Clinical Trials on Heterozygous Familial Hypercholesterolaemia

Total 2097 results

Organon and Co

Completed

Ezetimibe Plus (+) Simvastatin Versus Atorvastatin Comparative Study (0653A-092)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Observational Study to Evaluate LDL-C Lowering Effect of Ezetimibe (0653-070)

Hypercholesterolemia
Organon and Co

Completed

Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224)

Hypercholesterolemia
Organon and Co

Completed

Study to Evaluate the Cholesterol Lowering Effects of Two Marketed Drugs in Patients With Elevated Cholesterol Levels (0653A-058)

Hypercholesterolemia
Organon and Co

Completed

A Study of MK0653A (Ezetimibe (+) Simvastatin) in Patients With Hypercholesterolemia (0653A-038)

Hypercholesterolemia
Organon and Co

Completed

MK0653A (Ezetimibe (+) Simvastatin) Compared to an Approved Drug (Atorvastatin) for the Treatment of High Cholesterol (0653A-051)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

To Evaluate Ezetimibe Plus Atorvastatin Versus Atorvastatin in Patients With High Cholesterol Not Controlled on Atorvastatin 20 mg (0653-079)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

MK0653C in High Cardiovascular Risk Patients With High Cholesterol (Switch Study)(MK-0653C-162)

Hypercholesterolemia
Organon and Co

Completed

A Study to Evaluate the Effectiveness of Ezetimibe/Atorvastatin 10 mg/40 mg Combination Tablet Compared to Marketed Ezetimibe 10 mg and Atorvastatin 40 mg Tablets in Participants With High Cholesterol (MK-0653C-190 AM1)

Hypercholesterolemia
Raisio Group

Completed

Lipid Lowering Effect of Plant Stanol Ester in a Spoonable Non-dairy Product

Hypercholesterolemia

Finland
Chinese University of Hong Kong

Completed

Genome-wide Analysis of Lipid-lowering Efficacy and Drug Level of Simvastatin and Rosuvastatin

Hypercholesterolemia

Hong Kong
Regeneron Pharmaceuticals
Sanofi

Completed

Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo

Hypercholesterolemia

United States, Bulgaria, Chile, Estonia, Japan, Mexico, Russian Federation, South Africa, Ukraine
JW Pharmaceutical

Completed

Efficacy and Safety of Pitavastatin in a Real-world Setting (PROOF)

Hypercholesterolemia
UCSF Benioff Children's Hospital Oakland
Merck Schering-Plough

Completed

Effects of Ezetimibe on the Absorption of Oxidized Cholesterol

Hypercholesterolemia

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Actual Use Trial of Atorvastatin Calcium 10 mg

Hypercholesterolemia

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Bioequivalence Study Comparing A New 80 Mg Atorvastatin Tablet To A 80 Mg Atorvastatin Commercial Tablet

Hypercholesterolemia

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Canadians Achieve Cholesterol Targets Fast With Atorvastatin Stratified Titration (CANACTFAST)

Hypercholesterolemia

Canada
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Bioequivalence Study Of Pediatric Appropriate Formulation

Hypercholesterolemia

United States
Catabasis Pharmaceuticals

Completed

A 2-Part, Phase 1, Single and Multiple Ascending Dose Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of CAT-2054 in Healthy Subjects

Hypercholesterolemia

United States
AstraZeneca
Parexel

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8233 in Healthy Male Subjects With Increased Elevated LDL-C Levels.

Hypercholesterolemia

United States
AB Biotics, SA
University of Extremadura

Completed

Combination of AB-LIFE Probiotic Plus Monacolin K to Reduce Blood Cholesterol

Hypercholesterolemia
Azienda di Servizi alla Persona di Pavia

Completed

Artichoke and Bergamot Phytosome

Hypercholesterolemia

Italy
Regeneron Pharmaceuticals
Sanofi

Terminated

Praluent® (Alirocumab) Pregnancy Exposure Registry: An OTIS Pregnancy Surveillance Study

Hypercholesterolemia

United States
Chong Kun Dang Pharmaceutical

Completed

Clinical Trial to to Compare of the Efficacy and Safety of Lipilou® 20 mg and Lipilou® 10 mg

Hypercholesterolemia

Korea, Republic of
Regeneron Pharmaceuticals
Sanofi

Completed

Study of Alirocumab (REGN727/SAR236553) in Patients With Primary Hypercholesterolemia and Moderate, High, or Very High Cardiovascular (CV) Risk, Who Are Intolerant to Statins (ODYSSEY ALTERNATIVE)

Hypercholesterolemia

United States, France, Italy, Israel, United Kingdom, Austria, Canada, Norway
Merck Sharp & Dohme LLC

Completed

A Study of the Safety and Efficacy of Anacetrapib (MK-0859) Among Participants With Hypercholesterolemia When Added to Ongoing Statin Therapy (MK-0859-022)

Hypercholesterolemia
NeuroBo Pharmaceuticals Inc.

Completed

Efficacy and Safety of Gemcabene in Hypercholesterolemic Patients as Monotherapy or in Combination With Atorvastatin

Hypercholesterolemia
NeuroBo Pharmaceuticals Inc.

Completed

Pharmacokinetics and Pharmacodynamics Study of Gemcabene in Healthy Volunteers

Hypercholesterolemia
NeuroBo Pharmaceuticals Inc.

Completed

Efficacy and Safety of Gemcabene in Hypercholesterolemic Patients on Stable Statin Therapy

Hypercholesterolemia
Esperion Therapeutics, Inc.

Completed

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg When Added to PCSK9 Inhibitor Therapy

Hypercholesterolemia

United States
Pfizer

Completed

Pharmacokinetics And Relative Bioavailability Of Bococizumab (PF-04950615; RN316) When Administered To The Abdomen, Thigh Or Upper Arm

Hypercholesterolemia

United States
Amgen

Completed

Open-label Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Hypercholesterolemia

Canada, Netherlands, Spain, Belgium, United States, Russian Federation, Czechia, Mexico, Korea, Republic of, Australia, United Kingdom, Argentina, Israel, France, Hungary, Germany, Greece, Poland, Switzerland, Italy, Brazil, Sweden, Norwa... and more
University of California, Los Angeles

Terminated

Effects of a Supplement Derived From Palm Oil on Cholesterol Levels in the Blood (TRF)

Hypercholesterolemia

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety of Alirocumab in Patients With Hypercholesterolemia Not Adequately Controlled With Non-statin Lipid Modifying Therapy or the Lowest Strength of Statin (ODYSSEY-NIPPON)

Hypercholesterolemia

Japan
Merck Sharp & Dohme LLC

Completed

A Study of MK-6213 Co-Administered With Atorvastatin in Participants With Hypercholesterolemia (MK-6213-006)

Hypercholesterolemia
Eli Lilly and Company

Terminated

A Study of Evacetrapib (LY2484595) in Combination With Atorvastatin in Japanese Participants With Primary Hypercholesterolemia

Hypercholesterolemia

Japan
B. Braun Medical Inc.

Completed

(H.E.L.P.)Apheresis Therapy to Compare the Reduction of LDL (Low Density Lipoprotein) Cholesterol (FUTURA)

Hypercholesterolemia

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Phase III Study To Evaluate Alirocumab in Patients With Hypercholesterolemia Not Treated With a Statin (ODYSSEY CHOICE II)

Hypercholesterolemia

United States, Australia, Belgium, Canada, Denmark, Netherlands, New Zealand, Spain
IlDong Pharmaceutical Co Ltd

Completed

A Clinical Trial to Compare the Efficacy and Safety of a Combination Therapy of Ezetimibe and Rosuvastatin Versus Monotherapy of Rosuvastatin in Hypercholesterolemia Patients (I-ROSETTE Study) (I-ROSETTE)

Hypercholesterolemia

Korea, Republic of
Hospital General Universitario Gregorio Marañon

Completed

Evolocumab Versus LDL Apheresis in Patients With Hypercholesterolemia

Hypercholesterolemia

Spain
Sanofi
Regeneron Pharmaceuticals

Completed

A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous (SC) Administered Alirocumab in Healthy Chinese Subjects

Hypercholesterolemia

China
Affiris AG
Medical University of Vienna

Completed

Study Assessing Safety, Immunogenicity and LDLc -Lowering Activity of 2 PCSK9 Targeting AFFITOPE Vaccines in Healthy Subjects (AFF012)

Hypercholesterolemia

Austria
Shin Poong Pharmaceutical Co. Ltd.

Completed

The Efficacy and Safety of Combination Therapy of Rosuvastatin and Ezetimibe and Rosuvastatin Monotherapy in Patients With Primary Hypercholesterolemia

Hypercholesterolemia

Korea, Republic of
University of Reading
Medical Research Council

Completed

Replacement of Saturated Fat in Dairy on Total Cholesterol (RESET)

Hypercholesterolemia

United Kingdom
Clinical Research Center for End Stage Renal Disease...
Ministry of Health & Welfare, Korea

Completed

The Effects of Lowering Low-density Lipoprotein Cholesterol Levels to New Targets on Cardiovascular Complications in Peritoneal Dialysis Patients

Hypercholesterolemia

Korea, Republic of
Durham VA Medical Center

Completed

Cholesterol Medication Packaging Study (MWV_CAPS)

Hypercholesterolemia

United States
Sanofi

Terminated

Evaluation of Safety and Efficacy of AVE5530 as add-on to Ongoing High Doses of Statins in Patients With Primary Severe Hypercholesterolemia

Hypercholesterolemia

United States, France, Canada, Russian Federation, Ukraine, Netherlands, Bulgaria, Belgium, Czech Republic, Israel, Slovakia, Australia, South Africa
USDA Beltsville Human Nutrition Research Center

Completed

A Comparison of the Effects on Cardiovascular Risk Factors of Korean and American Dietary Profiles

Hypercholesterolemia

United States
Yonsei University

Completed

Effects of α-linolenic Acid Supplementation on Hemostasis in Nondiabetic and Hypercholesterolemic Subjects

Hypercholesterolemia

Korea, Republic of
Sanofi
Regeneron Pharmaceuticals

Completed

Long-term Safety and Tolerability of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY Long Term)

Hypercholesterolemia

Sweden, Germany, Russian Federation, Denmark, Israel, South Africa, Spain, Hungary, United States, Colombia, Czech Republic, Argentina, Belgium, Bulgaria, Canada, Chile, Finland, France, Italy, Mexico, Netherlands, Norway, Poland, Por... and more

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