Clinical Trials on High Grade Malignant Neoplasm

Total 5521 results

ADC Therapeutics S.A.

Recruiting

A Study to Evaluate the Pharmacokinetics and Safety of Loncastuximab Tesirine in Participants With Relapsed or Refractory Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma With Hepatic Impairment (LOTIS-10)

Diffuse Large B-Cell Lymphoma | High-grade B-cell Lymphoma

Taiwan, Korea, Republic of, United States, Brazil
Northwestern University
National Cancer Institute (NCI)

Completed

Radiation Therapy and Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With High-Grade Lymphoma or Acute Lymphoblastic Leukemia

Lymphoma | Leukemia

United States
Fujian Cancer Hospital

Completed

POF Versus FOLFOX Versus FOLFOX Plus ip Paclitaxel in AGC

Malignant Neoplasm of Stomach Stage IV

China
National Cancer Institute (NCI)

Completed

Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment

Recurrent Childhood Ependymoma | Recurrent Neuroblastoma | Recurrent Osteosarcoma | Recurrent Childhood Rhabdomyosarcoma | Recurrent Renal Cell Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Recurrent Childhood Soft Tissue Sarcoma | Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | KRAS Gene Mutation | Metastatic Malignant Solid Neoplasm | EGFR Gene Mutation | ERBB2 Gene Amplification | ERBB2 Gene Mutation | EGFR Gene Amplification | ERBB3 Gene Mutation | ERBB4 Gene Mutation

United States
Nationwide Children's Hospital

Recruiting

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

High Grade Glioma | Diffuse Intrinsic Pontine Glioma

United States, Australia, Canada, Germany
Virginia Commonwealth University
National Cancer Institute (NCI)

Active, not recruiting

Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma

Glioblastoma | Malignant Glioma | WHO Grade III Glioma | Recurrent Adult Brain Neoplasm

United States
Jonsson Comprehensive Cancer Center
California Institute for Regenerative Medicine (CIRM)

Terminated

Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer (NYESO SCT)

Sarcoma | Unresectable Malignant Neoplasm | Locally Advanced Malignant Neoplasm | HLA-A*0201 Positive Cells Present | NY-ESO-1 Positive

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Shared Healthcare Actions and Reflections Electronic Systems in Survivorship

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Cancer | Survivorship

United States
AbbVie

Completed

A Study to Evaluate the Safety, Pharmacokinetics and Oral Bio Availability of Veliparib in Subjects With Solid Tumors

Oncology | High Grade Serous Ovarian Cancer | BRCA Mutated | BRCA Mutated Breast Cancer
First Affiliated Hospital Xi'an Jiaotong University

Recruiting

Construction of a Database of Prognostic Risk Factors and Quality of Life of Patients With Primary Solid Malignant Cancers Receiving Immunotherapy for the First Time Based on Questionnaire Survey

Malignant Neoplasm

China
University of Southern California
National Cancer Institute (NCI)

Withdrawn

Oncology Research Information Exchange Network in Improving Genetic Screening Rate in Patients With Cancer

Malignant Neoplasm

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...

Terminated

Haploidentical Donor Hematopoietic Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Malignant Neoplasm

United States
National Cancer Institute (NCI)

Completed

Cixutumumab and Temsirolimus in Treating Patients With Locally Advanced or Metastatic Cancer

Malignant Neoplasm

United States
Hospital Sao Rafael

Completed

Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced Radiation Dose and Improved Image Quality (pet-ct)

Hodgkin Disease | Malignant Neoplasm of Breast | Malignant Neoplasm of Colon | Non-Hodgkin Lymphoma, Follicular (Nodular) | Malignant Neoplasm of Bronchus and Lung | Secondary Neoplasm Malignant and Unspecified Lymph Nodes | Malignant Melanoma of the Skin | Malignant Neoplasm of Small Intestine

Brazil
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors

Brain Metastases | Brain Metastases, Adult | High-grade Glioma

United States
Roswell Park Cancer Institute

Recruiting

Single-Fraction SBRT Versus Standard Palliative Radiation Therapy in Treating Patients With Metastatic Cancer

Metastatic Malignant Neoplasm

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Ketoconazole in Treating Participants With Ongoing EGFR Inhibitor-Induced Rash

Malignant Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Acalabrutinib, Lenalidomide, and Rituximab for the Treatment of CD20 Positive Stage III-IV, Grade 1-3a Follicular Lymphoma

Grade 3a Follicular Lymphoma | Ann Arbor Stage III Grade 1 Follicular Lymphoma | Ann Arbor Stage III Grade 2 Follicular Lymphoma | Ann Arbor Stage IV Grade 1 Follicular Lymphoma | Ann Arbor Stage IV Grade 2 Follicular Lymphoma | Ann Arbor Stage III Grade 3 Follicular Lymphoma | Ann Arbor Stage...

United States
National Cancer Institute (NCI)

Completed

Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas

High Grade Glioma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma

United States
Syndax Pharmaceuticals

Completed

A Phase 1 Study to Investigate Axatilimab Alone or in Combination With Durvalumab in Patients With Solid Tumors

Solid Tumor | Unresectable Malignant Neoplasm | Locally Advanced Malignant Neoplasm | Metastatic Tumor

United States
Mayo Clinic

Not yet recruiting

An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma

WHO Grade 3 Glioma | WHO Grade 2 Glioma | WHO Grade 4 Glioma

United States
University of Minnesota

Recruiting

Radioembolization of Primary and Secondary Liver Malignancies and The Effect On The Immune System

Hepatocellular Carcinoma | Secondary Malignant Neoplasm of Liver

United States
Massachusetts General Hospital
GlaxoSmithKline

Recruiting

Niraparib In Recurrent IDH 1/2 Gliomas

Recurrent Glioma | Low-grade Glioma | Glioma, Malignant | IDH2 Gene Mutation | IDH1 Mutation

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Combination Chemotherapy and Bevacizumab With the NovoTTF-100L(P) System in Treating Participants With Advanced, Recurrent, or Refractory Hepatic Metastatic Cancer

Metastatic Malignant Neoplasm in the Liver | Advanced Malignant Neoplasm | Refractory Malignant Neoplasm | Colorectal Carcinoma Metastatic in the Liver

United States
UNC Lineberger Comprehensive Cancer Center

Not yet recruiting

Pharmacokinetics of Intravaginal, Self-administered Artesunate Vaginal Pessaries Among Women in Kenya

Cervix Cancer | Cervix Intraepithelial Neoplasia Grade 3 | Cervix; Intraepithelial Neoplasia, Grade I | Cervix; Intraepithelial Neoplasia, Grade II

Kenya
Novelwise Pharmaceutical Corporation

Recruiting

NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma

Malignant Neoplasm | Malignant Neoplasm of Brain

Taiwan
National Cancer Institute (NCI)

Active, not recruiting

Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | NF1 Mutation Positive Malignant Peripheral Nerve Sheath Tumor

United States
Amsterdam UMC, location VUmc
Novartis; Borstkanker Onderzoek Groep

Unknown

Analysis of Tumor Tissue and Circulating Genetic Material in the Blood to Obtain Further Insight in the Effectiveness of Everolimus When Combined With Exemestane

Metastatic Breast Cancer | Hormone Receptor Positive Malignant Neoplasm of Breast

Netherlands
Zhongnan Hospital

Recruiting

68Ga-FAPI PET/CT in Malignant Tumors

Malignant Neoplasm | PET/CT | Fibroblast Activation Protein Inhibitor

China
Advanced Integrative Medical Science Institute

Recruiting

AIMS Cancer Outcomes Study (ACOS)

Neoplasms | Advanced Solid Tumor | Advanced Cancer | Oncology | Neoplasm Malignant

United States
Jonsson Comprehensive Cancer Center

Recruiting

Germ-Line Mutations in Blood and Saliva Samples From Patients With Cancer

Malignant Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Ultrasound-Guided Photoacoustic Imaging for the Detection of Metastases in Inguinal Lymph Nodes

Malignant Neoplasm

United States
Roswell Park Cancer Institute

Completed

Talking Pictures Social Media Intervention in Reducing Depressive Symptoms and Improving Spiritual Well-Being and Quality of Life in Adolescent and Young Adult Cancer Patients

Malignant Neoplasm

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Spiritual Care in Improving Quality of Life of Patients, Caregivers, and Hospital Staff

Malignant Neoplasm

United States
Genmab
AbbVie

Approved for marketing

Expanded Access Program for Epcoritamab

Primary Mediastinal Large B-cell Lymphoma (PMBCL) | Large B-cell Lymphoma | Diffuse Large B-Cell Lymphoma, Not Otherwise Specified | High Grade B-cell Lymphoma (HGBCL) | Grade 3B Follicular Lymphoma
Edward Ziga

Terminated

Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors

Glioma | Brain Cancer | Brain Tumor | Glioblastoma Multiforme | High Grade Glioma

United States
Tata Memorial Hospital

Completed

Tomotherapy in Locally Advanced Gallbladder and Pancreatic Cancers

Pancreatic Neoplasms Malignant | Malignant Neoplasm of Gall Bladder Non-resectable

India
University of Pretoria
University of Stellenbosch

Recruiting

Screening Study for Cervical Pre-cancer and Cancer Prevention in South African Women. (DiaVACCS)

Cervical Cancer | CIN2 | High Grade Sil

South Africa
National Cancer Institute (NCI)

Not yet recruiting

Testing the Addition of ASTX660 (Tolinapant) to the Usual Chemotherapy Treatment (Paclitaxel With or Without Bevacizumab) in Patients With Recurrent Ovarian Cancer

Recurrent Ovarian High Grade Serous Adenocarcinoma | Recurrent Platinum-Resistant Ovarian Carcinoma | Recurrent Fallopian Tube Clear Cell Adenocarcinoma | Recurrent Fallopian Tube Undifferentiated Carcinoma | Recurrent Ovarian Clear Cell Adenocarcinoma | Recurrent Ovarian Undifferentiated Carcinoma and other conditions
M.D. Anderson Cancer Center

Recruiting

Data Collection for Patients With Low Grade Ovarian or Peritoneal Tumors

Ovarian Carcinoma | Primary Peritoneal Carcinoma | Malignant Ovarian Neoplasm | Low Grade Ovarian Serous Adenocarcinoma | Primary Peritoneal Low Grade Serous Adenocarcinoma | Psammocarcinoma

United States
Albert Einstein College of Medicine
National Cancer Institute (NCI)

Terminated

Anti-NY ESO-1 mTCR Peripheral Blood Lymphocytes

Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm | HLA-A2 Positive Cells Present

United States
Northwestern University
National Cancer Institute (NCI)

Active, not recruiting

Combination Chemotherapy and TAK-659 as Front-Line Treatment in Treating Patients With High-Risk Diffuse Large B Cell Lymphoma

Diffuse Large B-Cell Lymphoma | Diffuse Large B-Cell Lymphoma, Not Otherwise Specified | High Grade B-Cell Lymphoma, Not Otherwise Specified | T-Cell/Histiocyte-Rich Large B-Cell Lymphoma | High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements | Diffuse Large B-Cell Lymphoma... and other conditions

United States
Sixth Affiliated Hospital, Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University; Second Affiliated Hospital...

Recruiting

Comparison of Hepatectomy and Local Ablation for Resectable Synchronous and Metachronous Colorectal Liver Metastasis (HELARC)

Secondary Malignant Neoplasm of Liver

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Cement Augmentation in Preventing Vertebral Body Compression Fracture Following Spine Stereotactic Radiosurgery in Patients With Solid Tumors and Spinal Metastases

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Spine

United States
Massachusetts General Hospital
National Institutes of Health (NIH)

Enrolling by invitation

Low-field MRI for Breast Cancer Screening

Malignant Neoplasm of Breast | Breast Benign | Breast Malignant Tumor

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Combination of the Study Drugs Cediranib and Olaparib in Recurrent Ovarian Cancer

Fallopian Tube Carcinoma | Ovarian Carcinoma | Fallopian Tube Endometrioid Adenocarcinoma | Fallopian Tube Serous Adenocarcinoma | Primary Peritoneal Serous Adenocarcinoma | Primary Peritoneal Carcinoma | Ovarian High Grade Serous Adenocarcinoma | Primary Peritoneal Endometrioid Adenocarcinoma | Ovarian...

United States
St. Jude Children's Research Hospital

Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

Glioblastoma | Central Nervous System Neoplasms | High Grade Glioma | Ependymoma | Medulloblastoma | Diffuse Midline Glioma, H3 K27M-Mutant | Atypical Teratoid/Rhabdoid Tumor

United States
Seoul National University Hospital

Unknown

Bortezomib and Pegylated Liposomal Doxorubicin in BRCA Wild-type Platinum-resistant Recurrent Ovarian Cancer Patients

High Grade Serous Carcinoma | Ovarian Neoplasm Epithelial

Korea, Republic of
City of Hope Medical Center

Completed

A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas

Recurrent High Grade Glioma | Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Tumor | Recurrent Grade III Glioma | Adult Brain Tumor | Recurrent Grade IV Glioma | Adult Anaplastic...

United States

Clinical Trials on High Grade Malignant Neoplasm

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