Clinical Trials on Hepatic Insufficiency

Total 12728 results

Helsinki University Central Hospital
University of Helsinki; Academy of Finland

Completed

Donor Simvastatin Treatment in Organ Transplantation (SIMVA)

Liver Failure | Heart Failure | Respiratory Failure | Kidney Failure | Transplantation

Finland
Qin Ning

Unknown

A Study of MHE in Patients With Liver Diseases

Liver Diseases | Acute-On-Chronic Liver Failure | Hepatic Encephalopathy | Cirrhosis, Liver | Minimal Hepatic Encephalopathy

China
University Hospital, Strasbourg, France

Recruiting

Hydrodissection of the Hepatoduodenal Ligament (Duodenal)

Hepatic Lesions

France
Rennes University Hospital

Completed

Pharmacogenetic Study of Tacrolimus in Hepatic Transplant (CYPTAC'H)

Hepatic Transplantation

France
Maastricht University

Completed

Liver Glycogen Dynamics (LGD)

Hepatic Glycogen

Netherlands
Shire

Completed

Pharmacokinetics (PK) of 20 mg Teduglutide in Participants With Moderately Impaired Hepatic Function Compared to Healthy Participants

Hepatic Impairment

United States
University of Michigan Rogel Cancer Center

Completed

Assessment Of Liver Function in Patients Undergoing Hepatic Irradiation (IC-Green)

Hepatic Irradiation

United States
Assiut University

Unknown

Implication of Fluid Strategies Upon Hepatic Outcome in Hepatobiliary Surgery

Hepatic Complication
Ramsay Générale de Santé
European Clinical Trial Experts Network

Not yet recruiting

Multicenter Study on Dialysis Modalities for End-stage Chronic Renal Failure Patients With Heparin-induced Thrombocytopenia (MODIATIH)

Chronic Renal Failure | Heparin-induced Thrombocytopenia | Dialysis; Complications

France
Hunter Holmes Mcguire Veteran Affairs Medical Center
Otsuka America Pharmaceutical

Completed

Effect of Tolvaptan on Cognitive Function in Cirrhosis

Hepatic Encephalopathy | Cirrhosis | Hyponatremia

United States
Daiichi Sankyo, Inc.

Completed

A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment

Hepatic Impairment | Moderate Impaired Hepatic Function

United States
Mitsubishi Tanabe Pharma Corporation

Completed

PK Study in Subjects With Severe Hepatic Impairment (MCI-186-E05 HP)

Healthy | Severe Hepatic Impairment

Czechia, Hungary, Slovakia
Cairo University

Completed

Aerobic Capacity Muscle Strength and Health Related Quality of Life in Children With Chronic Liver Disease

Chronic Liver Failure

Egypt
University of Pennsylvania
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Technology Enabled Strategies to Promote Treatment Adherence in Liver Transplant (TEST)

Cirrhosis | Medication Adherence | Liver Transplant; Complications | End Stage Liver DIsease

United States
University of Pennsylvania

Completed

Prehabilitation Intervention to Maximize Early Recovery (PRIMER) in Liver Transplantation (PRIMER)

End Stage Liver Disease | Liver Diseases | Frailty

United States
Aarhus University Hospital

Unknown

Ammonia Metabolism Assessed by Ammonia Infusion (NH4 inf)

Liver Failure, Chronic | Ammonia; Metabolic Disorder

Denmark
Azienda Ospedaliera di Padova

Unknown

Everolimus in de Novo Liver Transplantation: a Multicentre Randomized Study (EPOCAL)

Liver Diseases | Liver Failure | Liver Cirrhosis | Liver Neoplasms

Italy
Kaiser Permanente

Completed

Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge

Liver Failure | Heart Failure | Diabetes Mellitus | Cancer | End Stage Renal Disease | Copd

United States
KBP Biosciences
Covance

Completed

Pharmacokinetics of KBP-5074 in Patients With Moderate Hepatic Impairment

Healthy | Moderate Hepatic Impairment

United States
Rennes University Hospital

Completed

Comparison of the Variability of Hepatic Load Quantification in Iron and Fat Estimated by MRI at 1.5 and 3 Tesla (HEMOCOMPARE)

Iron Hepatic Overload | Fat Hepatic Overload

France
Tibotec BVBA

Completed

A Study of TMC207 in Patients With Moderately Impaired Hepatic Function

Moderate Hepatic Impairment
Jazz Pharmaceuticals

Completed

Assessment of the Single Dose Pharmacokinetics and Tolerability of Sativex in Patients With Impaired Hepatic Function and Healthy Patients

Hepatic Impairment

United States
Seagen Inc.

Completed

A Safety Study of Tucatinib in Healthy and Hepatically-Impaired Subjects

Hepatic Impairment

United States
Mansoura University

Completed

Clamp-crush Technique Versus Harmonic Scalpel in Living Donor Hepatectomy (KK_HS)

Hepatic Transplantation

Egypt
Nuh Rahbari

Completed

Stapler Hepatectomy for Elective Liver Resection (CRUNSH)

Hepatic Resection

Germany
AdventHealth

Completed

Endoscopic Ultrasound Guided Liver Biopsy

Hepatic Cancer | Hepatic Carcinoma | Hepatic Neoplasm

United States
Baylor Research Institute

Recruiting

Veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) Heparin Study

Respiratory Failure | Heparin | ECMO

United States
Sunshine Lake Pharma Co., Ltd.

Completed

To Evaluate the Pharmacokinetics and Safety of Yimitasvir Phosphate Capsules in Subjects With Moderate and Severe Liver Function Impairment and in Healthy Subjects

Hepatic Impairment

China
Central Hospital, Nancy, France

Completed

Hepatic Artery From Origin to Segmental Branching: a 500 Case CT Study

Hepatic Artery

France
Janssen Research & Development, LLC

Withdrawn

A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Odalasvir and AL-335 Alone and in Combination With Simeprevir in Participants With Moderately Impaired Hepatic Function

Hepatic Impairment
NYU Langone Health

Withdrawn

The Effect of a Large-volume Paracentesis on Fatigue, Sleep, and Quality of Life in Cirrhosis

Hepatic Encephalopathy | Fatigue | Cirrhosis | Ascites

United States
Robert J. Porte
King's College Hospital NHS Trust; Universitaire Ziekenhuizen KU Leuven; Erasmus... and other collaborators

Completed

Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation (DHOPE-DCD)

End Stage Liver Disease | Liver Failure | Biliary Tract Diseases

Netherlands, Belgium, United Kingdom
William Lee
Medical University of South Carolina; National Institute of Diabetes and Digestive... and other collaborators

Completed

Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury (STOP-ALF)

Acute Liver Failure | Acute Liver Injury

United States
Postgraduate Institute of Medical Education and...

Completed

Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF (BCAA-ACLF)

Acute-On-Chronic Liver Failure | Hepatic Encephalopathy

India
Bogomolets National Medical University

Completed

Efficacy and Safety of E.Coli Nissle 1917 in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy

Liver Cirrhosis | Hepatic Encephalopathy | End Stage Liver DIsease
Third Affiliated Hospital, Sun Yat-Sen University

Unknown

Early Postoperative CRRT After Liver Transplantation in ACLF Patients With Overt HE (LTeCRRT)

Acute-On-Chronic Liver Failure | Hepatic Encephalopathy
UPECLIN HC FM Botucatu Unesp
Conselho Nacional de Desenvolvimento Científico e Tecnológico; Biophisics Department...

Unknown

Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy

Liver Cirrhosis | Hepatic Encephalopathy | Hypertension, Portal

Brazil
University of Pittsburgh
American Association for the Study of Liver Diseases (AASLD); Pittsburgh Liver...

Completed

Use of EL-FIT App to Promote Physical Activity (EL-FIT)

Cirrhosis, Liver | End Stage Liver DIsease

United States
Hospital General Universitario Gregorio Marañon

Completed

Major Liver Resection: Early Clotting Disorders and Functional Impairment.

Hepatic Insufficiency | Blood Coagulation Disorders

Spain
Bridge to Life Ltd.

Active, not recruiting

Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

Liver Failure | End Stage Liver DIsease

United States
Eisai Inc.

Completed

A Post-marketing Observational Study on Risk Factors for Hepatic Encephalopathy in Participants With Unresectable Hepatocellular Carcinoma

Carcinoma, Hepatocellular

Japan
University Medical Center Groningen

Completed

Non-invasive Measurement of Hemoglobin Concentration With Pulse Co-oximetry

Elective Hepatic Resection

Netherlands
Sanofi

Completed

A Pharmacokinetic and Tolerability Study of Fexinidazole in a Single Oral Dose in Adult Participants With Mild and Moderate Hepatic Impairment

Hepatic Function Abnormal

Bulgaria, France
Sanofi

Completed

Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Mild Hepatic Impairment Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Belgium
Sanofi

Terminated

Pharmacokinetics of Amcenestrant in Female Hepatic Impaired Participants as Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

Korea, Republic of, Germany
Case Comprehensive Cancer Center

Completed

Comparison of Yttrium-90 Absorbed Doses Using PET/CT Versus PET/MR Imaging for Hepatic Malignancies

Hepatic Malignancies

United States
NGM Biopharmaceuticals, Inc

Completed

Study of Aldafermin (NGM282) in Participants With Impaired Hepatic Function

Impaired Hepatic Function

United States
Tetraphase Pharmaceuticals, Inc.

Completed

A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects

Impaired Hepatic Function

United States
Baxter Healthcare Corporation
Gambro Lundia AB; Statistical Analysis : CIC CHU Brabois Nancy

Completed

HepZero:Heparin Free Dialysis With Evodial

Chronic Kidney Disease | Patients Requiring Heparin Free Dialysis Treatments

United Kingdom, Netherlands, Belgium, France, Spain, Canada, Poland
Taisho Pharmaceutical Co., Ltd.

Completed

A Pharmacokinetic Study of TS-142 in Patients With Hepatic Impairment

Patients With Mild or Moderate Hepatic Impairment

Japan

Clinical Trials on Hepatic Insufficiency

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