Clinical Trials on Locally Advanced Prostate Cancer

Total 8549 results

University of California, Irvine

Completed

MRI Temperature Mapping of the Prostate and Urogenital Pelvis Cooled by an Endorectal Balloon

Urinary Incontinence | Erectile Dysfunction | Prostate Cancer | Hypothermia

United States
M.D. Anderson Cancer Center
Edwards Lifesciences

Completed

Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy

Liver Diseases | Gastrointestinal Diseases | Kidney Diseases | Esophageal Diseases | Prostate Cancer | Pancreatic Diseases | Gynecologic Diseases | Spinal Disease | Disorder of the Genitourinary System

United States
Brandon Huffman
Stand Up To Cancer; Lustgarten Foundation; K-Group, Beta, Inc., a wholly owned...

Recruiting

ZN-c3 + Gemcitabine in Pancreatic Cancer

Pancreatic Cancer | Pancreatic Ductal Adenocarcinoma | Advanced Pancreatic Adenocarcinoma

United States
National Cancer Institute (NCI)

Recruiting

Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Triple-Negative Breast Carcinoma

United States
Anaveon AG

Recruiting

A Study Evaluating Safety and Therapeutic Activity of ANV419 in Patients With Advanced Cancer. (ANV419-001)

Lung Cancer | Advanced Solid Tumor | Adult Disease

United Kingdom, Switzerland, Spain
Dragonboat Biopharmaceutical Company Limited
Fudan University

Recruiting

the Efficacy and Safety of LDP in Patients With Urinary and Male Genital Tumors

Bladder Cancer | Renal Carcinoma | Advanced Penile Carcinoma

China
Jun Gong, MD
Emmaus Medical, Inc.

Active, not recruiting

Trial of First-line L-glutamine With Gemcitabine and Nab-paclitaxel in Advanced Pancreatic Cancer

Pancreatic Cancer | Pancreatic Ductal Adenocarcinoma | Advanced Pancreatic Adenocarcinoma

United States
CHU de Quebec-Universite Laval
GlaxoSmithKline

Completed

Efficacy and Toxicity of Bicalutamide and Dutasteride vs. Standard Care for Prostate Cytoreduction for Brachytherapy

Lower Urinary Tract Symptoms | Erectile Dysfunction | Prostate Cancer

Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Sintilimab for the Treatment of Locally Advanced, Metastatic, Recurrent, or Unresectable Undifferentiated Pleomorphic Sarcoma, SiARa Cancer Study

Metastatic Undifferentiated Pleomorphic Sarcoma | Recurrent Undifferentiated Pleomorphic Sarcoma | Locally Advanced Undifferentiated Pleomorphic Sarcoma | Unresectable Undifferentiated Pleomorphic Sarcoma

United States
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of agenT-797 in Combination With Botensilimab, Balstilimab, Ramucirumab, and Paclitaxel for People With Esophageal, Gastric, or Gastro-esophageal Junction Cancer

Metastatic Gastric Adenocarcinoma | Metastatic Gastroesophageal Junction Adenocarcinoma | Unresectable Gastric Adenocarcinoma | Unresectable Gastroesophageal Junction Adenocarcinoma | Metastatic Gastric Cancer | Unresectable Esophageal Cancer | Metastatic Esophageal Carcinoma | Metastatic Gastric... and other conditions

United States
Keythera Pharmaceuticals (Australia) Pty Ltd

Recruiting

A Study of KF-0210 in Advanced Solid Tumors Patients

Gastric Cancer | Colorectal Cancer | Lung Cancer | Bladder Cancer | Advanced Solid Tumor | Squamous Cell Carcinoma of the Esophagus

Australia
Five Prime Therapeutics, Inc.
Bristol-Myers Squibb

Completed

Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers (FPA008-003)

Renal Cell Carcinoma | Head and Neck Cancer | Pancreatic Cancer | Ovarian Cancer | Malignant Glioma | Advanced Solid Tumors | Non-small Cell Lung Cancer

United States
Western Regional Medical Center

Terminated

Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus) (NivoPlus)

Pancreatic Cancer | Non Small Cell Lung Cancer | Advanced Cancer | Renal Cell Cancer | Colorectal Carcinoma | Endometrial | Uterine

United States
Millennium Pharmaceuticals, Inc.

Completed

Alisertib in Adults With Nonhematological Malignancies, Followed by Alisertib in Lung, Breast, Head and Neck or Gastroesophageal Malignancies

Small Cell Lung Cancer | Non-Small Cell Lung Cancer | Metastatic Breast Cancer | Head and Neck Squamous Cell Carcinoma | Gastroesophageal Adenocarcinoma | Advanced Nonhematological Malignancies

United States
Mayo Clinic

Recruiting

Associations Between Chemotherapy-Induced Nausea in Patients With Genitourinary, Sarcoma or Melanoma Cancers and Changes in Gut Microbiome: Potential for Precision Therapeutics

Melanoma | Sarcoma | Prostate Cancer | Bladder Cancer | Bladder Carcinoma | Prostate Carcinoma | Testicular Cancer | Genitourinary System Carcinoma | Malignant Testicular Neoplasm

United States
Taiho Oncology, Inc.

Recruiting

REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors) (REZILIENT3)

Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation

United States, Spain, Canada, Italy, Israel, Japan, United Kingdom, Korea, Republic of, Germany, France, Turkey, Belgium, Netherlands, Philippines, Poland, Singapore
Tan Tock Seng Hospital

Recruiting

HALO Trial: Haloperidol vs Olanzapine in Hyperactive Delirium in Palliative Care Patients; A Multi-Centre, Randomised-Controlled Trial

Advanced Cancer | Hyperactive Delirium | Olanzapine | Haloperidol | End-stage Organ Disease

Singapore
Istituto Scientifico Romagnolo per lo Studio e...
Pierre Fabre Laboratories

Terminated

Open-label, Multicenter, Randomized Phase II Trial of Treatment With Cisplatin and Pemetrexed or Cisplatin and Oral Vinorelbine in Chemotherapy Naïve Patients Affected by Stage IIIB-IV Non-Squamous Non-Small Cell Lung Cancer With High Thymidylate Synthase Expression (HighTySy)

Carcinoma, Non-Small-Cell Lung | Secondary | Advanced Stage IIIB | High Thymidylate Synthase Expression

Italy
Bristol-Myers Squibb
Exelixis

Completed

Multiple Ascending Dose (MAD) Combination in Subjects With Multiple Myeloma

Advanced Cancer, Various, NOS

United States
University Hospital Olomouc
Palacky University

Recruiting

Effect of Beta-alanine and Pelvic Floor Muscle Training on Urinary Incontinence After Radical Prostatectomy (BELA) (BELA)

Urinary Incontinence | Prostate Cancer | Radical Prostatectomy | Pelvic Floor Muscle Training | Beta-Alanine

Czechia
Hospital de Clinicas de Porto Alegre

Unknown

Pentafecta Outcomes After Robot-assisted Laparoscopic Radical Prostatectomy

Urinary Incontinence | Erectile Dysfunction | Prostate Cancer | Complication of Surgical Procedure

Brazil
Johns Hopkins University

Withdrawn

Health Interventions in Men Undergoing Radical Prostatectomy (HIM-UP)

Urinary Incontinence | Prostate Cancer | Erectile Dysfunction Following Radical Prostatectomy

United States
Zhujiang Hospital
Guangdong Xiangxue Precision Medical Technology Co., Ltd.; Xiangxue Life Science... and other collaborators

Completed

To Evaluate the Efficacy of NY-ESO-1-specific T Cell Receptor Affinity Enhancing Specific T Cell in Solid Tumors

Solid Tumor | Breast Cancer Stage IV | Gastric Cancer Stage IV | Ovarian Cancer Stage IV | Liver Cancer Stage IV | Esophageal Cancer, Stage IV | Bone and Soft Tissue Tumors | Bladder Carcinoma Stage IV | Prostate Carcinoma Stage IV | Thyroid Cancer Stage IV

China
ADC Therapeutics S.A.

Terminated

Study of ADCT-301 in Patients With Selected Advanced Solid Tumors

Melanoma | Renal Cell Carcinoma | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Fallopian Tube Cancer | Bladder Cancer | Non-small Cell Lung Cancer | Pancreas Cancer | Colo-rectal Cancer | Triple-negative Breast Cancer | Advanced Solid Tumors With Literature Evidence of CD25(+) Treg Content | Head and Neck...

United States, Belgium, United Kingdom
Merck Sharp & Dohme LLC

Recruiting

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

Cervical Cancer | Small Cell Lung Carcinoma | Neuroendocrine Tumor | Advanced Solid Tumors | Mesothelioma | Vulvar Cancer | Cholangiocarcinoma | Bile Duct Cancer | Endometrial Cancer | Advanced Cancer | Cervical Carcinoma | Endometrial Carcinoma | Thyroid Carcinoma | Thyroid Cancer | Anal Cancer | Colorectal Carcinoma | Carcinoid... and other conditions

Canada, France, Germany, Italy, Mexico, Netherlands, Poland, Russian Federation, Taiwan, United States, Brazil, Colombia, Israel, Korea, Republic of, Norway, Philippines, South Africa, Spain, Australia, Denmark, Chile, Portugal, Peru
Novartis Pharmaceuticals

Completed

Dose Finding Study of RAD001 (Everolimus, Afinitor®) in Combination With BEZ235 in Patients With Advanced Solid Tumors

Metastatic Renal Cell Carcinoma | Advanced Solid Tumors | Metastatic Breast Cancer

Spain, Belgium, Italy, France, United States, New Zealand, United Kingdom
Revolution Medicines, Inc.

Recruiting

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Advanced Solid Tumors | Non-small Cell Lung Cancer (NSCLC) | Pancreatic Ductal Adenocarcinoma (PDAC) | Colorectal Cancer (CRC)

United States
University of Alabama at Birmingham

Completed

Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy (RELIEF)

Breast Cancer | Anesthesia, Local | Mastectomy | Narcotic Use

United States
Compugen Ltd
Bristol-Myers Squibb

Active, not recruiting

COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.

Breast Cancer | Ovarian Cancer | Lung Cancer | Triple Negative Breast Cancer | Endometrial Cancer | Advanced Cancer | Colo-rectal Cancer | Ovarian Neoplasm | Neoplasm Malignant | Lung Neoplasm

United States
Exelixis

Active, not recruiting

Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Renal Cell Carcinoma | Head and Neck Cancer | Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Triple Negative Breast Cancer | Endometrial Cancer | Castration-resistant Prostate Cancer | Urothelial Carcinoma | Differentiated Thyroid Cancer | Gastroesophageal... and other conditions

United States, Australia, Belgium, France, Germany, Italy, Netherlands, Spain, United Kingdom
Ankyra Therapeutics, Inc

Recruiting

Phase I Study of ANK-101 in Advanced Solid Tumors (ANCHOR)

Solid Tumor | Non Small Cell Lung Cancer | Advanced Solid Tumor | Metastatic Solid Tumor | Malignant Solid Tumor | Cutaneous Tumor | Subcutaneous Tumor | Metastasis to Soft Tissue

United States, Canada
National Cancer Centre, Singapore
Singapore Translational Cancer Consortium; Genome Institute of Singapore; Cancer...

Recruiting

Phase-2 Dacomitinib Study on Patients With EGFR-Driven Advanced Solid Tumours With Low EGFR-AS1 IncRNA Expr or Other Novel Emerging Biomarkers

Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Advanced Solid Tumours

Singapore
Pfizer

Completed

Study In Patients With Kidney Cancer Treated With Sutent

Renal Cancer | Advanced or Metastatic Renal Cell Carcinoma

Slovakia
Gilead Sciences

Completed

Study of Sacituzumab Govitecan-hziy (IMMU-132) in Adults With Epithelial Cancer

Cervical Cancer | Urinary Bladder Neoplasms | Small Cell Lung Cancer | Hepatocellular Carcinoma | Pancreatic Cancer | Esophageal Cancer | Ovarian Epithelial Cancer | Glioblastoma Multiforme | Gastric Adenocarcinoma | Triple Negative Breast Cancer | Endometrial Cancer | Non-small Cell Lung Cancer | Renal Cell Cancer and other conditions

United States
OncoResponse, Inc.

Recruiting

A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents

Melanoma | Cancer | Non Small Cell Lung Cancer | Metastatic Cancer | Advanced Solid Tumor | Leiomyosarcoma | Head and Neck Squamous Cell Carcinoma | Liposarcoma | Malignant Neoplasm | Tumor, Solid

United States
Sandoz

Completed

Multi-level Evaluation of Chemotherapy-induced Febrile Neutropenia Prophylaxis, Outcomes, and Determinants With Granulocyte-colony Stimulating Factor (Monitor-GCSF)

B-cell Lymphoma | Cancer | Breast Cancer | Multiple Myeloma | Ovarian Cancer | Lung Cancer | Febrile Neutropenia | Prostate Cancer | Bladder Cancer

Germany, Italy, Poland, Hungary, Romania, Austria, Belgium, Czech Republic, France, Spain, Switzerland, United Kingdom
M.D. Anderson Cancer Center
Celgene

Completed

Lenalidomide in Combination With Bevacizumab, Sorafenib, Temsirolimus, or 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX)

Advanced Cancers

United States
Incyte Corporation

Completed

INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors

Hepatocellular Carcinoma | Colorectal Cancer | Ovarian Cancer | Non Small Cell Lung Cancer | Squamous Cell Carcinoma of Head and Neck | Bladder Cancer | Triple Negative Breast Cancer | Pancreatic Ductal Adenocarcinoma | Castration Resistant Prostate Cancer | Gastric/ Gastroesophageal Junction | Squamous Carcinoma...

United States, Spain, France, United Kingdom, Italy, Belgium
Kymab Limited
Sanofi

Active, not recruiting

Safety and Efficacy of KY1044 and Atezolizumab in Advanced Cancer

Melanoma | Renal Cell Carcinoma | Cervical Cancer | Hepatocellular Carcinoma | Gastric Cancer | Pancreatic Cancer | Esophageal Cancer | Metastatic Cancer | Squamous Cell Carcinoma of Head and Neck | Triple Negative Breast Cancer | Non-small Cell Lung Cancer | Advanced Cancer

United States, Hungary, Italy, Poland, Taiwan, United Kingdom
Charite University, Berlin, Germany

Not yet recruiting

Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors (HETERERO)

Sarcoma | Cervical Cancer | Esophageal Cancer | Rectal Cancer | Prostate Cancer | Neuroendocrine Tumors | Pancreas Cancer | Anal Cancer | Squamous Cell Carcinoma | Recurrent Cancer

Germany
Revolution Medicines, Inc.

Recruiting

Study of RMC-9805 in Participants With KRASG12D-Mutant Solid Tumors

Advanced Solid Tumors | Non-small Cell Lung Cancer (NSCLC) | Pancreatic Ductal Adenocarcinoma (PDAC) | Colorectal Cancer (CRC)

United States
SWOG Cancer Research Network
National Cancer Institute (NCI)

Active, not recruiting

Combination Treatment (Talazoparib Plus Avelumab) for Stage IV or Recurrent Non-Squamous Non-Small Cell Lung Cancer With STK11 Gene Mutation (A LUNG-MAP Treatment Trial)

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Advanced Lung Non-Squamous Non-Small Cell Carcinoma | Recurrent Lung Non-Squamous Non-Small Cell Carcinoma

United States
Carey Anders, M.D.
Seagen Inc.

Recruiting

Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib (BRIDGET)

Advanced Breast Cancer | Brain Metastases | Human Epidermal Growth Factor 2 Positive Carcinoma of Breast

United States
National Cancer Institute (NCI)

Active, not recruiting

Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IV Lung Cancer AJCC v8 | Advanced Lung Non-Small Cell Carcinoma

United States
BicycleTx Limited

Recruiting

Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression

Head and Neck Cancer | Ovarian Cancer | Triple Negative Breast Cancer | Non-small Cell Lung Cancer | Advanced Solid Tumor Historically Known for High EphA2 Expression | Urothelial Cancer | Gastric/Upper Gastrointestinal Cancer

United States, Belgium, Korea, Republic of, Spain, United Kingdom
University of Michigan Rogel Cancer Center

Terminated

Phase I Study of Vorinostat in Combination With Docetaxel in Patients With Advanced and Relapsed Solid Malignancies.

Prostate Cancer | Bladder Cancer | Urothelial Carcinoma | Non-Small-Cell Lung Carcinoma

United States
The Netherlands Cancer Institute
Daiichi Sankyo, Inc.

Not yet recruiting

Whole Body HER3 Quantification With Radiolabelled Patritumab Deruxtecan (HER3-DXd) PET/CT

EGFR Gene Mutation | Non-Small Cell Lung Carcinoma | Advanced Non-Small Cell Squamous Lung Cancer
Bruno Bockorny
Dana-Farber Cancer Institute; Agenus Inc.

Not yet recruiting

AGEN1423 Plus Balstilimab With or Without Chemo in Pancreatic Cancer

Pancreatic Cancer | Pancreatic Ductal Adenocarcinoma | Advanced Pancreatic Ductal Adenocarcinoma

United States
Haihe Biopharma Co., Ltd.

Recruiting

Study to Evaluate the Safety, Tolerate, Pharmacokinetics and Preliminary Efficacy of CYH33

Advanced Solid Tumors

China
Memorial Sloan Kettering Cancer Center
Medivation, Inc.

Completed

Enzalutamide in Patients With Androgen Receptor Positive (AR+) Ovarian, Primary Peritoneal or Fallopian Tube Cancer and One, Two or Three Prior Therapies

Primary Peritoneal Carcinoma | Fallopian Tube | Advanced Epithelial Ovarian | Recurrent Epithelial Ovarian

United States

Clinical Trials on Locally Advanced Prostate Cancer

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