Clinical Trials on Healthy and Acutely Ill Children & Adults in South Africa

Total 848 results

Immtech Pharmaceuticals, Inc

Terminated

Randomized, Double-Blind Phase 1 Safety and Tolerability Study of Pafuramidine Maleate (DB289) in Healthy Subjects

Healthy

South Africa
Boehringer Ingelheim

Completed

To Determine Blood Concentrations of Ibuprofen and Caffeine in a Tablet Against Ibuprofen Alone From Another Tablet

Healthy

South Africa
Medical University of South Carolina

Completed

Low Intensity Focused Ultrasound Pulses (LIFUP) to Modulate Pain

Healthy Adults

United States
Novo Nordisk A/S

Completed

Bioequivalence of Two Formulations of Biphasic Insulin Aspart 70 in Healthy Male Subjects

Healthy | Diabetes

South Africa
Novo Nordisk A/S

Completed

Comparison of Two Insulin Aspart Formulations in Healthy Volunteers

Healthy | Diabetes

South Africa
Novo Nordisk A/S

Completed

Bioequivalence of Two Formulations of Biphasic Insulin Aspart 50 in Healthy Male Subjects

Healthy | Diabetes

South Africa
University of Cape Town
University of Oxford; Orion Corporation, Orion Pharma

Completed

Single-dose Novel Selective alpha2c Antagonist Pharmaco-MRI Study in Healthy Volunteers (SNAP_MRI)

Healthy Volunteer

South Africa
Alvotech Swiss AG

Active, not recruiting

AVT03 With Xgeva in Healthy Male Subjects

This is a Phase Study Conducted in Healthy Volunteers

South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); Medical Research Council, South Africa

Active, not recruiting

Siyakhana Peer: Evaluating a Peer Recovery Coach Model to Reduce Substance Use Stigma in South African HIV Care

Substance-Related Disorders | HIV | Substance Use | Substance Use Disorders | Treatment Adherence | Treatment Adherence and Compliance | Stigmatization | Delivery of Health Care | Stigma, Social | Attitude of Health Personnel | Community Health Workers | Health Personnel | Health Personnel Attitude | Health Care Seeking... and other conditions

South Africa
Statens Serum Institut
Bill and Melinda Gates Foundation; Aurum Institute; Leiden University Medical... and other collaborators

Recruiting

First-in-Human Trial of the Novel Tuberculosis Vaccine Candidate, H107e/CAF®10b (nTB-01)

Healthy

South Africa
University of Houston
Michigan State University; Bar-Ilan University, Israel; University of the Free...

Completed

MISC-CBO in Children Affected by HIV/AIDS

HIV Affected Children (Single and/or Double Orphans)

South Africa
Harriet Shezi Children's Clinic

Unknown

Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra (RBT)

Children With Confirmed HIV Infection | Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose | Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment

South Africa
Microbiome Health Research Institute
University of Cape Town

Terminated

Transfer of Healthy Gut Flora for Restoration of Intestinal Microbiota Via Enema for Patients in the Rehabilitative Phase of Malnutrition (THRIVE)

Moderate Acute Malnutrition | Severe Acute Malnutrition

South Africa
University of Maryland, College Park
National Institute of Mental Health (NIMH); Medical Research Council, South...

Completed

Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa (Siyakhana)

Substance-Related Disorders | Depression | Tuberculosis | Hiv | Mental Health Disorder | Mental Disorder | Health Care Utilization | Treatment Adherence and Compliance | Social Stigma | Attitude of Health Personnel | Community Health Workers | Health Care Delivery

South Africa
University of Cape Town

Completed

Health System Dynamic & Resource Requirement in a South African COVID-19 Field Hospital

COVID-19 Pandemic | Low-Income Population | Global Health | Health Resources | Field Hospitals | Health Systems

South Africa
Aarhus University Hospital
University of Aarhus

Completed

Acute Kidney Injury After Cardiac Surgery: Novel Ultrasound Techniques for Prediction of Acute Kidney Injury

Acute Kidney Injury | Cardiac Surgery | Acute Renal Failure

Denmark, South Africa
North-West University, South Africa
GlaxoSmithKline; Novartis; Pfizer; Boehringer Ingelheim; Medical Research Council; Medical... and other collaborators

Active, not recruiting

The African-PREDICT Study (PREDICT)

Cardiovascular Diseases | Hypertension | Health Risk Behaviors | Arterial Stiffness | Young | Renin Hypertension

South Africa
IGM Biosciences, Inc.

Terminated

Evaluation of IGM-6268 in Healthy Adults and Patients With Mild to Moderate COVID-19

COVID-19 | Healthy Volunteers

South Africa
Innovations for Poverty Action
Bill and Melinda Gates Foundation; U.S. National Science Foundation; Broadening... and other collaborators

Completed

Evaluation of Impacts of Access to Credit and Loan Size for Microcredit Clients in South Africa

Depression | Stress | Mental Health

South Africa
Nova Laboratories Limited

Completed

Bioequivalence of An Oral Mercaptopurine Suspension 100 Mg / 5 Ml Versus Tablet in Healthy Male Subjects Under Fasting Conditions

Acute Lymphoblastic Leukemia

South Africa
PENTA Foundation
King's College Hospital NHS Trust; Karolinska Institutet; Hospital General Universitario... and other collaborators

Recruiting

European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) SARS-CoV-2 Antibody Study Protocol. Covid-19 (SARS-Cov2)

Sars-Cov2 Antibodies in Children and Adolescents Living With HIV

Spain, United Kingdom, South Africa, Belgium, Greece, Ukraine
GlaxoSmithKline

Completed

Study to Identify and Characterize Bacteria Causing Acute Otitis Media in South African Children

Acute Otitis Media

South Africa
Eastern Virginia Medical School
Gilead Sciences; United States Agency for International Development (USAID); FHI... and other collaborators

Active, not recruiting

Project Engage: Oral PrEP Acceptability

Adherence, Medication | Acceptability of Health Care

South Africa, Zimbabwe
University of Limpopo

Unknown

Effect of Vitamin D Supplementation in Young South African Children Hospitalized With Acute Lower Respiratory Infection

Pneumonia | Bronchiolitis | Acute Lower Respiratory Tract Infection

South Africa
University of Cape Town
University of KwaZulu

Unknown

African Covid-19 Critical Care Outcomes Study

Severe Acute Respiratory Syndrome Coronavirus 2

South Africa
University of Witwatersrand, South Africa
SynaVir

Completed

Study of Oral Administration of Ribavirin and Nitazoxamide Versus Placebo in COVID-19 (DuACT)

Covid19 | SARS-CoV Infection

South Africa
Boston University
National Institute of Mental Health (NIMH); Africa Health Research Institute

Completed

Life Plans Intervention Study

HIV/AIDS | Health Knowledge, Attitudes, Practice | Chronic HIV Infection

South Africa
University of Witwatersrand, South Africa

Completed

COVID-19 Prophylaxis South Africa (COVER HCW) (COVER)

Covid19 | SARS-CoV Infection

South Africa
University of California, San Francisco
Johns Hopkins University; National Institute of Allergy and Infectious Diseases... and other collaborators

Recruiting

Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)

Tuberculosis | Diagnostics | Global Health

Mozambique, South Africa, Uganda
University of Witwatersrand, South Africa

Active, not recruiting

A Cross-sectional, Observational Study to Characterise Long COVID-19 in an Urban Sample of South African Adults (ChaLOC)

Long COVID

South Africa
The Aurum Institute NPC
Ludwig-Maximilians - University of Munich; Chris Hani Baragwanath Academic...

Completed

Tuberculosis as a Risk Factor for a Worse Outcome Post-Sars-CoV-2 Infection (Co-TB)

COVID-19 | Tuberculosis | Post-acute COVID-19 Syndrome

South Africa
University of Illinois at Chicago
National Institute of Dental and Craniofacial Research (NIDCR)

Completed

Coordinated Oral Health Promotion (CO-OP) Chicago

Dental Caries in Children | Health Behavior | Healthcare Disparities

United States
University of Cape Town
Momentum Research, Inc.

Unknown

Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure (B-AHEF)

Acute Heart Failure | Left Ventricular Dysfunction

South Africa
Desmond Tutu HIV Foundation
Karolinska Institutet; University of North Carolina, Chapel Hill; ViiV Healthcare and other collaborators

Completed

Bidirectional, Upbeat Communication and Differentiated, Distanced Care for Young People (BUDDY)

HIV Infections | Covid19 | Health Care Utilization | Gender-based Violence

South Africa
University of Western Sydney

Active, not recruiting

Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia

Mild Cognitive Impairment | Mild Dementia | Healthy Older Adults

Australia
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride

Acute Intermittent Porphyria | Anti-Psychotic | Management of Manifestations of Psychotic Disorders | Treatment of Schizophrenia | Control Nausea and Vomiting | Relief of Restlessness and Apprehension Before Surgery | Adjunct in the Treatment of Tetanus | Control Manifestations of the Manic Type... and other conditions

South Africa
South African National Blood Service

Unknown

Therapeutic Use of Convalescent Plasma in the Treatment of Patients With Moderate to Severe COVID-19

COVID-19 | SARS-CoV-2 Infection | Severe Acute Respiratory Syndrome Coronavirus 2

South Africa
University of Cape Town

Completed

the PrEsentation, Rationale and Impact of reperFUSION for Acute Coronary Syndromes in Cape Town and the Garden Route Health District - the PERFUSION Registry (PERFUSION)

Acute Coronary Syndrome | Unstable Angina | ST Elevated Myocardial Infarction | Non ST Elevation Myocardial Infarction

South Africa
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia

Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic... and other conditions

United States, Israel, India
Sanofi Pasteur, a Sanofi Company

Recruiting

Study of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Given With Routine Pediatric Vaccines in Healthy Infants and Toddlers in India and the Republic of South Africa (MEQ00064)

Healthy Volunteers | Meningococcal Immunisation

South Africa, India
International Partnership for Microbicides, Inc.

Completed

An Expanded Safety Study of Dapivirine Gel 4789 in Africa

HIV Infections | Acquired Immunodeficiency Syndrome | Healthy

South Africa
National Cancer Institute (NCI)

Completed

Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia in Remission | Myelodysplastic Syndrome With Excess Blasts | Adult Acute Monocytic Leukemia | Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 and other conditions

United States, Israel, Peru
National Cancer Institute (NCI)

Active, not recruiting

Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

Acute Myeloid Leukemia | Secondary Acute Myeloid Leukemia | Adult Acute Monoblastic Leukemia | Adult Acute Monocytic Leukemia | Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 | Adult Acute Myeloid Leukemia With Maturation | Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22)... and other conditions

United States
National Cancer Institute (NCI)

Active, not recruiting

Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | Recurrent Adult Acute Lymphoblastic Leukemia | Adult B Acute Lymphoblastic Leukemia | Adult T Acute Lymphoblastic Leukemia | Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | Adult L1 Acute Lymphoblastic Leukemia | Adult L2 Acute Lymphoblastic...

United States
Sanofi Pasteur, a Sanofi Company

Completed

Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Healthy Adults, Adolescents, Children, and Toddlers in India and Healthy Adolescents and Children in the Republic of South Africa (MET55)

Healthy Volunteers (Meningococcal Infection)

India, South Africa
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases

Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Tumor | Tumors Metastatic to Brain | Adult Anaplastic Oligoastrocytoma

United States
Leiden University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Enrolling by invitation

"Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve Early Diagnosis of Celiac Disease" (GLUTEN-GEN)

Celiac Disease in Children

Netherlands
Janssen Vaccines & Prevention B.V.
National Institute of Allergy and Infectious Diseases (NIAID); Beth Israel... and other collaborators

Completed

Safety, Tolerability, and Immunogenicity Study of Homologous Ad26 Mosaic Vector Vaccine Regimens or Heterologous Ad26 Mosaic and MVA Mosaic Vector Vaccine Regimens With Glycoprotein 140 (gp140) for Human Immunodeficiency Virus (HIV) Prevention

Healthy

United States, South Africa, Thailand, Uganda, Rwanda
Aghia Sophia Children's Hospital of Athens
BioGaia AB

Completed

Efficacy of Dietary Supplementation With Lactobacilllus Reuteri DSM 17938 on Functional Abdominal Pain (FAP) in Children

Functional Abdominal Pain (FAP) in Children

Greece, Poland, Slovenia
Instituto de Atención Pediátrica

Completed

Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction (Microbiology)

Otitis Media in Children

Costa Rica

Clinical Trials on Healthy and Acutely Ill Children & Adults in South Africa

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