Clinical Trials on Leptomeningeal Carcinomatosis

Total 278 results

M.D. Anderson Cancer Center
Genentech, Inc.

Completed

A Pilot Study of Bevacizumab for Neoplastic Meningitis

Neoplastic Meningitis

United States
Baylor College of Medicine
National Cancer Institute (NCI); Mayo Clinic; University of Pittsburgh; Brown University and other collaborators

Terminated

Intrathecal Gemcitabine to Treat Neoplastic Meningitis, IT Gemcitabine

Neoplasms | Meningitis

United States
Centre Jean Perrin

Withdrawn

Study of the Isotopic Distribution of Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis of Ovarian Origin (ISOTOVE)

Ovarian Cancer

France
Laval University

Recruiting

Diagnostic Value of DWI-MRI for Detection of Peritoneal Metastases in High-risk Pancreatic Ductal Adenocarcinoma. (DWI-PDAC)

Pancreas Adenocarcinoma | Pancreas Cancer, Duct Cell Adenocarcinoma | Peritoneal Carcinomatosis | Peritoneal Metastases

Canada
National Cancer Institute (NCI)

Completed

Veliparib and Radiation Therapy in Treating Patients With Advanced Solid Malignancies With Peritoneal Carcinomatosis, Epithelial Ovarian, Fallopian, or Primary Peritoneal Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Peritoneal Carcinomatosis | Adult Solid Neoplasm

United States, Canada
National Cancer Center, Korea

Completed

Development for the Peritoneal Carcinomatosis Index (PCI) in Ovarian Cancer

Ovarian Cancer

Korea, Republic of
University of Kansas Medical Center

Recruiting

Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis

ColoRectal Cancer | Cancer, Appendiceal

United States
Andrea McCart
Ontario Institute for Cancer Research

Withdrawn

Phase 2 Study of JX-594 in Patients With Peritoneal Carcinomatosis of Ovarian Cancer Origin

Ovarian Cancer

Canada
David Bartlett
National Cancer Institute (NCI)

Completed

αDC1 Vaccine + Chemokine Modulatory Regimen (CKM) as Adjuvant Treatment of Peritoneal Surface Malignancies

Peritoneal Carcinomatosis | Malignant Neoplasm of Pancreas Metastatic to Peritoneal Surface | Malignant Peritoneal Mesothelioma

United States
Clemens Tempfer

Completed

A Study With Intraperitoneal Cisplatin and Doxorubicin in Recurrent Ovarian Cancer and Peritoneal Carcinomatosis

Ovarian Cancer

Germany
Universitaire Ziekenhuizen KU Leuven

Recruiting

Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was Performed (HIPEC)

Pseudomyxoma Peritonei | Peritoneal Carcinomatosis | Peritoneal Mesothelioma

Belgium
Jules Bordet Institute

Completed

Imaging of Peritoneal Carcinomatosis From Ovarian Carcinoma Patients (OV-AP-ICG-IV)

Ovarian Cancer | Peritoneal Carcinomatosis

Belgium
Wuhan University
NPO Organization to Support Peritoneal Dissemination Treatment; Kishiwada Tokushukai... and other collaborators

Unknown

Surgery Plus Intraoperative Peritoneal Hyperthermic Chemotherapy (IPHC) to Treat Peritoneal Carcinomatosis (IPHC)

Stomach Neoplasms | Neoplasm Metastasis | Colorectal Neoplasms | Mesothelioma

China
H. Lee Moffitt Cancer Center and Research Institute
Bayer

Terminated

Depocyt® With Sorafenib in Neoplastic Meningitis

Neoplastic Meningitis

United States
Hospices Civils de Lyon

Completed

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Carcinomatosis From Ovarian Cancer (Cyto-chip 2) (Cyto-chip 2)

Ovarian Cancer | Peritoneal Carcinoma

France
Charite University, Berlin, Germany
German Cancer Aid

Completed

Cytoreductive Surgery (CRS) With/Without HIPEC in Gastric Cancer With Peritoneal Carcinomatosis (GASTRIPEC)

Malignant Neoplasm of Stomach | Secondary Malignant Neoplasm of Peritoneum | Secondary Malignant Neoplasm of Other and Unspecified Sites

Germany
Sorrento Therapeutics, Inc.

Withdrawn

CAR-T Intraperitoneal Infusions for CEA-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites (IPC)

Breast Cancer | Gastric Cancer | Colorectal Cancer | Pancreas Cancer | Peritoneal Carcinomatosis | Peritoneal Metastases | Carcinoembryonic Antigen

United States
H. Lee Moffitt Cancer Center and Research Institute
United States Department of Defense

Recruiting

A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)

Triple Negative Breast Cancer | HER2-positive Breast Cancer | Leptomeningeal Disease

United States
Centre Hospitalier Régional Metz-Thionville
University of Lorraine

Completed

Optical Spectroscopy for Skin Carcinomas' Surgical Management (SPECTROLIVE)

Carcinomatous or Polymorphous Skin Lesions

France
Ipsen

Completed

Efficacy and Safety of Lanreotide Microparticles as Palliative Treatment in Peritoneal Carcinomatosis

Carcinoma | Peritoneal Neoplasms | Intestinal Obstruction

France, Netherlands, Belgium
Pacira Pharmaceuticals, Inc

Completed

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

Meningeal Neoplasms

United States, Canada
Shanghai Yunying Medical Technology
Shanghai 10th People's Hospital

Recruiting

A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Ovarian Cancer

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Carcinomatosis

China
National Cancer Institute (NCI)

Active, not recruiting

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Leptomeningeal Neoplasm | Recurrent Lung Non-Small Cell Carcinoma

United States
University Hospital, Ghent

Completed

Perioperative Chemotherapy With Bevacizumab for Colorectal Carcinomatosis

Colorectal Neoplasms

Belgium
Genelux Corporation

Completed

GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent or Refractory Ovarian Cancer

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Carcinomatosis

United States
National Cancer Institute (NCI)

Completed

Phase I Trial of Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin Plus Early Postoperative Intraperitoneal Paclitaxel and 5-FU for Peritoneal Carcinomatosis

Carcinoma | Peritoneal Neoplasm

United States
Maimónides Biomedical Research Institute of Córdoba

Completed

Role of Intraperitoneal Intraoperative Chemotherapy With Paclitaxel in the Surgical Treatment of Peritoneal Carcinomatosis From Ovarian Cancer. Hyperthermia Versus Normothermia

Peritoneal Carcinomatosis
University of Sao Paulo
University of Sao Paulo General Hospital

Completed

B-type Natriuretic Peptide in the Diagnosis of Heart Failure Related Ascites

Liver Cirrhosis | Heart Failure | Ascites | Carcinomatosis

Brazil
Oncoinvent AS

Active, not recruiting

Study of Radspherin® in Recurrent Ovarian Cancer Subjects With Peritoneal Carcinomatosis

Ovarian Cancer | Peritoneal Carcinomatosis

Belgium, Spain, Norway
Fundacion para la Formacion e Investigacion Sanitarias...

Unknown

Cytoreduction With or Without Intraoperative Intraperitoneal Hyperthermic Chemotherapy (HIPEC) in Patients With Peritoneal Carcinomatosis From Ovarian Cancer, Fallopian Tube or Primary Peritoneal Carcinoma (CARCINOHIPEC)

Fallopian Tube Carcinoma | Primary Peritoneal Carcinoma | Peritoneal Carcinomatosis From Ovarian Cancer

Spain
University Hospital, Strasbourg, France

Unknown

Establishment of an Artificial Larynx After Total Laryngectomy (LA)

Carcinomatous Disease

France
University of Aarhus

Completed

Changes in Coagulation in Colorectal Cancer Patients Undergoing Surgical Treatment (CONTEST)

Laparoscopic Surgery | Postoperative Complications | Intestinal Neoplasms | Bleeding | Venous Thromboembolism | Peritoneal Carcinomatosis | Cytoreductive Surgery | Peritoneal Metastases | Laparoscopy | Surgical Procedures, Operative | Coagulation | Colorectal Neoplasms Malignant | Minimally Invasive Surgical Procedures and other conditions

Denmark
University of Pisa

Completed

Defining Inflammation Related to Peritoneal Carcinomatosis in Women With Ovarian or Colon Cancer. (CarFlog)

Ovarian Cancer | Colon Cancer | Peritoneal Carcinomatosis

Italy
Washington University School of Medicine

Terminated

A Phase II Study of Surgical Debulking With Peritonectomy and Biweekly Intraperitoneal 5FU With Systemic Oxaliplatin/5FU/Leucovorin in Patients With Pseudomyxoma Peritonei or Peritoneal Carcinomatosis

Peritoneal Neoplasms

United States
British Columbia Cancer Agency

Recruiting

CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease

Non Small Cell Lung Cancer | EGFR Activating Mutation | Leptomeningeal Metastasis

Canada
Hospices Civils de Lyon

Recruiting

Pleural Carcinomatosis Tissue Banking (TICP)

Pleural Effusion, Malignant

France
Albert Einstein College of Medicine

Completed

Single Arm Study Treating Patients of Peritoneal Surface Malignancy (Colorectal, Appendical, Pseudomyxoma, Gastric) With Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C

Gastric Cancer | Colorectal Cancer | Pseudomyxoma Peritonei | Peritoneal Carcinomatosis | Peritoneal Mesothelioma | Appendiceal Cancer

United States
Northwestern University
National Cancer Institute (NCI)

Withdrawn

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Breast Carcinoma | Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm in the Leptomeninges

United States
National Cancer Institute (NCI)

Recruiting

Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies

Ovarian Cancer | Gastrointestinal Cancer | Peritoneal Carcinomatosis | Peritoneal Mesothelioma | Appendiceal Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

Metastatic Lung Non-Small Cell Carcinoma | Metastatic Melanoma | Stage IV Lung Cancer AJCC v8 | Metastatic Uveal Melanoma | Acral Lentiginous Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Leptomeningeal Neoplasm | Metastatic Mucosal Melanoma | Central Nervous System Melanoma | Melanocytoma

United States
Hospitales Universitarios Virgen del Rocío

Completed

Perioperative Coagulopathy in Patients Undergoing Cytoreductive Surgery and HIPEC Intraperitoneal Chemotherapy (HIPEC) (HIPEC-COAG)

Coagulation Disorder | Carcinomatosis

Spain
National Cancer Institute (NCI)

Completed

Phase I Study of Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Escalating Dose I.P. Platinum for Gastrointestinal Peritoneal Carcinomatosis

Stomach Neoplasms | Peritoneal Neoplasms

United States
Edward-Elmhurst Health System

Completed

HIPEC For Peritoneal Surface Malignancies Including Carcinomatosis or Sarcomatosis - Data Registry

Sarcoma | Adenocarcinoma | Neoplasm Metastasis | Peritoneal Neoplasms

United States
University Hospital, Ghent
University Ghent; Kom Op Tegen Kanker

Recruiting

Intraperitoneal Aerosolized Nanoliposomal Irinotecan (Nal-IRI) in Peritoneal Carcinomatosis From Gastrointestinal Cancer (PIPAC-NAL-IRI)

Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Small Bowel Cancer | Bile Duct Cancer | Peritoneal Carcinomatosis | Peritoneal Metastases | Appendix Cancer

Belgium
Rutgers, The State University of New Jersey
National Cancer Institute (NCI)

Recruiting

Peritoneal Carcinomatosis Leveraging ctDNA Guided Treatment in GI Cancer Study (PERICLES Study)

Peritoneal Carcinomatosis | Digestive System Neoplasm | Liver and Intrahepatic Bile Duct Carcinoma | Appendix Carcinoma by AJCC V8 Stage | Colorectal Carcinoma by AJCC V8 Stage | Esophageal Carcinoma by AJCC V8 Stage | Gastric Carcinoma by AJCC V8 Stage

United States
MedSIR
Daiichi Sankyo, Inc.

Completed

DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease (DEBBRAH)

Advanced Breast Cancer | HER2-positive Breast Cancer | Brain Metastases | Leptomeningeal Metastasis

Spain, Portugal
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

Glioblastoma | Ependymoma | Medulloblastoma | Recurrent Metastatic Malignant Neoplasm in the Leptomeninges

United States
City of Hope Medical Center
National Cancer Institute (NCI); California Institute for Regenerative Medicine...

Recruiting

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Breast Cancer | HER2-positive Breast Cancer | Malignant Neoplasm | Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm in the Leptomeninges

United States
Mundipharma Research Limited

Completed

Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis.

Brain Metastases | Solid Tumour Neoplastic Meningitis

Austria, Germany
M.D. Anderson Cancer Center
Reata Pharmaceuticals, Inc.

Terminated

RTA 744 Injection in Patients With Leptomeningeal Disease

Lymphoma | Leukemia | Solid Tumor | Brain Tumor | Neoplastic Meningitis

United States

Clinical Trials on Leptomeningeal Carcinomatosis

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CROs in Kazakhstan

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