Clinical Trials on Heavy Chain Deposition Disease

Total 410 results

Memorial Sloan Kettering Cancer Center
Millennium Pharmaceuticals, Inc.

Completed

Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis

Amyloidosis | Light Chain Deposition Disease (LCDD or MIDD) | Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD) | Monoclonal Immunoglobulin Deposition Disease (MIDD)

United States
Yonsei University

Completed

Evaluation of Efficacy and Safety of General Anesthesia Using Dexmedetomidine With Sevoflurane in Patients Undergoing Arthroscopic Shoulder Surgery: Preliminary Study

Arthroscopic Shoulder Surgery in the Beach-chair Position

Korea, Republic of
Mayo Clinic
National Cancer Institute (NCI)

Withdrawn

Ibrutinib With or Without Bortezomib and Dexamethasone in Treating Patients With Relapsed or Refractory Immunoglobulin Light Chain Amyloidosis

Amyloidosis | Immunoglobulin Light Chain Deposition
National Cancer Institute (NCI)

Completed

Melphalan and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Systemic Light-Chain Amyloidosis

Primary Systemic Amyloidosis | Light Chain Deposition Disease

United States
Larissa University Hospital

Completed

Effect of Interscalene Block on Heart Rate Variability (HRV)

Shoulder Surgery | Autonomic Nervous System | Interscalene Block | HRV | Beach Chair Position

Greece
UNC Lineberger Comprehensive Cancer Center

Recruiting

Registry for Adults With Plasma Cell Disorders (PCD's)

Multiple Myeloma | Amyloidosis | Smoldering Multiple Myeloma | Plasma Cell Leukemia | Cryoglobulinemia | Light Chain Deposition Disease | Castleman's Disease | Heavy Chain Deposition Disease | Polyneuropathy Organomegaly Endocrinopathy Monoclonal Gammopathy and Skin Changes

United States
Stanford University

Active, not recruiting

DTPA (Diethylenetriaminepenta-acetate) Chelation for Symptoms After Gadolinium-assisted MRI Exposure

Gadolinium Deposition Disease

United States
Boston Medical Center

Terminated

HD Melphalan and SCT in Patients With IGDD or LCDD

Multiple Myeloma

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Completed

Bortezomib, Melphalan, and Dexamethasone in Treating Patients With Primary Amyloidosis or Light Chain Deposition Disease

Primary Systemic Amyloidosis | Light Chain Deposition Disease

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Terminated

First-line Pomalidomide, Bortezomib, and Dexamethasone For AL Amyloidosis or LCDD

Primary Systemic Amyloidosis | Light Chain Deposition Disease

United States, Canada
Peking University First Hospital

Recruiting

A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH

Multiple Myeloma | Amyloidosis | Smoldering Multiple Myeloma | Plasma Cell Leukemia | Cryoglobulinemia | Light Chain Deposition Disease | Castleman's Disease | Heavy Chain Deposition Disease | Polyneuropathy Organomegaly Endocrinopathy Monoclonal Gammopathy and Skin Changes | Monoclonal Gammopathy of Undetermined... and other conditions

China
University of Nottingham

Completed

Perspectives on CPPD Outcome Domains

CPPD - Calcium Pyrophosphate Deposition Disease

United Kingdom
Stanford University

Not yet recruiting

Long-term Result of DTPA (Diethylenetriamine Pentaacetate) Chelation for Gadolinium Deposition Disease

Gadolinium Deposition Disease | Ca-DTPA

United States
Loyola University

Completed

Effect of Compression Stockings on Cerebral Desaturation Events in Obese Patients Undergoing Shoulder Arthroscopy in the Beach Chair

Obese | Beach Chair Position | Shoulder Arthoscopy | Cerebral Desaturation Events

United States
University of Arkansas
Siemens Molecular Imaging

Terminated

Detecting Early Myocardial Infiltration w/Amyloid & Light Chain Deposition Disease in Multiple Myeloma Subjects

Multiple Myeloma

United States
Karabuk University

Completed

Investigation of Wet Cupping Therapy on Heavy Metal Levels of Steel Industry Workers

Heavy Metal Toxicity

Turkey
National Cancer Institute (NCI)

Active, not recruiting

Lenalidomide and Vaccine Therapy in Treating Patients With Early-Stage Asymptomatic Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma | Stage 0 Chronic Lymphocytic Leukemia | Stage I Chronic Lymphocytic Leukemia | Stage II Chronic Lymphocytic Leukemia | Ann Arbor Stage I Small Lymphocytic Lymphoma | Ann Arbor Stage II Small Lymphocytic Lymphoma | Chronic Lymphocytic Leukemia... and other conditions

United States
National Cancer Institute (NCI)

Completed

Viral Therapy in Treating Patients With Relapsed or Refractory Multiple Myeloma

Refractory Plasma Cell Myeloma | Light Chain Deposition Disease

United States
Margarida Magalhaes-Silverman
National Cancer Institute (NCI)

Completed

Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma

Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Primary Systemic Amyloidosis | Light Chain Deposition Disease | Extramedullary Plasmacytoma | Isolated Plasmacytoma of Bone

United States
Millennium Pharmaceuticals, Inc.

Completed

Study of Oral Ixazomib in Adult Participants With Relapsed or Refractory Light Chain Amyloidosis

Light-Chain Amyloidosis

United States, Canada, France, Germany, Italy
Criterium, Inc.
Amgen

Completed

A Safety Study of Carfilzomib in Patients With Previously-Treated Systemic Light Chain Amyloidosis

Amyloidosis | Systemic Light Chain Amyloidosis

United States
Larissa University Hospital

Unknown

Effect of the Side of Interscalene Block on Bradycardia and Hypotension in Beach Chair Position

Bradycardia | Hypotension | Shoulder Surgery | Autonomic Nervous System | Interscalene Block | Beach Chair Position

Greece
Mt. Sinai Medical Center, Miami

Withdrawn

Prolonged Gadolinium Retention After MRI Imaging

Heavy Metal Toxicity

United States
Oregon Health and Science University

Completed

High Protein Diet in Patients With Long-chain Fatty Acid Oxidation Disorders

Trifunctional Protein Deficiency | Carnitine Palmitoyltransferase 2 Deficiency | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency
National Cancer Institute (NCI)

Active, not recruiting

Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma

Smoldering Multiple Myeloma | Light Chain Deposition Disease

United States, Puerto Rico, Ireland
Peking University People's Hospital

Recruiting

Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone Therapy for Patients With MIDD

Monoclonal Gammopathy of Renal Significance

China
Peking Union Medical College Hospital

Recruiting

Venetoclax and Dexamethasone for Newly Diagnosed Light-Chain Amyloidosis With Translocation (11;14)

Light Chain (AL) Amyloidosis | Venetoclax | CCND1 Translocation

China
Alfred Chung, MD
AbbVie; Janssen Pharmaceuticals

Recruiting

Venetoclax, Daratumumab, and Dexamethasone for Systemic Light-Chain Amyloidosis With Translocation (11;14) (ALTITUDE)

AL Amyloidosis | Light Chain (AL) Amyloidosis | Systemic Light Chain Disease

United States
Assiut University

Recruiting

Reconstructive Ear Surgery in Pediatrics

Ossicle Chain Disarticulation

Egypt
VA Office of Research and Development

Completed

Effect of Probenecid on Synovial Fluid ATP Levels in CPPD

Calcium Pyrophosphate Deposition Disease

United States
Oregon Health and Science University

Completed

Oral Ketones and Exercise Among Patients With Long-chain Fatty Acid Oxidation Disorders

Trifunctional Protein Deficiency | Very Long Chain Acyl Coa Dehydrogenase Deficiency | Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Carnitine Palmitoyltransferase Deficiency 2

United States
Tufts Medical Center
Sanofi

Withdrawn

Isatuximab and Bendamustine in Systemic Light Chain Amyloidosis

Amyloidosis | Light Chain (AL) Amyloidosis
Millennium Pharmaceuticals, Inc.

Terminated

Study of Dexamethasone Plus IXAZOMIB (MLN9708) or Physicians Choice of Treatment in Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis

Relapsed or Refractory Systemic Light Chain Amyloidosis

United States, Canada, Spain, Israel, France, Australia, Denmark, Germany, Korea, Republic of, Greece, Netherlands, Brazil, Czechia, Italy, United Kingdom
Rigshospitalet, Denmark
Groupe Hospitalier Pitie-Salpetriere

Completed

Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects (Bezafibrate)

Carnitine Palmitoyltransferase II Deficiency | Very Long Chain Acyl Coa Dehydrogenase Deficiency

Denmark
Oregon Health and Science University

Completed

Fatty Acid Oxidation Defects and Insulin Sensitivity

Normal Volunteers | Trifunctional Protein Deficiency | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Carnitine Palmitoyltransferase II Deficiency, Myopathic

United States
Nanjing University School of Medicine

Recruiting

Daratumumab for Patients With Light Chain Amyloidosis

Light Chain (AL) Amyloidosis

China
University of Roma La Sapienza

Unknown

Simultaneous Coronary Artery Evaluation and Lung Cancer CT Screening (SIMULTANEOUS)

HEAVY SMOKING
Guangdong Provincial People's Hospital

Recruiting

Comparison of BTD and BCD Based Regimens in the Treatment of AL Amyloidosis

Immunoglobulin Light-Chain Amyloidosis

China
Peking Union Medical College Hospital

Unknown

the Association Between Blood's and Urinary Heavy Metal Level in Pregnant Women and the Spontaneous Abortion (HMLandSA)

Heavy Metal Toxicity | Spontaneous Abortion

China
Mayo Clinic

Completed

MRS Probe Study of Alcohol

Heavy Dose Drinkers

United States
Oregon Health and Science University
University of Pittsburgh

Completed

Study of Triheptanoin for Treatment of Long-Chain Fatty Acid Oxidation Disorder (Triheptanoin)

Very Long-chain acylCoA Dehydrogenase (VLCAD) Deficiency | Carnitine Palmitoyltransferase 2 (CPT2) Deficiency | Mitochondrial Trifunctional Protein (TFP) Deficiency | Long-chain 3 hydroxyacylCoA Dehydrogenase (LCHAD) Deficiency

United States
University of Pittsburgh
Horizon Pharma Ireland, Ltd., Dublin Ireland

Completed

Use of Ravicti™ in Patients With MCAD Deficiency With the 985A>G (K304E) Mutation

Medium-chain Acyl-CoA Dehydrogenase (MCAD) Deficiency

United States
Ultragenyx Pharmaceutical Inc

Completed

A Study of UX007 (Triheptanoin) in Participants With Long-Chain Fatty Acid Oxidation Disorders (LC-FAOD)

Long-chain Fatty Acid Oxidation Disorders (LC-FAOD) | Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Deficiency | Trifunctional Protein (TFP) Deficiency | Carnitine Palmitoyltransferase (CPT II) Deficiency | Longchain 3-hydroxy-acyl-CoA Dehydrogenase (LCHAD) Deficiency

United States, United Kingdom
Ultragenyx Pharmaceutical Inc

Completed

Clinical Outcome of Triheptanoin Treatment in Patients With Long-chain Fatty Acid Oxidation Disorders (LC-FAOD) Treated Under Expanded Access Program

Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)

United States
Oslo University Hospital

Recruiting

Infectious Pseudochromdrosis Caused by Bacillus Cereus (Blue sweat)

Infectious Disease | Bacterial Overgrowth | Pigment Deposition

Norway
Regeneron Pharmaceuticals

Not yet recruiting

A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis) (LINKER-AL2)

Relapsed/Refractory Systemic Light Chain Amyloidosis
University of Pennsylvania

Terminated

Topiramate to Reduce Heavy Drinking in HIV-Positive Heavy Drinkers

Alcohol Dependence | HIV | Heavy Drinking

United States
Emory University
The Leukemia and Lymphoma Society

Recruiting

Rifaximin in Patients With Monoclonal Gammopathy

Waldenstrom Macroglobulinemia | Light Chain Deposition Disease | IgA Monoclonal Gammopathy | IgG Monoclonal Gammopathy | IgM Monoclonal Gammopathy | Monoclonal Gammopathy | Smoldering Waldenstrom Macroglobulinemia | Gammopathy, Monoclonal | Gammopathy Igg

United States
Southwest College of Naturopathic Medicine

Completed

Dimercaptosuccinic Acid (DMSA) Treatment of Children With Autism and Heavy Metal Toxicity

Autism

United States
Air Force Military Medical University, China

Not yet recruiting

Probiotic Supplementation Reduces Gastrointestinal Symptoms During the Therapy and Improves Therapeutic Response in AL Amyloidosis

Immunoglobulin Light-chain Amyloidosis

Clinical Trials on Heavy Chain Deposition Disease

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Germany

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations