease

Von Willebrand Diseases

United States, Austria, South Africa, United Kingdom
BioMarin Pharmaceutical

Active, not recruiting

Gene Therapy Study in Severe Hemophilia A Patients With Antibodies Against AAV5 (GENEr8-AAV5+)

Hemophilia A | Gene Therapy | Blood Disorder | Clotting Disorders

Taiwan, Korea, Republic of, United Kingdom, South Africa
Abiomed Inc.

Active, not recruiting

SURPASS Impella 5.5 Study

Acute Decompensated Heart Failure | Cardiogenic Shock

United States
Catalyst Biosciences

Completed

Study of Coagulation Factor VIIa Variant Marzeptacog Alfa (Activated) in Adult Subjects With Hemophilia A and B

Hemophilia A With Inhibitor | Hemophilia B With Inhibitor

Armenia, Georgia, South Africa, Poland, Russian Federation
Eli Lilly and Company

Completed

Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients With Septic Shock

Sepsis

Italy, United Kingdom, United States, Germany, Spain, Belgium, France, Australia, Czech Republic, Netherlands, Canada, Mexico, New Zealand, Finland, Portugal, Brazil, India, Switzerland
John Hunter Children's Hospital
Thrasher Research Fund; Aerocrine AB; University of Newcastle, Australia; Hunter... and other collaborators

Completed

PEAnut Anaphylaxis Predictors (PEAAP)

Peanut Hypersensitivity | Anaphylaxis

Australia
Millennium Pharmaceuticals, Inc.
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Completed

An Open-Label Study to Assess the Effect of CYP3A4 Induction on the Pharmacokinetics of VELCADE (Bortezomib)

Multiple Myeloma | Non-Hodgkin's Lymphoma

Israel, Italy, Poland, South Africa, United Kingdom
La Jolla Pharmaceutical Company

Completed

A Phase 3 Study of LJPC-501 in Patients With Catecholamine-Resistant Hypotension (ATHOS-3)

Sepsis | Catecholamine-resistant Hypotension (CRH) | Distributive Shock | High Output Shock

United States, Canada, Belgium, Australia, United Kingdom, Finland, New Zealand, France, Switzerland, Germany
Pfizer

Completed

PF-06741086 Multiple Dose Study in Severe Hemophilia

Hemophilia A or B

United States, Chile, Croatia, Poland, South Africa, Switzerland
Laboratoire français de Fractionnement et de Biotechnologies
LFB USA, Inc.

Completed

LR769 in Congenital Hemophilia Patients With Inhibitors Undergoing Elective Surgery or Invasive Procedures (PerSept3)

Hemophilia

United States, Ukraine, Mexico, Russian Federation, South Africa, Spain
Novo Nordisk A/S

Completed

Efficacy and Safety of Activated Recombinant Human Factor VII in Severely Injured Trauma Patients

Trauma | Acquired Bleeding Disorder

Germany, Austria, Israel, France, Canada, Singapore, South Africa, Australia, United Kingdom
Laboratoire français de Fractionnement et de Biotechnologies
LFB USA, Inc.

Completed

A Phase III Study on the Safety, Pharmacokinetics and Efficacy of Coagulation Factor VIIa (PERSEPT2)

Hemophilia A With Inhibitors | Hemophilia B With Inhibitors

Bulgaria, Ukraine, Czechia, United States, Georgia, South Africa
Medexus Pharma, Inc.

Completed

Evaluation of a Recombinant Factor IX Product, APVO101, in Previously-Treated Pediatric Patients With Hemophilia B

Hemophilia B

Turkey, Brazil, Georgia, Moldova, Republic of, South Africa, Ukraine
Pfizer

Completed

PF-06741086 Long-term Treatment in Severe Hemophilia

Hemophilia A or B

Poland, Switzerland, South Africa, United States, Croatia, Brazil, Chile
CSL Behring

Terminated

Study of Recombinant Factor VIIa Fusion Protein (rVIIa-FP, CSL689) for On-demand Treatment of Bleeding Episodes in Patients With Hemophilia A or B With Inhibitors

Hemophilia A With Inhibitors | Hemophilia B With Inhibitors

Georgia, Italy, Malaysia, Russian Federation, South Africa, Spain, Thailand, Ukraine, United Kingdom
Senesco Technologies, Inc.

Unknown

Safety and Tolerability Study of SNS01-T in Relapsed or Refractory B Cell Malignancies (Multiple Myeloma, B Cell Lymphoma, or Plasma Cell Leukemia (PCL)

Multiple Myeloma | Plasma Cell Leukemia | Multiple Myeloma in Relapse | Mantle Cell Lymphoma in Relapse | Diffuse Large B Cell Lymphoma in Relapse | Other B Cell Lymphoma in Relapse

United States, South Africa
Prisma Health-Upstate

Completed

Therapeutic Plasma Exchange Alone or in Combination With Ruxolitinib in COVID-19 Associated CRS

COVID19 | Cytokine Release Syndrome

United States
Henry Ford Health System
Chiesi Farmaceutici S.p.A.; Abiomed Inc.

Completed

National Cardiogenic Shock Initiative (NCSI)

Acute Myocardial Infarction | Cardiogenic Shock | NSTEMI - Non-ST Segment Elevation MI | Heart Attack | STEMI - ST Elevation Myocardial Infarction

United States
Arginox Pharmaceuticals

Terminated

A Study of the Safety and Efficacy of Nitric Oxide Reduction in Patients With Cardiogenic Shock After a Heart Attack

Shock, Cardiogenic

United States, Canada
BioMarin Pharmaceutical

Recruiting

Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitors (GENEr8-INH)

Hemophilia A With Inhibitor | Hemophilia A With Anti Factor VIII

United States, United Kingdom, Taiwan, Israel, Korea, Republic of, South Africa, Brazil, Italy, Germany
Christian Medical College, Vellore, India

Unknown

Musculoskeletal Function in Hemophilia

Hemophilia

India, Argentina, Brazil, Egypt, Iran, Islamic Republic of, Singapore, South Africa, Thailand, Venezuela
Spirox, Inc.
New Arch Consulting

Completed

Latera RCT - Latera vs. Sham Control for Lateral Nasal Valve Collapse

Nasal Breathing | Nasal Valve Collapse

United States
Hellenic Society of Hematology
GlaxoSmithKline

Active, not recruiting

Blmf, Lenalidomide and Dexamethasone in Transplant-ineligible Patients With Newly Diagnosed Multiple Myeloma (BelaRd)

Multiple Myeloma

Greece
Hellenic Society of Hematology
Takeda; Janssen Pharmaceutica NV

Unknown

Safety and Efficacy of Daratumumab in Combination With Ixazomib and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma (DARIA)

Multiple Myeloma

Greece

Clinical Trials on Haemorrhagic Shock in South Africa

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