Clinical Trials on Immunologic Activity Alteration

Total 7434 results

Shire
Takeda Development Center Americas, Inc.

No longer available

Expanded Access for the Prevention of Acute Attacks of 1) Hereditary Angioedema (HAE) in Children and 2) Non-histaminergic Angioedema With Normal C1-Inhibitor (C1-INH) in Teenagers and Adults

Angioedema | Hereditary Angioedema (HAE)

United States, Canada, Germany, Hungary, Spain
National Human Genome Research Institute (NHGRI)
National Institute of Allergy and Infectious Diseases (NIAID); National Institute...

Completed

Participation in a Research Registry for Immune Disorders

CGD | Wiskott-Aldrich Syndrome | Primary Immunodeficiencies | APECED | SCID

United States
Carolyn Lauckner
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Technological Intervention for Reducing Alcohol Use Among People Living With HIV/AIDS (TRAC)

Acquired Immunodeficiency Syndrome | Alcohol Drinking | HIV/AIDS

United States
BioCryst Pharmaceuticals

Completed

A Long Term Safety Study of BCX7353 in Hereditary Angioedema (APeX-S)

Hereditary Angioedema | Prophylaxis | HAE

Austria, Denmark, France, Germany, Hungary, Israel, Italy, North Macedonia, Poland, Switzerland, United Kingdom, United States, Australia, Hong Kong, Korea, Republic of, New Zealand, Serbia, Slovakia, South Africa, Spain
George Washington University

Completed

Immune Response to Seasonal Influenza Vaccine in HIV Infected Individuals

Influenza, Human | Human Immunodeficiency Virus I Infection

United States
Shire

Completed

Efficacy and Safety of Lanadelumab (SHP643) in Japanese Participants With Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

Japan
AB Biotek

Completed

Efficacy and Tolerability of ABBC1 in Volunteers Receiving the Influenza or Covid-19 Vaccine

Immunologic Deficiency Syndromes | Covid19 | Vaccine Reaction | Influenza | Immunity | Cytokine Storm

Spain
University of Colorado, Denver
National Institute on Drug Abuse (NIDA); Gilead Sciences; Denver Health and Hospital...

Completed

Antiviral Pharmacology and Adherence in Drug Users

Virus, Human Immunodeficiency | HEPATITIS C

United States
National Institute of Allergy and Infectious Diseases...

Completed

An Open Trial of Zidovudine (AZT) Treatment of the AIDS Dementia Complex in Patients With AIDS or Low CD4+ Lymphocyte Counts

HIV Infections | AIDS Dementia Complex

United States
Napo Pharmaceuticals, Inc.

Completed

Effects of Crofelemer on the Gut Microbiome in Healthy Volunteers and in HIV+ Patients With Non-Infectious Diarrhea

Acquired Immunodeficiency Syndrome | HIV/AIDS | Healthy Volunteers | Human Immunodeficiency Virus | HIV Diarrhea

United States
Shire

Completed

A Pharmacokinetic, Tolerability and Safety Study of Icatibant in Children and Adolescents With Hereditary Angioedema

Hereditary Angioedema (HAE)

United States, Canada, Australia, Austria, Colombia, Germany, Hungary, Israel, Italy, Spain
Shire

Completed

Safety and Efficacy Study of Repeated Doses of DX-88 (Ecallantide) to Treat Attacks of Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

United States, Canada, Jordan
Shire

Completed

Observational Safety Study for KALBITOR (Ecallantide) in the Treatment of Acute Attacks of Hereditary Angioedema

Hereditary Angioedema (HAE)

United States
Shire

Completed

Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of Recombinant Human C1 Esterase Inhibitor in Healthy Adult Subjects

Hereditary Angioedema (HAE)

United States
Shire

Completed

Study of C1 Inhibitor (Human) for the Prevention of Angioedema Attacks and Treatment of Breakthrough Attacks in Japanese Subjects With Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

Japan
Shire

Completed

EDEMA2: Evaluation of DX-88's Effect in Mitigating Angioedema

Hereditary Angioedema (HAE)
Shire
Dyax Corp.

Completed

A Single Increasing Dose Study to Assess Safety and Tolerability of DX-2930 in Healthy Subjects

Hereditary Angioedema (HAE)

United States
Elizabeth Glaser Pediatric AIDS Foundation
UNITAID

Completed

Evaluating the Feasibility of Point of Care Birth Testing in Eswatini

HIV Infections | HIV/AIDS | Neonatal Infection | Infant Morbidity | Pediatric HIV Infection | Transmission, Perinatal Infection

Swaziland
Radboud University Medical Center
Merck Sharp & Dohme LLC

Completed

Pharmacokinetic Study of the HCV Protease Inhibitor Boceprevir and the HIV Integrase Inhibitor Raltegravir (OPAL)

HIV Infections | HCV Infections

Netherlands
ViiV Healthcare

Completed

New Tablet Containing Two FDA Approved Anti-HIV Drugs For Antiretroviral Therapy Experienced HIV-1 Infected Subjects

HIV Infection | Infection, Human Immunodeficiency Virus I

United States, Spain, Germany, Canada, Belgium, Portugal, Italy, France, United Kingdom
ViiV Healthcare

Completed

A HIV Study Of A Fixed-Dose Combination Tablet In Antiretroviral Experienced Patients

HIV Infection | Infection, Human Immunodeficiency Virus I

United States, Puerto Rico, Costa Rica, Panama
ANRS, Emerging Infectious Diseases
Hopital Paul Brousse; University of Health Sciences, Cambodia

Unknown

HIV and HCV Infections in 2 Communes From the Battambang Province, Cambodia: Prevalence Rates, Viral Strains, and Unsafe Injection Practices (12352 ANRS ROK INVEST)

HIV Seropositivity | HCV Infection

Cambodia
Weill Medical College of Cornell University
Novartis Pharmaceuticals

Terminated

Thrombocytopenia and Bleeding in Wiskott-Aldrich Syndrome (WAS) Patients (WAS)

Bleeding | Thrombocytopenia | Wiskott-Aldrich Syndrome

United States
Emory University
National Institute of Mental Health (NIMH)

Completed

Observational Study of HIV-associated Neurocognitive Disorder (HAND2)

Human Immunodeficiency Virus | HIV Associated Neurocognitive Disorder

United States
Pharming Technologies B.V.

Completed

A Study of the Safety and Immunogenicity of Repeated rhC1INH Administration (OPERA)

Hereditary Angioedema | Genetic Disorders

Netherlands, Romania
University of North Carolina, Chapel Hill
Janssen Pharmaceuticals

Terminated

HIV Viremia and Persistence in Acutely HIV-Infected Patients Treated With Darunavir/Ritonavir and Etravirine

HIV Infections | Acute HIV Infection

United States
National Institute of Allergy and Infectious Diseases...

Completed

Posaconazole to Treat Invasive Fungal Infections

Granulomatous Disease, Chronic | Infection | Job's Syndrome

United States
ViiV Healthcare

Terminated

A Dose Ranging Study Of GW640385 Boosted With Ritonavir (Rtv) In Comparison To A RTV-Boosted Protease Inhibitor (PI) In HIV-1 Infected PI-Experienced Adults

HIV-1 Infection | Infection, Human Immunodeficiency Virus I

United States, France, Germany, Canada, Italy, Australia, Belgium, Portugal, Puerto Rico, Romania, United Kingdom
University of North Carolina, Chapel Hill
National Institute on Drug Abuse (NIDA); National Institute of Mental Health...

Completed

Correlates of Oral Human Papillomavirus Infection in Adolescents and Young Adults With Behaviorally Acquired HIV

HIV Infection

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Viral Activation Transfusion Study (VATS)

HIV Infections | Acquired Immunodeficiency Syndrome | Cytomegalovirus Infections | Blood Transfusion
Erasmus Medical Center
Radboud University Medical Center; University Medical Center Groningen; Maastricht... and other collaborators

Completed

Dutch Acute HCV in HIV Study (DAHHS) (DAHHS)

Hepatitis C | Human Immunodeficiency Virus

Netherlands
National Heart, Lung, and Blood Institute (NHLBI)

Completed

HIV-Associated Heart Disease

Heart Diseases | Cardiovascular Diseases | HIV Infections | Acquired Immunodeficiency Syndrome | Myocardial Diseases
National Heart, Lung, and Blood Institute (NHLBI)

Completed

AIDS-Associated Cardiomyopathy

Heart Diseases | HIV Infections | Acquired Immunodeficiency Syndrome | Myocardial Diseases
University of Pennsylvania
National Institute of Mental Health (NIMH)

Completed

Being Responsible for Ourselves HIV Risk Reduction for Black MSM (BRO)

Sexually Transmitted Disease (STD) | Human Immunodeficiency Virus Infection (HIV)

United States
Cheikh Anta Diop University, Senegal
UNICEF

Completed

Impact of RUTF on Body Composition, Anemia and Zinc Status of PLWHA (PLWHA)

Malnutrition | HIV-infection/Aids

Senegal
Columbia University

Completed

Enhanced HIV Prevention in Couples: Feasibility Study #1 (EPIC)

Human Immunodeficiency Virus (HIV) | Acquired Immune Deficiency Syndrome (AIDS)

Lesotho
ANRS, Emerging Infectious Diseases
Janssen-Cilag Ltd.

Completed

Telaprevir in HIV-HCV Coinfected Patients Who Had Previously Failed a Peginterferon-Ribavirin Regimen (TelapreVIH)

HIV Infection | Hepatitis C, Chronic

France
Stony Brook University

Completed

Novel Therapy for Glucose Intolerance in HIV Disease

Insulin Resistance

United States
University of Washington
GlaxoSmithKline; Asociación Civil Impacta Salud y Educación, Peru

Completed

HSV-2 Suppression to Reduce HIV-1 Levels in HIV-1 Co-infected Persons

HIV Infections | Sexually Transmitted Diseases | Herpes Simplex

Peru
ANRS, Emerging Infectious Diseases
Merck Sharp & Dohme LLC

Completed

Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients (LIVERAL)

Liver Failure | HIV Infection | Evidence of Liver Transplantation

France
Baylor College of Medicine
Center for Cell and Gene Therapy, Baylor College of Medicine

Terminated

Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders (MASCI)

Severe Combined Immunodeficiency Disease | Severe Primary Immunodeficiency Disorder | Undefined T Cell Deficiency Disorder | Wiskott-Aldrick Syndrome

United States
Pharming Technologies B.V.

Completed

Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema

Genetic Disorders

Netherlands
Pharming Technologies B.V.

Completed

Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema

Hereditary Angioedema | Angioneurotic Edema

Netherlands
Pharming Technologies B.V.

Completed

Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema

Hereditary Angioedema | Genetic Disorders | Angioneurotic Edema

Netherlands, Romania
GlaxoSmithKline

Completed

Monotherapy Versus Placebo Over 10 Days in Integrase Naive HIV-1 Infected Adults

Infection, Human Immunodeficiency Virus | HIV-1 Infection

United States
ViiV Healthcare
GlaxoSmithKline

Completed

HIV-1 Infection Study of Once a Day Versus Twice a Day Protease Inhibitor in Antiretroviral Treatment Naive Adults

HIV-1 Infection | Infection, Human Immunodeficiency Virus I

Germany, Spain, France, Belgium, United Kingdom, Italy, Romania, Russian Federation, Switzerland
International Vaccine Institute
Siriraj Hospital; Vaccine Technologies Inc.

Completed

Safety and Immunogenicity of Single Dose Choleragarde® in HIV-Seropositive Adults

Diarrhea | Cholera | Vibrio Infections

Thailand
Sociedad Andaluza de Enfermedades Infecciosas

Completed

Retreatment With High Doses of pegIFN Alfa-2a and Ribavirin of Previous Nonresponders HIV-coinfected Patients With Cirrhosis Due to HCV 1-4

Liver Cirrhosis | HIV Infection | Hepatitis C Virus

Spain
NHS Lothian

Completed

Psychological Morbidity and Facial Volume in HIV Lipodystrophy: Quantification of Treatment Outcome

HIV-Associated Lipodystrophy Syndrome
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Evaluate the Safety and Efficacy of Epoetin Alfa Versus Placebo for the Treatment of Anemia in Patients With Acquired Immunodeficiency Syndrome (AIDS) Who Are Receiving Zidovudine (AZT) Therapy

Acquired Immunodeficiency Syndrome | Anemia

Clinical Trials on Immunologic Activity Alteration

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