- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03000192
HORIZONS: Understanding the Impact of Cancer Diagnosis and Treatment on Everyday Life
HORIZONS: a Cohort Study to Explore Recovery of Health and Well-being in Adults Diagnosed With Cancer
Study Overview
Status
Conditions
- Cervical Cancer
- Fallopian Tube Neoplasms
- Ovarian Cancer
- Fallopian Tube Cancer
- Breast Neoplasm
- Endometrial Neoplasms
- Vulvar Cancer
- Vulvar Neoplasms
- Endometrial Cancer
- Diffuse Large B Cell Lymphoma
- Ovarian Neoplasm
- Breast Cancer Female
- Primary Peritoneal Carcinoma
- NonHodgkin Lymphoma
- Cervical Neoplasm
- Non-Hodgkin's Lymphoma, Adult High Grade
- Non-Hodgkin's B-cell Lymphoma
- Diffuse Large Cell Lymphoma, Adult
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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Aberystwyth, United Kingdom
- Bronglais General Hospital
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Airdrie, United Kingdom
- Monklands Hospital
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Antrim, United Kingdom
- Antrim Hospital
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Ashford, United Kingdom
- William Harvey Hospital
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Ashington, United Kingdom
- Wansbeck General Hospital
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Ashton, United Kingdom
- Tameside Hospital
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Ayr, United Kingdom
- University Hospital Ayr
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Bangor, United Kingdom
- Ysbyty Gwynedd
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Basildon, United Kingdom
- Basildon Hospital
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Basingstoke, United Kingdom
- Basingstoke and North Hampshire Hospital
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Bath, United Kingdom
- Royal United Hospital
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Bedford, United Kingdom
- Bedford Hospital
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Birkenhead, United Kingdom
- Arrowe Park Hospital
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Birkenhead, United Kingdom
- Clatterbridge Hospital
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Birmingham, United Kingdom
- Birmingham City Hospital
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Blackburn, United Kingdom
- Royal Blackburn Hospital
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Boston, United Kingdom
- Pilgrim Hospital
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Bradford, United Kingdom
- Bradford Hospital
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Brighton, United Kingdom
- Royal Sussex County Hospital
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Bristol, United Kingdom
- Bristol Royal Infirmary, University Hospital Bristol
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Burnley, United Kingdom
- Burnley General Teaching Hospital
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Canterbury, United Kingdom
- Kent and Canterbury Hospital
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Cardiff, United Kingdom
- University Hospital of Wales
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Carlisle, United Kingdom
- North Cumbria University Hospital
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Carshalton, United Kingdom
- Epsom & St Helier Hospital
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Chelsea, United Kingdom
- The Royal Marsden Hospital
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Colchester, United Kingdom
- Colchester General Hospital
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Cosham, United Kingdom
- Queen Alexandra Hospital
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Cramlington, United Kingdom
- Northumbria Specialist Emergency Care Hospital
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Crewe, United Kingdom
- Leighton Hospital
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Crumpsall, United Kingdom
- North Manchester General Hospital
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Dartford, United Kingdom
- Darent Valley Hospital
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Derby, United Kingdom
- Royal Derby Hospital
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Dudley, United Kingdom
- Russells Hall Hospital
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Dumfries, United Kingdom
- Dumfries and Galloway Royal Infirmary
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Dundee, United Kingdom
- Ninewells Hospital
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Dundonald, United Kingdom
- Ulster Hospital
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East Kilbride, United Kingdom
- Hairmyres Hospital
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Eastbourne, United Kingdom
- Eastbourne District General Hospital
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Edinburgh, United Kingdom
- Western General Hospital
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Epping, United Kingdom
- Whipps Cross University Hospital
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Gateshead, United Kingdom
- Queen Elizabeth Hospital
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Gillingham, United Kingdom
- Medway Maritime Hospital
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Glasgow, United Kingdom
- Beatson West Scotland Cancer Centre
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Great Yarmouth, United Kingdom
- James Paget University Hospital
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Guildford, United Kingdom
- Royal Surrey County Hospital
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Halifax, United Kingdom
- Calderdale Royal Hospital
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Hammersmith, United Kingdom
- Charing Cross Hospital
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Hammersmith, United Kingdom
- Hammersmith Hospital
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Harrow, United Kingdom
- Northwick Park Hospital
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Hastings, United Kingdom
- Conquest Hospital
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Haverfordwest, United Kingdom
- Withybush District General Hospital
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Headington, United Kingdom
- Churchill Hospital
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Hexham, United Kingdom
- Hexham General Hospital
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Hillingdon, United Kingdom
- Hillingdon Hospital
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Huddersfield, United Kingdom
- Huddersfield Royal Infirmary
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Inverness, United Kingdom
- Raigmore Hospital
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Ipswich, United Kingdom
- Ipswich Hospital
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Isleworth, United Kingdom
- West Middlesex University Hospital
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Kilmarnock, United Kingdom
- University Hospital Crosshouse
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King's Lynn, United Kingdom
- Queen Elizabeth Hospital
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Leeds, United Kingdom
- St James' Hospital
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Lincoln, United Kingdom
- Lincoln County Hospital
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Livingston, United Kingdom
- St John's Hospital
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Llandough, United Kingdom
- University Hospital Llandough
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Llantrisant, United Kingdom
- Royal Glamorgan Hospital
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London, United Kingdom
- University College London Hospital
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London, United Kingdom
- St Bartholomew's Hospital
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Macclesfield, United Kingdom
- Macclesfield Hospital
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Maidstone, United Kingdom
- Maidstone Hospital
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Manchester, United Kingdom
- Manchester Royal Infirmary
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Manchester, United Kingdom
- The Christie Hospital
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Manchester, United Kingdom
- Saint Mary's Hospital
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Margate, United Kingdom
- Queen Elizabeth the Queen Mother Hospital
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Melrose, United Kingdom
- Borders General Hospital
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Newcastle, United Kingdom
- Newcastle Freeman Hospital
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North Shields, United Kingdom
- North Tyneside General Hospital
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Norwich, United Kingdom
- Norwich University Hospital
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Nottingham, United Kingdom
- Nottingham University Hospitals NHS Trust - City Hospital campus
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Oldham, United Kingdom
- Royal Oldham Hospital
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Peterborough, United Kingdom
- Peterborough City Hospital
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Plymouth, United Kingdom
- Derriford Hospital
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Preston, United Kingdom
- Royal Preston Hospital
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Redhill, United Kingdom
- East Surrey Hospital
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Rhyl, United Kingdom
- Ysbyty Glan Clwyd Hospital
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Salford, United Kingdom
- Salford Royal
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Salisbury, United Kingdom
- Salisbury District Hospital
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Scarborough, United Kingdom
- Scarborough Hospital
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Sheffield, United Kingdom
- Royal Hallamshire Hospital
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Slough, United Kingdom
- Wexham Park Hospital
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Southall, United Kingdom
- Ealing Hospital
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Southampton, United Kingdom
- Southampton General Hospital, University Hospital Southampton
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Southend, United Kingdom
- Southend University Hospital
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St Albans, United Kingdom
- St Albans City Hospital
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Stoke-on-Trent, United Kingdom
- Royal Stoke University Hospital
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Sutton, United Kingdom
- St Helier Hospital
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Sutton, United Kingdom
- The Royal Marsden Hospital (Surrey)
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Sutton In Ashfield, United Kingdom
- King's Mill Hospital
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Taunton, United Kingdom
- Musgrove Park Hospital
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Tooting, United Kingdom
- St George's Hospital
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Truro, United Kingdom
- Royal Cornwall Hospital
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Watford, United Kingdom
- Watford General Hospital
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Wednesfield, United Kingdom
- New Cross Hospital
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West Bromwich, United Kingdom
- Sandwell General Hospital
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Weston-super-Mare, United Kingdom
- Weston General Hospital
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Whitehaven, United Kingdom
- West Cumberland Hospital
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Winchester, United Kingdom
- Royal Hampshire County Hospital
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Wishaw, United Kingdom
- University Hospital Wishaw
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Wrexham, United Kingdom
- Wrexham Maelor Hospital
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Wythenshawe, United Kingdom
- Wythenshawe Hospital
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York, United Kingdom
- York Teaching Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
OVERALL ELIGIBILITY CRITERIA:
Inclusion Criteria:
- Have a new diagnosis of one of the selected cancer types determined through clinical assessment, cytology, histology or imaging or
- Have new / second primary cancer at a site previously treated for cancer
- Be awaiting primary curative intent treatment, including neoadjuvant treatment
- Be ≥16 years old.
- Be able to complete questionnaires in English
- Be able to provide written, informed consent
Exclusion Criteria:
- They do not have one of the specified cancer types
- Disease is recurrence / progression (either locally advanced or metastatic) at an existing cancer site
- They are having treatment for a potentially curative recurrence of disease e.g. locally advanced disease (i.e. they have been previously treated for the same cancer)
- They have metastatic disease from a cancer at another site (Previous diagnosis of cancer at any other site would not be grounds for exclusion unless disease was metastatic)
- They have synchronous primary cancers involving two or more of the HORIZONS specified cancer types (Please exclude synchronous gynaecological primary cancers, synchronous breast and gynaecological primary cancers, synchronous breast and non-Hodgkin's lymphoma primary cancers and synchronous non-Hodgkin's lymphoma and gynaecological cancers)
COHORT-SPECIFIC ELIGIBILITY CRITERIA:
BREAST CANCER COHORT
Inclusion:
- Women aged under 50 years old
- Stage 1, 2 or 3 breast cancer
- Have no distant metastases
- Patients due to undergo neoadjuvant treatment should be approached before this starts
For those whose core biopsy shows ductal carcinoma in situ (DCIS) only but post-excision biopsy pathology confirms invasive cancer, approach should be made as soon as possible following diagnosis and completion of the baseline questionnaire should be prior to the start of adjuvant treatment
Exclusion:
- Confirmed diagnosis of CIS (ductal or lobular) only
- Men
NON-HODGKIN LYMPHOMA COHORT
Inclusion:
- Any pathological diagnosis of Diffuse Large B Cell lymphoma (DLBCL) including;
- Secondary transforming or transformed DLBCL which has transformed from an indolent/low grade lymphoma (most commonly Follicular Lymphoma) as long as the low grade lymphoma was not treated and this is a recent transformation for which curative intent treatment has not yet started.
- Rare sub-types such as T cell rich Large B Cell Lymphoma and primary mediastinal (thymic) large B-cell lymphoma
Patients who have started steroid pre-phase treatment are eligible for approach before the start of chemotherapy.
GYNAECOLOGICAL CANCERS COHORT
ALL GYNAECOLOGICAL CANCERS
Gynaecological Cancer Exclusion criteria:
Synchronous gynaecological primary cancers. For example, synchronous ovarian and endometrial primary cancers.
OVARIAN CANCER SUB-COHORT
Ovarian Inclusion criteria:
Have a confirmed diagnosis either from cytology, histology, imaging or diagnostic primary surgery of either;
- Epithelial ovarian cancer including primary peritoneal cancer; fallopian tube cancer
- Ovarian carcinosarcoma
- Granulosa tumour of the ovary
- Patients should be entered prior to any treatment including surgery. However, where the diagnosis is only made at the time of surgery, these women may enter the study following surgery. Approach should be made as soon as possible following diagnosis and completion of the baseline questionnaire should occur prior to the start of adjuvant treatment.
- FIGO Stages: IA, IB, IC1, IC2, IC3, IIA, IIB, IIIA1
Ovarian Exclusion criteria:
- Borderline ovarian cancer
- Germ cell tumour
- Sarcoma
ENDOMETRIAL CANCER SUB-COHORT
Endometrial Inclusion criteria:
Have a confirmed diagnosis either from cytology, histology or imaging of;
- endometrial cancer
- endometrial carcinosarcoma
Patients should be entered prior to any treatment including surgery. However, where the diagnosis is only made at the time of surgery, these women may enter the study following surgery. Approach should be made as soon as possible following diagnosis and completion of the baseline questionnaire should occur prior to the start of adjuvant treatment.
- International Federation of Gynecology and Obstetrics (FIGO) Stages: IA, IB, II, IIIA, IIIB, IIIC1, IIIC2
Endometrial Exclusion criteria
- Choriocarcinoma
- Germ cell tumour
- Sarcoma
CERVICAL CANCER SUB-COHORT
Cervical Inclusion criteria:
Have a confirmed diagnosis either from cytology, histology or imaging of;
- Cervical cancer FIGO Stages: IA2, IB1, IB2, IIA1, IIA2, IIB, IIIA, IIIB
Cervical Exclusion criteria:
- FIGO stage IA1
- Cervical carcinoma in situ (CIS)
- Sarcoma
- Small cell cancer of the cervix
VULVAL CANCER SUB-COHORT
Vulval Inclusion criteria:
Have a confirmed diagnosis either from clinical assessment, cytology, histology, imaging of;
- Vulval cancer
- FIGO stages IA, IB, II, IIIA, IIIB, IIIC
Vulval Exclusion criteria:
- Basal cell carcinoma
- Melanoma
- Sarcoma
- Vulval intra-epithelial neoplasia (VIN)
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
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Breast cancer
Women aged <50 years
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Gynaecological cancers
Includes: cervical cancer, endometrial cancer, ovarian cancer, fallopian tube cancer, primary peritoneal cancer and vulval cancer
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Non-Hodgkin Lymphoma
Diffuse large B cell
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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Quality of Life in Adult Cancer Survivors (QLACS)
Time Frame: Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Primary outcome measure which assesses the quality of life in adult cancer survivors. It is comprised of 12 domains regarding cancer survivorship: generic (pain, fatigue, positive and negative feelings, cognitive and sexual problems, social avoidance) and cancer-specific (financial problems, family distress, recurrence distress, appearance concerns, benefits from cancer). Changes will be assessed at the following time-points:
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Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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EuroQoL 5 Dimensions 5 Levels (EQ-5D-5L) & Visual Analogue Scale (VAS)
Time Frame: Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Assesses health status for clinical and economic appraisal.
Includes five domains: mobility, self-care, usual activities, pain/discomfort, anxiety/depression and five levels of severity.
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Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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EORTC-QLQ-C30
Time Frame: Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Captures the impact of cancer and its treatment with 30 items assessing function (physical, role, cognitive, emotional, and social), symptoms (e.g.
fatigue, pain, and nausea and vomiting) as well as global health and QoL.
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Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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EORTC Site Specific Modules: EORTC-QLQ -BR23, -CX24, -EN24, -NHL-HG29, -OV28, VU34
Time Frame: Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Site-specific modules included to capture disease-specific consequences for Breast, Cervical, Endometrial, Ovarian and Vulval cancers, as well as High Grade Non-Hodgkin's Lymphoma (NHL).
Modules will be supplemented with additional items from the EORTC item library to assess consequences not otherwise captured.
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Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Hospital Anxiety and Depression Scale (HADS)
Time Frame: Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Comprises of 14 items with two 7-item subscales assessing anxiety and depression symptoms.
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Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Medical Outcomes Study Social Support Survey (MOS-SSS)
Time Frame: Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Assesses the level of social support available and covers 4 domains (emotional/informational, tangible, affectionate support and positive social interaction).
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Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Self-efficacy for Managing Chronic Disease (SEMCD) scale & Cancer Survivors' Self-Efficacy Scale (CS-SES)
Time Frame: Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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SEMCD evaluates self-efficacy among patients with chronic medical conditions; whilst the CS-SES examines self-efficacy with reference to cancer-specific issues.
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Change from Baseline (pre-treatment) up to 5 years [Anticipated]
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Collaborators and Investigators
Collaborators
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Skin Diseases
- Immune System Diseases
- Neoplasms by Histologic Type
- Lymphoproliferative Disorders
- Lymphatic Diseases
- Immunoproliferative Disorders
- Urogenital Neoplasms
- Neoplasms by Site
- Uterine Neoplasms
- Genital Neoplasms, Female
- Uterine Cervical Diseases
- Uterine Diseases
- Endocrine System Diseases
- Ovarian Diseases
- Adnexal Diseases
- Gonadal Disorders
- Endocrine Gland Neoplasms
- Breast Diseases
- Fallopian Tube Diseases
- Vulvar Diseases
- Neoplasms
- Lymphoma
- Lymphoma, B-Cell
- Lymphoma, Large B-Cell, Diffuse
- Uterine Cervical Neoplasms
- Breast Neoplasms
- Lymphoma, Non-Hodgkin
- Ovarian Neoplasms
- Fallopian Tube Neoplasms
- Endometrial Neoplasms
- Vulvar Neoplasms
Other Study ID Numbers
- RHM CAN1199
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
We encourage and facilitate data sharing by researchers from all disciplines.
More detail can be found on our website: http://horizons-hub.org.uk/access_data.html
If you have further questions about this process please contact us on 023 8059 6885 or msrg@soton.ac.uk.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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