Clinical Trials on High-grade Gliomas

Total 5146 results

Beth Israel Deaconess Medical Center
National Cancer Institute (NCI)

Completed

Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain

Brain and Central Nervous System Tumors | Metastatic Cancer | Melanoma (Skin)

United States
Adnexus, A Bristol-Myers Squibb R&D Company

Unknown

CT-322 in Treating Patients With Recurrent Glioblastoma Multiforme and Combination Therapy With Irinotecan

Brain and Central Nervous System Tumors | Recurrent Glioblastoma Multiforme

United States
National Taiwan University Hospital

Withdrawn

Photodynamic Therapy in the Treatment of Malignant Intracranial Tumors

Glioblastoma Multiforme | Anaplastic Ependymoma | Anaplastic Astrocytomas | Anaplastic Oligodendrogliomas | Malignant Intracranial Tumors

Taiwan
Gustave Roussy, Cancer Campus, Grand Paris

Unknown

Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse

Neoplasms, Connective and Soft Tissue | Osteosarcomas | Medulloblastomas | Rhabdomyosarcomas | Ewing Tumor | Neuroblastomas

France
Mayo Clinic
National Cancer Institute (NCI)

Completed

Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma

Diffuse Large B-Cell Lymphoma | Splenic Marginal Zone Lymphoma | Mantle Cell Lymphoma | Mycosis Fungoides | Sezary Syndrome | Lymphoplasmacytic Lymphoma | Anaplastic Large Cell Lymphoma | Blastic Plasmacytoid Dendritic Cell Neoplasm | Primary Effusion Lymphoma | Adult T-Cell Leukemia/Lymphoma | Post-Transplant... and other conditions

United States
Seoul National University Hospital

Recruiting

SeOuL cOhort of Brain Tumor MONitoring Study (SOLOMON) (SOLOMON)

Pituitary Adenoma | Meningioma | Schwannoma | Brain Tumor, Primary | Gliomas Benign

Korea, Republic of
St. Jude Children's Research Hospital

Completed

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

Brain and Central Nervous System Tumors

United States, Australia, Canada
Massachusetts General Hospital
M.D. Anderson Cancer Center; National Cancer Institute (NCI)

Active, not recruiting

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

Brain Tumor | Medulloblastoma | Pineoblastoma

United States
National Cancer Institute (NCI)
NRG Oncology

Completed

Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors

Glioblastoma | Gliosarcoma | Recurrent Glioblastoma | Oligodendroglioma | Giant Cell Glioblastoma | Recurrent Brain Neoplasm

United States, Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Lonafarnib and Temozolomide in Treating Patients With Glioblastoma Multiforme That Is Recurrent or Did Not Respond to Previous Treatment With Temozolomide

Recurrent Glioblastoma | Recurrent Gliosarcoma | Malignant Supratentorial Neoplasm

United States
National Cancer Institute (NCI)
Radiation Therapy Oncology Group; American College of Radiology Imaging Network

Completed

Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma

Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Neoplasm

United States
Ann & Robert H Lurie Children's Hospital of Chicago

Completed

MicroRNAs in Patients With Neurofibromatosis Type 1

Glioma | Neurofibromatosis Type 1

United States
National Cancer Institute (NCI)

Terminated

Bortezomib in Treating Patients With Recurrent Glioma

Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor

United States
Gesellschaft fur Medizinische Innovation - Hamatologie...
Celgene; Amgen

Terminated

Therapy of Non-Hodgkin-Lymphoma by Combination of Lenalidomide + Rituximab, Dexa, High-dose ARA-C and CisP (R²-DHAP)

Diffuse Large B-cell Lymphoma (DLBCL) | Burkitt Lymphoma (BL) | Follicular Lymphoma Grade III (FL III°) | Mantle Cell Lymphoma (MCL), Blastoid Variant | Aggressive Marginal Zone Lymphoma (MZL)

Germany
PX Biosolutions

Completed

Development of Immunological Assays for the Evaluation of Tumor Antigen Specific Immunity

Cervical Cancer | Acute Myeloid Leukemia | Chronic Myeloid Leukemia | Ovarian Serous Adenocarcinoma | Undifferentiated Carcinoma of Ovary | Cervical Intraepithelial Neoplasia, Grade 3

Australia
Northwell Health

Recruiting

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

Glioma | Glioblastoma | Brain Cancer | Brain Tumor | Brain Neoplasm | Anaplastic Oligoastrocytoma | Anaplastic Astrocytoma | Brain Tumor, Recurrent | Brain Neoplasm, Malignant

United States
Abramson Cancer Center of the University of Pennsylvania

Withdrawn

Multimodality MRI and Liquid Biopsy in GBM

Glioblastoma Multiforme | Brain Tumor, Recurrent | Brain Tumor, Primary | Brain Tumor, Adult: Glioblastoma

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas

Anaplastic Oligoastrocytoma | Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor

United States
National Cancer Institute (NCI)

Completed

Sorafenib Tosylate and Temsirolimus in Treating Patients With Recurrent Glioblastoma

Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Neoplasm

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Withdrawn

EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory Glioblastoma

Adult Gliosarcoma | Recurrent Brain Neoplasm | Adult Brain Glioblastoma
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors

Brain Tumor | Central Nervous System Tumor

United States, Canada, Puerto Rico, Australia, Netherlands, Switzerland
Duke University
National Cancer Institute (NCI)

Completed

Gliadel Wafer and O6-Benzylguanine in Treating Patients With Recurrent Glioblastoma Multiforme

Recurrent Adult Brain Tumor

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

Genetically Modified Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor

United States
National Cancer Institute (NCI)
Children's Oncology Group

Recruiting

Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

Malignant Solid Neoplasm | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Ependymoma | Recurrent Hepatoblastoma | Recurrent Langerhans Cell Histiocytosis | Recurrent Malignant Germ Cell Tumor | Recurrent Malignant Glioma | Recurrent Malignant Solid Neoplasm | Recurrent... and other conditions

United States, Puerto Rico, Australia
National Cancer Institute (NCI)

Active, not recruiting

Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Hepatoblastoma | Recurrent Langerhans Cell Histiocytosis | Recurrent Malignant Glioma | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma and other conditions

United States, Puerto Rico
National Cancer Institute (NCI)

Completed

Ixabepilone in Treating Patients With Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma

Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Anaplastic Large Cell Lymphoma

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer

Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell... and other conditions

United States, Italy
Oslo University Hospital

Recruiting

Microbiota Transplant to Cancer Patients Who Have Failed Immunotherapy Using Faeces From Clinical Responders (MITRIC)

Clear Cell Renal Cell Carcinoma | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Melanoma Stage IV | Cutaneous Squamous Cell Carcinoma | MSI-High

Norway
DePuy Orthopaedics

Recruiting

Actis Total Hip System 2 Year Follow-up (Actis14014)

Osteoarthritis | Rheumatoid Arthritis | Congenital Hip Dysplasia | Traumatic Arthritis | Avascular Necrosis of the Femoral Head | Acute Traumatic Fracture of the Femoral Head or Neck | Certain Cases of Ankylosis | Non-union of Femoral Neck Fractures | Certain High Sub-Capital & Femoral Neck Fractures...

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Gestional Trophoblastic Neoplasia Ultrasound Assessment: Titanium Study (TITANIUM)

Describe Typical Gray Scale/Color Doppler Ultrasound Features of Gestational Trophoblastic Neoplasia at the US Examination | To Assess if There Are Differences at the Baseline US Scan Between Low-risk and High-risk Patients | To Identify Ultrasound Predictors of Resistance to First-line... and other conditions

Italy
Sheba Medical Center
Prof. Ronit Satchi-Fainaro, Director, Cancer Biology Research Center, Tel...

Recruiting

Crizanlizumab Alone or in Combination With Nivolumab for Glioblastoma and Melanoma With Brain Metastases (14)

Advanced Glioblastoma | MGMT-Unmethylated Glioblastoma | Metastatic Melanoma in the Central Nervous System

Israel
Gan and Lee Pharmaceuticals, USA

Completed

Evaluation of GLR2007 for Advanced Solid Tumors

Glioblastoma Multiforme | Non-small Cell Lung Cancer

United States
Kartos Therapeutics, Inc.

Completed

A Phase 1 Study Evaluating AMG 232 in Advanced Solid Tumors or Multiple Myeloma

Cancer | Glioblastoma | Multiple Myeloma | Advanced Solid Tumors | Oncology | Tumors | Advanced Malignancy | Oncology Patients

United States, France, Netherlands
Case Comprehensive Cancer Center

Terminated

Feasibility and Clinically Application of Magnetic Resonance Fingerprinting

Glioma | Brain Tumor | Neurofibromatosis Type 1

United States
National Cancer Institute (NCI)

Completed

Cediranib Maleate and Cilengitide in Treating Patients With Progressive or Recurrent Glioblastoma

Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Neoplasm

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

Brain and Central Nervous System Tumors

United States
National Institute of Neurological Disorders and...

Completed

Evaluation of Factors in Human Brain Tumors

Glioma | Glioblastoma | Brain Neoplasm | Pituitary Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Unknown

NK Cells in Cord Blood Transplantation

Recurrent Hodgkin Lymphoma | Refractory Hodgkin Lymphoma | Secondary Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Recurrent Small Lymphocytic Lymphoma | Refractory Chronic Lymphocytic Leukemia | Recurrent Non-Hodgkin Lymphoma | Refractory Non-Hodgkin Lymphoma | Recurrent Acute Lymphoblastic Leukemia and other conditions

United States
Beijing Tiantan Hospital

Recruiting

Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China (GRIPP)

Glioma | Ependymoma | Medulloblastoma | Central Nervous System Tumor, Pediatric | Germ Cell Tumor | Brain Tumor, Pediatric

China
Valent Technologies, LLC

Recruiting

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Ewing Sarcoma | Medulloblastoma | Neuroblastoma | Solid Tumors | Rhabdomyosarcoma | Hepatoblastoma

United States
SCRI Development Innovations, LLC
Novartis

Completed

INC280 Combined With Bevacizumab in Patients With Glioblastoma Multiforme

Renal Cell Carcinoma | Colorectal Cancer | Glioblastoma Multiforme | Gliosarcoma

United States
Monteris Medical

Completed

Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors

Brain Cancer | Brain Tumor | Glioblastoma Multiforme | Brain Neoplasm | Recurrent Glioblastoma Multiforme | Brain Tumor, Recurrent

United States
Chimerix

Withdrawn

A First-in-man Phase I/II Study of Oral ONC201 in Patients With Advanced Cancer

Advanced Colorectal Cancer | Advanced Glioblastoma | Advanced Triple-negative Breast Cancer | Advanced Non-small Cell Lung Cancer

United States
National Cancer Institute (NCI)

Terminated

Cilengitide and Sunitinib Malate in Treating Patients With Advanced Solid Tumors or Glioblastoma Multiforme

Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Neoplasm | Adult Solid Neoplasm

United States
Royal Free Hospital NHS Foundation Trust
Fisher and Paykel Healthcare; Royal Free Charity

Active, not recruiting

Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom

Chronic Obstructive Pulmonary Disease | Chronic Hypercapnic Respiratory Failure | Health-related Quality of Life | Obesity Hypoventilation Syndrome (OHS) | Nasal High Flow

United Kingdom
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

Metastatic Malignant Solid Neoplasm | Stage IV Colon Cancer AJCC v8 | Stage IV Rectal Cancer AJCC v8 | Stage IVA Colon Cancer AJCC v8 | Stage IVA Rectal Cancer AJCC v8 | Stage IVB Colon Cancer AJCC v8 | Stage IVB Rectal Cancer AJCC v8 | Rectal Adenocarcinoma | Colon Adenocarcinoma | High-Frequency Microsatellite... and other conditions

United States
Virginia Commonwealth University

Not yet recruiting

CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial (CBT-I in PBT)

Glioblastoma | Astrocytoma | Oligodendroglioma | Meningioma | Primary Brain Tumor | Primary Central Nervous System (CNS) Lymphoma

United States
University of Birmingham
University of Leeds; Jazz Pharmaceuticals; The Brain Tumour Charity

Recruiting

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids (ARISTOCRAT)

Glioblastoma | Brain Tumor | Cannabis | Brain Tumor, Recurrent

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield

Recruiting

Ex VIvo DEtermiNed Cancer Therapy (EVIDENT)

Melanoma | Sarcoma | Kidney Cancer | Head and Neck Cancer | Glioblastoma | Bladder Cancer

United Kingdom
National Cancer Institute (NCI)
NRG Oncology; Radiation Therapy Oncology Group

Completed

Dasatinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Neoplasm

United States, Canada, Saudi Arabia

Clinical Trials on High-grade Gliomas

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