Clinical Trials on MPN in United Kingdom

Total 172 results

H. Lundbeck A/S

Completed

D2 Dopamine Receptor Occupancy After Oral Dosing of Lu AF35700 in Healthy Men Using [11C]-PHNO as Tracer Compound

Healthy Men

United Kingdom
King's College London

Completed

Absorption, Metabolism and Excretion of Artichoke Polyphenols in Healthy Individuals

Healthy Men and Women

United Kingdom
King's College London
Lucozade Ribena Suntory

Completed

The Effects of a Polyphenol-enriched Fruit Drink on Metabolic Health

Healthy Men and Women

United Kingdom
Vernalis (R&D) Ltd

Completed

Single and Multiple Ascending Dose Study of V158866 in Healthy Volunteers

First in Man Study

United Kingdom
King's College London
Lucozade Ribena Suntory

Completed

The Effects of a Polyphenol-enriched Fruit Drink on Metabolic Health(2)

Healthy Men and Women

United Kingdom
King's College London
Naturex-Dbs

Completed

Aronia Berry Consumption on Vascular Function

Healthy Young Men

United Kingdom
King's College London

Completed

The Effects of Dragon Fruit Consumption on Vascular Function.

Healthy Men and Women

United Kingdom
King's College London

Completed

Effects of an Organic Plant-rich Diet on Gut Microbiome and Vascular Function (ORGAMIC Pilot Study)

Healthy Men and Women

United Kingdom
H. Lundbeck A/S

Completed

Bioequivalence Study in Healthy Men and Women to Compare Two Pharmaceutical Formulations of Flupentixol/Melitracen (Deanxit®)

Healthy Men and Women

United Kingdom
King's College London
Naturex-Dbs

Completed

Randomized, Double-blind, Controlled Study to Evaluate the Effect of Concord Grape Extract on Vascular Function in Healthy Men and Women (CONCARD)

Healthy Men and Women

United Kingdom
University of Oxford

Completed

Understanding Immunity Persistence After Adolescent MenC Vaccination

Antibody Persistance After Booster Dose of Men C Vaccine

United Kingdom
King's College London

Completed

Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia

Healthy Men | Raised Fasting Plasma Triacylglycerol Concentrations

United Kingdom
King's College London

Completed

The Acute Effects of Interesterification of Commercially Used Fats on Postprandial Lipaemia and Satiety (INTERFAT)

Healthy Men

United Kingdom
Sigilon Therapeutics, Inc.

Withdrawn

Safety and Efficacy of Encapsulated Allogeneic MPS-1 Therapy

MPS I | MPS1-S | MPS1-HS

Brazil, United Kingdom
Michael Savona
Incyte Corporation; Astex Pharmaceuticals, Inc.; Theradex

Recruiting

Active Myeloid Target Compound Combinations in MDS/MPN Overlap Syndromes Overlap Syndromes (ABNL-MARRO) (ABNL-MARRO)

MDS/MPN

United States
Alexion Pharmaceuticals

Terminated

A Open Label Study in Previously Studied, SBC-103 Treatment Naïve MPS IIIB Subjects to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics/Efficacy of SBC-103 Administered Intravenously (CL01-T)

Mucopolysaccharidosis III, Type B (MPS IIIB) | Sanfilippo B

United Kingdom
Alexion Pharmaceuticals

Completed

Evaluation of Blood Brain Barrier Integrity and Structural Abnormalities in MPS IIIB Patients Using Multimodal Magnetic Resonance Imaging

MPS IIIB (Sanfilippo B Syndrome)

United Kingdom
Shire

Completed

Safety, Tolerability, Ascending Dose and Dose Frequency Study of rhHNS Via an IDDD in MPS IIIA Patients

Mucopolysaccharidosis (MPS)

United Kingdom, Netherlands
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Active, not recruiting

Study of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception

Healthy | Men | Male Contraception

United States, Sweden, Chile, Italy, Kenya, United Kingdom, Zimbabwe
CSL Behring

Completed

A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)

Multifocal Motor Neuropathy (MMN)

Switzerland, Italy, United Kingdom
Incyte Corporation

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement - (FIGHT-203)

MPN (Myeloproliferative Neoplasms)

United States, France, United Kingdom, Spain, Canada, Japan, Germany, Switzerland, Belgium, Austria, Italy
Gliknik Inc.

Recruiting

Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease

First in Man Study to Evaluate Initial Safety

United Kingdom
Celgene

Completed

Study of Pomalidomide in Persons With Myeloproliferative-Neoplasm-Associated Myelofibrosis and RBC-Transfusion-Dependence (RESUME)

Primary Myelofibrosis | MPN-associated Myelofibrosis

United States, Netherlands, France, Australia, Italy, United Kingdom, Canada, Germany, China, Spain, Belgium, Austria, Poland, Sweden, Japan, Russian Federation
USDA Beltsville Human Nutrition Research Center

Completed

Garlic Intake And Biomarkers Of Cancer Risk

Healthy Men | Healthy Women

United States
Metabolic Technologies Inc.

Completed

Effect of Whey and Albumin Protein on Plasma Levels of Amino Acids

Healthy Men and Women

United States
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Unknown

Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal Men

Healthy | Men | Male Contraception

United States
Walton Centre NHS Foundation Trust
Instituto Grifols, S.A.

Recruiting

Do IgG Level Variations in CIDP and MMN Patients Following Initial Intravenous IVIg Treatment Correlate With Ultimate Dosing (digG)

Chronic Inflammatory Demyelinating Polyradiculoneuropathy | Multifocal Motor Neuropathy (MMN)

United Kingdom
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Assess the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Mycophenolate Mofetil in Healthy Adult Subjects

Healthy Subjects | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Plasma Mycophenolic Acid (MPA) | Pharmacokinetics of Plasma Phenolic Glucuronide of MPA (MPAG)

United States
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Injectable DMAU for Male Contraception in Healthy Male Volunteers (CCN015) (DMAU)

Healthy Men | Male Contraception

United States
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Unknown

28-Day Repeat-Dose, Dose Escalation Study of 11-β Methyl Nortestosterone Dodecylcarbonate (11β-MNTDC) in Healthy Men (CCN014A)

Healthy Men | Male Contraception

United States
Leonard S. Marks, M.D.
Watson Pharmaceuticals; Solvay Pharmaceuticals

Completed

Study to Determine the Effects of Testosterone Replacement Therapy in Aging Men With Androgen Deficiency

Men With Low Testosterone Levels

United States
Benjamin Tomlinson

Recruiting

5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies

Myelodysplastic Syndromes | MDS/MPN Crossover Syndromes

United States
University of Alabama at Birmingham

Recruiting

Peripheral Blood Flow Responses to Electromagnetic Energy

Exposure to Man-made Visible Light

United States
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Unknown

Single Dose, Dose-Ranging Study of 11-β Methyl Nortestosterone Dodecylcarbonate (11β-MNTDC) in Healthy Men (CCN014)

Healthy Men | Male Contraception

United States
Lundquist Institute for Biomedical Innovation at...
National Institutes of Health (NIH); University of Washington

Completed

Phase 1 Study of Dimethandrolone Undecanoate in Healthy Men (DMAUPhase1)

Healthy Men | Male Contraception

United States
Incyte Corporation

Terminated

A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis

MPN (Myeloproliferative Neoplasms)

United States
Allievex Corporation

Completed

A Study of Mucopolysaccharidosis Type IIIB (MPS IIIB)

Mucopolysaccharidosis Type IIIB | Mucopolysaccharidosis Type 3 B | MPS III B | MPS 3 B

United States, Spain, Turkey, Taiwan, Australia, Colombia, Germany, United Kingdom
Procter and Gamble

Completed

Study to Evaluate the Effects of Psyllium on Blood Glucose

Healthy Men

United States
Incyte Corporation

Completed

A Study of Itacitinib in Combination With Low-Dose Ruxolitinib or Itacitinib Alone Following Ruxolitinib in Participants With Myelofibrosis

MPN (Myeloproliferative Neoplasms)

United States, Netherlands, Austria
BioMarin Pharmaceutical

Completed

A Study to Evaluate the Safety, Tolerability and Efficacy of BMN 110 in Subjects With Mucopolysaccharidosis IVA

MPS IV A

United Kingdom
VA Office of Research and Development

Recruiting

A Balanced Reach Training Platform to Address Balance Disorders in Older and Neurologically Disabled Veterans (BRTP)

Older Men and Women With High Fall Risk

United States
Charles Drew University of Medicine and Science
University of California, Los Angeles; University of Southern California; Los...

Completed

Reducing HIV Risk With High Risk HIV Negative Black MSM-Passport to Wellness (PtW)

HIV | Men

United States
Lateral Pharma Pty Ltd

Completed

Oral LAT8881 in Neuropathic Pain

Neuropathic Pain | Diabetic Peripheral Neuropathy (DPN) | Post Herpetic Neuralgia (PHN)

Australia, United Kingdom
Apellis Pharmaceuticals, Inc.

Active, not recruiting

An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis (VALE)

C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Dense Deposit Disease | DDD | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative...

United States, Australia, Brazil, Czechia, France, Italy, Korea, Republic of, Netherlands, Spain, Switzerland, United Kingdom
Alexion Pharmaceuticals

Completed

Safety, Pharmacokinetics, and Pharmacodynamics/Efficacy of SBC-103 in Mucopolysaccharidosis III, Type B (MPS IIIB)

Mucopolysaccharidosis IIIB

United States, United Kingdom, Spain
Memorial Sloan Kettering Cancer Center

Completed

The First-in-human Phase I Trial of PU-H71 in Patients With Advanced Malignancies

Lymphoma | Metastatic Solid Tumor | Myeloproliferative Neoplasms (MPN)

United States
BioMarin Pharmaceutical

Terminated

A Study to Evaluate the Long-Term Efficacy and Safety of BMN 110 in Patients With Mucopolysaccharidosis IVA (Morquio A Syndrome)

Morquio A Syndrome | MPS IV A | Mucopolysaccharidosis IVA

United Kingdom
University of California, San Francisco
Duke University

Recruiting

In Utero Enzyme Replacement Therapy for Lysosomal Storage Diseases (IUERT)

Wolman Disease | MPS IVA | Pompe Disease Infantile-Onset | Gaucher Disease, Type 2 | MPS VI | MPS I | Gaucher Disease, Type 3 | MPS II | Mps VII

United States
Lundquist Institute for Biomedical Innovation at...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Project 1: Diet and Exercise Modulate the Sperm Epigenome in Men

Obese | Healthy Lifestyle | Men

United States
Allievex Corporation

Enrolling by invitation

Safety, Tolerability and Efficacy of ICV AX 250 Treatment in MPS IIIB -OLE

MPS III B

United States, Germany, Turkey, United Kingdom, Colombia

Clinical Trials on MPN in United Kingdom

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