Clinical Trials on High Grade Squamous Intraepithelial Neoplasia

Total 4940 results

Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions

High Grade Anal Canal Intraepithelial Neoplasia | High Grade Vulvar Squamous Intraepithelial Lesion

United States
David Finch
Lancashire Teaching Hospitals NHS Foundation Trust

Not yet recruiting

COrSIcA: Disease Measurement

Anal Intraepithelial Neoplasia | Anal High-grade Squamous Intraepithelial Lesion | Anal HSIL
Inovio Pharmaceuticals

Completed

REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)

Cervical Dysplasia | Cervical High Grade Squamous Intraepithelial Lesion | HSIL

United States, Spain, Lithuania, Estonia, South Africa, Argentina, Brazil, Finland, Poland, Puerto Rico
Medtronic - MITG

Completed

A Safety and Tolerability of Circumferential Anal Canal Radiofrequency Ablation For Anal Intraepithelial Neoplasia

Anal Intraepithelial Neoplasia (AIN) | High-grade Squamous Intraepithelial Lesions (HSIL)

United States
Antiva Biosciences

Completed

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection.

Cervical Cancer | Human Papilloma Virus | HSIL, High Grade Squamous Intraepithelial Lesions | Cervical Dysplasia | HSIL of Cervix | High-Grade Cervical Intraepithelial Neoplasia | HIV Negative | CIN - Cervical Intraepithelial Neoplasia | Cervical Neoplasm

South Africa
Catharina Ziekenhuis Eindhoven
ZonMw: The Netherlands Organisation for Health Research and Development; Stichting... and other collaborators

Recruiting

Predicting Response In Cervical Intraepithelial Neoplasia to Topical Imiquimod Treatment (PRedICT-TOPIC)

Cervical Intraepithelial Neoplasia | CIN 2/3 | Cervical Intraepithelial Neoplasia Grade 2/3 | Cervical High Grade Squamous Intraepithelial Lesion

Netherlands
Muğla Sıtkı Koçman University

Completed

Evaluation of Thioldisulfide Balance in Cervical Preinvasive Lesions

Oxidative Stress | Low Grade Squamous Intraepithelial Lesion | High-Grade Squamous Intraepithelial Lesions

Turkey
Institut de Cancérologie de Lorraine

Recruiting

Evaluation of New Diagnostic Tool Using Fluorescence to Detect High-grade Vulvar Intraepithelial Neoplasia (PhotodiVIN)

Vulvar Intraepithelial Neoplasia | Vulvar High Grade Squamous Intraepithelial Lesion | Differentiated Vulvar Intraepithelial Neoplasia

France
University Fernando Pessoa

Recruiting

ANAL PRECANCEROUS LESIONS IN HIGH-RISK PATIENTS. (PACCO)

HSIL, High Grade Squamous Intraepithelial Lesions | AIN3 | AIN2

Portugal
Peking University People's Hospital
Hangzhou Newhorizon Health Technology Co., Ltd.; Hangzhou Mingze Medical Research... and other collaborators

Recruiting

Clinical Evaluation of Detection of High Risk HPV in Urine (Urine-hrHPV)

Cervical Cancer | Cervical Adenocarcinoma | Cervical Squamous Cell Carcinoma | Human Papillomavirus Infection | Human Papilloma Virus | Adenocarcinoma in Situ | High-Grade Squamous Intraepithelial Lesions | Cervical Intraepithelial Neoplasia Grade II | Cervical Intraepithelial Neoplasia, Grade III | Atypical... and other conditions

China
National Cancer Institute (NCI)

Terminated

Immunotherapy With E6 T Cell Receptor (TCR) T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions

Human Papillomavirus | HPV-16 | High Grade Squamous Intraepithelial Lesion

United States
University of Witwatersrand, South Africa
Merck Sharp & Dohme LLC

Completed

Randomized, Double Blind Trial of the Quadrivalent HPV Vaccine to Improve Responses to LEEP Treatment of Cervical HSIL

Cervical High Grade Squamous Intraepithelial Lesion
Southwest Oncology Group
National Cancer Institute (NCI)

Withdrawn

S0212 Celecoxib in Treating Patients With High-Grade Squamous Intraepithelial Lesions of the Cervix

Stage 0 Cervical Cancer | High-grade Squamous Intraepithelial Lesion
Brugmann University Hospital

Completed

A Prolongation of a Clinical Study to Evaluate the Efficacy of an Aqueous Gel Containing 2% (w/w) of Cidofovir, Directly Applied on the Cervix Exhibiting High Grade Squamous Intraepithelial Lesions.

High Grade Cervical Epithelial Neoplasia (CIN2+)

Belgium
Lei Li

Unknown

DNA Methylation for Screening Uterine Cervical Lesions

DNA Methylation | Uterine Cervical Cancer | High Grade Squamous Intraepithelial Lesions | Low Grade Squamous Intraepithelial Lesions

China
Lei Li

Unknown

DNA Methylation for Screening Uterine Cervical Lesions: A Case-control Study

DNA Methylation | Uterine Cervical Cancer | High Grade Squamous Intraepithelial Lesions | Low Grade Squamous Intraepithelial Lesions

China
Peking University People's Hospital
BeijingNewBiorayTechnologyCo.,Ltd.; Hangzhou Newhorizon Health Technology Co...

Active, not recruiting

Primary Cervical Cancer Screening by Self-sampling HPV Test (PREVENT)

Cervical Cancer | Cervical Adenocarcinoma | Cervical Squamous Cell Carcinoma | Human Papillomavirus Infection | Adenocarcinoma in Situ | Low-Grade Squamous Intraepithelial Lesions | High-Grade Squamous Intraepithelial Lesions | Cervical Intraepithelial Neoplasia Grade II | Cervical Intraepithelial Neoplasia... and other conditions

China
Medtronic - MITG

Completed

A Trial of Radiofrequency Ablation for Anal Intraepithelial Neoplasia Using the HALO Ablation System (AIN)

HIV-negative Subjects With Intra-anal Intraepithelial Neoplasia Containing High-Grade Squamous Intraepithelial Lesions

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Papillomavirus Post-THErapeutique (PAPOTHE)

High Grade Intraepithelial

France
National Cancer Institute (NCI)

Completed

SGN-00101 Vaccine in Treating Human Papillomavirus in Patients Who Have Abnormal Cervical Cells

Cervical Cancer | High-grade Squamous Intraepithelial Lesion | Atypical Squamous Cells of Undetermined Significance | Low-grade Squamous Intraepithelial Lesion

United States
National Cancer Institute (NCI)

Active, not recruiting

Topical Fluorouracil and Imiquimod in Treating Patients With High-Grade Cervical Intraepithelial Neoplasia

Cervical Intraepithelial Neoplasia Grade 2/3 | High Grade Cervical Intraepithelial Neoplasia | Cervical Squamous Cell Carcinoma In Situ | Cervical Squamous Intraepithelial Neoplasia 2

United States
Institute of HIV Research and Innovation Foundation...
National Institutes of Health (NIH); amfAR, The Foundation for AIDS Research

Recruiting

Anal HSIL Screening Algorithm (0007/65)

Anal High-grade Squamous Intraepithelial Lesion

Thailand
Newish Technology (Beijing) Co., Ltd.

Recruiting

NWRD08 DNA Plasmid for HPV-16 and/or HPV-18 Related Cervical HSIL

High-grade Squamous Intraepithelial Lesion (HSIL)

China
Hospital Universitari Vall d'Hebron Research Institute

Not yet recruiting

Intraoperative HPV Testing Evaluation

Recurrence | HSIL, High Grade Squamous Intraepithelial Lesions
Tigris Pharmaceuticals

Completed

Safety and Efficacy of A-007 Topical Gel in the Treatment of High-Grade Squamous Intraepithelial Lesions (HSIL) of the Cervix

Cervical Intraepithelial Neoplasia | Uterine Cervical Dysplasia

United States
Inovio Pharmaceuticals

Completed

Evaluation of VGX-3100 and Electroporation Alone or in Combination With Imiquimod for the Treatment of HPV-16 and/or HPV-18 Related Vulvar HSIL (Also Referred as: VIN 2 or VIN 3)

Human Papillomavirus (HPV) | Vulvar Dysplasia | Vulvar Intraepithelial Neoplasia (VIN) | Vulvar High Grade Squamous Intraepithelial Lesion (HSIL) | VIN2 | VIN3 | Pre-cancerous Lesions of the Vulva

United States
Antiva Biosciences

Completed

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection

Cervical Cancer | Cervical Intraepithelial Neoplasia | CIN | Human Papilloma Virus | Cervical Dysplasia | HSIL of Cervix | Cervical Neoplasm | HSIL | High-Grade Squamous Intraepithelial Lesions | High-grade Cervical Intraepithelial Neoplasia

United States, Australia
Tigris Pharmaceuticals

Completed

A Two-Stage Phase 2 Study Of A-007 Topical Gel in High-Grade Squamous Intraepithelial Lesions (HSIL) (TG-003)

Cervical Intraepithelial Neoplasia | Uterine Cervical Dysplasia

United States
Baylor College of Medicine
Medical University of South Carolina; M.D. Anderson Cancer Center; The University... and other collaborators

Completed

The Effectiveness of High Resolution Microendoscopy for People Living With HIV

Anal High Grade Squamous Intraepithelial Lesion

United States
Barretos Cancer Hospital
Fundação de Amparo à Pesquisa do Estado de São Paulo; Farmoquimica S.A.; Hospital...

Not yet recruiting

Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients Treated With Imiquimod

Biomarkers | HSIL, High-Grade Squamous Intraepithelial Lesions | Vaginal Microbiome
Memorial Sloan Kettering Cancer Center
Northwestern University; The City College of New York

Completed

Validation of a Health-Related Symptom Index for Persons Diagnosed With and Either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions (HSIL)

Anal High-Grade Squamous Intraepithelial Lesions

United States
Inovio Pharmaceuticals

Completed

REVEAL 1 (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL) (REVEAL 1)

Cervical Dysplasia | Cervical High Grade Squamous Intraepithelial Lesion | HSIL

United States, Spain, Portugal, Italy, Philippines, Thailand, Slovakia, Lithuania, Estonia, Belgium, South Africa, Germany, Argentina, United Kingdom, Poland, Puerto Rico, Finland, Mexico, Peru
Nykode Therapeutics ASA
Theradex; Vaccibody AS

Completed

An Exploratory Safety and Immunogenicity Study of HPV16+ Immunotherapy VB10.16 in Women With HSIL; CIN 2/3)

High Grade Cervical Intraepithelial Neoplasia

Germany
University of Alabama at Birmingham
National Cancer Institute (NCI)

Completed

An Alternative Treatment for Cervical Intraepithelial Neoplasia Using the Focal Loop Electrosurgical Excision Procedure

High-grade Cervical Intraepithelial Neoplasia

United States
Brookdale University Hospital Medical Center

Unknown

Multispectral Digital Colposcope With Probe for Detection of Cervical Intraepithelial Neoplasia (MDCwProbe)

Carcinoma in Situ of Uterine Cervix | Cervical Intraepithelial Neoplasias | High Grade Cervical Intraepithelial Neoplasia

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); The Emmes Company, LLC; Inovio Pharmaceuticals

Active, not recruiting

VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

Anal Intraepithelial Neoplasia | High Grade Squamous Intraepithelial Neoplasia | HIV Positivity | Human Papillomavirus-16 Positive | Human Papillomavirus-18 Positive

United States, Puerto Rico
Saint Thomas Hospital, Panama

Completed

Observational vs. Ablative Treatment for Low-grade Squamous Intraepithelial Lesions.

LSIL, Low-Grade Squamous Intraepithelial Lesions

Panama
Hospital Universitari Vall d'Hebron Research Institute

Unknown

Clinical Trial for Evaluating the Efficacy and Safety of Electrocoagulation vs Topic Sinecatechins vs Topic Cidofovir Within the Treatment to High-grade Anal Intraepithelial Neoplasia in HIV Homosexual Males (TreatAIN)

High-grade Anal Intraepithelial Neoplasia
Huazhong University of Science and Technology

Recruiting

Comparison of pCLE and EB in Gastric Lesion Diagnosis

Early Gastric Cancer | Low Grade Intraepithelial Neoplasia | High Grade Intraepithelial Neoplasia | Gastric Intraepithelial Neoplasia

China
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC

Active, not recruiting

Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions

HIV Infection | Anal Intraepithelial Neoplasia | High-grade Squamous Intraepithelial Lesion

United States, Puerto Rico
Gynecologic Oncology Group
National Cancer Institute (NCI)

Terminated

Megestrol in Treating Patients With Endometrial Neoplasia or Endometrial Hyperplasia

High Grade Squamous Intraepithelial Neoplasia | Stage 0 Uterine Corpus Cancer

United States
Evangelisches Krankenhaus Düsseldorf

Completed

ESD Versus EMR for Treatment of Early Barrett's Adenocarcinoma

Barrett Adenocarcinoma | High Grade Intraepithelial Neoplasia

Germany
University of California, San Francisco

Completed

Focal Ablation of Cervical Precancer

High-grade Cervical Intraepithelial Neoplasia

United States
Khon Kaen University

Terminated

Cryotherapy for Human Papillomavirus Clearance in Biopsy-confirmed Cervical Low-grade Squamous Intraepithelial Lesions (Cryotherapy)

Human Papillomavirus Clearance at 12 Months

Thailand
Universitätsklinikum Hamburg-Eppendorf

Terminated

Piecemeal Versus En Bloc Resection of Large Rectal Adenomas (PERLA)

Colorectal Adenomatous Polyp | Colorectal Adenoma With Mild Dysplasia | Colorectal Adenoma With Severe Dysplasia | Colorectal Low Grade Intraepithelial Neoplasia | Colorectal High Grade Intraepithelial Neoplasia

Germany, United Kingdom
University of Southern California
National Cancer Institute (NCI); Brooklyn ImmunoTherapeutics, LLC

Active, not recruiting

IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3

Cervical Squamous Cell Carcinoma In Situ | Vulvar High Grade Squamous Intraepithelial Lesion

United States
Fundació Institut de Recerca de l'Hospital de la...

Unknown

Conservative Management in Patients Diagnosed With Grade 2 or Grade 3 CIN

Disease Progression | Papillomavirus Infections | High-Grade Squamous Intraepithelial Lesions | Neoplasm Regression, Spontaneous

Spain
DySIS Medical Inc.

Completed

IMproved PRactice Outcomes and Value Excellence in Colposcopy (IMPROVE-COLPO)

High Grade Cervical Intraepithelial Neoplasia

United States
THEVAX Genetics Vaccine
Clinical Research Management, Inc.

Unknown

Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL

Human Papillomavirus | High-Grade Squamous Intraepithelial Lesions

United States
Frantz Viral Therapeutics, LLC
Anal Dysplasia Clinic MidWest; Laser Surgery Care, LLC

Recruiting

Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative Participants (ART-AIN IIB-2)

Anal High-grade Squamous Intraepithelial Lesion | Anal HSIL | Anal HPV Infection

United States

Clinical Trials on High Grade Squamous Intraepithelial Neoplasia

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