Clinical Trials on Injection-related Infections in South Africa

Total 5771 results

University of Witwatersrand, South Africa

Completed

Influenza Vaccine in HIV Infected Children

Influenza With Pneumonia, Influenza Virus Identified

South Africa
International Partnership for Microbicides, Inc.
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Phase 3 Safety and Effectiveness Trial of Dapivirine Vaginal Ring for Prevention of HIV-1 in Women (ASPIRE)

HIV Infections

Malawi, South Africa, Uganda, Zimbabwe
New York State Psychiatric Institute
Brown University; Medical Research Council, South Africa

Active, not recruiting

A Gender-Enhanced Pre-Exposure Prophylaxis (PrEP) Information-Motivational Workshop for Young South African Women (Masibambane)

HIV Infections

South Africa
Duke University
The Emmes Company, LLC

Recruiting

Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana (BMS02)

HIV Infections | Lactating Women on Select DOI | Breastmilk Fed Infants of Mothers on Select DOI

South Africa
TASK Applied Science
GlaxoSmithKline; European and Developing Countries Clinical Trials Partnership...

Recruiting

EBA, Safety and Tolerability of Sanfetrinem Cilexetil

Tuberculosis, Pulmonary

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Acceptability, Safety, and Use of Daily Truvada Pre-Exposure Prophylaxis in Adolescents

HIV Infections

South Africa
RTI International
Medical Research Council, South Africa

Completed

Cape Town Young Women's Health CoOp

Human Immunodeficiency Virus (HIV) | Condomless Sex | Alcohol and Drug Use | Sexually Transmitted Infections (STIs) | Violence and Victimization | Access and Linkage to Healthcare | Education Advancement

South Africa
University of Stellenbosch
Fundació Institut Germans Trias i Pujol

Recruiting

Nyaditum Resae® as a Co-adjuvant During Treatment for Active Pulmonary Tuberculosis and Its Impact on the Gut Microbiota

Tuberculosis

South Africa
TASK Applied Science
GlaxoSmithKline; Research Center Borstel; Eduardo Mondlane University; Barcelona...

Completed

Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Meropenem Plus Amoxycillin/CA and Faropenem Plus Amoxycillin/CA in Adult Patients With Newly Diagnosed Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
Global Alliance for TB Drug Development

Completed

PA-824-CL-007: Phase IIa Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
University of Stellenbosch

Completed

Xpert Ultra and Xpert HIV-VL in People Living With HIV

HIV/AIDS | TB - Tuberculosis | Antiretroviral Therapy, Highly Active

South Africa
University of Stellenbosch
London School of Hygiene and Tropical Medicine; Makerere University; Leiden University... and other collaborators

Recruiting

Point-of-care Triage Test for Active Tuberculosis (TriageTB)

Tuberculosis | Tuberculosis, Pulmonary

South Africa
University of Cape Town
Baylor Research Institute

Completed

Pharmacometric Optimization of Second Line Drugs for MDR Tuberculosis Treatment (PODrtb)

Multidrug-resistant Tuberculosis

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Strategies for Delivering Anti-HIV Therapy in South Africa

HIV Infections

South Africa
Africa Health Research Institute

Recruiting

Long-Acting HIV Pre-Exposure Prophylaxis Integrated With Sexual and Reproductive Health - cRCT (LAPIS)

HIV Infections

South Africa
University of Sussex
University of Cape Town; Africa Health Research Institute

Not yet recruiting

Optimised Electronic Patient Records to Improve Clinical Monitoring of HIV-positive Patients in Rural South Africa (MONART)

HIV Infections

South Africa
London School of Hygiene and Tropical Medicine
Department for International Development, United Kingdom; University of Witwatersrand... and other collaborators

Completed

The Intervention With Microfinance for AIDS and Gender Equity (IMAGE) Study

HIV Infections | Gender Based Violence

South Africa
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Essentiality of INH in TB Therapy

Tuberculosis

South Africa
Foundation for Professional Development (Pty) Ltd
National Institutes of Health (NIH); University of California, Irvine; National... and other collaborators

Completed

Acceptability and Feasibility of Home-based TB Testing

Tuberculosis, Pulmonary | Households

South Africa
Sanofi Pasteur, a Sanofi Company

Completed

Study to Evaluate the Immune Response After Booster Vaccination With Tdap-IPV Vaccine (Against Tetanus, Diphtheria, Pertussis and Poliomyelitis) in Children Who Received Different Pertussis Primary Vaccine Regimens in Republic of South Africa

Pertussis Immunisation | Diphtheria Immunisation | Tetanus Immunisation | Poliomyelitis Vaccine

South Africa
Universiteit Antwerpen
Aurum Institute; University of Stellenbosch; University of the Free State; Free...

Recruiting

Sequencing Mycobacteria and Algorithm-determined Resistant Tuberculosis Treatment Trial (SMARTT)

Drug-resistant Tuberculosis | Rifampicin Resistant Tuberculosis | Pulmonary Tuberculoses | Multidrug Resistant Tuberculosis

South Africa
Walter Sisulu University
Medical University of Graz; Nelson Mandela Academic Hospital; Umtata General...

Not yet recruiting

Cardiometabolic Health of Children Exposed to Anti-retroviral Therapy (ART) in Utero (ARTMOMSBABES)

In Utero Drug Exposure

South Africa
Global Alliance for TB Drug Development

Completed

A Phase 2 Trial to Evaluate the Efficacy and Safety of Linezolid in Tuberculosis Patients. (LIN-CL001)

Pulmonary Tuberculosis

South Africa
Tuberculosis Clinical Diagnostics Research Consortium
University of Cape Town

Unknown

Feasibility of a Lateral Flow Urine LAM Test for Diagnosis of Tuberculosis in South Africa

Tuberculosis | Tuberculosis, Pulmonary | Tuberculosis, Miliary

South Africa
Boston Medical Center
Boston University; National Institute of Allergy and Infectious Diseases (NIAID) and other collaborators

Completed

The Impact of Alcohol Consumption on Tuberculosis Treatment Outcomes

Tuberculosis | Alcohol Consumption | Treatment Adverse Effect

South Africa
TASK Applied Science

Completed

Study to Evaluate EBA, Safety and Tolerability of Carbapenems in Adults With Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
GlaxoSmithKline

Completed

Study to Asses DTPw-HBV/Hib at 15-18 Months (m) and Mencevax™ ACW at 24 to 30 m in Primed Subjects

Infections, Meningococcal

South Africa
Johns Hopkins Bloomberg School of Public Health
National Institute of Mental Health (NIMH); Unity Health Toronto; TB/HIV Care

Recruiting

Project Phakama: Testing Support Strategies to Empower Young Women on PrEP in South Africa

HIV Infections | Pre-exposure Prophylaxis

South Africa
Massachusetts General Hospital
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa (RESOLVE)

HIV Infections | AIDS | Virologic Failure

South Africa, Uganda
Johns Hopkins University
University of Cape Town Lung Institute; University of Cape Town

Completed

Study of Daily Rifapentine for Pulmonary Tuberculosis

Tuberculosis

South Africa
University of Cape Town
Population Health Research Institute

Completed

A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis (IMPI)

Tuberculous Pericarditis

South Africa
Helen Reynolds
Desmond Tutu HIV Centre; Infectious Disease Institute, Kampala, Uganda

Active, not recruiting

Drug Interactions Between Dolutegravir and Escalating Doses of Rifampicin (DoRIS)

Tuberculosis | Hiv

Uganda, South Africa
Ark Biosciences Inc.

Terminated

A Study of AK0529 in Infants Hospitalized With RSV

Respiratory Syncytial Virus Infections

Australia
Klaus Reither
Radboud University Medical Center; Charite University, Berlin, Germany; Institute... and other collaborators

Recruiting

Tuberculosis Diagnostic Trial of CAD4TB Screening Alone Compared to CAD4TB Screening Combined With a CRP Triage Test, Both Followed by Confirmatory Xpert MTB/RIF Ultra in Communities of Lesotho and South Africa

Tuberculosis

Lesotho, South Africa
Aeras
Sanofi Pasteur, a Sanofi Company

Completed

Evaluation of Safety, Immunogenicity, and Prevention of TB With AERAS-404 and BCG Revaccination in Healthy Adolescents

Tuberculosis

South Africa
HIV Prevention Trials Network
National Institute of Allergy and Infectious Diseases (NIAID); National Institute... and other collaborators

Completed

Effects of Cash Transfer for the Prevention of HIV in Young South African Women

HIV

South Africa
University of Cape Town
Imperial College London; Institute of Tropical Medicine, Belgium; European and... and other collaborators

Completed

Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone (Pred-ART)

HIV | Tuberculosis | Immune Reconstitution Inflammatory Syndrome

South Africa
University of California, San Francisco
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Phase 2 Trial of LACTIN-V in Women at High Risk of HIV Acquisition

HIV Infections | Bacterial Vaginosis

South Africa
RTI International
University of Cape Town

Completed

Treating South African Pregnant Women for Methamphetamine

HIV | Drug Addiction

South Africa
Medicines for Malaria Venture
University of Cape Town

Completed

Phase I Study of Ascending Doses of MMV390048 in Healthy Adult Volunteers

Malaria

South Africa
Medicines for Malaria Venture
University of Cape Town

Terminated

Safety, Tolerability & Pharmacokinetics (PK) of Co-administered Single Doses of OZ439 and Mefloquine (MQ) in Healthy Volunteers

Malaria

South Africa
Foundation for Innovative New Diagnostics, Switzerland

Completed

Evaluation of the Performance of Rapid Diagnostics for SARS-CoV-2 Self-testing in the Hands of Untrained (CV009)

COVID-19

South Africa, Uganda
AB Science

Recruiting

Masitinib in Patients With Symptomatic Mild to Moderate COVID-19

Covid19 | Coronavirus Disease 2019 | SARS-CoV2 Infection

France, Russian Federation, South Africa
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Terminated

Rifampin-Based Tuberculosis Treatment Versus Rifabutin-Based Tuberculosis Treatment in Persons With HIV

HIV Infection | Tuberculosis

Peru, Brazil, South Africa, Haiti, Kenya
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

High-Dose Isoniazid Among Adult Patients With Different Genetic Variants of INH-Resistant Tuberculosis (TB)

Tuberculosis

Haiti, South Africa
University of Massachusetts, Worcester
National Institute of Allergy and Infectious Diseases (NIAID); Aurum Institute and other collaborators

Recruiting

Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) (METHOD)

Tuberculosis | Pulmonary Tuberculosis | HIV Coinfection

South Africa
GlaxoSmithKline

Completed

Assess the Immune Response Following Primary Vaccination With GSK Biologicals' Tritanrix™-HepB/Hib-MenAC vs Tritanrix™-HepB/Hiberix™ Given at 6,10 & 14 Wks of Age to Infants Who Received Hepatitis B Vaccine at Birth

Diphtheria; Haemophilus Influenzae Type b; Hepatitis B; Tetanus; Whole Cell Pertussis

South Africa
Elizabeth Glaser Pediatric AIDS Foundation
Harvard School of Public Health (HSPH); Centre for Infectious Disease Research... and other collaborators

Completed

Elizabeth Glaser Pediatric AIDS Foundation Maternal Events and Pregnancy Outcomes (MEP Project)A Multi-site Protocol (MEPProject)

HIV Infections | Pregnant Women | HIV Positive

South Africa, Zambia
Boehringer Ingelheim

Completed

Open Label Study of NVP+CBV Treatment in Women Who Have Received sdNVP for the pMTCT of HIV

Acquired Immunodeficiency Syndrome

South Africa
University of Witwatersrand, South Africa

Completed

Immunogenicity and Safety of Different Dosing Schedules of Trivalent Influenza Vaccine in HIV-infected Pregnant Women

Influenza

South Africa

Clinical Trials on Injection-related Infections in South Africa

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