Clinical Trials on Hepatitis C Viral in South Africa

Total 1159 results

Carilion Clinic
Sanofi

Terminated

A Phase II Evaluation of Docetaxel and Carboplatin Followed by Tumor Volume Directed Pelvic Irradiation

Advanced Endometrial Adenocarcinoma, Stage III A, B, C

United States
Alvea Holdings, LLC

Completed

Safety, Tolerability and Immunogenicity of Alveavax-v1.2, a BA.2/Omicron-optimized, DNA Vaccine for COVID-19 Prevention

Sars-CoV-2 Infection

South Africa
Providence Therapeutics Holdings Inc.

Completed

PTX-COVID19-B, an mRNA Humoral Vaccine, Intended for Prevention of COVID-19 in a General Population. This Study is Designed to Demonstrate the Safety, Tolerability, and Immunogenicity of PTX-COVID19-B in Comparison to the Pfizer-BioNTech COVID-19 Vaccine.

Covid19 Vaccine

Canada, South Africa
The Aurum Institute NPC
Johns Hopkins University

Recruiting

Comparing Treatment Completion Of Daily Rifapentine & Isoniazid For One Month (1HP) To Weekly High Dose Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in Household Contacts of Recently Diagnosed Tuberculosis Patients (1 to 3)

Tuberculosis | HIV Seropositivity | Household Contact

South Africa, India, Indonesia, Mozambique
National Institute of Allergy and Infectious Diseases...
Microbicide Trials Network

Completed

Adherence and Acceptability to and Blood Levels of Tenofovir Gel and Tablets in HIV Uninfected Women

HIV Infections

United States, Uganda, South Africa
Bristol-Myers Squibb

Completed

Pharmacokinetics of Atazanavir/Ritonavir in HIV-1 Infected Pregnant Women

HIV Infection

South Africa, Puerto Rico, United States
Janssen Sciences Ireland UC

Active, not recruiting

A Roll-over Study With Rilpivirine for Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants Who Participated in Rilpivirine Pediatric Studies

Human Immunodeficiency Virus Type 1

Portugal, South Africa, Thailand, Uganda, Spain
National Institute of Allergy and Infectious Diseases...
GlaxoSmithKline; Sanofi Pasteur, a Sanofi Company; HIV Vaccine Trials Network

Completed

Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine (HVTN107)

HIV Infections

South Africa, Mozambique, Zimbabwe
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Pharmacokinetics, Safety, and Tolerability of Doravirine (MK-1439) and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (MK-1439A) in HIV-1-Infected Children and Adolescents

HIV Infections

United States, South Africa, Thailand
National Institute of Allergy and Infectious Diseases...
Microbicide Trials Network

Completed

Safety and Effectiveness of TFV 1% Gel, TDF Tablets, and FTC/TDF Tablets in Preventing HIV in Women

HIV Infections

South Africa, Uganda, Zimbabwe
University of Washington
Bill and Melinda Gates Foundation

Completed

Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission

HIV Infection | Sexually Transmitted Diseases | Herpes Simplex, Genital

South Africa, Kenya, Botswana, Rwanda, Tanzania, Uganda, Zambia
University of Oxford
Bill and Melinda Gates Foundation; Department for International Development... and other collaborators

Recruiting

Randomised Evaluation of COVID-19 Therapy (RECOVERY)

Severe Acute Respiratory Syndrome

Ghana, Indonesia, Nepal, South Africa, United Kingdom, Vietnam, India
Vital Therapies, Inc.

Completed

Assess Safety and Efficacy of ELAD (Extracorporeal Liver Assist System) in Subjects With Alcohol-Induced Liver Failure

Acute Alcoholic Hepatitis

United States, Spain, Australia, United Kingdom
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Study of Effects of Tenofovir on Bone Health and Kidneys During Pregnancy and Breastfeeding

HIV Infections

Malawi, South Africa, Zimbabwe, Uganda
Bill & Melinda Gates Medical Research Institute
Wellcome Trust

Completed

Safety and Immunogenicity of a Mycobacterium Tuberculosis Vaccine M72/AS01E in Participants With Well-controlled HIV (MESA-TB)

Human Immunodeficiency Virus

South Africa
Microbicide Trials Network
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Observational Study of HIV Infected Women Previously Enrolled in Other Microbicide Trials

HIV Infections

Malawi, Zimbabwe, Uganda, South Africa, Zambia
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

NNRTI vs PI Regimens for HIV Infected Women After They Have Taken Nevirapine to Prevent Mother-To-Child HIV Transmission (OCTANE)

HIV Infections

South Africa, Botswana, Kenya, Malawi, Uganda, Zambia, Zimbabwe
International Partnership for Microbicides, Inc.

Completed

A Safety Study of Dapivirine Vaginal Ring in Africa

HIV Infections

South Africa, Tanzania, Malawi, Kenya
PENTA Foundation
ViiV Healthcare; Hospital Universitario 12 de Octubre; Cromsource; PHPT Foundation

Recruiting

Safety and Pharmacokinetics Evaluation of Fostemsavir + (OBT) in HIV-1 Infected Children and Adolescents Who Are Failing Their cART and Have Dual- or Triple-class Antiretroviral Resistance

HIV Infections With Multi Drug Resistant Virus

United States, South Africa, Mexico, Spain
National Institute of Allergy and Infectious Diseases...
National Institute on Drug Abuse (NIDA); Eunice Kennedy Shriver National Institute... and other collaborators

Completed

BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women

HIV Infections

United States, Malawi, South Africa, Zambia, Zimbabwe
Tibotec Pharmaceuticals, Ireland
Tibotec Pharmaceutical Limited

Completed

A Safety Study to Evaluate the Antiviral Activity of Darunavir in Combination With Ritonavir in HIV 1 Infected Children

Human Immunodeficiency Virus 1

South Africa, Argentina, Brazil, India, Kenya
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID); National Institute...

Completed

A Study of Dementia and Neurological Problems in HIV Infected Patients Who Are Participating in ACTG A5175

HIV Infections

South Africa, Brazil, Zimbabwe, India, Malawi
Boehringer Ingelheim

Completed

A Phase I Multiple Dose Pharmacokinetic Study of Nevirapine Extended Release (XR) in HIV-1 Infected Children.

HIV Infections

United States, Botswana, Germany, South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Comparison of Three Anti-HIV Regimens to Prevent Nevirapine Resistance in Women Who Take Nevirapine During Pregnancy

HIV Infections

Tanzania, Haiti, Malawi, South Africa, India, Uganda
Institut Pasteur
University of Copenhagen; Institut Cochin

Completed

Study on the Association Between Vitamin C Deficiency and Diarrhea in Children (VITAL)

Diarrhea | Infantile

France, New Caledonia, Central African Republic
The University of Queensland
Griffith University; The Prince Charles Hospital; Princess Alexandra Hospital... and other collaborators

Completed

Reducing Acute Severe Respiratory Events in Health Care Workers During the Covid-19 Pandemic With OM85 (COVIDRASP)

Covid19 | Respiratory Viral Infection

Australia
BerGenBio ASA

Completed

A Study of Bemcentinib for the Treatment of COVID-19 in Hospitalised Patients

COVID-19

India, South Africa
National Institute of Allergy and Infectious Diseases...
Department of Health and Human Services; HIV Vaccine Trials Network; Inovio Pharmaceuticals and other collaborators

Active, not recruiting

Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding NP-GT8 and IL-12, With or Without a TLR-agonist-Adjuvanted HIV Env Trimer 4571 Boost, in Adults Without HIV

HIV Infections

United States, South Africa
International Maternal Pediatric Adolescent AIDS...
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy...

Completed

Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV (P1060)

HIV Infections

Uganda, India, Malawi, South Africa, Tanzania, Zambia, Zimbabwe
PENTA Foundation
Baylor College of Medicine; University Hospital Birmingham NHS Foundation Trust and other collaborators

Recruiting

DTG/3TC Fixed Dose Formulations for the Maintenance of Virological Suppression in Children With HIV Infection Aged 2 to <15 Years Old (D3 (Penta21))

HIV Infections

Spain, United Kingdom, Thailand, South Africa, Uganda
French National Agency for Research on AIDS and...

Completed

Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212)

Ulcer | Herpes Genitalis

Central African Republic, Ghana
International Partnership for Microbicides, Inc.

Completed

Trial to Assess the Continued Safety of and Adherence to a Vaginal Ring Containing Dapivirine in Women

Human Immunodeficiency Virus

Malawi, South Africa, Uganda, Zimbabwe
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Tolerability of Etravirine in HIV-1 Infected Infants and Children

HIV Infections

United States, Brazil, South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Acute HIV Infection Observational Study

HIV Infections

United States, Malawi, South Africa, Tanzania, Uganda
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Determining the Effects of Observed and Self-Administered Drug Regimens in HIV Infected Adults

HIV Infections

Peru, Brazil, South Africa, Uganda, Botswana, Haiti, Zambia, Zimbabwe
Tourmaline Bio, Inc.

Recruiting

A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRP (TRANQUILITY)

Chronic Kidney Diseases | Chronic Renal Insufficiency | Chronic Kidney Insufficiency | C-Reactive Protein | Chronic Renal Diseases | Kidney Insufficiency, Chronic | hsCRP | High Sensitivity C-Reactive Protein | Hs-CRP

United States
Peter MacCallum Cancer Centre, Australia

Completed

COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial; (C-SMART)

Cancer | Covid19 | Respiratory Viral Infection

Australia
Gilead Sciences

Terminated

Two Part Study to Evaluate Pharmacokinetics, Safety, and Antiviral Activity of Elvitegravir Administered With a PI/r Background Regimen for ARV Treatment-Experienced Pediatric Participants

HIV Infections | Acquired Immune Deficiency Syndrome (AIDS)

United States, Thailand, Spain, Uganda, South Africa, Italy
Sanofi Pasteur, a Sanofi Company

Completed

Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants

Pertussis Immunisation | Diphtheria Immunisation | Tetanus Immunisation | Pneumococcal Immunisation | Hepatitis B Immunisation | Haemophilus Influenzae Type b Immunisation | Polio Immunisation | Measles Immunisation | Rubella Immunisation | Varicella Immunisation | Mumps Immunisation

United States, Canada, Honduras, Puerto Rico
Medical University of South Carolina
Grassroots Health Nutrition Institute; ZRT Laboratory

Active, not recruiting

Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection (VitD-COVID19)

COVID-19 | Vitamin D Deficiency | Respiratory Viral Infection

United States
NEAT ID Foundation

Terminated

International Sites: Novel Experimental COVID-19 Therapies Affecting Host Response (NECTAR)

COVID-19 | Coronavirus Infection | SARS-CoV2 Infection

Germany, Spain, Brazil, Italy, South Africa
BeiGene

Completed

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Neutralizing Antibody BGB-DXP593 in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19)

Covid19

United States, Mexico, Brazil, South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety, Tolerability, and Pharmacokinetics of an Investigational, Injectable HIV Medicine (GSK1265744) in HIV-Uninfected Adults

HIV Infections

United States, Malawi, Brazil, South Africa
Associate Professor Helen Marshall
Merck Sharp & Dohme LLC

Unknown

Impact of Rotavirus Vaccine Introduction for South Australian Children

Gastroenteritis | Viral Gastroenteritis Due to Rotavirus

Australia
GlaxoSmithKline

Completed

Study to Determine the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals; Infanrix Hexa at 2, 4 and 6 Months of Age in Healthy Infants

Hepatitis B | Tetanus | Diphtheria | Acellular Pertussis | Poliomyelitis | Haemophilus Influenzae Type b

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating Strategies to Reduce Mother-to-Child Transmission of HIV Infection in Resource-Limited Countries (PROMISE)

HIV Infections

Malawi, South Africa, Tanzania, Zimbabwe, India, Uganda, Zambia
Medical University of South Carolina
Pandorum International, Inc.

Not yet recruiting

Mesenchymal Stromal Cells for COVID-19 and Viral Pneumonias (SAMPSON-1)

COVID-19 Pneumonia | Viral Pneumonia

United States
Immune Biosolutions Inc

Completed

Phase 1/2 Study to Evaluate the Efficacy and Safety of Inhaled IBIO123 in Participants With Mild to Moderate COVID-19 Illness

COVID-19

South Africa, Brazil
National Institute of Allergy and Infectious Diseases...
Bill and Melinda Gates Foundation

Completed

Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men (iPrEx)

HIV Infections

United States, Brazil, Ecuador, Peru, South Africa, Thailand
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Evaluating the Safety and Efficacy of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women

HIV Infections

Zimbabwe, South Africa, Botswana, Kenya, Malawi, Uganda, Swaziland

Clinical Trials on Hepatitis C Viral in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

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CROs in Belgium

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Rare Diseases

Drug Interventions

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