Clinical Trials on Malignant Skull Base Neoplasm

Total 4328 results

Mayo Clinic
National Cancer Institute (NCI)

Completed

Brain Imaging Changes Following Proton Therapy for Pediatric Primary Central Nervous System and Base of Skull Tumors

Malignant Central Nervous System Neoplasm | Malignant Skull Base Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors

Osteoradionecrosis | Malignant Skull Base Neoplasm | Malignant Oral Cavity Neoplasm

United States
University of Pittsburgh

Recruiting

Molecular and Cellular Characterization of Skull Base Tumors

Skull Base Neoplasm | Cellular Pathology

United States
Icahn School of Medicine at Mount Sinai
NX Development Corp

Recruiting

The Role of 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Cancers: a Pilot Trial

Neoplasm | Skull Base Neoplasm

United States
M.D. Anderson Cancer Center

Recruiting

Assessment of Functional and Symptom Outcomes for Survivors of Paranasal Sinus, Nasopharyngeal and Skull Base Tumors

Tumors

United States
Massachusetts General Hospital
National Cancer Institute (NCI)

Completed

In-Room PET in Proton Radiation Therapy

Brain Tumor | Head and Neck Tumor | Skull Base Tumor

United States
Baptist Health South Florida
Nicklaus Children's Hospital f/k/a Miami Children's Hospital

Active, not recruiting

Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.

Brain Cancer | Brain Tumor | Skull Base Tumor

United States
Fundacion Clinic per a la Recerca Biomedica

Completed

Effects on the Awakening With Laryngeal Mask vs Endotracheal Tube in Endoscopic Endonasal Transsphenoidal Base Surgery

Skull Base Neoplasms

Spain
Assiut University

Unknown

Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts

Skull Base Neoplasms

Egypt
Ohio State University

Completed

ICG Use in Angiography for Nasoseptal Flap Harvest (ICG)

Skull Base Neoplasms

United States
Integra LifeSciences Corporation

Withdrawn

The CUSA Clarity Bone Tip Study

Cranial Skull Base Bone Removal

Italy, Germany, Greece
Ricardo L. Carrau, MD

Unknown

Olfactory Function Following Endoscopic Endonasal Skull Base Surgery (UPSIT)

Skull Base Pathology

United States
Ohio State University

Completed

Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery (ICG2)

Neoplasms | Bone Diseases | Musculoskeletal Disease | Skull Base Neoplasms | Skull Neoplasms | Bone Neoplasm

United States
CNAO National Center of Oncological Hadrontherapy
Dept. of Electronics, Informatics, Bioengineering, Politecnico di Milano,...

Recruiting

Multi-parametric Imaging in Personalized Radiotherapy

Skull Base Chordoma

Italy
University Medical Centre Ljubljana
University of Ljubljana, Faculty of Medicine

Recruiting

Prospective Study of Sinonasal and Skull-base Tumours Management (Sinonasal_Tu)

Skull Base Neoplasms | Sinus Disease | Nasal Neoplasm | Nasal Neoplasm Benign | Skull Base Osteomyelitis | Sinonasal Disorder

Slovenia
Johns Hopkins University
North American Skull Base Society

Recruiting

Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

Anosmia | Skull Base Neoplasms

United States
Taipei Veterans General Hospital, Taiwan

Unknown

Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base

Quality of Life | Acupuncture | Neuromuscular Blockade | Complication of Treatment | Tumor, Brain | Skull Base Tumor | Cerebellopontine Angle Tumor

Taiwan
Institut Curie

Active, not recruiting

Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers (PROTONCHORDE01)

Skull Base Chordoma | Vertebral Chordoma

France
Sidney Kimmel Comprehensive Cancer Center at Johns...
Canon Medical Systems, USA

Not yet recruiting

Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma (Canon)

Chordoma of Sacrum | Chordoma of Spine | Chordoma of Skull Base
University Hospital Tuebingen

Completed

Simulator Training for Direct Ophthalmoscopy

Simulator-based Medical Skill Training
University of Chicago
Stand Up To Cancer

Recruiting

Novel Outreach Methods to Increase Enrollment to Early Phase Clinical Trials

Cancer | Malignant Neoplasm | Malignancy

United States
Xiangya Hospital of Central South University

Completed

Clinical Outcomes and Decision-making Choice of Skull Base Approaches for Petroclival Meningiomas

Skull Base Meningioma

China
Indiana University
3-D Matrix Medical Technology

Not yet recruiting

Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery

Skull Base Neoplasms | Cerebrospinal Fluid Leakage | Nasal; Hypertrophy, Mucous Membrane (Septum)

United States
University Hospital Heidelberg

Withdrawn

Comparison of Proton and Carbon Ion Radiotherapy With Advanced Photon Radiotherapy in Skull Base Meningiomas: The PINOCCHIO Trial. (PINOCCHIO)

Skull Base Meningioma

Germany
CNAO National Center of Oncological Hadrontherapy

Recruiting

HRQoL in Patients With Solid Tumors Treated With Hadrontherapy (HadroQoL)

Head and Neck Cancer | Brain Cancer | Skull Base--Cancer

Italy
University of Virginia

Unknown

Prospective Quality of Life Study in Pituitary Surgery

Postoperative Period | Post Operative Care | Endoscopic Skull Base Surgery
Royal Marsden NHS Foundation Trust
University College London Hospitals; University of Southampton; St George's University... and other collaborators

Completed

Information Needs Around Parenteral nUTrition in Cancer (INPUT)

Neoplasms | Cancer | Tumor | Malignant Neoplasm | End Stage Cancer | Malignancy | Terminal Cancer

United Kingdom
Vanderbilt University

Completed

Forces During Skull Base Surgery

Pituitary | Robotics | Sinus Surgery | Skull Base | Endonasal Surgery

United States
Massachusetts General Hospital
M.D. Anderson Cancer Center; National Cancer Institute (NCI)

Active, not recruiting

High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull

Chordoma of Sacrum | Chordoma of Spine | Chordoma of Base of Skull | Chondrosarcoma of the Spine | Chondrosarcoma of the Sacrum

United States
St. Paul's Sinus Centre

Not yet recruiting

Utility of Indocyanine Green Fluorescence in Endoscopic Sinonasal and Skull Base Surgery (NIRFICG)

Chronic Sinusitis | Skull Base Neoplasms | Tumor of Nasal Sinus | Posterior Epistaxis
University of Illinois at Chicago
Millennium Pharmaceuticals, Inc.

Completed

Phase I Study of MLN8237 and Pazopanib in Patients With Solid Tumors

Melanoma | Head and Neck Neoplasms | Malignant Neoplasm of Breast | Malignant Neoplasm of Thorax | CNS Malignancy | Malignant Neoplasm of Gastrointestinal Tract | Genitourinary Neoplasms Malignancy and Gender Unspecified

United States
Ohio State University

Recruiting

Cognitive Status After Removal of Skull Base Meningioma

Cognitive Impairment | Cognitive Decline | Meningioma | Skull Base Meningioma | Frontal Meningioma | Temporal Meningioma | Post-Surgical Cognition

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Muscadine Grape Skin Extract in Treating Patients With Malignancy That Is Metastatic or Cannot Be Removed by Surgery

Metastatic Malignant Neoplasm | Unresectable Malignant Neoplasm | Advanced Malignant Neoplasm

United States
National Cancer Institute (NCI)

Recruiting

Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and M1774 for Advanced Solid Tumors

Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations

Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
National Cancer Institute (NCI)

Completed

Testing the Addition of the Anti-Cancer Drug Talazoparib to the Combination of Carboplatin and Paclitaxel for the Treatment of Advanced Cancer

Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Lucid Lane, Inc
M.D. Anderson Cancer Center

Recruiting

Digital and Behavioral Tele-Health Tapering Program for Lowering Dependence on Opioids in Patients Undergoing Surgery

Malignant Solid Neoplasm | Malignant Thoracic Neoplasm | Malignant Head and Neck Neoplasm | Malignant Abdominal Neoplasm

United States
National Cancer Institute (NCI)

Recruiting

Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With AKT Mutations, A ComboMATCH Treatment Trial

Locally Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States, Puerto Rico
University of California, San Francisco

Completed

Integrative Palliative Care/Psycho-Oncology Telehealth Intervention in Patients With Advanced Cancer

Advanced Malignant Solid Neoplasm | Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies

Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Liver | Metastatic Malignant Neoplasm in the Lung

United States
M.D. Anderson Cancer Center

Active, not recruiting

Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

Refractory Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Videos and Questionnaires in Assessing Patient Perception of Physician's Compassion, Communication Skills, and Professionalism During Clinic Visits

Malignant Neoplasm | Metastatic Malignant Neoplasm | Advanced Malignant Neoplasm | Recurrent Malignant Neoplasm | Locally Advanced Malignant Neoplasm

United States
Assiut University

Not yet recruiting

Validity of Mediastinal Blood Pool SUV Ratio

Validity of Blood Pool SUV Ratio in Identification of Malignancy in Case of Diseased Liver
National Cancer Institute (NCI)

Not yet recruiting

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm
National Cancer Institute (NCI)

Recruiting

Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
M.D. Anderson Cancer Center

Recruiting

Cabozantinib and Pamiparib for the Treatment of Advanced of Refractory Solid Tumors

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm

United States
National Cancer Institute (NCI)

Active, not recruiting

Pembrolizumab and Recombinant Interleukin-12 in Treating Patients With Solid Tumors

Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Ribociclib and Gemcitabine Hydrochloride in Treating Patients With Advanced or Metastatic Solid Tumors

Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
M.D. Anderson Cancer Center

Terminated

Pevonedistat and Pembrolizumab for the Treatment of dMMR/MSI-H Metastatic or Locally Advanced Unresectable Solid Tumor

Locally Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States

Clinical Trials on Malignant Skull Base Neoplasm

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