Clinical Trials on Increased Drug Resistance

Total 8466 results

University of Washington
National Institute of General Medical Sciences (NIGMS)

Completed

The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity (FLUOXETINE)

Healthy Volunteers | Drug-Drug Interaction
AstraZeneca

Completed

Evaluation of the Drug-drug Interaction Between FosD and Verapamil When Taken Together in Healthy Volunteers

Healthy Volunteers | Drug Drug Interactions

United States
University of the Basque Country (UPV/EHU)

Unknown

Online Support Program for Dementia Caregivers (OKenCASA)

Effect Increased

Spain
State Budgetary Healthcare Institution, National...

Enrolling by invitation

Thermocoagulation in Drug Resistant Focal Epilepsy

Epilepsy | Epilepsies, Partial | Epilepsy Intractable | Seizures, Focal

Russian Federation
American University
Children's National Research Institute

Completed

The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy

Randomized Controlled Trial | Refractory Epilepsy | Diet Intervention | Epilepsy in Children | Epilepsy in Youth

United States
University of Alabama at Birmingham

Withdrawn

Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus

Refractory Epilepsy

United States
Mayo Clinic

Completed

Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy

Focal Epilepsy

United States
Peking University Third Hospital
Beijing Friendship Hospital; Beijing Chao Yang Hospital

Enrolling by invitation

Epidemiological Investigation of Sepsis in Obstetrics Admitted to ICU

Intensive Care Units | Drug Resistance, Multiple | Maternal Sepsis

China
Norwegian Institute of Public Health

Completed

Effects of Fetal Movement Counting in Third Trimester of Pregnancy

Pregnancy | Decreased Fetal Movements, Unspecified Trimester, Other Fetus | Worries

Norway
National Health Research Institutes, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital; Taipei Veterans General... and other collaborators

Unknown

The Emergence of RAS Mutations in Metastatic Colorectal Cancer Patients Receiving Cetuximab Treatment

Colorectal Cancer | Drug Resistance | Mass Spectrometry | RAS-RAF Pathway Deregulation

Taiwan
Astellas Pharma Europe B.V.

Completed

A Study to Evaluate Whether Verapamil Has an Effect on the Uptake and Elimination of Solifenacin and Tamsulosin When Administered in a Combination Tablet

Healthy Subjects | Drug-Drug Interaction (DDI)

France
AstraZeneca

Completed

Study in Healthy Volunteers to Investigate the Effects of Ketoconazole on the Pharmacokinetics of NKTR-118

Healthy Volunteers | Bioavailability | Drug- Drug Interactions

United States
Suodi ZHAI
Peking University; The Second Hospital of Hebei Medical University; West China... and other collaborators

Completed

Post-Marketing Surveillance of the Tanreqing Injection: a Real World Study

Adverse Drug Reaction | Drug Allergy

China
University of Pennsylvania
Medical University of South Carolina

Recruiting

Localizing Epileptic Networks Using MRI and iEEG

Epilepsy | Epilepsy, Temporal Lobe | Epilepsy Intractable

United States
University of Colorado, Denver
Colorado Department of Public Health and Environment

Unknown

The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy

Epilepsy, Unspecified, Refractory (Medically)

United States
Centre Hospitalier St Anne
APHP; FFRE; LFCE

Unknown

Vitamine D in Drug Resistant Epilepsy (EPI-D)

Drug Resistant Epilepsy
University Health Network, Toronto

Unknown

Personalizing Health Outcome in Epilepsy Now - An Introduction to Clinical Services (PHOENICS)

Medically Intractable Epilepsy

Canada
Deraya University

Active, not recruiting

An Evaluation of Healthcare Providers' Adherence to Pharmacovigilance Practices in an African Community

Drug Hypersensitivity | Drug Abuse | Drug Reaction | Drug Interaction

Egypt
Chestnut Health Systems
National Institute on Drug Abuse (NIDA)

Not yet recruiting

Leveraging Parents and Peers to Increase Recovery Capital in Emerging Adults (Launch)

Polysubstance Drug Use (Indiscriminate Drug Use)

United States
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Drug-Drug Interaction of Pyrotinib With a Moderate CYP3A Inducer

Healthy Subjects, Drug-drug Interaction, Pyrotinib

China
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

Drug-drug Interaction Study With MDV3100 (ASP9785) and Gemfibrozil and Itraconazole

Healthy Subjects | Pharmacokinetics | Drug-Drug Interaction

France
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Effect of Multiple Doses of Gemfribozil on a Single Dose of ASP3652, and to Assess the Effects of Multiple Doses of ASP3652 on a Single Dose of Repaglinide in the Body of Healthy Subjects

Healthy Subjects | Drug-Drug Interaction (DDI)

United Kingdom
National Heart, Lung, and Blood Institute (NHLBI)

Completed

COV2Base-A Rare Disease by COVID Study

Chronic Health Conditions | Older Age is Associated With Increased Pathogenicity

United States
Universität Duisburg-Essen
Software AG Stiftung; Universität Freiburg

Completed

Sub-study of the Essen Study Centre for the ENTAiER Trial

Elderly Patients | Chronically Ill | Increased Risk of Falling

Germany
Ondokuz Mayıs University

Completed

Effect of Fluid Challenge on Intracranial Pressure

Fluid Challenge | Increased Intracranial Pressure

Turkey
HaEmek Medical Center, Israel

Completed

The Utility of Performing Brain CT Scan in Non Trauma Patients at the Pediatric Emergency Unit

Convulsions | Increased Intracraneal Pressure

Israel
Tabula Rasa HealthCare

Withdrawn

Implementation of a Pharmacist-led Pharmacogenomic Clinical Service

Elderly | Adverse Drug Event | Pharmacogenomics | Drug Drug Interaction

United States
University of Pennsylvania
National Institute of Mental Health (NIMH)

Completed

Cognitive and Drug Therapy for Drug-Resistant Depression

Personality Disorders | Depression | Anxiety Disorders | Drug-resistant Depression
Daiichi Sankyo Co., Ltd.

Completed

A Study of the Effect of Quizartinib on the Pharmacokinetics of the P-gp Substrate Dabigatran Etexilate in Healthy Participants

Healthy Subjects | Pharmacokinetics | Drug-drug Interaction | Quizartinib

United States
Astellas Pharma Europe B.V.

Completed

Study to Evaluate the Effect of Solifenacin and Mirabegron on the Tamsulosin Hydrochloride (HCl) Concentrations in Blood in Healthy Male Subjects

Healthy Subjects | Pharmacokinetics | Drug-Drug Interaction (DDI)

Germany
Daiichi Sankyo Co., Ltd.

Completed

A Study of the Effect of a Moderate CYP3A Inducer Efavirenz on Quizartinib Pharmacokinetics in Healthy Participants

Healthy Subjects | Pharmacokinetics | Drug-drug Interaction | Quizartinib

United States
Jiangsu HengRui Medicine Co., Ltd.

Completed

Drug-Drug Interaction of SHR1459 With a Strong CYP3A Index Inducer (Rifampicin)

Healthy Subjects, Drug-drug Interaction, Pharmacokinetics, SHR1459

China
Boryung Pharmaceutical Co., Ltd

Completed

Drug Interaction Study of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects

Drug-Drug Interaction

Korea, Republic of
Astellas Pharma Europe B.V.

Completed

Study to Evaluate the Effect of Solifenacin and Mirabegron on the Digoxin Concentrations in Blood in Healthy Subjects

Healthy Subjects | Pharmacokinetics | Drug-Drug Interaction (DDI)

Germany
Anhui Medical University

Recruiting

High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Refractory Epilepsy

Transcranial Magnetic Stimulation | Functional Magnetic Resonance Imaging | Refractory Epilepsy | Transcranial Direct Current Stimulation | EEG

China
West China Hospital

Not yet recruiting

TQB3616 Capsules Combined With Abiraterone Acetate Plus Prednisone in Metastatic Castration-Resistant Prostate Cancer

Prostatic Neoplasms, Castration-Resistant | Drug Therapy, Combination

China
Eisai Inc.

Available

Extended Access Program With Lorcaserin For The Treatment of Dravet Syndrome and Other Refractory Epilepsies

Epilepsies, Myoclonic | Drug Resistant Epilepsy
University of British Columbia
Canadian Institutes of Health Research (CIHR); Vancouver Coastal Health; Ministry...

Not yet recruiting

Evaluating ActionADE in Reducing Adverse Drug Reactions

Adverse Drug Event | Adverse Drug Reaction
Prof Gérard WAEBER
Centre Hospitalier Universitaire Vaudois; University of Lausanne; Center for...

Terminated

A Double Blind Randomised Placebo-controlled Trial to Assess the Role of Iron Repletion in Glucose Homeostasis. (DIAFER)

Iron-deficiency | Safety Issues | Metabolic Disorder, Glucose | Iron Toxicity | Glucose Metabolism Disorders (Including Diabetes Mellitus) | Metabolic Side Effects of Drugs

Switzerland
Crolll Gmbh
University of Magdeburg; Estimate, GmbH

Completed

The Impact of Deferasirox on Non-Alcoholic-Steatohepatitis (DEFINE)

Non-alcoholic Steatohepatitis | Increased Iron Storage / Disturbed Distribution

Germany
Peking University People's Hospital
Peking University; Northwestern University

Unknown

Epigenetic Biomarker for Advanced Osteosarcoma Using Famitinib and Camrelizumab (EBAOFC)

Drug Resistance to Famitinib and Camrelizumab | Biomarkers for Efficacy and Toxicity

China
Hacettepe University

Recruiting

Drug-Related Problems in Neonatal Patients

Machine Learning | Adverse Drug Event | Drug-Drug Interaction | Neonatal Intensive Care Unit | Medication Errors | Drug-Related Problems | Clinical Pharmacy

Turkey
NeuroPace

Recruiting

RNS System RESPONSE Study (RESPONSE)

Epilepsy | Drug Resistant Epilepsy | Focal Epilepsy | Partial Seizure | Neurostimulator; Complications

United States
National Institute of Neurological Disorders and...

Recruiting

Surgery as a Treatment for Medically Intractable Epilepsy

Epilepsy | Epilepsy, Temporal Lobe | Partial Epilepsy

United States
University of Buenos Aires
DrApp S.A.

Suspended

Drug Interactions in Outpatients.

Polypharmacy | Drug Interaction | Adverse Drug Reaction | Outpatient

Argentina
Jianxiang Wang
Xian-Janssen Pharmaceutical Ltd.

Unknown

Therapeutic Effect and Safety Study of Decitabine in Elderly Acute Myeloid Leukemia Patients

Untreated Adult Acute Myeloid Leukemia | Effect of Drugs | Drug Safety
Mario Negri Institute for Pharmacological Research

Completed

E-learning to Improve Oral Anticoagulant Use in Hospitalized Older People With AF (SIM-AF)

Atrial Fibrillation | Elderly | Geriatrics | Simulation Training | Anticoagulant Drugs | Internal Medicine | Drug Prescriptions

Italy
Faculty of Medicine

Completed

Uterotonic Efficacy of Oxytocin 2.5 Versus 10 Units During Caesarean Section at Mulago Hospital

Uterine Hemorrhage | Adverse Effect of Oxytocic Drugs | Inappropriate Dose of Drug Administered

Uganda
UMC Utrecht

Unknown

REC2Stim as a Treatment for Refractory Epilepsy in the Primary Sensorimotor Cortex. (REC2Stim)

Epilepsy Intractable | Epileptic Seizure | Motor Seizure

Netherlands
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University College, London; University... and other collaborators

Completed

Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s) (TB-PRACTECAL)

Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa, Uzbekistan

Clinical Trials on Increased Drug Resistance

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Philippines

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations