Clinical Trials on Hyperkolesterolemia

Total 1167 results

Tang-Du Hospital
Air Force Military Medical University, China

Not yet recruiting

Exosome-based Nanoplatform for Ldlr mRNA Delivery in FH (ENDFH)

Familial Hypercholesterolemia

China
Children's Hospital of Fudan University

Not yet recruiting

Child-Parent Familial Hypercholesterolemia Screening

Familial Hypercholesterolemia
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of MK-0616 (Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids

Hypercholesterolemia | Familial Hypercholesterolemia

Colombia, Israel, Taiwan, United States, Argentina, China, Germany, Italy, Japan, Korea, Republic of, Mexico, South Africa, Spain, Turkey
Organon and Co

Completed

Ezetimibe (SCH 58235) Taken With Either Atorvastatin or Simvastatin in Participants With Familial Hypercholesterolemia (MK-0653-018)

Familial Hypercholesterolemia
Northwestern University
University of Pennsylvania; Family Heart Foundation

Enrolling by invitation

Penn Family Screening for Familial Hypercholesterolemia (NHLBI-R33)

Familial Hypercholesterolemia

United States
Amgen

Completed

Long Term Post Marketing Specified Drug Use Result Survey for Evolocumab in Japan

Hypercholesterolemia | Familial Hypercholesterolemia

Japan
Academisch Medisch Centrum - Universiteit van Amsterdam...
Dutch Heart Foundation

Completed

Coronary and Heart Effects of Early Treatment in Familial Hypercholesterolemia (CHEETAH)

Familial Hypercholesterolemia

Netherlands
University of Pennsylvania
Regeneron Pharmaceuticals

Completed

Regeneron 1331 Kinetics Sub-Study HoFH

Hypercholesterolemia, Familial

United States, Netherlands
Columbia University
Amgen

Terminated

Impact of LDL-cholesterol Lowering on Platelet Activation

Familial Hypercholesterolemia

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Atorvastatin Three Year Pediatric Study

Familial Hypercholesterolemia

United States, Spain, Turkey, Canada, Belgium, Germany, Greece, Hungary, Italy, Norway, Poland, Puerto Rico, Russian Federation, Slovakia, Switzerland
University of Pennsylvania

Completed

Screening Protocol for a Gene Therapy Trial in Subjects With Homozygous Familial Hypercholesterolemia

Hypercholesterolemia, Familial

United States
University of Nottingham
University College, London; Newcastle University; University of Manchester

Unknown

Improving Identification of Familial Hypercholesterolaemia in Primary Care (FAMCAT) (FAMCAT)

Familial Hypercholesterolemia

United Kingdom
China Cardiovascular Association
Amgen

Unknown

a Prospective Pilot Study of Screening Out Rate and Clinical Management of Familial Hypercholesterolemia

Familial Hypercholesterolemia

China
Isfahan University of Medical Sciences

Unknown

Developing and Implementing Familial Hypercholesterolemia Registry

Familial Hypercholesterolemia

Iran, Islamic Republic of
Emory University
Kaneka Medical America LLC

Completed

Effects of Low-density Lipoprotein (LDL) Apheresis on Inflammatory and Lipid Markers (INFLAME)

Familial Hypercholesterolemia

United States
Takeda

Terminated

Efficacy of Lapaquistat Acetate Co-Administered With Current Lipid-Lowering Treatment on Blood Cholesterol Levels in Subjects With Homozygous Familial Hypercholesterolemia

Hypercholesterolemia

France, United Kingdom, United States, Israel, Poland, Canada
AstraZeneca

Completed

PLUTO: Pediatric Lipid-redUction Trial of rOsuvastatin

Familial Hypercholesterolemia

United States, Spain, Netherlands, Norway, Canada
Medical University of Vienna

Unknown

Effect of Rapeseed Oil and Sunflower Oil

Familial Hypercholesterolemia

Austria
University of Tehran

Completed

Bone Marrow Stem Cells as a Source of Allogenic Hepatocyte Transplantation in Homozygous Familial Hypercholesterolemia

Hypercholesterolemia, Familial

Iran, Islamic Republic of
Medical Research Laboratories International

Terminated

Implitapide in Patients With Homozygous Familial Hypercholesterolemia (HoFH) on Maximal Concurrent Lipid-Lowering Therapy

Familial Hypercholesterolemia

Israel, Netherlands, United States, Canada, Norway
Federico II University

Recruiting

Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Inclisiran in Italy (CHOLINET)

Hypercholesterolemia

Italy
Valbiotis

Recruiting

Effect of the Food Supplement TOTUM-070 on Lipid Metabolism (HEARTII)

Hypercholesterolemia

Germany
Kowa Company, Ltd.

Recruiting

A Phase III Confirmatory Study of K-877 (Pemafibrate) in Patients With Hypercholesterolemia and Statin Intolerance

Hypercholesterolemia

Japan
Federico II University

Recruiting

Evaluation of Adherence, Persistence and Efficacy of Treatment With PCSK9 Inhibitors in Italy (AT-TARGET-IT)

Hypercholesterolemia

Italy
Assistance Publique Hopitaux De Marseille

Recruiting

Role of A2A Receptor in Hypercholesterolemic Patients (RASCAS)

Hypercholesterolemia

France
Organon and Co

Completed

Coadministration of Ezetimibe and Simvastatin in Patients With Primary Hypercholesterolemia (P05457)

Hypercholesterolemia
Organon and Co

Completed

Ezetimibe (EZ)/Atorvastatin (Ator) (MK-0653C) vs. Ator in Chinese Hypercholesterolemic Participants (MK-0653C-439)

Hypercholesterolemia

China
Organon and Co

Completed

A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832)

Hypercholesterolemia
Organon and Co

Completed

Ezetimibe/Simvastatin (10 mg/40 mg) vs. the Doubling of Atorvastatin in High Risk Participants (MK-0653A-134 AM1)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

A Clinical Trial to Assess the Efficacy and Safety of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-383)

Hypercholesterolemia
Organon and Co

Completed

An Efficacy and Safety Study of Ezetimibe (MK-0653, SCH 58235) in Addition to Atorvastatin Compared to Placebo in Participants With Primary Hypercholesterolemia (MK-0653-013)

Hypercholesterolemia
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Multiple Ascending Dose Study of PCSK-9 Inhibitor (IBI306) in Chinese Patients With Hypercholesterolemia

Hypercholesterolemia

China
Vaxxinity, Inc.
Novotech (Australia) Pty Limited

Active, not recruiting

A Study to Investigate the Safety, Tolerability, Immunogenicity, and Pharmacodynamics of VXX-401 Administered IM in Adult Participants

Hypercholesterolemia

Australia
HighTide Biopharma Pty Ltd

Completed

A Multiple Ascending Dose Study of HTD1801 in Adults With Hypercholesterolemia

Hypercholesterolemia

Australia
Akeso
AD Pharmaceuticals Co., Ltd.

Completed

A Study of PCSK9 Inhibitor AK102 in Patients With Hypercholesterolemia

Hypercholesterolemia

China
Lescuyer Laboratory
Université d'Auvergne; Hopital Gabriel Montpied; CRNH Auvergne; Clinique Médicale...

Completed

Combined Effect of LIMICOL and Physical Activity on LDL Cholesterol and Muscle Function. (L2012-12)

Hypercholesterolemia

France
Amgen

Completed

Open Label Study of Long Term Evaluation Against LDL-C Trial (OSLER)

Hypercholesterolemia

United States, Denmark, Finland, Czechia, Hungary, South Africa, Spain, Australia, Belgium, Canada, Netherlands, Germany, Sweden, Hong Kong, Japan, Singapore, United Kingdom, Norway
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Safety and Efficacy of IBI306 in Chinese Subjects With Non-familial Hypercholesterolemia

Hypercholesterolemia

China
Sanofi
Regeneron Pharmaceuticals

Completed

Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)

Hypercholesterolemia

France, Belgium, Austria, Canada, Czechia, Denmark, Finland, Germany, Greece, Hungary, Poland, Romania, Slovakia, Slovenia, Spain, Switzerland
Guangzhou JOYO Pharma Co., Ltd
The First Hospital of Jilin University

Completed

Multiple Ascending Dose Study to Evaluate the Safety, Tolerability of DC371739 Treatment in Hypercholesterolemic

Hypercholesterolemia

China
Organon and Co

Completed

Randomized Parallel Group Trial Of The Efficacy And Safety Of Ezetimibe With A Statin Versus Statin Dose Doubling In Patients With Persistent Primary Hypercholesterolemia (0653-152)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Comparing an Investigational Medication Versus an Approved Medication in Reducing Cholesterol Levels (0653-025)

Hypercholesterolemia
Organon and Co

Completed

A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)

Hypercholesterolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

An Extension Study of An Investigational Drug in Patients With Hypercholesterolemia (0653A-038)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Post-marketing Surveillance of the Safety, Tolerability and Efficacy of Vytorin (Ezetimibe + Simvastatin) Tablet Among Filipino Patients (Study P05647)

Hypercholesterolemia
Organon and Co

Completed

A Study to Evaluate the Effectiveness of Ezetimibe/Atorvastatin 10 mg/20 mg Combination Tablet Compared to Marketed Ezetimibe 10 mg and Atorvastatin 20 mg Tablets in Participants With High Cholesterol (MK-0653C-185 AM1)

Hypercholesterolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Comparison of Ezetimibe Added to Ongoing Statin Therapy Versus Doubling the Dose of Statin in the Treatment of Hypercholesterolemia (P04355)

Hypercholesterolemia
Organon and Co

Completed

EZETROL® Re-examination Study (MK0653-175)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Evaluation of the LDL-C Lowering Effects of Ezetimibe Achieved in Co-administration Therapy With Statins in an Indonesian Population (Study P04276)(COMPLETED)

Hypercholesterolemia

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