Clinical Trials on Homozygous Familial Hypercholesterolemia HoFH

Total 234 results

Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

Familial Hypercholesterolemia

United States
Region Örebro County

Recruiting

Genetic Causes of Familial Hypercholesterolemia

Familial Hypercholesterolemia

Sweden
The Familial Hypercholesterolemia Foundation

Recruiting

Study of Awareness and Detection of Familial Hypercholesterolemia (CASCADE-FH)

Hypercholesterolemia

United States
B. Braun Medical Inc.

Completed

Low-Density Lipoprotein (LDL) Apheresis Using H.E.L.P. Therapy (Secura)

Familial Hypercholesterolemia
Hospital do Coracao
University of Sao Paulo; National Institute of Cardiology, Laranjeiras, Brazil

Active, not recruiting

Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Patients With Familial Hypercholesterolemia (DICA-HF)

Familial Hypercholesterolemia

Brazil
Center for Primary Care and Public Health (Unisante)...
Swiss Heart Foundation

Completed

Cascade Genetic Testing of Familial Hypercholesterolemia (CATCH)

Familial Hypercholesterolemia

Switzerland
Merck Sharp & Dohme LLC

Completed

A Study of the Efficacy and Safety of MK-0616 (Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-008)

Hypercholesterolemia | Familial Hypercholesterolemia

United States, Germany, Japan, Korea, Republic of, Mexico, Norway, Turkey, United Kingdom
Northwestern University
University of Pennsylvania; Family Heart Foundation

Completed

Equitable Implementation of Cascade Screening for Familial Hypercholesterolemia

Familial Hypercholesterolemia

United States
Sanofi
Regeneron Pharmaceuticals

Completed

An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia

Hypercholesterolemia

Slovenia, Taiwan, Russian Federation, Canada, Netherlands, Brazil, Denmark, Mexico, Spain, Turkey
Hellenic College of Treatment of Atherosclerosis

Unknown

Greek Registry - Familial Hypercholesterolaemia (GRegistry-FH)

Familial Hypercholesterolemia

Greece
Ankara Yildirim Beyazıt University

Completed

Treatment Rates and Compliance to Treatment in Patients With Familial Hypercholesterolemia

Familial Hypercholesterolemia
French Cardiology Society

Terminated

French Observatory of Familial Hypercholesterolemia in Cardiology (FH Care)

Familial Hypercholesterolemia

France
Nordlandssykehuset HF
Pronova BioPharma

Completed

Effect of Omega-3 Fatty Acid on Endothelial Function

Familial Hypercholesterolemia

Norway
University of Pennsylvania
Lancaster General Hospital; The Familial Hypercholesterolemia Foundation

Completed

IN-TANDEM Familial Hypercholesterolemia Pilot Study

Familial Hypercholesterolemia

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy (ODYSSEY JAPAN)

Hypercholesterolemia

Japan
Merck Sharp & Dohme LLC

Terminated

Carotid IMT (Intima Media Thickening) Study (0524A-041)(TERMINATED) (ACHIEVE)

Hypercholesterolemia, Familial
Laval University

Completed

Relationships Between Plasma PCSK9 Levels, LDL-cholesterol Concentrations and Lipoprotein (a) Levels in Familial Hypercholesterolemia

Familial Hypercholesterolemia

Canada
Genzyme, a Sanofi Company

Completed

A Study of the Safety and Efficacy of Patients With Familial Hypercholesterolaemia Taking Colesevelam as add-on Therapy to Their Existing Medication

Familial Hypercholesterolemia

Netherlands, France, Germany, Sweden, United Kingdom
Medical University of Vienna

Unknown

Soy Food Intervention Trial (SOYFIT)

Familial Hypercholesterolemia

Austria
Pfizer

Completed

Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Patients With Genetic High Cholesterol Disorder

Hypercholesterolemia, Familial

Canada, United States, South Africa
Arrowhead Pharmaceuticals

Completed

Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients

Dyslipidemias | Hypertriglyceridemia | Familial Hypercholesterolemia

Australia, New Zealand
Boston Children's Hospital
Wellth Inc.; MMAS-8 with permission from Dr Donald Morisky. as written below

Recruiting

The Use of Mobile Health Technology and Behavioral Economics to Encourage Adherence in Adolescents

Adherence, Medication | Familial Hypercholesterolemia

United States
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate the Effects of Laropiprant on the Antiplatelet Effects of Clopidogrel and Aspirin in Combination (MK-0524A-114)(COMPLETED)

Primary Hypercholesterolemia | Mixed Hyperlipidemia
Sociedad Española de Arteriosclerosis
Universidad de Zaragoza; Hospital Miguel Servet

Unknown

Cardiovascular Disease in FH Heterozygous

Familial Hypercholesterolemia

Spain
Amgen

Completed

Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study-2 (RUTHERFORD-2)

Hyperlipidemia

Canada, France, Netherlands, United Kingdom, New Zealand, South Africa, Spain, United States, Australia, Germany, Sweden, Hong Kong, Switzerland, Norway
Pfizer

Completed

Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone. (RADIANCE 1)

Hyperlipidemia | Hypercholesterolemia, Familial

United States, Canada, South Africa, Czech Republic, Italy, Finland, Netherlands, France
Pfizer

Completed

Study To Evaluate The Safety And Efficacy Of Torcetrapib/Atorvastatin In Subjects With Familial Hypercholerolemia

Hyperlipidemia | Hypercholesterolemia, Familial

Australia, Canada, United States, France, South Africa, Sweden, Norway, Denmark, Iceland
Fondazione SISA (Societa Italiana per lo Studio...

Recruiting

Lipid Transport Disorder Italian Genetic Record (LIPIGEN) (LIPIGEN)

Familial Hypercholesterolemia | Genetic Disorder

Italy
Imperial College London

Recruiting

EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Familial Hypercholesterolemia

United Kingdom
University Hospital, Linkoeping

Recruiting

Clinical Decision Support for Familial Hypercholesterolemia (CDS-FH)

Hypercholesterolemia, Familial | Clinical Decision Support

Sweden
Fundación Hipercolesterolemia Familiar

Completed

Alirocumab and Plaque Burden In Familial Hypercholesterolaemia (ARCHITECT)

Familial Hypercholesterolemia

Spain
Laval University

Recruiting

Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia.

Familial Hypercholesterolemia | Cholesterol, Elevated | Nutrition, Healthy

Canada
National Center for Research Resources (NCRR)
University of Pennsylvania

Completed

Phase I Study of Ex Vivo Liver-Directed Gene Therapy for Familial Hypercholesterolemia

Familial Hypercholesterolemia
Visirna Therapeutics HK Limited

Not yet recruiting

A VSA003 Phase 1 Study in Chinese Adult Healthy Volunteers

Dyslipidemias | Hypertriglyceridemia | Familial Hypercholesterolemia
Russian Cardiology Research and Production Center
Pfizer; AstraZeneca; Amgen

Recruiting

Russian Familial Hypercholesterolemia Registry (RuFH)

Familial Hypercholesterolemia

Russian Federation
Organon and Co

Terminated

Investigational Drug in Patients With Hypercholesterolemia or in Patients With Sitosterolemia (0653-026)(COMPLETED)

Lipid Metabolism, Inborn Errors | Hypercholesterolemia, Familial
Essentia Health
St. Luke's Hospital of Duluth; WHITESIDE Institute for Clinical Research

Recruiting

Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH) (ID-FH)

Familial Hypercholesterolemia | Genetic Disease | Cholesterol, Elevated

United States
University College, London
Aegerion Pharmaceuticals, Inc.

Completed

Detection of Familial Hypercholesterolaemia in Cardiovascular Disease Registry

Percutaneous Coronary Intervention | Familial Hypercholesterolemia | Cardiac Event
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Hyperlipoproteinemia Type II | Metabolic... and other conditions

United States, Canada, Brazil, Taiwan, Singapore, South Africa, United Kingdom
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial Hypercholesterolemia (RADICHOL 1)

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Hyperlipoproteinemia Type II | Metabolic... and other conditions

United States, Taiwan, Brazil, Canada, South Africa, United Kingdom, Singapore
McGill University Health Centre/Research Institute...
Sanofi; Merck Sharp & Dohme LLC; Pfizer; Amgen; Aegerion Pharmaceuticals, Inc.; Valeant...

Recruiting

Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale Canada (FHCanada)

Familial Hypercholesterolemia | Lipid Disorder

Canada
Fresenius Medical Care Deutschland GmbH

Completed

Comparison of the Plasma Lipoprotein Apheresis Systems DIAMED and MONET vs. the Whole Blood Apheresis System DALI (DIAMOND-2018)

Cardiovascular Diseases | Dyslipidemias | Hypercholesterolemia, Familial

Germany
Fresenius Medical Care Deutschland GmbH

Completed

Safety and Efficacy of the DALI LDL-adsorber and MONET Lipoprotein Filter (LINET)

Hypercholesterolemia, Familial | LIPOPROTEIN TYPES--Lp SYSTEM Lp(a) HYPERLIPOPROTEINEMIA

Germany
Atlantic Health System
Regeneron Pharmaceuticals

Not yet recruiting

Atlantic Lipid Lowering Treatment Optimization Program (ALLTOP)

Familial Hypercholesterolemia | High Density Lipoprotein Deficiency | Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia | Apolipoprotein B 100, Familial Defective | Low-Density-Lipoid-Type Hyperlipoproteinemia

United States
Assiut University

Active, not recruiting

Familial Hypercolerstremia as Risk Factor in Stemi Patient Who Underwent Ppci

Familial Hypercholesterolemia

Egypt
Laval University

Completed

Effects of LDL Apheresis System on the Expression of Genes Involved in Lipoprotein Metabolism and Inflammation in Homozygotes for Familial Hypercholesterolemia (LA-PBMC)

Familial Hypercholesterolemia

Canada
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Hyperlipoproteinemia Type II | Metabolic... and other conditions

United States
NewAmsterdam Pharma

Recruiting

Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapies (TANDEM)

Dyslipidemias | Hypercholesterolemia | Familial Hypercholesterolemia | High Cholesterol | ASCVD

United States
Laval University
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie... and other collaborators

Active, not recruiting

Diet Quality and Coronary Artery Calcification in Adults With Heterozygous Familial Hypercholesterolemia (FH-CAC)

Diet Habit | Hypercholesterolemia, Familial | Calcification; Heart

Canada
Merck Sharp & Dohme LLC

Completed

Phase 2 Dose-Ranging Efficacy and Safety Trial of SCH 900271 in Participants With Primary Hypercholesterolemia or Mixed Hyperlipidemia (P05675)

Primary Hypercholesterolemia | Mixed Hyperlipidemia

Clinical Trials on Homozygous Familial Hypercholesterolemia HoFH

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