Clinical Trials on Leukocyte-Adhesion Deficiency Syndrome

Total 6028 results

Willem Daniel Francois Venter
Bill and Melinda Gates Foundation

Completed

Dose Optimisation of Stavudine for the Treatment of HIV Infection (D4T)

Human Immunodeficiency Virus | Acquired Immune Deficiency Syndrome

South Africa, India, Uganda
National Medical Research Center for Rehabilitation...
Pirogov Russian National Research Medical University; DNKOM LLC; The Orenburg...

Recruiting

Study of Efficacy and Safety of the Plasmapheresis Method With Albumin Compensation Compared With the Plasmapheresis Method Without Albumin Compensation for Aging Biomarkers Correction in Men and Women Aged 40 to 55 Years Old

Cardiovascular Diseases | Nervous System Diseases | Urologic Diseases | Diabetes | Neuromuscular Diseases | Hypercholesterolemia | Gout | Hyperbilirubinemia | Hyper IgE Syndrome | Hyper-LDL-cholesterolemia | Hyper Beta Lipoproteinemia | Hyper Eosinophilic Syndrome

Russian Federation
Oswaldo Cruz Foundation

Unknown

Prospective Evaluation of HIV Patients Using Non-invasive Methods for Estimation of Liver Fibrosis and Steatosis (Prospec-HIV)

Liver Diseases | Fibrosis | Liver Cirrhosis | Human Immunodeficiency Virus | Acquired Immune Deficiency Syndrome Virus

Brazil
M.D. Anderson Cancer Center

Completed

2-Chlorodeoxyadenosine and Cytarabine in Patients With Idiopathic Hypereosinophilic Syndrome (HES)

Leukemia

United States
Assiut University

Not yet recruiting

Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease

CGD
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Transition From Pediatric to Adult Care Among Adolescents With Chronic Granulomatous Disease

CGD

United States
IRCCS San Raffaele
Fondazione Telethon

Completed

Gene Therapy for ADA-SCID

Severe Combined Immunodeficiency Syndrome
National Institute of Allergy and Infectious Diseases...

Completed

Anti-Interleukin-5 Antibody to Treat Hypereosinophilic Syndrome

Hypereosinophilic Syndrome

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by a Donor Stem Cell Transplant in Treating Patients With Immunodeficiency or Other Nonmalignant Inherited Disorders

Immunodeficiency Syndrome | Non-Cancer Diagnosis

United States
National Human Genome Research Institute (NHGRI)

Completed

Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency

Severe Combined Immunodeficiency Syndrome

United States
University of Nebraska

Completed

Treatment of Vitamin D Deficiency in Intestinal Rehabilitation Clinic Patients With a Portable Ultraviolet B Lamp

Vitamin D Deficiency | Short Bowel Syndrome

United States
Boston Children's Hospital

Withdrawn

Use of Tocofersolan (Vedrop®) to Prevent or Treat Refractive Vitamin E Deficiency in Infants and Children

Short Bowel Syndrome | Vitamin E Deficiency
Scripps Health
J. Craig Venter Institute

Completed

Biomarker Monitoring in TP53 Mutation Carriers

Li-Fraumeni Syndrome | Hereditary Cancer Syndromes | TP53 Gene Germline Mutation Carrier

United States
Takeda
Ovid Therapeutics Inc.

Completed

A Multicenter, Open-label, Pilot Study of Soticlestat (TAK-935/OV935) in Participants With 15Q Duplication Syndrome (Dup 15q) or Cyclin-Dependent Kinase-Like 5 (CDKL5) Deficiency Disorder (ARCADE STUDY)

15q Duplication Syndrome | CDKL5 Deficiency Disease

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Isavuconazole in Preventing Invasive Fungal Infections in Adult Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome and Neutropenia

Acute Myeloid Leukemia | Neutropenia | Myelodysplastic Syndrome

United States
John Sampson

Completed

Evaluation of Recovery From Drug-Induced Lymphopenia Using Cytomegalovirus-specific T-cell Adoptive Transfer (ERaDICATe)

Glioblastoma

United States
Amgen

Completed

A Randomized, Controlled, Multicenter Trial of Filgrastim (Recombinant-Methionyl Human Granulocyte Colony Stimulating Factor; G-CSF) for the Prevention of Grade 4 Neutropenia in Patients With HIV Infection.

HIV Infections | Cytopenias

United States, Canada
Northern Italy Leukemia Group

Completed

Efficacy of Imatinib Mesylate in Hypereosinophilic Syndromes (NILG-HES1-03)

Hypereosinophilic Syndrome | Chronic Eosinophilic Leukemia | Chronic Idiopathic Hypereosinophilia

Italy
Novartis

Completed

Efficacy, Safety, and Tolerability of ACZ885 in Patients With Muckle-Wells Syndrome (REMITTER)

Muckle Wells Syndrome

United States, Spain, United Kingdom, France, Germany, India
Biogen

Completed

Real World Analysis on Lymphocyte Reconstitution After Lymphopenia in Participants Treated by Tecfidera (Lympho-TEC)

Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting

France
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI); NeoImmuneTech

Terminated

Study of the Effect NT-I7 on CD4 Counts in Patients With High Grade Gliomas

Malignant Glioma | Lymphopenia

United States
AstraZeneca
Bristol-Myers Squibb

Completed

Risk Factors for Low Lymphocyte Count in Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Chemotherapy in Treating Patients With Newly Diagnosed Acute or Chronic Myelogenous Leukemia or Myelodysplastic Syndrome

Myelodysplastic Syndromes | Leukemia | Neutropenia

United States
Novartis

Completed

Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease

Familial Cold Autoinflammatory Syndrome | Cryopyrin-Associated Periodic Syndromes | Neonatal Onset Multisystem Inflammatory Disease | Muckle Wells Syndrome

United States, Germany, Italy, Spain, United Kingdom, Turkey, France, Belgium, India
Juan Pascual
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Treatment Development of Triheptanoin (G1D)

Glucose Metabolism Disorders | Epilepsy | Glucose Transporter Type 1 Deficiency Syndrome | Glut1 Deficiency Syndrome 1, Autosomal Recessive | Glucose Transporter Protein Type 1 Deficiency Syndrome | Glucose Transport Defect | GLUT1DS1

United States
Charles University, Czech Republic

Recruiting

Immune Homeostasis in Sepsis and Septic Shock (IMHOTEP)

Sepsis | Immune Deficiency | Immunologic Paralysis | Immunologic Suppression

Czechia
University of Texas Southwestern Medical Center
National Institute of Neurological Disorders and Stroke (NINDS)

Active, not recruiting

Diet Treatment Glucose Transporter Type 1 Deficiency (G1D)

Glucose Metabolism Disorders | Epilepsy | Glucose Transporter Type 1 Deficiency Syndrome | Glut1 Deficiency Syndrome 1, Autosomal Recessive | Glucose Transporter Protein Type 1 Deficiency Syndrome | Glucose Transport Defect | GLUT1DS1

United States
Xiao-dong Zhuang
Sun Yat-sen University

Unknown

Rosuvastatin Effect on Telomere-telomerase System in ACS

Telomere Length, Mean Leukocyte | Telomere Shortening | 22q Telomere Deletion Syndrome
GlaxoSmithKline

No longer available

This Record Contains Information About the Mepolizumab Compassionate Use (CU) Product Activities: 104317: CU and Long-Term Access Study of Mepolizumab in HES. 201956:A Long-term Access Programme for Subjects With Severe Asthma 112562: Expanded Access for Patients With Hypereosinophilic

Hypereosinophilic Syndrome
Pfizer

Completed

Azithromycin in the Treatment of Cryptosporidiosis in Patients With Acquired Immune Deficiency Syndrome (AIDS): A Randomized, Multi-Center, Placebo-Controlled, Double-Blind Study

HIV Infections | Cryptosporidiosis

United States
Chang Gung Memorial Hospital

Completed

Persistent Lymphopenia in Liver Transplantation and Its Molecular Insights for Hepatocellular Carcinoma

Lymphopenia

Taiwan
Gary Archer Ph.D.
National Cancer Institute (NCI)

Completed

Basiliximab in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Undergoing Targeted Immunotherapy and Temozolomide-Caused Lymphopenia (REGULATe)

Malignant Neoplasms Brain

United States
Merck Sharp & Dohme LLC

Completed

Prophylaxis Trial of Posaconazole Versus Standard Azole Therapy for Neutropenic Patients (Study P01899)

Myelodysplastic Syndromes | Neutropenia | Leukemia, Myelocytic, Acute
Abramson Cancer Center of the University of Pennsylvania
Children's Hospital of Philadelphia

Recruiting

Li-Fraumeni Syndrome/TP53 Biobank

Li-Fraumeni Syndrome | Li-Fraumeni-Like Syndrome

United States
Gustave Roussy, Cancer Campus, Grand Paris

Completed

LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome) (LIFSCREEN)

Li Fraumeni Syndrome

France
Novartis Pharmaceuticals

Completed

Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase

Familial Cold Autoinflammatory Syndrome | Muckle-Wells Syndrome | Neonatal Onset Multisystem Inflammatory Disease | Cryopyrin-associated Periodic Syndromes

Japan
Novartis Pharmaceuticals

Completed

Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease

Familial Cold Autoinflammatory Syndrome | Muckle-Wells Syndrome | Neonatal Onset Multisystem Inflammatory Disease | Cryopyrin-associated Periodic Syndromes

Germany, France, Belgium, Canada, Spain, Switzerland, United Kingdom
Columbia University
Clínica de Familia La Romana, Dominican Republic

Recruiting

WiseApp for Spanish Speakers Living With HIV

HIV Infections | Sexually Transmitted Diseases, Viral | Acquired Immune Deficiency Syndrome

United States, Dominican Republic
Jena University Hospital
University of Leipzig; Technische Universität Dresden; University of Magdeburg; University of Rostock and other collaborators

Completed

Regional Differences in Human Immunodeficiency Virus (HIV) Testing (HIVRegional)

HIV Seropositivity | CD4+ T Lymphocytopenia

Germany
Bio Products Laboratory

Completed

Efficacy, Safety and Pharmacokinetics of Gammaplex in Primary Immunodeficiency Diseases.

Primary Immunodeficiency | Wiskott-Aldrich Syndrome | Hypogammaglobulinemia | Common Variable Hypogammaglobulinemia | X-linked Hypogammaglobulinemia | Immunodeficiency With Hyper-IgM

United States
Centre Hospitalier Universitaire de Saint Etienne

Completed

Assessment of Postoperative Lymphopenia as Risk Factor for Postoperative Infections (EVALYMPH)

Thoracic Diseases | Cancer of the Digestive System

France
Hubert Serve, Prof., MD

Unknown

Gene Therapy for X-CGD

X-linked Chronic Granulomatous Disease

Germany
University of Colorado, Denver
Colorado Clinical & Translational Sciences Institute

Recruiting

Mechanisms of Immune Deficiency

Immune Deficiency

United States
Johann Wolfgang Goethe University Hospital

Unknown

Bronchial Inflammation in Patients With Severe Immune Deficiency Under Immunoglobulin Treatment

Immune Deficiency

Germany
Novartis Pharmaceuticals

Completed

Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease

Familial Cold Autoinflammatory Syndrome | Muckle-Wells Syndrome | Neonatal Onset Multisystem Inflammatory Disease | Cryopyrin-associated Periodic Syndromes

Germany, France, Belgium, Canada, Spain, Switzerland, United Kingdom
Yonsei University

Completed

Effect of Fermented Maillard Reacted Whey Protein on Immune Function

Immune Deficiency

Korea, Republic of
Yonsei University

Completed

Immune Benefits of Consumption of Dairy Yogurt in Elderly

Immune Deficiency

Korea, Republic of
Fred Hutchinson Cancer Center

Completed

Study of Total Body Irradiation and Fludarabine Followed By Allogeneic Peripheral Blood Stem Cell or Bone Marrow Transplantation in Combination With Cyclosporine and Mycophenolate Mofetil in Patients With Inherited Disorders

Metabolism, Inborn Errors | Granulomatous Disease, Chronic

United States
Shanghai Children's Medical Center

Unknown

Chronic Granulomatous Disease Study in China

Granulomatous Disease, Chronic

China
Zealandina Agency

Completed

Mountain Food and Natural Probiotic in Nutrition

Immune Deficiency

United Kingdom

Clinical Trials on Leukocyte-Adhesion Deficiency Syndrome

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CROs in Ecuador

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