Clinical Trials on Localized Unresectable Adult Primary Liver Cancer

Total 690 results

ImmunoVaccine Technologies, Inc. (IMV Inc.)
Merck Sharp & Dohme LLC

Active, not recruiting

Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors

Hepatocellular Carcinoma | Ovarian Cancer | Bladder Cancer | Non-small Cell Lung Cancer | Microsatellite Instability-High

United States, Canada
ZielBio, Inc.

Completed

A Phase 1/2, First-in-Human, Open Label, Dose Escalation Study Of A CSP Targeting Functional Antibody in Solid Tumors

Ovarian Serous Cystadenocarcinoma | Solid Tumor, Adult | Ovarian Serous Adenocarcinoma | Biliary Cancer Metastatic | Pancreatic Ductal; Adenocarcinoma

United States
University Hospital Southampton NHS Foundation...
University of Southampton

Active, not recruiting

HORIZONS: Understanding the Impact of Cancer Diagnosis and Treatment on Everyday Life

Cervical Cancer | Fallopian Tube Neoplasms | Ovarian Cancer | Fallopian Tube Cancer | Breast Neoplasm | Endometrial Neoplasms | Vulvar Cancer | Vulvar Neoplasms | Endometrial Cancer | Diffuse Large B Cell Lymphoma | Ovarian Neoplasm | Breast Cancer Female | Primary Peritoneal Carcinoma | NonHodgkin Lymphoma | Cervical... and other conditions

United Kingdom
Hutchison Medipharma Limited
BeiGene

Active, not recruiting

A Study of Fruquintinib in Combination With Tislelizumab in Advanced Solid Tumors

Colorectal Cancer | Triple Negative Breast Cancer | Endometrial Cancer | Solid Tumor, Unspecified, Adult

United States
National Cancer Institute (NCI)

Completed

Sunitinib Malate and Bevacizumab in Treating Patients With Kidney Cancer or Advanced Solid Malignancies

Clear Cell Renal Cell Carcinoma | Unspecified Adult Solid Tumor, Protocol Specific | Stage III Renal Cell Cancer | Stage IV Renal Cell Cancer | Recurrent Renal Cell Cancer | Stage I Renal Cell Cancer | Stage II Renal Cell Cancer

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant

Clear Cell Renal Cell Carcinoma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent... and other conditions

United States, Germany, Italy
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant (GVHD)

Primary Myelofibrosis | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal... and other conditions

United States
The Rogosin Institute
Vital Systems Inc.

Completed

Open-Label Phase 2 Efficacy Trial of Cancer Macrobeads in Patients With Treatment-Resistant Pancreatic/Colorectal Cancer (Macrobead)

Colorectal Cancer Metastatic | Pancreatic Adenocarcinoma Metastatic | Pancreatic Adenocarcinoma Non-resectable

United States
Rahul Aggarwal
National Institute of Mental Health (NIMH); U.S. Army Medical Research Acquisition...

Recruiting

11C-YJH08 PET Imaging for Detection of Glucocorticoid Receptor Expression

Solid Tumor | Castration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Stage IV Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8 | Stage IVB Prostate Cancer AJCC v8 | Solid Tumor, Adult | Metastatic Castration-resistant Prostate Cancer

United States
University of Alberta
Canadian Institutes of Health Research (CIHR)

Active, not recruiting

Evidence Based Mental Wellness Programming Online for Adults Across Chronic Physical Conditions (EMPOwer)

Heart Failure | Cancer | Chronic Kidney Diseases | Cirrhosis, Liver | Primary Biliary Cholangitis | Digestive Diseases | Women Who Have Experienced a Cardiac Event | Post-Transplant | Other Chronic Physical Condition

Canada
Eli Lilly and Company

Completed

A Study of Emibetuzumab in Combination With Ramucirumab (LY3009806) in Participants With Advanced Cancer

Renal Cell Carcinoma | Non-Small Cell Lung Cancer | Gastric Adenocarcinoma | Advanced Cancer | Hepatocellular Cancer | Gastroesophageal Junction Adenocarcinoma

United States
ModeX Therapeutics, An OPKO Health Company

Recruiting

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

Cervical Cancer | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Pancreatic Cancer | Esophageal Cancer | Rectal Cancer | Prostate Cancer | Endometrial Cancer | Non-small Cell Lung Cancer | Colon Cancer | Thyroid Cancer | Renal Cancer | Biliary Tract Cancer | Hepatocellular Cancer | GastroEsophageal Cancer

United States
King's College Hospital NHS Trust
King's College London

Completed

SELF-BREATHE RCT for Chronic Breathlessness

Liver Failure | Cancer | Asthma | Renal Failure | Cystic Fibrosis | Chronic Heart Failure | Sickle Cell Disease | Interstitial Lung Disease | COPD | Dyspnea | Post COVID-19 | Bronchiectasis Adult

United Kingdom
Merus N.V.

Available

Early Access Program Providing HER2/HER3 Bispecific Antibody, MCLA-128, for a Patient With Advanced NRG1-Fusion Positive Solid Tumor

Renal Cell Carcinoma | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Prostate Cancer | Non Small Cell Lung Cancer | Cholangiocarcinoma | Solid Tumor, Unspecified, Adult | Unknown Primary Tumors | NRG1 Fusion
Milton S. Hershey Medical Center

Completed

Detection of CTCs in Patients Undergoing Surgery for Stage IV Colorectal Cancer

Lung Metastases | Liver Metastases | Stage IV Colorectal Cancer

United States
University of Zurich
University Hospital, Geneva; University Hospital Inselspital, Berne; University... and other collaborators

Completed

Cancer Development In Organ Transplant Recipients

Kidney Cancer | Lung Cancer | Pancreas Cancer | Liver Cancer | Heart Cancer

Switzerland
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Study (SAMURAI)

Metastatic Renal Cell Carcinoma | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Unresectable Renal Cell Carcinoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies

Metastatic Renal Cell Carcinoma | Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Metastatic Melanoma | Fallopian Tube Carcinoma | Advanced Malignant Solid Neoplasm | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage III Renal... and other conditions

United States
Duke University
Pfizer

Completed

Pillars4Life Trial (Pillars4Life)

Cervical Cancer | Breast Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer | Bladder Cancer | Colon Cancer | Renal Cancer | Liver Cancer | Uterine Cancer

United States
SpeciCare
University of Washington; Georgia Institute of Technology; Predictive Oncology; Netnoid... and other collaborators

Recruiting

The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology) (PIONEER)

Melanoma | Sarcoma | Renal Cell Carcinoma | Breast Cancer | Hepatocellular Carcinoma | Transitional Cell Carcinoma | Glioblastoma Multiforme | Cholangiocarcinoma | Small-cell Lung Cancer | Oligodendroglioma | Cancer of Head and Neck | Cancer of Liver | Cancer of Pancreas | Cancer of Brain and Nervous System | Adrenal... and other conditions

United States
Envita Medical Center, Inc.

Suspended

Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on Cancer

Glioma | Breast Cancer | Pancreatic Cancer | Prostate Cancer | Colon Cancer | Hepatocellular Cancer | Squamous Cell Lung Cancer

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid... and other conditions

United States
Duke University
Varian Medical Systems

Recruiting

Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy (SPiRiT)

Lung Cancer | Primary Brain Tumor | Brain Metastases, Adult

United States
Hospices Civils de Lyon

Recruiting

Predictive Value of Progastrin Titer at Diagnosis and of Progastrin Kinetics During Treatment in Cancer Patients (ONCOPRO)

Melanoma | B-cell Lymphoma | Cancer | Breast Cancer | Head and Neck Cancer | Glioblastoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer | Bladder Cancer | Endometrial Cancer | Renal Cancer | Hepatocellular Cancer

France
National Cancer Institute (NCI)

Completed

Sunitinib Malate in Treating Patients With Unresectable or Metastatic Kidney Cancer or Other Advanced Solid Tumors

Clear Cell Renal Cell Carcinoma | Recurrent Renal Cell Carcinoma | Stage III Renal Cell Cancer | Stage IV Renal Cell Cancer | Adult Solid Neoplasm

United States
Rahul Aggarwal
National Cancer Institute (NCI); U.S. Army Medical Research Acquisition Activity

Recruiting

64Cu-GRIP B in Patients With Advanced Malignancies

Prostate Cancer | Advanced Solid Tumor | Renal Cancer | Urethral Cancer | Solid Tumor, Adult | Metastatic Castration-resistant Prostate Cancer

United States
National Cancer Institute (NCI)

Completed

Sorafenib Tosylate in Treating Younger Patients With Relapsed or Refractory Rhabdomyosarcoma, Wilms Tumor, Liver Cancer, or Thyroid Cancer

Recurrent Thyroid Cancer | Recurrent Childhood Rhabdomyosarcoma | Papillary Thyroid Cancer | Recurrent Wilms Tumor and Other Childhood Kidney Tumors | Previously Treated Childhood Rhabdomyosarcoma | Recurrent Childhood Liver Cancer | Childhood Hepatocellular Carcinoma

United States, Canada, Australia
Emory University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; Astellas Pharma Inc; Seagen...

Recruiting

Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology

Stage III Bladder Cancer AJCC v8 | Stage IV Bladder Cancer AJCC v8 | Bladder Adenocarcinoma | Bladder Squamous Cell Carcinoma | Metastatic Bladder Carcinoma | Urachal Adenocarcinoma | Locally Advanced Bladder Carcinoma | Malignant Renal Pelvis Neoplasm | Malignant Ureter Neoplasm | Malignant Urethral Neoplasm and other conditions

United States
G1 Therapeutics, Inc.

Terminated

Trilaciclib, a CDK 4/6 Inhibitor, in Patients With Advanced/Metastatic Bladder Cancer Receiving Chemotherapy Then Avelumab (PRESERVE3)

Bladder Cancer | Urothelial Carcinoma | Chemotherapy-induced Neutropenia | Myelosuppression Adult | Metastatic Bladder Cancer

Hungary, Spain, United States, France, Georgia
City of Hope Medical Center

Recruiting

Stomach Cancer Exosome-based Detection (DESTINEX)

Gastric Cancer | Gastric Adenocarcinoma | Gastric Cancer Stage IV | Gastric Neoplasm | Gastric Cancer Metastatic to Lung | Gastric Cancer Stage | Gastric Cancer Metastatic to Liver | Gastric Cancer Stage III | Gastric Cancer Stage II | Gastric Lesion | Gastric Cancer in Situ | Gastric Cancer Stage IIIB | Gastric... and other conditions

United States, Japan
Pfizer

Terminated

Study of PF-07263689 in Participants With Selected Advanced Solid Tumors

Melanoma | Sarcoma | Head and Neck Cancer | Colorectal Cancer | Ovarian Cancer | Bladder Cancer | Renal Cell Cancer | Hepatocellular Cancer | Squamous Cell Carcinoma | Non-Small-Cell Lung Cancer

United States
MacroGenics

Active, not recruiting

MGD019 DART® Protein in Unresectable/Metastatic Cancer

Colorectal Cancer | Advanced Cancer | Prostate Cancer Metastatic | Cutaneous Melanoma | Solid Tumor, Adult | Squamous Cell Non Small Cell Lung Cancer

United States, Spain, Bulgaria, Poland, Ukraine
University of Chicago
National Cancer Institute (NCI)

Completed

Genetic Analysis-Guided Dosing of FOLFIRABRAX in Treating Patients With Advanced Gastrointestinal Cancer

Pancreatic Adenocarcinoma | Gastric Adenocarcinoma | Metastatic Pancreatic Adenocarcinoma | Malignant Gastrointestinal Neoplasm | Stage III Pancreatic Cancer | Stage IV Pancreatic Cancer | Gallbladder Carcinoma | Stage IV Gallbladder Cancer | Stage IV Gastric Cancer | Stage IIIA Gallbladder Cancer | Stage... and other conditions

United States
Exact Sciences Corporation

Completed

Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors

Kidney Cancer | Stomach Cancer | Breast Cancer | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer | Bladder Cancer | Liver Cancer | Renal Pelvis Cancer | Uterine Cancer

United States
Grit Biotechnology

Recruiting

Clinical Study of GT201 in the Treatment of Advanced Gynecological Tumors (Advanced Cervical Cancer)

Adult | Gynecological Tumors

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic

Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Metastatic Skin Squamous Cell Carcinoma | Unresectable Solid Neoplasm | Metastatic Kidney Medullary Carcinoma | Metastatic Penile Carcinoma | Small Cell Carcinoma | Metastatic Adrenal Gland Pheochromocytoma | Stage IV Penile Cancer... and other conditions

United States
UNC Lineberger Comprehensive Cancer Center

Withdrawn

Relationship Between Circulating Tumor Cell Cultures' Treatment Response and Clinical Outcomes

Cancer | Bladder Cancer | Gastrointestinal Cancer | Circulating Tumor Cell | Metastasis Lung | Metastasis to Liver
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Magnetic Resonance Imaging-guided Thermal Radiofrequencey Ablation of Primary Renal Cell Carcinoma, Hepatic Metastasis, and Other Sites of Solid Organ Tumor and Metastases

Kidney Cancer | Unspecified Adult Solid Tumor, Protocol Specific | Metastatic Cancer

United States
National Cancer Institute (NCI)

Terminated

Monoclonal Antibody Therapy in Treating Patients With Ovarian Epithelial Cancer, Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Non-Small Cell Lung Cancer

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) | Previously Treated Myelodysplastic... and other conditions

United States
NCIC Clinical Trials Group

Completed

Liposomal Lurtotecan Plus Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors

Head and Neck Cancer | Ovarian Cancer | Lung Cancer | Unspecified Adult Solid Tumor, Protocol Specific

Canada
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Small Cell Lung Carcinoma | Lung Cancer | Lung Cancer Metastatic | Small-cell Lung Cancer | Brain Metastases | Brain Metastases, Adult

United States
St. Jude Children's Research Hospital
National Cancer Institute (NCI)

Completed

Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin

Unspecified Childhood Solid Tumor, Protocol Specific | Colorectal Cancer | Unspecified Adult Solid Tumor, Protocol Specific | Carcinoma of Unknown Primary

United States
Sensei Biotherapeutics, Inc.
Regeneron Pharmaceuticals

Recruiting

A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

Melanoma | Sarcoma | Kidney Cancer | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Prostate Cancer | Non Small Cell Lung Cancer | Metastatic Cancer | Bladder Cancer | Cervix Cancer | Advanced Solid Tumor | Advanced Cancer | Colon Cancer | Thyroid Cancer | Solid Tumor... and other conditions

United States
NCIC Clinical Trials Group

Completed

OGX-011 and Docetaxel in Treating Patients With Metastatic or Locally Recurrent Solid Tumors

Kidney Cancer | Breast Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer | Unspecified Adult Solid Tumor, Protocol Specific | Bladder Cancer
National Cancer Institute (NCI)

Completed

Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent... and other conditions

United States
Cancer Research UK

Terminated

Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating Patients With Cancer

Breast Cancer | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Lung Cancer | Unspecified Adult Solid Tumor, Protocol Specific

United Kingdom
Roswell Park Cancer Institute

Completed

Body Warming in Improving Blood Flow and Oxygen Delivery to Tumors in Patients With Cancer

Melanoma | Soft Tissue Sarcoma | Breast Carcinoma | Lung Carcinoma | Malignant Neoplasm | Colon Carcinoma | Ovarian Neoplasm | Malignant Head and Neck Neoplasm | Adult Liver Carcinoma | Kidney Neoplasm

United States
Second Affiliated Hospital of Guangzhou Medical...

Recruiting

Triplex Checkpoint Inhibitors Therapy for Advanced Solid Tumors

Sarcoma | Cervical Cancer | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Colorectal Cancer | Esophageal Cancer | Lung Cancer | Pancreas Cancer | Liver Cancer | Ovary Cancer

China
Royal Marsden NHS Foundation Trust

Unknown

Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer

Sarcoma | Cervical Cancer | Testicular Germ Cell Tumor | Colorectal Cancer | Ovarian Cancer | Prostate Cancer | Bladder Cancer | Endometrial Cancer | Radiation Toxicity | Vaginal Cancer | Gastrointestinal Complications | Long-term Effects Secondary to Cancer Therapy in Adults

United Kingdom
Western University, Canada

Recruiting

(3D) Ultrasound Imaging Liver and Kidney

Kidney Cancer | Liver Cancer

Canada

Clinical Trials on Localized Unresectable Adult Primary Liver Cancer

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