Clinical Trials on High-risk Medications
Total 4428 results
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Mayo ClinicNational Cancer Institute (NCI)RecruitingRecurrent Hodgkin Lymphoma | Chronic Myelomonocytic Leukemia | Refractory Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Recurrent Lymphoma | Clonal Cytopenia of Undetermined Significance | High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 RearrangementsUnited States
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TCR2 TherapeuticsBristol-Myers SquibbActive, not recruitingOvarian Cancer | Non Small Cell Lung Cancer | Mesothelioma | Mesothelioma, Malignant | Cholangiocarcinoma | Non Small Cell Lung Cancer Metastatic | Mesotheliomas Pleural | Mesothelioma Peritoneum | Mesothelioma; Pleura | Cholangiocarcinoma Recurrent | High Grade Ovarian Serous AdenocarcinomaUnited States, Canada
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THERAPIM PTY LTDNovotech (Australia) Pty LimitedTerminatedOvarian Cancer | Fallopian Tube Cancer | Primary Peritoneal Carcinoma | High Grade Serious or Endometrioid Carcinoma of the Ovary, Fallopian Tube, or Primary Peritoneal CancerAustralia
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Universitaire Ziekenhuizen KU LeuvenNorwegian Institute of Public Health; KU Leuven; University Ghent; SciensanoCompletedLiver Diseases | Cardiovascular Diseases | Sexually Transmitted Diseases | Hypertension | Obesity | Diabetes Mellitus | Fatigue | Chronic Kidney Diseases | Thyroid Diseases | Rheumatoid Arthritis | Diarrhea | Anemia | Acute Coronary Syndrome | Gout | Lung Embolism | Medication Monitoring | General Check-upBelgium
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IDP Discovery Pharma S.L.RecruitingChronic Lymphocytic Leukemia (CLL) | Diffuse Large B-Cell Lymphoma, Not Otherwise Specified | Multiple Myeloma (MM) | High Grade B-Cell Lymphoma, Not Otherwise Specified | Double Hit Lymphoma | Triple Hit LymphomaSpain
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Ralph NULL SalloumChildren's Hospital Medical Center, CincinnatiRecruitingHigh Grade Glioma | Medulloblastoma | Meningioma | Anaplastic Ependymoma | Recurrent Malignant Glioma | Recurrent Medulloblastoma | Refractory Malignant Glioma | Refractory Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Primary Central Nervous System Neoplasm | Refractory Primary... and other conditionsUnited States
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National Cancer Institute (NCI)RecruitingSmall Cell Carcinoma of the Bladder | High Grade Neuroendocrine Tumors of the Urinary TractUnited States
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Wake Forest University Health SciencesNational Heart, Lung, and Blood Institute (NHLBI)RecruitingKidney Diseases | Hypertension | Pediatric Obesity | Proteinuria | Albuminuria | Kidney Injury | Blood Pressure Disorders | Autonomic Dysfunction | Pediatric Kidney Disease | Left Ventricular Dysfunction | Left Ventricular Hypertrophy | Kidney Dysfunction | Autonomic Imbalance | Left Ventricular Diastolic Dysfunction and other conditionsUnited States
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City of Hope Medical CenterCompletedEsophageal Cancer | Esophageal Neoplasms | Gastroesophageal Reflux | Barrett Esophagus | Esophageal Adenocarcinoma | Reflux Disease | Barretts Esophagus With High Grade Dysplasia | Barrett Adenocarcinoma | Esophagus Cancer | Barrett's Esophagus Without Dysplasia | Barretts Esophagus With Dysplasia | Esophagus... and other conditionsUnited States
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Bristol-Myers SquibbNektar TherapeuticsTerminatedEwing Sarcoma | Ependymoma | Medulloblastoma | Neuroblastoma | Rhabdomyosarcoma | High-grade Glioma | Leukemia and Lymphoma | Miscellaneous Brain Tumors | Miscellaneous Solid Tumors | Relapsed, Refractory Malignant NeoplasmsUnited States, Australia, France, Germany, Italy, Spain
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National Cancer Institute (NCI)NRG OncologyRecruitingOvarian Endometrioid Adenocarcinoma | Endometrial Carcinoma | Endometrial Clear Cell Adenocarcinoma | Endometrial Endometrioid Adenocarcinoma | Ovarian Clear Cell Adenocarcinoma | Ovarian High Grade Serous Adenocarcinoma | Platinum-Resistant Ovarian Carcinoma | Endometrial Low Grade Endometrioid... and other conditionsUnited States
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Hugo W. Moser Research Institute at Kennedy Krieger...RecruitingNeurodegenerative Diseases | Ataxia | Cerebellar Ataxia | Leukodystrophy | Adrenomyeloneuropathy | LBSL | Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation | Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)United States
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Affiliated Hospital to Academy of Military Medical...Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Peking...RecruitingAge Range ≥16 Years, Gender Unlimited | Histopathology Confirmed Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma | Received Prior First-line Chemotherapy for DLBCL or HGBL, Failed to Reach CR for Four Cycles, or Relapsed | At Least One Positive Lesion According to the 2014... and other conditionsChina
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Cancer Research UKActive, not recruitinga. Colorectal Cancer | b. High Grade Serous Ovarian Cancer | c. Non Small-cell Lung Cancer (Squamous Cell Variant) | d. Squamous Carcinoma of the Oesophagus | e. Squamous Carcinoma of the Head and Neck (HPV Negative) | f. Urothelial Cancer | g. Breast Cancer (Triple Negative Type) | h. Pancreatic...United Kingdom
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Nova Scotia Health AuthorityUniversity Health Network, TorontoTerminatedOsteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Ankylosing Spondylitis | Post-traumatic; Arthrosis | Congenital Dysplasia of the Hip | Injury of Hip and Thigh
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National Cancer Institute (NCI)CompletedRecurrent Childhood Rhabdomyosarcoma | Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Dermatofibrosarcoma Protuberans | Previously Treated Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Adult Rhabdomyosarcoma | Adult Angiosarcoma and other conditionsUnited States
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Incyte Biosciences International SàrlCompletedCervical Cancer | Hepatocellular Carcinoma | Esophageal Cancer | Ovarian Cancer | Mesothelioma | Non-small Cell Lung Cancer (NSCLC) | Urothelial Carcinoma | Merkel Cell Carcinoma | Diffuse Large B-cell Lymphoma | Triple-negative Breast Cancer | Renal Cell Carcinoma (RCC) | Small Cell Lung Cancer (SCLC) | Squamous... and other conditionsUnited States
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Pediatric Brain Tumor ConsortiumNational Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center; American...Active, not recruitingGlioblastoma Multiforme | Medulloblastoma | Low-Grade Astrocytoma, Nos | Anaplastic Astrocytoma | Anaplastic Oligodendroglioma | Pilocytic Astrocytoma | Pineoblastoma | Supratentorial Primitive Neuroectodermal Tumor | Atypical Teratoid/Rhabdoid Tumor | Choroid Plexus Carcinoma | High-grade Astrocytoma NOS | CNS... and other conditionsUnited States
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St. Jude Children's Research HospitalRecruitingHodgkin Lymphoma | Osteosarcoma | Ewing Sarcoma | Ependymoma | Medulloblastoma | Non Hodgkin Lymphoma | Neuroblastoma | Craniopharyngioma | Rhabdomyosarcoma | Other | Brain Stem Glioma | Brain Tumors and/or Solid Tumors Including | High Grade CNS Tumors | Low Grade CNS TumorsUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)WithdrawnRecurrent B-Cell Non-Hodgkin Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Recurrent T-Cell Non-Hodgkin Lymphoma | Recurrent High Grade B-Cell Lymphoma | Recurrent Aggressive Non-Hodgkin Lymphoma | Recurrent Burkitt Lymphoma | Recurrent Transformed B-Cell Non-Hodgkin LymphomaUnited States
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SynthekineRecruitingRenal Cell Carcinoma | Cervical Cancer | Gastric Cancer | Non Small Cell Lung Cancer | Advanced Solid Tumor | Head and Neck Squamous Cell Carcinoma | Urothelial Carcinoma | Microsatellite Instability High | Malignant Melanoma | GastroEsophageal Cancer | Mismatch Repair DeficiencyUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingRecurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Uterine Corpus Carcinoma | Endometrial Adenocarcinoma | Recurrent Breast Carcinoma | Estrogen Receptor Negative | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative Breast... and other conditionsUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingCervical Intraepithelial Neoplasia | Cervical Adenocarcinoma | Cervical Squamous Cell Carcinoma, Not Otherwise Specified | Vaginal Adenocarcinoma | Vulvar Intraepithelial Neoplasia | Stage I Cervical Cancer AJCC v8 | Stage IA Cervical Cancer AJCC v8 | Stage IA1 Cervical Cancer AJCC v8 | Stage IA2 Cervical... and other conditionsUnited States
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National Cancer Institute (NCI)CompletedUnspecified Childhood Solid Tumor, Protocol Specific | Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Recurrent Childhood Grade III Lymphomatoid Granulomatosis | Recurrent Childhood Large Cell Lymphoma | Recurrent Childhood Lymphoblastic Lymphoma | Recurrent Childhood Small... and other conditionsUnited States
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University of WashingtonMinnesota Ovarian Cancer AllianceTerminatedStage III Ovarian Cancer AJCC v8 | Stage IIIA Ovarian Cancer AJCC v8 | Stage IIIA1 Ovarian Cancer AJCC v8 | Stage IIIA2 Ovarian Cancer AJCC v8 | Stage IIIB Ovarian Cancer AJCC v8 | Stage IIIC Ovarian Cancer AJCC v8 | Stage IV Ovarian Cancer AJCC v8 | Stage IVA Ovarian Cancer AJCC v8 | Stage IVB Ovarian... and other conditionsUnited States
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Inovio PharmaceuticalsCompletedAnal NeoplasmUnited States, Canada
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Mayo ClinicRecruitingHematologic Neoplasms | Myeloid Malignancy | Cytopenia | Bone Marrow Failure Syndrome | Clonal Cytopenia of Undetermined Significance | Clonal Hematopoiesis of Indeterminate Potential | Low Risk Myelodysplastic Syndrome | Inherited Bone Marrow Failure Syndrome | Clonal Expansion | Hereditary Neoplastic... and other conditionsUnited States
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7 Hills Pharma, LLCRecruitingMelanoma | Kidney Cancer | Renal Cell Carcinoma | Hepatocellular Carcinoma | Colorectal Cancer | NSCLC | Non Small Cell Lung Cancer | Skin Cancer | Metastasis | Advanced Solid Tumor | Advanced Cancer | Renal Cell Cancer | Hepatocellular Cancer | Mismatch Repair Deficiency | Pleural Mesothelioma | MSI-High | Anaplastic Lymphoma... and other conditionsUnited States
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Molecular Templates, Inc.RecruitingMelanoma | Renal Cell Carcinoma | Cervical Cancer | Hepatocellular Carcinoma | Non Small Cell Lung Cancer | Mesothelioma | Squamous Cell Carcinoma of Head and Neck | Esophageal Squamous Cell Carcinoma | Urothelial Carcinoma | Microsatellite Instability High | Mismatch Repair DeficiencyUnited States
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Drexel UniversityMercy HealthNot yet recruitingQuality of Life | Hypertension | Obesity | Body Weight | Cognitive Impairment | Dyslipidemias | Dementia | Alzheimer Disease | Blood Pressure | Aging | Mild Cognitive Impairment | Lewy Body Disease | Frontotemporal Dementia | Dementia, Vascular | Obesity, Abdominal | Blood Glucose, High | Blood Glucose, Low
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Massachusetts General HospitalJohns Hopkins University; M.D. Anderson Cancer Center; National Cancer Institute... and other collaboratorsRecruitingOvarian Neoplasms | Fallopian Tube Neoplasms | Stage III Ovarian Cancer AJCC v8 | Stage IIIA Ovarian Cancer AJCC v8 | Stage IIIA1 Ovarian Cancer AJCC v8 | Stage IIIA2 Ovarian Cancer AJCC v8 | Stage IIIB Ovarian Cancer AJCC v8 | Stage IIIC Ovarian Cancer AJCC v8 | Stage IV Ovarian Cancer AJCC v8 | Stage... and other conditionsUnited States
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National Cancer Institute (NCI)Active, not recruitingOvarian Endometrioid Adenocarcinoma | Fallopian Tube Carcinoma | Triple-Negative Breast Carcinoma | Ovarian Serous Adenocarcinoma | Primary Peritoneal Serous Adenocarcinoma | Ovarian High Grade Serous Adenocarcinoma | Ovarian Serous Surface Papillary AdenocarcinomaUnited States
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Incyte CorporationMerck Sharp & Dohme LLCCompletedMelanoma | Lymphoma | Head and Neck Cancer | Gastric Cancer | Ovarian Cancer | Hepatocellular Carcinoma (HCC) | Lung Cancer | Bladder Cancer | Endometrial Cancer | Solid Tumors | Renal Cell Carcinoma (RCC) | Triple Negative Breast Cancer (TNBC) | UC (Urothelial Cancer) | Microsatellite-instability (MSI) High Colorectal...United States
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Medical College of WisconsinNational Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaboratorsCompletedChronic Granulomatous Disease | Hemophagocytic Lymphohistiocytosis | Leukocyte Adhesion Deficiency | Chronic Active Epstein-Barr Virus Infection | HIGM-1 | IPEXUnited States, Canada
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NextCure, Inc.Merck Sharp & Dohme LLCRecruitingCervical Cancer | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Endometrial Cancer | Colo-rectal Cancer | Advanced or Metastatic Solid Tumors | Microsatellite Instability Low | Microsatellite Instability High | Microsatellite Stable | Head Neck CancerUnited States
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Craig L Slingluff, JrTheraclionActive, not recruitingMelanoma | Cervical Cancer | Breast Cancer | Hepatocellular Carcinoma | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Non Small Cell Lung Cancer | Small-cell Lung Cancer | Urothelial Carcinoma | Merkel Cell Carcinoma | Microsatellite Instability High | Squamous Cell CancerUnited States
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Dana-Farber Cancer InstituteBristol-Myers SquibbActive, not recruitingAdrenocortical Carcinoma | Penile Cancer | Genitourinary Cancer | Non-urothelial Bladder | Non-urothelial Upper Tract | Non-adenocarcinoma Prostate Cancer | Refractory Germ-cell | High Grade Neuroendocrine Carcinoma/Small Cell CarcinomaUnited States
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National Cancer Institute (NCI)CompletedRecurrent Childhood Ependymoma | Recurrent Neuroblastoma | Recurrent Osteosarcoma | Recurrent Childhood Rhabdomyosarcoma | Recurrent Renal Cell Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Recurrent Childhood Soft Tissue Sarcoma | Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal... and other conditionsUnited States
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Erik MittraNational Cancer Institute (NCI)TerminatedUntreated Childhood Brain Stem Glioma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Diffuse Astrocytoma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Adult Oligodendroglioma | Adult Pilocytic Astrocytoma | Adult Pineal Gland Astrocytoma and other conditionsUnited States
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23andMe, Inc.Active, not recruitingClear Cell Renal Cell Carcinoma | Fallopian Tube Cancer | Solid Tumor | Neuroendocrine Tumors | Epithelial Ovarian Cancer | Primary Peritoneal Carcinoma | Extensive-stage Small-cell Lung Cancer | MSI-H Cancer | Cancer With A High Tumor Mutational BurdenUnited States, Canada
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National Cancer Institute (NCI)CompletedUnspecified Childhood Solid Tumor, Protocol Specific | Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Childhood Chronic Myelogenous Leukemia | Recurrent Childhood Acute Lymphoblastic Leukemia | Recurrent Childhood Acute Myeloid Leukemia | Relapsing Chronic Myelogenous Leukemia and other conditionsUnited States
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Universitair Ziekenhuis BrusselKom Op Tegen Kanker; Agentschap voor Innovatie door Wetenschap en Technologie...RecruitingGastric Cancer | Colorectal Cancer | Prostate Cancer | Non Small Cell Lung Cancer | Cholangiocarcinoma | Endometrial Cancer | Urothelial Carcinoma | Biliary Tract Cancer | Locally Advanced Breast Cancer | Cancer of Pancreas | Uterine Cancer | Salivary Gland Cancer | Metastatic Breast Carcinoma | Solid Tumor With Intermediate...Belgium
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National Cancer Institute (NCI)Active, not recruitingRecurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Stage IV Fallopian Tube Cancer AJCC v6 and v7 | Stage IV Ovarian Cancer AJCC v6 and v7 | Stage IV Primary Peritoneal Cancer AJCC v7 | Ovarian High Grade Serous Adenocarcinoma | Platinum-Sensitive... and other conditionsUnited States
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University Hospital Southampton NHS Foundation...University of SouthamptonActive, not recruitingCervical Cancer | Fallopian Tube Neoplasms | Ovarian Cancer | Fallopian Tube Cancer | Breast Neoplasm | Endometrial Neoplasms | Vulvar Cancer | Vulvar Neoplasms | Endometrial Cancer | Diffuse Large B Cell Lymphoma | Ovarian Neoplasm | Breast Cancer Female | Primary Peritoneal Carcinoma | NonHodgkin Lymphoma | Cervical... and other conditionsUnited Kingdom
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VA Office of Research and DevelopmentCompletedDepression | Insomnia | Dementia | Fibromyalgia | Anxiety | Chronic Low Back Pain | Lumbar Spinal Stenosis | Myofascial Pain Syndrome | Sacroiliac Joint Pain | Hip Ostearthritis | Maladaptive Coping | Lateral Hip and Thigh Pain | Recent Leg Length DiscrepancyUnited States
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AstraZenecaRecruitingCervical Cancer | Breast Cancer | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Prostate Cancer | Bladder Cancer | Endometrial Cancer | Non-small Cell Lung Cancer | Biliary Cancer | Additional Indications Below for Module 4 and 5 | Small Cell Lung Cancer Only in Module 5Canada, Spain, China, Korea, Republic of, Italy, Poland, United States, Australia, United Kingdom, Japan, Hungary, Russian Federation, Czechia
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OncoC4, Inc.Avance Clinical; OncoC4 AU Pty LtdRecruitingMelanoma | Renal Cell Carcinoma | Cervical Cancer | Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Esophageal Cancer | Fallopian Tube Cancer | Non Small Cell Lung Cancer | Bile Duct Cancer | Bladder Cancer | Endometrial Cancer | Head and Neck Squamous Cell Carcinoma | Anal Cancer | Primary Peritoneal... and other conditionsAustralia
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University Hospital Southampton NHS Foundation...CompletedFollicular Lymphoma | Burkitt Lymphoma | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Peripheral T-cell Lymphoma | Diffuse Large B Cell Lymphoma | Classical Hodgkin Lymphoma | Small Lymphocytic Lymphoma | High-grade B-cell Lymphoma | Nodular Lymphocyte... and other conditionsUnited Kingdom
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ProfoundBio US Co.RecruitingOvarian Cancer | Fallopian Tube Cancer | Mesothelioma | Triple Negative Breast Cancer | Endometrial Cancer | Non-small Cell Lung Cancer | Primary Peritoneal Carcinoma | Breast Adenocarcinoma | High Grade Epithelial Ovarian Cancer | Hormone Receptor-positive/Her2 Negative Breast CancerUnited States, China
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M.D. Anderson Cancer CenterBristol-Myers Squibb; National Cancer Institute (NCI); Iovance BiotherapeuticsActive, not recruitingMalignant Solid Neoplasm | Metastatic Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Platinum-Resistant Ovarian Carcinoma | Metastatic Pancreatic Ductal Adenocarcinoma | Metastatic Ovarian Carcinoma and other conditionsUnited States