Clinical Trials on Hepatic Impairment in Germany

Total 313 results

H. Lundbeck A/S

Completed

Pharmacokinetics Properties of Single Oral Dosing of Lu AE58054 in Subjects With Hepatic Impairment (Mild and Moderate) and in Healthy Subjects

Heptic Impairment

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Effect of Hepatic Impairment on M2951 (BTK Inhibitor) PK

Hepatic Impairment

Germany
Janssen Sciences Ireland UC

Completed

A Study to Evaluate the Effect of Hepatic Impairment on JNJ-56136379

Hepatic Impairment

Germany
Novartis Pharmaceuticals

Completed

Impact of Hepatic Impairment on the Pharmacokinetics of Deferasirox.

Hepatic Impairment

Germany
Poxel SA

Completed

Pharmacokinetics of Imeglimin in Hepatic Impaired Subjects

Hepatic Impairment

Germany
Janssen Sciences Ireland UC

Completed

A Study to Evaluate the Effect of Hepatic Impairment on JNJ-73763989

Hepatic Impairment

Germany
H. Lundbeck A/S

Completed

Study Investigating the Pharmacokinetic Properties of the Drug Lu AF35700 in Subjects With Liver Impairment and in Healthy Subjects

Hepatic Impairment

Germany
Novartis Pharmaceuticals

Completed

A Study of LCZ696 in Subjects With Mild and Moderate Hepatic Impairment Compared With Normal Healthy Volunteers

Hepatic Impairment

Germany
Newron Pharmaceuticals SPA

Completed

A Study to Assess the Effect of Hepatic Impairment on Safinamide Pharmacokinetics

Hepatic Impairment

Germany
Janssen-Cilag International NV

Completed

A Study of Orally Administered Pimodivir in Adult Participants With Hepatic Impairment

Hepatic Impairment

Germany
Janssen Research & Development, LLC

Terminated

A Study to Evaluate the Effect of Hepatic Impairment on the Pharmacokinetics of Erdafitinib

Hepatic Impairment

Germany
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Hepatic Impairment on Lazertinib (JNJ-73841937)

Healthy | Hepatic Impairment

Germany
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Hepatic Impairment on JNJ-42847922 in Adult Participants

Healthy | Hepatic Impairment

Germany
VectivBio AG

Completed

A Phase 1, Open-Label Evaluation of the Pharmacokinetics and Safety of a Single Dose of Apraglutide in Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment

Germany, Slovakia
LG Life Sciences

Completed

Influence of Hepatic Impairment on Pharmacokinetic (PK) and Pharmacodynamic (PD) of Gemigliptin PK and PD After Multiple Oral Doses in Healthy White Volunteers

Hepatic Impairment

Germany
Novo Nordisk A/S

Recruiting

A Research Study Looking at How a Single Dose of the Medicine Cagrilintide Behaves in Participants With Reduced Liver Function and in Healthy Participants With Normal Liver Function

Hepatic Impairment

Germany, Slovakia
Novartis Pharmaceuticals

Completed

Pharmacokinetics of RLX030 in Subjects With Mild, Moderate and Severe Hepatic Impairment Compared to Healthy Subjects

Hepatic Impairment

Germany, Russian Federation
Idorsia Pharmaceuticals Ltd.

Completed

The Effect of Reduced Liver Function on Selatogrel Pharmacokinetics

Healthy Subjects | Hepatic Impairment

Germany
Novartis Pharmaceuticals

Completed

Pharmacokinetic Study of BKM120 in Subjects With Hepatic Impairment

Hepatic Impairment

Germany, Russian Federation, Bulgaria
Novartis Pharmaceuticals

Completed

A Study to Evaluate the Pharmacokinetics of AFQ056 in Subjects With Hepatic Impairment Compared to Healthy Subjects

Hepatic Impairment

Germany, United States, Hungary
Janssen Infectious Diseases BVBA

Completed

A Study to Assess Safety and Pharmacokinetics of Telaprevir in Patients With Hepatic Impairment

Hepatic Impairment

Germany, Czech Republic
Novo Nordisk A/S

Recruiting

A Research Study Looking at How a Single Dose of the Study Medicine NNC0194-0499 Behaves in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function

Healthy Volunteers | Hepatic Impairment

Germany, Poland, Slovakia
Novartis Pharmaceuticals

Completed

PK and Safety of Midostaurin in Subjects With Impaired Hepatic Function and Subjects With Normal Hepatic Function

Hepatic Impairment

Germany, Belgium, Lithuania, United States, Bulgaria, Romania
Idorsia Pharmaceuticals Ltd.

Completed

The Effect of Hepatic Impairment on Aprocitentan Pharmacokinetics

Healthy Subjects | Hepatic Impairment

Germany, Poland
Novartis Pharmaceuticals

Completed

Pharmacokinetics (PK) of TKI258 in Cancer Patients With Normal and Impaired Hepatic Function

Hepatic Impairment | Solid Tumors

Belgium, Germany, Netherlands, Italy, Singapore, United States
Nuh Rahbari

Completed

Stapler Hepatectomy for Elective Liver Resection (CRUNSH)

Hepatic Resection

Germany
Klinikum Ludwigshafen

Completed

Influence of of a Lipid Emulsion on Inflammatory Response and Hepatic Function

Inflammatory Response | Hepatic Function

Germany
Polyganics BV
Genae

Completed

Safety and Performance of a Synthetic Tissue Sealant in Reducing Fluid Leakage in Hepatobiliary and Pancreatic Surgery (SHIELDS)

Pancreatectomy | Hepatic Resection

Germany
Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDE225..

Normal Hepatic Function | Impaired Hepatic Function

Belgium, Germany, Israel, Bulgaria, United States
Johannes Gutenberg University Mainz

Unknown

Cerebrovascular Autoregulation During and After Liver Transplantation (dARICULtx)

Liver Failure | Cerebrovascular Disorders | Encephalopathy, Hepatic

Germany
Sanofi

Terminated

Pharmacokinetics of Amcenestrant in Female Hepatic Impaired Participants as Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

Korea, Republic of, Germany
Boehringer Ingelheim

Completed

A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problems

Hepatic Insufficiency

Germany
University Hospital Heidelberg

Recruiting

Magnetic Resonance-guided Adaptive Stereotactic Body Radiotherapy for Hepatic Metastases (MAESTRO)

Hepatic Metastasis

Germany
Boehringer Ingelheim

Completed

A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Liver Problems

Hepatic Insufficiency

Germany
Boehringer Ingelheim

Completed

Nintedanib in Volunteers With Hepatic Impairment Compared With Healthy Volunteers

Hepatic Insufficiency

Germany
University Hospital, Bonn
Maximilian Kiebs, M.Sc. - University Hospital Bonn (Department of Medical...

Recruiting

Prediction of the Cognitive Effects of Electroconvulsive Therapy Via Machine Learning and Neuroimaging (CoEffECT)

Depression | Cognitive Impairment | Memory Impairment | ECT

Germany
EuroPharma, Inc.

Completed

Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects With Cognitive Impairment

Cognitive Impairment, Mild

Germany
Bayer

Completed

Study of Copanlisib in Hepatic or Renal Impairment

Hepatic Insufficiency, Renal Insufficiency

Germany, Romania
Denovo Biopharma LLC

Completed

A Study of LY2140023 in Hepatically-Impaired Participants

Hepatic Insufficiency

Germany, Hungary
Charite University, Berlin, Germany

Completed

Modulation of Visual-Spatial Learning in Patients With Mild Cognitive Impairment (MCI) by tDCS

Mild Cognitive Impairment (MCI)

Germany
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Charite University, Berlin, Germany

Withdrawn

Influence of tDCS on Cortical Plasticity in Patients With Mild Cognitive Impairment (MCI)

Patients With Mild Cognitive Impairment

Germany
Novartis Pharmaceuticals

Completed

Observation of Treatment Patterns With Lucentis in Approved Indications (OCEAN)

Neovascular AMD, Visual Impairment Due to DME, Visual Impairment Due to Macular Oedema Secondary to Branch or Central RVO, Visual Impairment Due to CNV

Germany
Vasopharm GmbH
Winicker Norimed GmbH

Completed

Effects of the NO-synthase Inhibitor VAS203 on Renal Function in Healthy Volunteers

Renal Function Impairment in Healthy Volunteers

Germany
Humedics GmbH

Completed

Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-test

Liver Failure

Germany
Charite University, Berlin, Germany

Completed

Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Patients With Mild Cognitive Impairment

Mild Cognitive Impairment, So Stated

Germany
Ludwig-Maximilians - University of Munich

Completed

Outcome Predictors of a Cognitive Intervention in aMCI (OutPreC MCI)

Amnestic Mild Cognitive Impairment

Germany
Charite University, Berlin, Germany

Withdrawn

Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Patients With Mild Cognitive Impairments

Mild Cognitive Impairment, So Stated

Germany
University Medicine Greifswald
University of Greifswald

Recruiting

Cognitive Training and Brain Stimulation in Women With Post-chemotherapy Cognitive Impairment (NeuroMod-PCCI)

Breast Cancer | Cognitive Impairment

Germany
Novartis Pharmaceuticals

Completed

An Open-label, Parallel-group Study to Determine the Pharmacokinetics of a Single Dose of AFQ056 in Subjects With Renal Impairment Compared to Healthy Subjects

Mild Moderate | or Severe Renal Impairment

Germany

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