Clinical Trials on Health Volunteers, Huntington Disease

Total 74984 results

Prilenia

Completed

A Study to Evaluate Sigma-1 and Dopamine-2 Receptor Occupancy by Pridopidine in the Human Brain of Healthy Volunteers and in Patients With Huntington's Disease

Health Volunteers, Huntington Disease

Germany
Hoffmann-La Roche

Completed

A Study to Investigate the Pharmacokinetics and Pharmacodynamics of RO7234292 (RG6042) in CSF and Plasma, and Safety and Tolerability Following Intrathecal Administration in Patients With Huntington's Disease

Huntingtons Disease

United Kingdom, Netherlands
Sanguine Biosciences
Hoffmann-La Roche

Recruiting

Prospective Single-Timepoint Huntington's Disease Biospecimen Collection Study (SAN-09611)

Huntington Disease | Huntington's Dementia | Huntington Disease, Late Onset | Huntington; Dementia (Etiology)

United States
Hoffmann-La Roche

Completed

A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Participants With Manifest Huntington's Disease

Huntingtons Disease

United States, United Kingdom, Australia, Canada, Japan, Poland, Netherlands, Germany, Russian Federation, France, Spain, Argentina, New Zealand, Austria, Denmark, Italy, Switzerland, Chile
University of Iowa
The University of Texas Health Science Center, Houston; Children's Hospital... and other collaborators

Recruiting

Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease

Juvenile Huntington Disease | Juvenile-Onset Huntington Disease

United States
SOM Innovation Biotech SA

Active, not recruiting

Efficacy and Safety on SOM3355 in Huntington's Disease Chorea

Huntington Chorea

Spain, Germany, Italy, United Kingdom, France, Poland, Switzerland
Assistance Publique - Hôpitaux de Paris
CEA

Completed

Dynamic Neuroimaging Biomarkers in Huntington's Disease (HDeNERGY)

Brain Neuroimaging Biomarkers in Huntington Disease

France
European Huntington's Disease Network

Completed

REGISTRY-JHD - an Observational Study of the European Huntington's Disease Network (EHDN) (JHD)

Huntington Disease, Juvenile

Germany, United Kingdom
Neurocrine Biosciences

Enrolling by invitation

Long-term Study to Evaluate Safety and Tolerability of Valbenazine in Participants With Chorea Associated With Huntington Disease in Canada

Chorea, Huntington

Canada
Neurocrine Biosciences
Huntington Study Group

Active, not recruiting

Open-Label Rollover Study for Continuing Valbenazine Administration for the Treatment of Chorea Associated With Huntington Disease

Chorea, Huntington

United States, Canada
Neurocrine Biosciences
Huntington Study Group

Completed

Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Chorea Associated With Huntington Disease (KINECT-HD)

Chorea, Huntington

United States, Canada
Syndax Pharmaceuticals

Completed

Study to Determine the Effect of the Timing of a Meal on the Pharmacokinetics of Entinostat

Healthy Volunteers | Volunteers | Normal Volunteers | Human Volunteers

United States
Syndax Pharmaceuticals

Completed

A Study to Examine the Effect of Omeprazole, Famotidine, and an Acidic Beverage on the Pharmacokinetics of Entinostat in Healthy Adult Subjects

Healthy Volunteers | Volunteers | Normal Volunteers | Human Volunteers

United States
Novartis Pharmaceuticals

Completed

A Dose Range Finding Study With Open-Label Extension to Evaluate the Safety of Oral LMI070/Branaplam in Early Manifest Huntington's Disease (VIBRANT-HD)

Early Manifest Huntington Disease

Canada, Germany, France, Spain, Hungary
University Hospital, Angers

Completed

Assessment of the Psychological, Cognitive and Social Resources of Applicants for Huntington's Disease and Presymptomatic Genetic Testing (PREHUNT)

Presymptomatic Huntington Disease

France
THIM - die internationale Hochschule für Physiotherapie
Vrije Universiteit Brussel

Completed

Effectivity of Slackline-Training in Physiotherapy

Healthy Volunteers | Persons With no Known Significant Health Problems

Switzerland
AstraZeneca

Completed

A Single Dose Study to Assess the Safety, Effects, and Blood and Urine Drug Levels of AZD3293 in Healthy Subjects

Healthy Elderly Volunteers | Healthy Young Volunteers

United States
Massachusetts General Hospital

Completed

Creatine Safety & Tolerability in Huntington's Disease (CREST-X)

Huntington's Disease (HD)

United States
SOM Innovation Biotech SA

Completed

Efficacy and Safety of SOM3355 in Huntington's Disease Chorea

Huntington's Chorea

Spain
Assistance Publique - Hôpitaux de Paris

Completed

Caregiver Burden in Huntington's Disease (PHRI-HD)

Caregiver of Huntington's Disease Patient

France
University Hospital, Clermont-Ferrand
Unite de Nutrition Humaine UMR 1019- INRAE; Unite MetaGenoPolis INRAE; France...

Completed

Sampling of Human Microbiota in Order to Test, on a Mouse Model, Individualized Intervention Strategies During Aging (FRAGIBIOTE)

Healthy Volunteers | Frail Volunteers

France
Auspex Pharmaceuticals, Inc.

Completed

Alternatives for Reducing Chorea in Huntington Disease (ARC-HD)

Chorea Associated With Huntington Disease

United States, Australia, Canada
AstraZeneca
Parexel

Completed

A Study to Assess the Relative Bioavailability and Safety of Different Formulations of AZD4831 in Fasted State in Healthy Volunteers.

Healthy Volunteers

United States
Regeneron Pharmaceuticals

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9035 in Healthy Adult Volunteers and Mildly Hypertensive Participants

Healthy Volunteers

Germany, Belgium
Novo Nordisk A/S

Completed

A Study in Healthy Participants Investigating Biomarkers After Exposure to Heparin When Heparin is Administered in the Fasted State or After a High-fat Meal. Heparin, a Registered Drug, is an Anticoagulant (Blood Thinner) That Prevents the Formation of Blood Clots.

Healthy Volunteers

Netherlands
AstraZeneca
Parexel

Completed

Multiple-ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 in Healthy Male Subjects

Healthy Volunteers

United Kingdom
Ionis Pharmaceuticals, Inc.

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION904

Healthy Volunteers

Canada
University of Aarhus
Aarhus University Hospital

Completed

Effects of Experimental Hyperketonemia on Myocardial Metabolism

Healthy Volunteers

Denmark
Pfizer

Completed

Bioequivalence Study Of Verapamil

Healthy Volunteers

United States
Centre Hospitalier Universitaire de Saint Etienne

Completed

Evaluation of Physical Capacities Within the Company and Effect of a Personalized Versus Traditional Training Program on the Quality of Life of Sedentary Employees (MOVING_LAB)

Healthy Volunteers | Health

France
Portola Pharmaceuticals

Completed

An Open-Label, Single-Dose, Mass-Balance Study to Assess the Disposition of 14C-Labeled PRT054021 in Healthy Male Subjects

Health Volunteers
Concert Pharmaceuticals

Completed

Study of the Effect of Food on the Bioavailability of the To-Be-Marketed Formulation of CTP-543 in Healthy Volunteers

Health Volunteers

United States
Concert Pharmaceuticals

Completed

Study to Evaluate Multiple Doses of Fluconazole, a CYP3A4 and CYP2C9 Inhibitor, on the Pharmacokinetics of CTP-543 in Healthy Subjects

Health Volunteers

United States
Concert Pharmaceuticals

Completed

Study To Evaluate The Effect Of Multiple Doses of CTP-543 On The Pharmacokinetics Of Single Doses of Midazolam In Healthy Subjects

Health Volunteers

United States
Newcastle University

Completed

Assessing the Glycaemic Index of Two Different Cultivars of Date Fruit

GI Glycaemic Index Healthy Volunteers | GL Glycaemic Load Healthy Volunteers

United Kingdom
Centre Hospitalier Universitaire de Saint Etienne

Terminated

Effect of Individualized Training Versus Non-individualized Training to Improve Quality of Life of Sedentary Employees (SELFIT)

Quality of Life | Exercise | Healthy Volunteers | Health

France
AstraZeneca
Parexel

Completed

A Single Oral Dose Study to Evaluate Four Different Formulations of AZD9977 and the Effect of Food in Healthy Male Subjects

Healthy Volunteers

United Kingdom
ForSight Vision5, Inc.

Completed

Bimatoprost Ocular Insert Pharmacokinetic Study

Healthy Volunteers

United States
National Institute of Neurological Disorders and...
National Institutes of Health Clinical Center (CC); United States Department... and other collaborators

Completed

Long-Term Improvement in Motor Learning by Transcranial Direct Current Stimulation

Healthy Volunteers

United States
Bristol-Myers Squibb

Completed

An Investigational Study to Assess the Effect of BMS-986177 on Aspirin in Healthy Participants

Healthy Volunteers

United States
University of Nottingham

Unknown

The Effect of Phenylephrine and Ephedrine on Microvascular Blood Flow

Healthy Volunteers

United Kingdom
Galera Therapeutics, Inc.
Celerion

Completed

A Study to Investigate the Absorption, Metabolism, Excretion, and Mass Balance of GC4419 in Healthy Adult Subjects

Healthy | Healthy Volunteers

United States
Galera Therapeutics, Inc.
Syneos Health

Completed

A Study Designed to Compare the Safety and Pharmacokinetics of Intravenously Administered Superoxide Dismutase Mimetic GC4711 and GC4419 in Healthy Volunteers

Healthy | Healthy Volunteers

Australia
Galera Therapeutics, Inc.
Syneos Health

Completed

A Phase 1, Randomized, Placebo-and Positive-Controlled Crossover Study to Determine the Effect of Single-Dose GC4419 on QTc Interval in Healthy Volunteers

Healthy | Healthy Volunteers

Australia
University Hospital, Caen

Completed

Dynamics of Stroke Volume and Cardiac Output During Parabolic Flight, and Its Relationship to Intravascular Volume (DYMCO)

Healthy Volunteers

France
PMV Pharmaceuticals, Inc

Recruiting

A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of PC14586 in Healthy Participants

Healthy Volunteers

United States
Taizhou Mabtech Pharmaceutical Co.,Ltd

Recruiting

Study of CMAB807 Post-change in Manufacturing Site and Prolia in Healthy Volunteers

Healthy Volunteers

China
Yuhan Corporation

Not yet recruiting

Bioequivalence Study Between YHP2205 and YHR2401 in Healthy Volunteers

Healthy Volunteers
Handok Inc.

Not yet recruiting

Pharmacokinetics of HD-P023 and Co-administration of Teneligliptin and Empagliflozin High in Healthy Volunteers

Healthy Volunteers
Hangzhou Sciwind Biosciences Co., Ltd.

Recruiting

A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin

Healthy Volunteers

China

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