- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04176003
Perspectives on CPPD Outcome Domains
OMERACT Core Domain Set Selection for Calcium Pyrophosphate Deposition (CPPD): Exploring Patient and Stakeholder Perspectives on Outcome Domains
The purpose of this study is to obtain patient and stakeholder perspectives on what outcome measures should be included in future trials on CPPD (Calcium PyroPhosphate Deposition), a common form of inflammatory arthritis. This will form part of a wider OMERACT (Outcome Measures in Rheumatology) study, involving multiple international sites, to determine a core domain set (an agreed set of outcome measures) for this disease.
In the UK, up to 10 patients with CPPD and their caregivers, healthcare professionals who care for patients with CPPD, and other stakeholders, which may include government organisations, non-government organisations, pharmaceutical representatives and health advocacy groups, will be invited to participate in a single, semi-structured interview.
Interviews will be face-to-face or telephone, last up to one hour and digitally audio-recorded. For patients and their caregivers, interviews will explore their lived experience of CPPD, its impact on their daily lives, and the perceived relevance of outcome measures used in previous studies. For healthcare professionals and other stakeholders, interviews will explore their experience dealing with patients with CPPD, how they perceive CPPD impacts patient lives, and the perceived relevance of the outcome measures used in previous studies.
Following analysis of the data, participants will be sent a short report with the researchers' findings, and asked to check the accuracy of these and provide brief written feedback.
Interviews will also take place with patients, caregivers, healthcare practitioners and stakeholders at the other international sites where ethics committee approval will be sought locally. It is anticipated that around 30 participants will be recruited across all sites. Analysis of all interviews will be primarily conducted and managed at the UK site.
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Nottinghamshire
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Nottingham, Nottinghamshire, United Kingdom, NG5 1PB
- Academic Rheumatology
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
Patients:
- People with a diagnosis of CPPD of any form and/or their caregiver (includes acute CPP crystal arthritis (pseudogout), chronic CPP crystal arthritis, crowned dens syndrome, and osteoarthritis with CPPD)
- Ability to give informed consent
- Age over 18 years
Healthcare professionals:
- A healthcare professional (nurse, GP or hospital doctor) who cares or has cared for patients with CPPD
Other stakeholders:
- Government organisations, non-government organisations, pharmaceutical representatives and health advocacy groups
Exclusion Criteria:
- Dementia
- Terminal illness
- Unable to give informed consent
- Stroke with receptive or expressive dysphasia
- Severe enduring mental illness
- Autoimmune rheumatic disease such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, gout
- Total joint replacement in the previous 3 months
Study Plan
How is the study designed?
Design Details
- Observational Models: Other
- Time Perspectives: Other
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Patients with CPPD
|
Qualitative interview to explore experiences and perceptions of living with CPPD, and outcome measures to use in future studies
Participants will be sent a short report with the researchers' findings from the qualitative interview, and asked to check the accuracy of these and provide brief written feedback.
|
Healthcare professionals working with CPPD patients
|
Qualitative interview to explore experiences and perceptions of living with CPPD, and outcome measures to use in future studies
Participants will be sent a short report with the researchers' findings from the qualitative interview, and asked to check the accuracy of these and provide brief written feedback.
|
Stakeholders working on behalf of CPPD patients
|
Qualitative interview to explore experiences and perceptions of living with CPPD, and outcome measures to use in future studies
Participants will be sent a short report with the researchers' findings from the qualitative interview, and asked to check the accuracy of these and provide brief written feedback.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Patient and stakeholders perception of core outcome domains identified from a systematic literature review of clinical studies of patients with CPPD
Time Frame: 1 day
|
This is a qualitative interview study, the primary aim is to collect patient and stakeholder perspectives on existing outcome measures of CPPD.
Currently there are no recommended core outcome measure sets for CPPD and this work is being undertaken within the framework of OMERACT.
Thematic analysis will be undertaken of interview transcripts and therefore there is no defined outcome measure.
|
1 day
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Experience of living with and perceptions of CPPD, and perceived impact of symptoms on daily life
Time Frame: 1 day
|
This is a qualitative interview study, the secondary aim is to collect patients' experiences of living with CPPD as well as their and stakeholders perception of the impact of CPPD symptoms, to identify any further outcome measures that could be used in studies of CPPD.
Currently there are no recommended core outcome measure sets for CPPD and this work is being undertaken within the framework of OMERACT.
Thematic analysis will be undertaken of interview transcripts and therefore there is no defined outcome measure.
There is no specific recall period for which experiences will be assessed as this will be dependent on each individual's disease duration.
|
1 day
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: A Abhishek, University of Nottingham
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 19061
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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