Clinical Trials on Hypertension, Renal in South Africa

Total 947 results

Novartis Pharmaceuticals

Completed

Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension

Ocular Hypertension | Glaucoma

United States
GlaxoSmithKline
Quintiles, Inc.; ERT: Clinical Trial Technology Solutions; Q2 Solutions; HemoCue

Completed

Anemia Study in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat-Blood Pressure (ASCEND-BP)

Anaemia

United States
Aerie Pharmaceuticals

Completed

Study of Rhopressa® for the Reduction of Elevated Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension in a Real-world Setting

Ocular Hypertension | Glaucoma, Open-Angle

United States
GB002, Inc., a wholly owned subsidiary of Gossamer...

Recruiting

Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)

Pulmonary Arterial Hypertension

United States, Australia, Spain, Czechia, France, Germany, United Kingdom, Belgium
Actelion

Completed

Iloprost Power 15 in Pulmonary Arterial Hypertension (PROWESS 15)

Pulmonary Arterial Hypertension

United States, Austria, Germany
Mitsubishi Tanabe Pharma Corporation

Completed

A Phase III, Multicentre, Double-Blind, Placebo-Controlled Withdrawal Study in Patients With Hyperphosphatemia

Chronic Kidney Disease | Hyperphosphatemia

France, Poland, United Kingdom, Spain, South Africa, Australia, Czech Republic, Germany, Hungary, Italy, Austria
Actelion

Completed

Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension (SERAPHIN OL)

Pulmonary Arterial Hypertension

United States, United Kingdom, Taiwan, Finland, Canada, Belarus, Belgium, Argentina, Australia, China, Colombia, Croatia, Germany, Hong Kong, India, Israel, Italy, Malaysia, Netherlands, Poland, Russian Federation, South Africa, Tha... and more
VenoStent

Recruiting

SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study (SAVE-FistulaS)

Chronic Kidney Diseases | Renal Insufficiency | Renal Failure | End Stage Renal Disease | Hemodialysis Access Failure | ESRD | Arteriovenous Fistula | Vascular Access Complication | Catheter Complications | Catheter Dysfunction

United States
University of British Columbia
Canadian Institutes of Health Research (CIHR); Sunnybrook Research Institute

Completed

The CHIPS Trial (Control of Hypertension In Pregnancy Study)

Gestational Hypertension

Canada, United Kingdom, Netherlands, United States, Israel, Australia, Chile, New Zealand, Hungary, Poland, Jordan, Argentina, Brazil, Colombia, Estonia
Actelion

Recruiting

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension (UNISUS)

Pulmonary Arterial Hypertension

Belgium, United States, Italy, Canada, Taiwan, Greece, China, Korea, Republic of, Germany, Israel, Austria, Russian Federation, Australia, Thailand, United Kingdom, Brazil, Malaysia, Spain, Ukraine, Bulgaria, Colombia, Mexico, Turkey, Vietna... and more
The George Institute
National Health and Medical Research Council, Australia; Takeda; Conselho Nacional... and other collaborators

Completed

Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) (ENCHANTED)

Ischemic Stroke | High Blood Pressure

Australia
Bayer

Completed

Open-Label Long-Term Safety and Efficacy Study of Fixed Dose Combination of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Subjects With Moderate to Severe Essential Hypertension

Hypertension

Germany, United States, Canada, Poland, United Kingdom, Belgium
United Therapeutics

Active, not recruiting

ADAPT - A Patient Registry of the Real-world Use of Orenitram® (ADAPT)

Pulmonary Arterial Hypertension

United States
United Therapeutics

Recruiting

Pulmonary Hypertension Screening in Patients With Interstitial Lung Disease for Earlier Detection (PHINDER)

Pulmonary Hypertension | Interstitial Lung Disease

United States
Actelion

Completed

Safety Study Extension of Iloprost Power 15 in Pulmonary Arterial Hypertension (PROWESS 15 Ext)

Pulmonary Arterial Hypertension

United States, Germany, Austria
King's College London

Completed

International T1 Multicentre CMR Outcome Study (T1-CMR)

Coronary Artery Disease | Fibrosis | Heart Failure | Inflammation | Chronic Kidney Diseases | Cardiomyopathy

United Kingdom, Germany, Australia
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Study (SAMURAI)

Metastatic Renal Cell Carcinoma | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Unresectable Renal Cell Carcinoma

United States
New World Medical, Inc.

Recruiting

STREAMLINE®SURGICAL SYSTEM Compared to iStent Inject W® in Patients With Open-Angle Glaucoma (VENICE)

Open Angle Glaucoma

United States, Costa Rica
Takeda

Completed

Efficacy and Safety of Azilsartan Medoxomil Co-Administered With Chlorthalidone in Participants With Essential Hypertension

Hypertension

United States
Medical University of South Carolina
Novartis Pharmaceuticals

Completed

Study of Panobinostat in Combination With Sorafenib in Kidney, Soft Tissue or Lung Cancers

Soft Tissue Sarcoma | Renal Cancer | Non Small Cell Lung Cancer (NSCLC)

United States
United Therapeutics

Completed

Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso® Compared to Other FDA Approved PAH Therapies (Aspire)

Pulmonary Arterial Hypertension

United States
Acceleron Pharma, Inc., a wholly-owned subsidiary...

Recruiting

A Long-term Follow-up Study of Sotatercept for PAH Treatment (MK-7962-004/A011-12) (SOTERIA)

Pulmonary Arterial Hypertension | PAH

United States, France, Germany, Spain, Sweden, Argentina, Australia, Austria, Colombia, Croatia, Denmark, Greece, Israel, Italy, Korea, Republic of, Netherlands, New Zealand, Portugal, Serbia, Taiwan, United Kingdom, Brazil, Canada, B... and more
University of Manitoba
Canadian Institutes of Health Research (CIHR)

Recruiting

Exercise and Cardiac Stunning During HD

Hemodialysis | End-stage Kidney Disease

Canada, Australia
Kibow Pharma

Recruiting

Rollover Extension Clinical Trial To Evaluate The Long-Term Safety And Efficacy Of KT-301 (Formerly US-APR2020) In Subjects With CKD IV Completing The US-APR2020-01 Study

Chronic Kidney Disease stage4

United States
Actelion

Completed

PORtopulmonary Hypertension Treatment wIth maCitentan - a randOmized Clinical Trial (PORTICO)

Portopulmonary Hypertension

United States, France, Germany, United Kingdom, Brazil, Czechia, Spain
Takeda

Completed

One-Year Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension

Hypertension

United States, Chile, Mexico
Santen Inc.

Completed

DE-117 Spectrum 5 Study

Primary Open-angle Glaucoma and Ocular Hypertension

United States
Astellas Pharma Inc
Astellas Pharma US, Inc.

Completed

Optimizing Prograf® Therapy in Renal Transplant Patients (OPTIMA)

Renal Transplantation

United States
Allergan

Completed

A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

Glaucoma | Open-Angle Ocular Hypertension

Spain, United States, Singapore, Australia, Denmark, France, Poland, Russian Federation, Thailand
Actelion

Terminated

A Study of Selexipag Assessing Right Ventricular Remodeling in Pulmonary Arterial Hypertension by Cardiac Magnetic Resonance Imaging (RESTORE)

Pulmonary Arterial Hypertension

Germany, Korea, Republic of, Israel, Singapore, United States, Russian Federation, Brazil, Netherlands, Malaysia, Saudi Arabia, United Kingdom, Hong Kong, France, United Arab Emirates, Argentina
Medical University of South Carolina

Terminated

PEG-Interferon Alfa-2b, Sargramostim, and Thalidomide in Treating Patients With Metastatic Kidney Cancer

Kidney Cancer

United States
Aerie Pharmaceuticals

Completed

Study of Netarsudil Ophthalmic Solution in Japanese/Japanese-American Subjects With Open-angle Glaucoma or Ocular Hypertension

Primary Open Angle Glaucoma or Ocular Hypertension

United States
AstraZeneca

Completed

Atacand Dose Range Finding Study in Pediatric Subjects 6 to <17 Years of Age

Pediatric Hypertension

United States, Hungary, Slovakia, Belgium
Allergan

Completed

Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma

Glaucoma | Angle-Closure

Australia, Canada, Korea, Republic of, Singapore, Taiwan, United Kingdom
United Therapeutics

Terminated

A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

Cardiovascular Diseases | Vascular Diseases | Lung Diseases | Hypertension | Pulmonary Arterial Hypertension | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary | Pulmonary Hypertension | PAH | Respiratory Tract Disease | Connective Tissue Disease

Spain, United States, Australia, Canada, United Kingdom, Italy, Argentina, Austria, Belgium, Brazil, Germany, Poland
Novartis

Completed

Study of the Efficacy and Safety of Aliskiren HCTZ vs Ramipril in Obese Patients (BMI ≥ 30) With Stage 2 Hypertension (ATTAIN)

Hypertension

United States
Rockwell Medical Technologies, Inc.

Completed

Safety Study of Soluble Ferric Pyrophosphate (SFP) in Dialysate in CKD Patients Receiving Chronic Hemodialysis

End Stage Renal Disease | Chronic Kidney Disease

United States, Canada
Bellerophon

Active, not recruiting

A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Hypertension Associated With Pulmonary Fibrosis

Pulmonary Fibrosis | Pulmonary Hypertension

United States
Solvay Pharmaceuticals
Quintiles, Inc.

Terminated

Study to Evaluate the Effect of SLV320 in Addition to Chronic Furosemide Treatment on Renal Function in Subjects With Congestive Heart Failure and Impaired Renal Function

Congestive Heart Failure

United States, Argentina, Belgium, Czech Republic, Former Serbia and Montenegro, Germany, Poland, Russian Federation, South Africa, Spain
W.L.Gore & Associates

Completed

GORE VIABAHN Endoprosthesis Versus Percutaneous Transluminal Angioplasty (PTA) to Revise AV Grafts in Hemodialysis (REVISE)

Renal Failure | Hemodialysis

United States
Boehringer Ingelheim

Completed

Telmisartan (Micardis) and Amlodipine (Norvasc) - Factorial Design Study for the Treatment of Hypertension

Hypertension

United States, Argentina, Brazil, Mexico, South Africa
Proteon Therapeutics

Completed

A Study of PRT-201 Administered After Arteriovenous Graft (AVG) Creation in Patients With Chronic Kidney Disease (PRT-201-102)

Chronic Kidney Disease

United States
National Cancer Institute (NCI)
Glaxosmithkline Biologicals S.A.

Terminated

Dabrafenib in Treating Patients With Solid Tumors and Kidney or Liver Dysfunction

Renal Failure | Solid Neoplasm | BRAF Gene Mutation | Hepatic Complication

United States, Canada
Actelion

Completed

The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension (TRITON)

Pulmonary Arterial Hypertension

United States, Spain, Denmark, Canada, Germany, United Kingdom, Belgium, Austria, Netherlands, Australia, France, Ireland, Sweden, Italy, Switzerland
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Comparison of Latanoprost With Travoprost and Bimatoprost in Patients With Elevated IOP. A 12-weeks, Masked Evaluator, Phase IV Multi-center Study in the US (XLT)

Ocular Hypertension | Glaucoma

United States
AbbVie

Completed

Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Glaucoma, Open-Angle

United States, Australia, Canada, Denmark, France, Germany, Israel, New Zealand, Philippines, Poland, Russian Federation, United Kingdom
Glaukos Corporation

Completed

GTS400 Stent Implantation in Conjunction With Cataract Surgery in Subjects With Open-angle Glaucoma

Glaucoma

United States
VA Office of Research and Development
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Financial Incentives to Translate ALLHAT Into Practice: A Randomized Trial

Hypertension

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating Sirolimus in Kidney Transplant Recipients in India

Graft vs Host Disease | Kidney Failure

India
AbbVie

Active, not recruiting

Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-Angle Glaucoma

United States, Argentina, Australia, Bulgaria, Czechia, Denmark, Germany, Hungary, Ireland, Italy, New Zealand, Poland, Russian Federation, South Africa, Sweden, United Kingdom

Clinical Trials on Hypertension, Renal in South Africa

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